ME01331B - Derivati izoksazolidina - Google Patents

Derivati izoksazolidina

Info

Publication number
ME01331B
ME01331B MEP-2012-28A MEP2812A ME01331B ME 01331 B ME01331 B ME 01331B ME P2812 A MEP2812 A ME P2812A ME 01331 B ME01331 B ME 01331B
Authority
ME
Montenegro
Prior art keywords
isoxazolidine derivatives
glucocorticosteroids
relates
present
compounds
Prior art date
Application number
MEP-2012-28A
Other languages
English (en)
French (fr)
Inventor
Elisabetta Armani
Eleonora Ghidini
Ilaria Peretto
Andrea Virdis
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01331(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of ME01331B publication Critical patent/ME01331B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

    Predmetni pronalazak se odnosi na nova anti-inflamatorna i antialergijska jedinjenja iz serije glukokortikosteroida, postupke za dobijanje takvih jedinjenja, farmaceutske preparate koji ih sadrže, njihove kombinacije i terapeutske primene. Konkretnije, predmetni pronalazak se odnosi na glukokortikosteroide koji su derivati izoksazolidina.
MEP-2012-28A 2009-09-11 2010-09-01 Derivati izoksazolidina ME01331B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09011665 2009-09-11
PCT/EP2010/005366 WO2011029547A2 (en) 2009-09-11 2010-09-01 Pregnane derivatives condensed in the 16, 17 position with an n-substituted isoxazolidine ring as anti-inflammatory agents

Publications (1)

Publication Number Publication Date
ME01331B true ME01331B (me) 2013-12-20

Family

ID=41666572

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2012-28A ME01331B (me) 2009-09-11 2010-09-01 Derivati izoksazolidina

Country Status (28)

Country Link
US (1) US8637662B2 (me)
EP (2) EP2475676B1 (me)
JP (1) JP2013504524A (me)
KR (1) KR101451486B1 (me)
CN (2) CN105175479B (me)
AR (2) AR078164A1 (me)
AU (1) AU2010294598B2 (me)
BR (1) BR112012005503B1 (me)
CA (1) CA2773594C (me)
CL (1) CL2012000450A1 (me)
CO (1) CO6511204A2 (me)
EA (1) EA025191B1 (me)
GE (1) GEP20146135B (me)
HK (2) HK1218759A1 (me)
IL (1) IL218539A (me)
JO (1) JO3760B1 (me)
MA (1) MA33561B1 (me)
ME (1) ME01331B (me)
MX (1) MX2012002967A (me)
MY (1) MY164842A (me)
NZ (1) NZ598662A (me)
PE (1) PE20120894A1 (me)
SG (2) SG179055A1 (me)
TN (1) TN2012000077A1 (me)
TW (1) TWI494318B (me)
UA (1) UA108858C2 (me)
WO (1) WO2011029547A2 (me)
ZA (1) ZA201201705B (me)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164842A (en) * 2009-09-11 2018-01-30 Chiesi Farm Spa Isoxazolidine derivatives
TW201139369A (en) * 2010-02-05 2011-11-16 Chiesi Farma Spa Pyrrolidine derivatives
AU2012228334B2 (en) 2011-03-15 2017-03-23 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
CA2829982A1 (en) 2011-03-15 2012-09-20 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
CA2843782A1 (en) 2011-08-01 2013-02-07 Chiesi Farmaceutici S.P.A. Anti-inflammatory steroids condensed in position 16,17 with pyrrolidine ring
US9155747B2 (en) * 2012-09-13 2015-10-13 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
SI3231444T1 (sl) 2014-05-12 2020-04-30 Verona Pharma Plc Novo zdravljenje
KR20170044203A (ko) 2014-09-03 2017-04-24 리젠 파마슈티컬스 소시에떼 아노님 이중 pi3k 델타-감마 키나제 억제제 및 코르티코스테로이드를 포함하는 조성물 및 치료방법
CN104262440B (zh) * 2014-09-10 2016-08-17 江西赣亮医药原料有限公司 一种16ɑ-羟基泼尼松龙的制备方法
CN109206471B (zh) * 2017-06-30 2022-07-12 天津药业研究院股份有限公司 一种哈西奈德的制备方法
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN112142820A (zh) * 2019-06-29 2020-12-29 天津药业研究院股份有限公司 曲安奈德的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1131213B (de) * 1958-06-13 1962-06-14 Syntex Sa Verfahren zur Herstellung neuer Pregnanverbindungen
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
BR6678983D0 (pt) * 1965-05-04 1973-09-18 Merck & Co Inc Processo para preparar 21-fosfato esteroides
SE307576B (me) * 1966-01-27 1969-01-13 Bofors Ab
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
GB1302572A (me) 1969-05-05 1973-01-10
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (me) * 1972-05-19 1975-08-18 Bofors Ab
US4018774A (en) * 1976-02-13 1977-04-19 E. R. Squibb & Sons, Inc. Steroidal [16α,17-d]isoxazolidines
DE3133631A1 (de) * 1981-08-21 1983-03-03 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue kortikoide ihre herstellung und verwendung
US5200518A (en) * 1991-02-21 1993-04-06 Kangweon National University Anti-inflammatory carboxycyclic acetal pregnane derivatives
JP2749778B2 (ja) * 1994-09-05 1998-05-13 日清食品株式会社 トリアムシノロン誘導体
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
GB0415747D0 (en) * 2004-07-14 2004-08-18 Novartis Ag Organic compounds
US20100209508A1 (en) * 2005-06-14 2010-08-19 Corus Pharma, Inc. Substituted Phenylphosphates as Mutual Prodrugs of Steroids and ß-Agonists for the Treatment of Title Pulmonary Inflammation and Bronchoconstriction
JP2011507878A (ja) * 2007-12-21 2011-03-10 シェーリング コーポレイション Ｃ２０−ｃ２１置換グルココルチコイド受容体アゴニスト
WO2009108118A1 (en) * 2008-02-27 2009-09-03 Astrazeneca Ab 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use
MY164842A (en) * 2009-09-11 2018-01-30 Chiesi Farm Spa Isoxazolidine derivatives

Also Published As

Publication number Publication date
AR118123A2 (es) 2021-09-22
US8637662B2 (en) 2014-01-28
WO2011029547A2 (en) 2011-03-17
BR112012005503A2 (pt) 2016-04-19
EP2993178A1 (en) 2016-03-09
MY164842A (en) 2018-01-30
HK1218759A1 (zh) 2017-03-10
CA2773594A1 (en) 2011-03-17
TN2012000077A1 (en) 2013-09-19
JP2013504524A (ja) 2013-02-07
EP2475676B1 (en) 2020-05-27
MA33561B1 (fr) 2012-09-01
IL218539A0 (en) 2012-05-31
PE20120894A1 (es) 2012-08-13
HK1166085A1 (zh) 2012-10-19
CO6511204A2 (es) 2012-08-31
EA201290091A1 (ru) 2012-12-28
EP2475676A2 (en) 2012-07-18
US20110065678A1 (en) 2011-03-17
AR078164A1 (es) 2011-10-19
UA108858C2 (xx) 2015-06-25
JO3760B1 (ar) 2021-01-31
SG179055A1 (en) 2012-04-27
KR101451486B1 (ko) 2014-10-22
KR20120055651A (ko) 2012-05-31
SG10201608490VA (en) 2016-11-29
BR112012005503B1 (pt) 2021-10-13
TWI494318B (zh) 2015-08-01
ZA201201705B (en) 2013-05-29
WO2011029547A3 (en) 2011-08-18
AU2010294598A1 (en) 2012-04-05
CA2773594C (en) 2018-09-25
WO2011029547A8 (en) 2011-06-16
CN102482318B (zh) 2015-11-25
IL218539A (en) 2015-09-24
GEP20146135B (en) 2014-08-11
CN105175479A (zh) 2015-12-23
NZ598662A (en) 2014-03-28
EA025191B1 (ru) 2016-11-30
MX2012002967A (es) 2012-04-30
AU2010294598B2 (en) 2016-09-01
CN102482318A (zh) 2012-05-30
TW201114776A (en) 2011-05-01
CN105175479B (zh) 2017-06-09
CL2012000450A1 (es) 2012-08-10

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