JO3760B1 - (مشتقات بريجنان مكثفة في الموضع 16، 17 ذات حلقة أيزوكسازوليدين بها استبدال عند - n كعوامل مضادة للالتهاب) - Google Patents

(مشتقات بريجنان مكثفة في الموضع 16، 17 ذات حلقة أيزوكسازوليدين بها استبدال عند - n كعوامل مضادة للالتهاب)

Info

Publication number
JO3760B1
JO3760B1 JOP/2010/0313A JOP20100313A JO3760B1 JO 3760 B1 JO3760 B1 JO 3760B1 JO P20100313 A JOP20100313 A JO P20100313A JO 3760 B1 JO3760 B1 JO 3760B1
Authority
JO
Jordan
Prior art keywords
inflammatory agents
pregnane derivatives
isoxazolidine ring
derivatives condensed
substituted isoxazolidine
Prior art date
Application number
JOP/2010/0313A
Other languages
English (en)
Inventor
Elisabetta ِArmani
Ilaria Peretto
Eleonora Ghidini
Andrea Virdis
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41666572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JO3760(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Application granted granted Critical
Publication of JO3760B1 publication Critical patent/JO3760B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0057—Nitrogen and oxygen
    • C07J71/0068—Nitrogen and oxygen at position 16(17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

يتعلق الاختراع الحالي بمركبات جديدة مضادة للالتهاب ومضادة للحساسية من سلسلة جلوكوكورتيكوسترويد, وطرق لتحضير هذه المركبات, وتركيبات صيدلانية تشتمل عليها وتوليفات واستخدامات علاجية لها. على وجه الخصوص, يتعلق الاختراع بمركبات جلوكوكورتيكوسترويد التي تعتبر من مشتقات أيزوكسازوليدين .
JOP/2010/0313A 2009-09-11 2010-09-08 (مشتقات بريجنان مكثفة في الموضع 16، 17 ذات حلقة أيزوكسازوليدين بها استبدال عند - n كعوامل مضادة للالتهاب) JO3760B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP09011665 2009-09-11

Publications (1)

Publication Number Publication Date
JO3760B1 true JO3760B1 (ar) 2021-01-31

Family

ID=41666572

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2010/0313A JO3760B1 (ar) 2009-09-11 2010-09-08 (مشتقات بريجنان مكثفة في الموضع 16، 17 ذات حلقة أيزوكسازوليدين بها استبدال عند - n كعوامل مضادة للالتهاب)

Country Status (28)

Country Link
US (1) US8637662B2 (ar)
EP (2) EP2993178A1 (ar)
JP (1) JP2013504524A (ar)
KR (1) KR101451486B1 (ar)
CN (2) CN105175479B (ar)
AR (2) AR078164A1 (ar)
AU (1) AU2010294598B2 (ar)
BR (1) BR112012005503B1 (ar)
CA (1) CA2773594C (ar)
CL (1) CL2012000450A1 (ar)
CO (1) CO6511204A2 (ar)
EA (1) EA025191B1 (ar)
GE (1) GEP20146135B (ar)
HK (2) HK1166085A1 (ar)
IL (1) IL218539A (ar)
JO (1) JO3760B1 (ar)
MA (1) MA33561B1 (ar)
ME (1) ME01331B (ar)
MX (1) MX2012002967A (ar)
MY (1) MY164842A (ar)
NZ (1) NZ598662A (ar)
PE (1) PE20120894A1 (ar)
SG (2) SG10201608490VA (ar)
TN (1) TN2012000077A1 (ar)
TW (1) TWI494318B (ar)
UA (1) UA108858C2 (ar)
WO (1) WO2011029547A2 (ar)
ZA (1) ZA201201705B (ar)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101451486B1 (ko) * 2009-09-11 2014-10-22 키에시 파르마슈티시 엣스. 피. 에이. N-치환된 이속사졸리딘 링과 함께 16, 17 위치 내에 응축된 항염증제로서의 프레그난 유도체
TW201139369A (en) * 2010-02-05 2011-11-16 Chiesi Farma Spa Pyrrolidine derivatives
TWI658047B (zh) 2011-03-15 2019-05-01 吉斯藥品公司 異唑啶衍生物
CA2829982A1 (en) 2011-03-15 2012-09-20 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
CN103814043A (zh) * 2011-08-01 2014-05-21 奇斯药制品公司 在16，17位与吡咯烷环稠合的抗炎类固醇
US9155747B2 (en) * 2012-09-13 2015-10-13 Chiesi Farmaceutici S.P.A. Isoxazolidine derivatives
PL3142701T3 (pl) 2014-05-12 2018-11-30 Verona Pharma Plc Nowe leczenie
US10786504B2 (en) 2014-09-03 2020-09-29 Rhizen Pharmaceuticals Sa Method of treatment and compositions comprising a dual PI3K delta-gamma kinase inhibitor and a corticosteroid
CN104262440B (zh) * 2014-09-10 2016-08-17 江西赣亮医药原料有限公司 一种16ɑ-羟基泼尼松龙的制备方法
CN109206471B (zh) * 2017-06-30 2022-07-12 天津药业研究院股份有限公司 一种哈西奈德的制备方法
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN112142820A (zh) * 2019-06-29 2020-12-29 天津药业研究院股份有限公司 曲安奈德的合成方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1131213B (de) * 1958-06-13 1962-06-14 Syntex Sa Verfahren zur Herstellung neuer Pregnanverbindungen
US3048581A (en) * 1960-04-25 1962-08-07 Olin Mathieson Acetals and ketals of 16, 17-dihydroxy steroids
BR6678983D0 (pt) * 1965-05-04 1973-09-18 Merck & Co Inc Processo para preparar 21-fosfato esteroides
SE307576B (ar) * 1966-01-27 1969-01-13 Bofors Ab
IL31997A (en) * 1968-05-03 1974-03-14 Lepetit Spa Process for the preparation of pregnano(17alpha,16alpha-d)oxazolines and 16alpha,21-dihydroxy-17alpha-aminopregnanes
GB1302572A (ar) 1969-05-05 1973-01-10
US3996359A (en) * 1972-05-19 1976-12-07 Ab Bofors Novel stereoisomeric component A of stereoisomeric mixtures of 2'-unsymmetrical 16,17-methylenedioxy steroid 21-acylates, compositions thereof, and method of treating therewith
SE378110B (ar) * 1972-05-19 1975-08-18 Bofors Ab
US4018774A (en) * 1976-02-13 1977-04-19 E. R. Squibb & Sons, Inc. Steroidal [16α,17-d]isoxazolidines
DE3133631A1 (de) * 1981-08-21 1983-03-03 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue kortikoide ihre herstellung und verwendung
US5200518A (en) * 1991-02-21 1993-04-06 Kangweon National University Anti-inflammatory carboxycyclic acetal pregnane derivatives
JP2749778B2 (ja) * 1994-09-05 1998-05-13 日清食品株式会社 トリアムシノロン誘導体
WO2005028495A1 (en) * 2003-09-24 2005-03-31 Glaxo Group Limited Anti-inflammatory glucocorticoids
GB0415747D0 (en) * 2004-07-14 2004-08-18 Novartis Ag Organic compounds
AU2006259604A1 (en) * 2005-06-14 2006-12-28 Gilead Sciences, Inc. Substituted phenylphosphates as mutual prodrugs of steroids and beta -agonists for the treatment of pulmonary inflammation and bronchoconstriction
MX2010007023A (es) * 2007-12-21 2010-09-30 Schering Corp Agonistas del receptor glucocorticoide sustituido de c20-c21.
MX2010009022A (es) * 2008-02-27 2010-09-07 Astrazeneca Ab Derivados 16 alfa, 17 alfa-acetal glucocorticoesteroideos y su uso.
KR101451486B1 (ko) * 2009-09-11 2014-10-22 키에시 파르마슈티시 엣스. 피. 에이. N-치환된 이속사졸리딘 링과 함께 16, 17 위치 내에 응축된 항염증제로서의 프레그난 유도체

Also Published As

Publication number Publication date
EP2993178A1 (en) 2016-03-09
SG10201608490VA (en) 2016-11-29
MA33561B1 (ar) 2012-09-01
EP2475676A2 (en) 2012-07-18
CL2012000450A1 (es) 2012-08-10
CN102482318B (zh) 2015-11-25
CN102482318A (zh) 2012-05-30
IL218539A0 (en) 2012-05-31
SG179055A1 (en) 2012-04-27
HK1166085A1 (zh) 2012-10-19
HK1218759A1 (zh) 2017-03-10
BR112012005503A2 (pt) 2016-04-19
CO6511204A2 (es) 2012-08-31
TWI494318B (zh) 2015-08-01
MY164842A (en) 2018-01-30
CN105175479A (zh) 2015-12-23
US8637662B2 (en) 2014-01-28
ZA201201705B (en) 2013-05-29
WO2011029547A8 (en) 2011-06-16
GEP20146135B (en) 2014-08-11
KR20120055651A (ko) 2012-05-31
PE20120894A1 (es) 2012-08-13
CA2773594C (en) 2018-09-25
MX2012002967A (es) 2012-04-30
AU2010294598B2 (en) 2016-09-01
AR118123A2 (es) 2021-09-22
TW201114776A (en) 2011-05-01
WO2011029547A2 (en) 2011-03-17
CN105175479B (zh) 2017-06-09
WO2011029547A3 (en) 2011-08-18
CA2773594A1 (en) 2011-03-17
TN2012000077A1 (en) 2013-09-19
UA108858C2 (xx) 2015-06-25
IL218539A (en) 2015-09-24
KR101451486B1 (ko) 2014-10-22
AU2010294598A1 (en) 2012-04-05
EP2475676B1 (en) 2020-05-27
US20110065678A1 (en) 2011-03-17
EA025191B1 (ru) 2016-11-30
BR112012005503B1 (pt) 2021-10-13
ME01331B (me) 2013-12-20
AR078164A1 (es) 2011-10-19
NZ598662A (en) 2014-03-28
JP2013504524A (ja) 2013-02-07
EA201290091A1 (ru) 2012-12-28

Similar Documents

Publication Publication Date Title
JO3760B1 (ar) (مشتقات بريجنان مكثفة في الموضع 16، 17 ذات حلقة أيزوكسازوليدين بها استبدال عند - n كعوامل مضادة للالتهاب)
BR112019024747A2 (pt) formulações de dose fixa
EP2576578A4 (en) POLYMORPHES OF 2'-O-FUCOSYLLACTOSE AND MANUFACTURE THEREOF
TW201129565A (en) Tricyclic heterocyclic compounds, compositions and methods of use thereof
EA201500650A1 (ru) Фенилацетат l-орнитина и способы его получения
UA109868C2 (ru) Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar)
TN2012000126A1 (en) Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2012024620A3 (en) Autotaxin inhibitors and uses thereof
WO2011095535A3 (en) Pregnane compounds condensed in position 16,17 with a pyrolidine ring with glucocorticoid activity
BR112012013431A8 (pt) composto, composição farmacêutica e seu uso
MY162186A (en) C-17 and c-3 modified triterpenoids with hiv maturation inhibitory activity
CO6450612A2 (es) Compuestos 1-cianoetilheterociclilcarboxamida sustituidos 750
MX2012013628A (es) Amidas c-28 de derivados del acido betulinico c-3 modificados como inhibidores de la maduracion del virus de inmunodeficiencia humana (vih).
TN2013000313A1 (en) Isoxazolidine derivatives
IN2014CN03307A (ar)
MX2011002065A (es) Composicion farmaceutica a base de progesterona micronizada y sus usos.
BR112014027981A2 (pt) compostos do tipo fumagilol e métodos de produção e utilização dos mesmos
MX2012000954A (es) Composicion far,aceutica topica que incuye la rel-n-[6-[(2r,6s)-2,6-dimetil-4-morfolinil]-3-piridinil]-2-metil- 4'-(trifluoro-metoxi)-[1,1'-bifenil]-3-carboxamida.
TN2015000093A1 (en) Isoxazolidine derivatives
WO2012123493A3 (en) Isoxazolidine derivatives
CR20110021A (es) Composiciones farmaceuticas basadas en antagonistas del receptor de quinina b2 y corticosteroides, y su uso
EA200900172A1 (ru) Фармацевтическая композиция для контрацепции