SE378110B - - Google Patents
Info
- Publication number
- SE378110B SE378110B SE7206645A SE664572A SE378110B SE 378110 B SE378110 B SE 378110B SE 7206645 A SE7206645 A SE 7206645A SE 664572 A SE664572 A SE 664572A SE 378110 B SE378110 B SE 378110B
- Authority
- SE
- Sweden
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7206645A SE378110B (fi) | 1972-05-19 | 1972-05-19 | |
ZA732956A ZA732956B (en) | 1972-05-19 | 1973-05-01 | A process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
IL42154A IL42154A (en) | 1972-05-19 | 1973-05-01 | Process for the separation of stereoisomeric mixtures of 16a,17a-alkylidenedioxy-pregnane derivatives into their components and components obtained thereby |
AU55252/73A AU478324B2 (en) | 1972-05-19 | 1973-05-04 | A process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
CY1012A CY1012A (en) | 1972-05-19 | 1973-05-09 | Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtainned thereby |
DE2323216A DE2323216C3 (de) | 1972-05-19 | 1973-05-09 | Verfahren zur Auftrennung von Stereoisomerengemischen von Pregna-1,4dien-11 -ol-33-dionen |
GB2219573A GB1428416A (en) | 1972-05-19 | 1973-05-09 | Process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby |
FI731543A FI50711C (fi) | 1972-05-19 | 1973-05-14 | Menetelmä kortikosteroidien stereoisomeeriseosten jakamiseksi stereois omeerikomponenteikseen. |
US359913A US3928326A (en) | 1972-05-19 | 1973-05-14 | Process for the separation of stereoisomeric mixtures into their components and components obtained hereby |
DK277073A DK133249C (da) | 1972-05-19 | 1973-05-17 | Fremgangsmade til opspaltning af stereoisomerblandinger af 16alfa,17alfa-alkylidendioxypregnan-11beta,21-diol-3,20-dioner |
NLAANVRAGE7306979,A NL175917C (nl) | 1972-05-19 | 1973-05-18 | Werkwijze voor het splitsen van isomere mengsels van steroiden, werkwijze voor het bereiden van een farmaceutisch preparaat en aldus verkregen gevormd farmaceutisch preparaat. |
BE131271A BE799728A (fr) | 1972-05-19 | 1973-05-18 | Procede pour la separation de steredoisomeres de certains steroides |
FR7318126A FR2185406B1 (fi) | 1972-05-19 | 1973-05-18 | |
CA171,781A CA1003402A (en) | 1972-05-19 | 1973-05-18 | Process for the separation of steroisomeric mixtures into their components and components obtained hereby |
SU1918554A SU468408A3 (ru) | 1972-05-19 | 1973-05-18 | Способ разделени стереоизомерных смесей |
JP5623473A JPS547794B2 (fi) | 1972-05-19 | 1973-05-19 | |
US05/629,390 US3992534A (en) | 1972-05-19 | 1975-11-06 | Compositions and method of treating with component B of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steriods |
US05/629,493 US3996359A (en) | 1972-05-19 | 1975-11-06 | Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith |
KE2969A KE2969A (en) | 1972-05-19 | 1979-06-20 | A process for the separation of sterioisomeric mixtures of steroid acetalsinto, their components and components obtained thereby |
HK490/79A HK49079A (en) | 1972-05-19 | 1979-07-19 | A process for the separation of stereoisomeric mixtures of steroid acetals into their components and components obtained thereby |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE7206645A SE378110B (fi) | 1972-05-19 | 1972-05-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
SE378110B true SE378110B (fi) | 1975-08-18 |
Family
ID=20269238
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE7206645A SE378110B (fi) | 1972-05-19 | 1972-05-19 |
Country Status (17)
Country | Link |
---|---|
US (1) | US3928326A (fi) |
JP (1) | JPS547794B2 (fi) |
BE (1) | BE799728A (fi) |
CA (1) | CA1003402A (fi) |
CY (1) | CY1012A (fi) |
DE (1) | DE2323216C3 (fi) |
DK (1) | DK133249C (fi) |
FI (1) | FI50711C (fi) |
FR (1) | FR2185406B1 (fi) |
GB (1) | GB1428416A (fi) |
HK (1) | HK49079A (fi) |
IL (1) | IL42154A (fi) |
KE (1) | KE2969A (fi) |
NL (1) | NL175917C (fi) |
SE (1) | SE378110B (fi) |
SU (1) | SU468408A3 (fi) |
ZA (1) | ZA732956B (fi) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404200A (en) * | 1980-12-04 | 1983-09-13 | Aktiebolaget Draco | 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL188581C (nl) * | 1974-07-15 | 1992-08-03 | Akzo Nv | Werkwijze voor het bereiden van 11beta-hydroxy-18-alkylestraanverbindingen. |
ZA763131B (en) * | 1975-05-27 | 1978-01-25 | Syntex Inc | Use of flunisolide to treat respiratory diseases |
IT1196142B (it) * | 1984-06-11 | 1988-11-10 | Sicor Spa | Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti |
SE8604059D0 (sv) * | 1986-09-25 | 1986-09-25 | Astra Pharma Prod | A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives |
GR1001529B (el) * | 1990-09-07 | 1994-03-31 | Elmuquimica Farm Sl | Μέ?οδος για την λήψη νέων 21-εστέρων της 16-17-ακετάλης της πρ να-1,4-διενο-3,20-διόνης. |
SE9100341D0 (sv) * | 1991-02-04 | 1991-02-04 | Astra Ab | Novel steroids |
BR9307746A (pt) * | 1993-01-08 | 1995-11-14 | Astra Ab | Derivados de esteróides especificos para otratamento de cólon e ileo |
DE19635498A1 (de) * | 1996-09-03 | 1998-03-26 | Byk Gulden Lomberg Chem Fab | Verfahren zur Epimerenanreicherung |
IT1291288B1 (it) | 1997-04-30 | 1999-01-07 | Farmabios Srl | Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22. |
US6266556B1 (en) | 1998-04-27 | 2001-07-24 | Beth Israel Deaconess Medical Center, Inc. | Method and apparatus for recording an electroencephalogram during transcranial magnetic stimulation |
IL144900A (en) | 2001-08-14 | 2013-12-31 | Neurim Pharma 1991 | Melatonin and drugs containing it for use in the treatment of primary insomnia, and the manufacture of those drugs |
AR045536A1 (es) * | 2003-08-29 | 2005-11-02 | Ranbaxy Lab Ltd | Inhibidores de la fosfodiesterasa tipo -iv |
EP1694655A2 (en) * | 2003-11-26 | 2006-08-30 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
AU2005233569B2 (en) | 2004-04-09 | 2010-08-19 | Merck Sharp & Dohme Corp. | Inhibitors of Akt activity |
ATE550019T1 (de) | 2005-05-17 | 2012-04-15 | Merck Sharp & Dohme | Cis-4-ä(4-chlorophenyl)sulfonylü-4-(2,5- difluorophenyl)cyclohexanepropansäure zur behandlug von krebs |
US7915286B2 (en) | 2005-09-16 | 2011-03-29 | Ranbaxy Laboratories Limited | Substituted pyrazolo [3,4-b] pyridines as phosphodiesterase inhibitors |
EP1948167A1 (en) * | 2005-10-19 | 2008-07-30 | Ranbaxy Laboratories, Ltd. | Compositions of phosphodiesterase type iv inhibitors |
US20090221664A1 (en) | 2005-10-19 | 2009-09-03 | Abhijit Ray | Pharmaceutical compositions of muscarinic receptor antagonists |
CA2664247A1 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Inhibitors of phosphodiesterase type-iv |
WO2008035316A2 (en) * | 2006-09-22 | 2008-03-27 | Ranbaxy Laboratories Limited | Phosphodiesterase inhibitors |
US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
ES2529147T3 (es) | 2006-12-26 | 2015-02-17 | Pharmacyclics, Inc. | Método para usar los inhibidores de la histona deacetilasa y monitorear biomarcadores en la terapia de combinación |
PL2109608T3 (pl) | 2007-01-10 | 2011-08-31 | Msd Italia Srl | Indazole podstawione grupą amidową jako inhibitory polimerazy poli(ADP-rybozy)-(PARP) |
US20080207659A1 (en) * | 2007-02-15 | 2008-08-28 | Asit Kumar Chakraborti | Inhibitors of phosphodiesterase type 4 |
MX2009009793A (es) * | 2007-03-14 | 2009-10-16 | Ranbaxy Lab Ltd | Derivados de pirazolo (3,4-b) piridina como inhibidores de fosfodiesterasa. |
US20110130403A1 (en) * | 2007-03-14 | 2011-06-02 | Ranbaxy Laboratories Limited | Pyrazolo [3, 4-b] pyridine derivatives as phosphodiesterase inhibitors |
CA2690191C (en) | 2007-06-27 | 2015-07-28 | Merck Sharp & Dohme Corp. | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
ITMI20080645A1 (it) | 2008-04-11 | 2009-10-12 | Ind Chimica Srl | Procedimento per la preparazione di budesonide |
EP2111861A1 (en) | 2008-04-21 | 2009-10-28 | Ranbaxy Laboratories Limited | Compositions of phosphodiesterase type IV inhibitors |
GB0900484D0 (en) | 2009-01-13 | 2009-02-11 | Angeletti P Ist Richerche Bio | Therapeutic agent |
WO2010114780A1 (en) | 2009-04-01 | 2010-10-07 | Merck Sharp & Dohme Corp. | Inhibitors of akt activity |
US8603521B2 (en) | 2009-04-17 | 2013-12-10 | Pharmacyclics, Inc. | Formulations of histone deacetylase inhibitor and uses thereof |
KR101451486B1 (ko) * | 2009-09-11 | 2014-10-22 | 키에시 파르마슈티시 엣스. 피. 에이. | N-치환된 이속사졸리딘 링과 함께 16, 17 위치 내에 응축된 항염증제로서의 프레그난 유도체 |
GB0916608D0 (en) | 2009-09-22 | 2009-11-04 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
BR112012008849A2 (pt) | 2009-10-14 | 2015-09-22 | Schering Corp | composto, composição farmacêutica, e, uso de um composto |
WO2011097594A2 (en) | 2010-02-08 | 2011-08-11 | Kinagen, Inc. | Therapeutic methods and compositions involving allosteric kinase inhibition |
EP2584903B1 (en) | 2010-06-24 | 2018-10-24 | Merck Sharp & Dohme Corp. | Novel heterocyclic compounds as erk inhibitors |
CN103068980B (zh) | 2010-08-02 | 2017-04-05 | 瑟纳治疗公司 | 使用短干扰核酸(siNA)的RNA干扰介导的联蛋白(钙粘蛋白关联蛋白质),β1(CTNNB1)基因表达的抑制 |
SI2606134T1 (sl) | 2010-08-17 | 2019-08-30 | Sirna Therapeutics, Inc. | RNA-INTERFERENČNO POSREDOVANO ZAVIRANJE IZRAŽANJA GENA VIRUSA HEPATITISA B (HBV) Z UPORABO KRATKE INTERFERENČNE NUKLEINSKE KISLINE (siNA) |
US8883801B2 (en) | 2010-08-23 | 2014-11-11 | Merck Sharp & Dohme Corp. | Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors |
WO2012030685A2 (en) | 2010-09-01 | 2012-03-08 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
EP2615916B1 (en) | 2010-09-16 | 2017-01-04 | Merck Sharp & Dohme Corp. | Fused pyrazole derivatives as novel erk inhibitors |
DK2632472T3 (en) | 2010-10-29 | 2018-03-19 | Sirna Therapeutics Inc | RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA) |
WO2012087772A1 (en) | 2010-12-21 | 2012-06-28 | Schering Corporation | Indazole derivatives useful as erk inhibitors |
IN2013MN02170A (fi) | 2011-04-21 | 2015-06-12 | Piramal Entpr Ltd | |
UA110853C2 (uk) | 2011-09-13 | 2016-02-25 | Фармасайклікс, Інк. | Лікарські форми інгібітора гістондеацетилази у комбінації з бендамустином та їхнє застосування |
EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
EP3919620A1 (en) | 2012-05-02 | 2021-12-08 | Sirna Therapeutics, Inc. | Short interfering nucleic acid (sina) compositions |
JP6453218B2 (ja) | 2012-08-24 | 2019-01-16 | ボード・オブ・リージエンツ,ザ・ユニバーシテイ・オブ・テキサス・システム | 疾患を治療するためのhif活性の複素環式修飾物質 |
US9155747B2 (en) * | 2012-09-13 | 2015-10-13 | Chiesi Farmaceutici S.P.A. | Isoxazolidine derivatives |
JP6280554B2 (ja) | 2012-09-28 | 2018-02-14 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | Erk阻害剤である新規化合物 |
PL2925888T3 (pl) | 2012-11-28 | 2018-03-30 | Merck Sharp & Dohme Corp. | Kompozycje i sposoby do stosowania w leczeniu nowotworów |
WO2014100065A1 (en) | 2012-12-20 | 2014-06-26 | Merck Sharp & Dohme Corp. | Substituted imidazopyridines as hdm2 inhibitors |
WO2014120748A1 (en) | 2013-01-30 | 2014-08-07 | Merck Sharp & Dohme Corp. | 2,6,7,8 substituted purines as hdm2 inhibitors |
US20160194368A1 (en) | 2013-09-03 | 2016-07-07 | Moderna Therapeutics, Inc. | Circular polynucleotides |
EP3475275B1 (en) | 2016-06-23 | 2024-04-10 | Merck Sharp & Dohme LLC | 3-aryl and heteroaryl substituted 5-trifluoromethyl oxadiazoles as histone deacetylase 6 (hdac6) inhibitors |
US10975084B2 (en) | 2016-10-12 | 2021-04-13 | Merck Sharp & Dohme Corp. | KDM5 inhibitors |
US10711032B2 (en) | 2016-11-08 | 2020-07-14 | Regeneron Pharmaceuticals, Inc. | Steroids and protein-conjugates thereof |
AU2018270784B2 (en) | 2017-05-18 | 2024-05-16 | Regeneron Pharmaceuticals, Inc. | Cyclodextrin protein drug conjugates |
SG11202006510XA (en) | 2018-01-08 | 2020-08-28 | Regeneron Pharma | Steroids and antibody-conjugates thereof |
KR20210008008A (ko) | 2018-05-09 | 2021-01-20 | 리제너론 파마슈티칼스 인코포레이티드 | 항-msr1 항체 및 이의 사용 방법 |
US11993602B2 (en) | 2018-08-07 | 2024-05-28 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
WO2020033284A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
BR112022012032A2 (pt) | 2019-12-17 | 2022-09-06 | Merck Sharp & Dohme Llc | Inibidores de prmt5 |
US20240116945A1 (en) | 2022-09-02 | 2024-04-11 | Merck Sharp & Dohme Llc | Exatecan-derived topoisomerase-1 inhibitors pharmaceutical compositions, and uses thereof |
WO2024091437A1 (en) | 2022-10-25 | 2024-05-02 | Merck Sharp & Dohme Llc | Exatecan-derived adc linker-payloads, pharmaceutical compositions, and uses thereof |
WO2024129628A1 (en) | 2022-12-14 | 2024-06-20 | Merck Sharp & Dohme Llc | Auristatin linker-payloads, pharmaceutical compositions, and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3133940A (en) * | 1956-04-10 | 1964-05-19 | Glaxo Group Ltd | Process for the separation of delta-1, 4-3-keto steroid compounds from mixtures thereof with other 3-keto steroids |
US3197469A (en) * | 1958-08-06 | 1965-07-27 | Pharmaceutical Res Products In | 16, 17-acetals and ketals of 6-halo-16, 17-dihydroxy steroids of the pregnane seriesand intermediates therefor |
US3048581A (en) * | 1960-04-25 | 1962-08-07 | Olin Mathieson | Acetals and ketals of 16, 17-dihydroxy steroids |
US3128238A (en) * | 1962-09-14 | 1964-04-07 | Lilly Co Eli | delta1-dehydrogenation of steroids by fermentation with actinoplanaceae |
-
1972
- 1972-05-19 SE SE7206645A patent/SE378110B/xx unknown
-
1973
- 1973-05-01 ZA ZA732956A patent/ZA732956B/xx unknown
- 1973-05-01 IL IL42154A patent/IL42154A/en unknown
- 1973-05-09 DE DE2323216A patent/DE2323216C3/de not_active Expired
- 1973-05-09 CY CY1012A patent/CY1012A/xx unknown
- 1973-05-09 GB GB2219573A patent/GB1428416A/en not_active Expired
- 1973-05-14 FI FI731543A patent/FI50711C/fi active
- 1973-05-14 US US359913A patent/US3928326A/en not_active Expired - Lifetime
- 1973-05-17 DK DK277073A patent/DK133249C/da not_active IP Right Cessation
- 1973-05-18 FR FR7318126A patent/FR2185406B1/fr not_active Expired
- 1973-05-18 NL NLAANVRAGE7306979,A patent/NL175917C/xx not_active IP Right Cessation
- 1973-05-18 CA CA171,781A patent/CA1003402A/en not_active Expired
- 1973-05-18 BE BE131271A patent/BE799728A/xx not_active IP Right Cessation
- 1973-05-18 SU SU1918554A patent/SU468408A3/ru active
- 1973-05-19 JP JP5623473A patent/JPS547794B2/ja not_active Expired
-
1979
- 1979-06-20 KE KE2969A patent/KE2969A/xx unknown
- 1979-07-19 HK HK490/79A patent/HK49079A/xx unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4404200A (en) * | 1980-12-04 | 1983-09-13 | Aktiebolaget Draco | 4-Pregnene-derivatives, a process for their preparation, composition and method for the treatment of inflammatory conditions |
Also Published As
Publication number | Publication date |
---|---|
DE2323216C3 (de) | 1978-06-22 |
IL42154A (en) | 1976-12-31 |
FI50711C (fi) | 1976-06-10 |
NL7306979A (fi) | 1973-11-21 |
HK49079A (en) | 1979-07-27 |
NL175917B (nl) | 1984-08-16 |
DK133249C (da) | 1976-09-13 |
IL42154A0 (en) | 1973-07-30 |
NL175917C (nl) | 1985-01-16 |
DE2323216B2 (de) | 1977-11-03 |
BE799728A (fr) | 1973-09-17 |
ZA732956B (en) | 1974-04-24 |
FR2185406A1 (fi) | 1974-01-04 |
KE2969A (en) | 1979-07-20 |
DK133249B (da) | 1976-04-12 |
CA1003402A (en) | 1977-01-11 |
FI50711B (fi) | 1976-03-01 |
JPS4941379A (fi) | 1974-04-18 |
DE2323216A1 (de) | 1973-11-29 |
FR2185406B1 (fi) | 1976-12-31 |
US3928326A (en) | 1975-12-23 |
AU5525273A (en) | 1974-11-07 |
JPS547794B2 (fi) | 1979-04-10 |
CY1012A (en) | 1979-11-23 |
GB1428416A (en) | 1976-03-17 |
SU468408A3 (ru) | 1975-04-25 |