SE333126B - Saett att framstaella ett nytt antibiotiskt aemne kallat adriamycin,dess aglykon och dess hydroklorid genom odling av en ny mikroorganism kallad streptomyces peucetius var caesius - Google Patents

Saett att framstaella ett nytt antibiotiskt aemne kallat adriamycin,dess aglykon och dess hydroklorid genom odling av en ny mikroorganism kallad streptomyces peucetius var caesius

Info

Publication number
SE333126B
SE333126B SE5098/68A SE509868A SE333126B SE 333126 B SE333126 B SE 333126B SE 5098/68 A SE5098/68 A SE 5098/68A SE 509868 A SE509868 A SE 509868A SE 333126 B SE333126 B SE 333126B
Authority
SE
Sweden
Prior art keywords
called
new
caesius
aglycon
hydrochloride
Prior art date
Application number
SE5098/68A
Other languages
English (en)
Swedish (sv)
Inventor
F Arcamone
G Cassinelli
A Marco
M Gaetani
Original Assignee
Farma Italia Soc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farma Italia Soc filed Critical Farma Italia Soc
Publication of SE333126B publication Critical patent/SE333126B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/252Naphthacene radicals, e.g. daunomycins, adriamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/8215Microorganisms
    • Y10S435/822Microorganisms using bacteria or actinomycetales
    • Y10S435/886Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SE5098/68A 1967-04-18 1968-04-17 Saett att framstaella ett nytt antibiotiskt aemne kallat adriamycin,dess aglykon och dess hydroklorid genom odling av en ny mikroorganism kallad streptomyces peucetius var caesius SE333126B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1505667 1967-04-18

Publications (1)

Publication Number Publication Date
SE333126B true SE333126B (sv) 1971-03-08

Family

ID=11146217

Family Applications (1)

Application Number Title Priority Date Filing Date
SE5098/68A SE333126B (sv) 1967-04-18 1968-04-17 Saett att framstaella ett nytt antibiotiskt aemne kallat adriamycin,dess aglykon och dess hydroklorid genom odling av en ny mikroorganism kallad streptomyces peucetius var caesius

Country Status (15)

Country Link
US (1) US3590028A (cs)
AT (1) AT276630B (cs)
BE (1) BE713773A (cs)
CH (1) CH496091A (cs)
DE (1) DE1770204B1 (cs)
DK (1) DK118652B (cs)
ES (1) ES352842A1 (cs)
FR (2) FR1583289A (cs)
GB (1) GB1161278A (cs)
IL (1) IL29813A (cs)
NL (1) NL6804925A (cs)
NO (1) NO124883B (cs)
SE (1) SE333126B (cs)
SU (1) SU378026A3 (cs)
YU (1) YU33730B (cs)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3965088A (en) * 1967-10-18 1976-06-22 Rhone-Poulenc S.A. Naphthacene derivatives
US3957755A (en) * 1967-10-18 1976-05-18 Rhone-Poulenc S.A. Naphthacene derivatives
FR2160716A1 (en) * 1971-11-23 1973-07-06 Rhone Poulenc Sa Antibiotics duborimycin and 27706rp - by reduction of daunorubicin and adriamycin
US3970641A (en) * 1971-01-20 1976-07-20 Rhone-Poulenc S.A. Antibiotic 27,706 RP and salt thereof
GB1457632A (en) * 1974-03-22 1976-12-08 Farmaceutici Italia Adriamycins
US3976667A (en) * 1975-06-19 1976-08-24 The Upjohn Company Steffimycinone, 7-deoxysteffimycinone and derivatives
US4012448A (en) * 1976-01-15 1977-03-15 Stanford Research Institute Synthesis of adriamycin and 7,9-epiadriamycin
ES444380A1 (es) * 1976-01-16 1977-06-16 Gosalvez Mario Un procedimiento para preparar derivados metalicos antraci- clinicos.
US4039736A (en) * 1976-04-15 1977-08-02 Bristol-Myers Company Antibiotic compounds marcellomycin and musettamycin
GB1509875A (en) * 1976-06-14 1978-05-04 Farmaceutici Italia Optically active anthracyclinones and anthracycline glycosides
US4192915A (en) * 1976-08-16 1980-03-11 Bristol-Myers Company Anthracycline glycosides from streptomyces
US4209588A (en) * 1976-10-05 1980-06-24 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Process for producing new antitumor anthracycline antibiotics
CH637160A5 (fr) * 1976-10-05 1983-07-15 Microbial Chem Res Found Procede de fabrication de glucosides anthracyclines.
US4112071A (en) * 1977-01-10 1978-09-05 Bristol-Myers Company Antibiotic complex
US4089872A (en) * 1977-03-09 1978-05-16 The Upjohn Company Antibiotics steffimycinol and 7-deoxysteffimycinol and process for preparing the same
US4246399A (en) * 1977-03-21 1981-01-20 Interx Research Corporation Complexes of doxorubicin exhibiting enhanced stability
US4077844A (en) * 1977-03-30 1978-03-07 The Upjohn Company Process for preparing steffimycinol
NL7900869A (nl) * 1978-02-09 1979-08-13 Erba Farmitalia Anthracyclinenantibiotica.
US4248970A (en) * 1978-05-30 1981-02-03 Bristol-Myers Company Antibiotic complex producing bacterial culture
US4196127A (en) * 1978-06-01 1980-04-01 Research Corporation Anthracyclines
US4201773A (en) * 1978-07-26 1980-05-06 The United States Of America As Represented By The Department Of Health, Education And Welfare 7-O-(2,6-Dideoxy-α-L-lyxo-hexopyranosyl)-daunomycinone, desmethoxy daunomycinone, adriamycinone, and carminomycinone
US4303785A (en) * 1978-08-05 1981-12-01 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Antitumor anthracycline antibiotics
IT1196402B (it) * 1978-11-21 1988-11-16 Erba Farmitalia Antibiotici antitumorali
JPS5648893A (en) * 1979-09-07 1981-05-02 Sanraku Inc Preparation of anthracycline glycoside
US4348388A (en) * 1980-04-02 1982-09-07 G.D. Searle & Co. 11-Amino-11-deoxydaunorubicin and analogs
JPS56156300A (en) * 1980-04-26 1981-12-02 Microbial Chem Res Found Novel preparative method of anthracyclin derivative
JPS5750994A (en) * 1980-09-12 1982-03-25 Microbial Chem Res Found Novel antibiotic mf266 substance and its preparation
JPS5756494A (en) * 1980-09-22 1982-04-05 Microbial Chem Res Found New anthracyclin derivative
JPS57163393A (en) * 1981-03-27 1982-10-07 Microbial Chem Res Found Novel anthracyclin derivative and its preparation
US4374979A (en) * 1981-04-27 1983-02-22 The University Of Kansas Endowment Association Regiospecific synthesis of anthracyclinone compounds such as daunomycinone
US4471052A (en) * 1982-01-18 1984-09-11 Adria Laboratories, Inc. Biosynthesis of simplified anthracyclines
GB2125030B (en) * 1982-08-13 1986-11-26 Erba Farmitalia Naphthacenequinone synthesis
US4562177A (en) * 1982-08-17 1985-12-31 The Ohio State University Research Foundation 3'-Amino-2' halo-anthracycline antibiotics
US4548927A (en) * 1983-05-25 1985-10-22 Eaton John W Method and agents for raising animal tolerance to oxidant stress-inducing antibiotics
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US4610977A (en) * 1985-04-08 1986-09-09 The University Of Tennessee Research Corporation N-alkyl and N-benzyl adriamycin derivatives
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
US4863739A (en) * 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
EP0396626A1 (en) * 1988-01-19 1990-11-14 Board Of Regents, The University Of Texas System Glycosides, liposomal compositions thereof, and methods for their use
GB8812697D0 (en) * 1988-05-27 1988-06-29 Erba Carlo Spa Isolation & characterisation of genes resistant to anthracycline antibiotics
US5220001A (en) * 1989-10-25 1993-06-15 Zaidan Hojim Biseibutsu Dong-A Pharm Co. Anthracycline glycoside derivatives
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법
DE4417865A1 (de) * 1994-05-20 1995-11-23 Behringwerke Ag Kombination von Tumornekrose-induzierenden Substanzen mit Substanzen, die durch Nekrosen aktiviert werden, zur selektiven Tumortherapie
US6103236A (en) * 1995-05-10 2000-08-15 Kyowa Hakko Kogyo Co., Ltd. Toxin conjugates
ATE399547T1 (de) 1996-10-15 2008-07-15 Searle Llc Verwendung von cyclooxygenase-2 inhibitoren zur behandlung und vorbeugung von neoplasia
US20030100532A1 (en) * 1997-02-14 2003-05-29 Gary S. Jacob Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy for treating hepatitis virus infections
US5948896A (en) * 1997-08-13 1999-09-07 Gem Pharmaceuticals Processes for preparing 13-deoxy anthracycline derivatives
AU753336B2 (en) 1997-11-10 2002-10-17 G.D. Searle & Co. Use of alkylated iminosugars to treat multidrug resistance
GB9727546D0 (en) * 1997-12-31 1998-03-18 Pharmacia & Upjohn Spa Anthracycline glycosides
EP1061922B9 (en) 1998-02-12 2007-03-07 United Therapeutics Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US6689759B1 (en) 1998-02-12 2004-02-10 G. D. Searle & Co. Methods of Treating hepatitis virus infections with N-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds in combination therapy
AU750738B2 (en) * 1998-10-16 2002-07-25 Microbiopharm Japan Co., Ltd. Crystallization of doxorubicin hydrochloride
CA2362914C (en) * 1999-02-12 2009-04-14 G.D. Searle & Co. Use of substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
CA2362785A1 (en) 1999-02-12 2001-02-08 G.D. Searle & Co. Glucamine compounds for treating hepatitis virus infections
WO2001060366A1 (en) * 2000-02-14 2001-08-23 Pharmacia Corporation Use of n-substituted-1,5-dideoxy-1,5-imino-d-glucitol compounds for treating hepatitis virus infections
US20060079463A1 (en) * 2003-05-20 2006-04-13 Zhong Hong J Anticancer compositions comprising methenamine
TW200526668A (en) * 2003-10-02 2005-08-16 Salmedix Inc Substituted indole derivatives
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CA2606390A1 (en) * 2005-05-11 2006-11-16 Sicor, Inc. Stable lyophilized anthracycline glycosides
EP2359825A2 (en) * 2006-10-06 2011-08-24 Takeda Pharmaceutical Company Limited Combination drug
EP2219672B1 (en) 2007-11-09 2016-02-17 Peregrine Pharmaceuticals, Inc. Anti-vegf antibody compositions and methods
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2189158A1 (en) * 2008-11-20 2010-05-26 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Combination of rocaglamide and apoptosis inducing substances for the treatment of cancer
MX2011006891A (es) * 2008-12-23 2011-10-06 Pharmasset Inc Fosforamidatos de nucleosidos.
TW201026716A (en) * 2008-12-23 2010-07-16 Pharmasset Inc Nucleoside analogs
NZ593647A (en) * 2008-12-23 2013-08-30 Gilead Pharmasset Llc Synthesis of purine nucleosides
BR112012024884A2 (pt) 2010-03-31 2016-10-18 Gilead Pharmasset Llc síntese estereosseletiva de ativos contendo fósforo
DK3012329T3 (da) 2010-06-18 2017-11-20 Myriad Genetics Inc Fremgangsmåder og materialer til at vurdere tab af heterozygositet
US9512485B2 (en) 2010-08-24 2016-12-06 Dana-Farber Cancer Institute. Inc. Methods for predicting anti-cancer response
CN102363755B (zh) * 2011-05-21 2013-04-03 浙江海正药业股份有限公司 一种链霉菌及其生产阿霉素的方法
EP3693473B1 (en) 2011-06-17 2025-02-19 Myriad Genetics, Inc. Methods and materials for assessing allelic imbalance
EP3660161B1 (en) 2011-12-21 2024-07-31 Myriad Genetics, Inc. Methods and materials for assessing loss of heterozygosity
EP2817630B1 (en) 2012-02-23 2018-07-11 Children's Medical Center Corporation Methods for predicting anti-cancer response
CN104125962B (zh) 2012-03-06 2016-06-22 天津和美生物技术有限公司 四环蒽醌衍生物
CA3126823C (en) 2012-06-07 2023-04-04 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
CN103087124B (zh) * 2012-11-21 2016-01-13 浙江海正药业股份有限公司 一种制备阿霉素的方法
WO2014160080A1 (en) 2013-03-14 2014-10-02 Children's Medical Center Corporation Cancer diagnosis, treatment selection and treatment
AU2014240950B2 (en) 2013-03-29 2018-11-01 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for treatment of cancer, neurological disorders, and fibrotic disorders
PT2981624T (pt) 2013-04-05 2020-03-23 Myriad Genetics Inc Métodos para avaliar deficiência na recombinação homóloga e prever resposta a tratamento para cancro
EP4023765A1 (en) 2013-12-09 2022-07-06 Institut Curie Methods for detecting inactivation of the homologous recombination pathway (brca1/2) in human tumors
CN104774229A (zh) * 2014-01-10 2015-07-15 浙江华谱新创科技有限公司 一种阿霉素及其衍生物的制备方法
ES2946251T3 (es) 2014-08-15 2023-07-14 Myriad Genetics Inc Métodos y materiales para evaluar la deficiencia de recombinación homóloga
US20170312246A1 (en) 2016-04-27 2017-11-02 Avoscience, Llc Lipidic furan, pyrrole, and thiophene compounds for use in the treatment of atrophic vaginitis
CN107773556B (zh) * 2016-08-26 2020-08-18 广州安好医药科技有限公司 一种具有抗肿瘤药物功效的联合用药物
EP4141127B1 (en) 2021-08-30 2024-10-09 Zentrum Familiärer Brust- und Eierstockkrebs Universitätsklinik Köln Method for assessing homologous recombination deficiency in ovarian cancer cells

Also Published As

Publication number Publication date
SU378026A3 (cs) 1973-04-17
US3590028A (en) 1971-06-29
FR1583289A (fr) 1969-10-24
YU33730B (en) 1978-02-28
AT276630B (de) 1969-11-25
BE713773A (fr) 1968-10-17
IL29813A (en) 1971-04-28
DE1770204B1 (de) 1971-12-23
IL29813A0 (en) 1968-06-20
ES352842A1 (es) 1969-08-01
GB1161278A (en) 1969-08-13
CH496091A (de) 1970-09-15
FR7406M (fr) 1969-11-03
YU71568A (en) 1977-08-31
NO124883B (cs) 1972-06-19
DK118652B (da) 1970-09-21
NL6804925A (cs) 1968-10-21

Similar Documents

Publication Publication Date Title
SE333126B (sv) Saett att framstaella ett nytt antibiotiskt aemne kallat adriamycin,dess aglykon och dess hydroklorid genom odling av en ny mikroorganism kallad streptomyces peucetius var caesius
SE434648B (sv) Forfarande for framstellning av nya antitumorantibiotika, kallade aklacinomycin a och b, genom odling av en stam av streptomyces galilaeus
BE853369A (fr) Nouvel antibiotique du type anthracycline et son procede de preparation
IL22998A (en) Antibiotic substance designated as antibiotic 467 produced by cultivating micromonospora halophytica
ES472306A1 (es) Un procedimiento para la produccion de un glicosido de an- traciclina
SE390542B (sv) Framstellning av ett nytt antibiotikum kallat a-2315 genom odling av en ny stam av actinoplanes philippinensis (nrrl 5462)
SE384690B (sv) Framstellning av antibiotikum a 16886 i och/eller antibiotikum a 16886 ii genom odling av streptomyces clavuligerus nrrl 3585
FI48585C (fi) Tapa valmistaa terapeuttisesti vaikuttavia 4'-demetyyliepipodofyllotok siiniglukosidin johdannaisia.
SE420214B (sv) Framstellning av ett nytt antibiotikum benemt fortimicin b genom odling av micromonospora olivoasterospora atcc 21819, 31009 eller 31010 samt isolering
ES326240A1 (es) Mejoras introducidas en la elaboracion de preparaciones orales que contienen macrolidos antimicrobianos.
FR1466268A (fr) Nouvel antibiotique préparé par culture des streptomyces et son procédé de fabrication
SE435068B (sv) Forfarande for framstellning av ett nytt antibiotikum, benemnt fortimicin c, genom odling av stammar av micromonospora olivoasterospora
DK120715B (da) Fremgangsmåde til fremstilling af antibiotiket 13.057 R.P., kaldet daunorubicin, ved dyrkning af en mikroorganisme af slægten Streptomyces i et vandigt næringsmedium.
SE387658B (sv) Framstellning av nytt antibiotikum betecknat myc-8003 genom odling av ny mikroorganism benemd streptomyces ramocissimus
SE390541B (sv) Framstellning av en antibiotiskt aktiv produkt, dess komponenter hittills okenda antibiotikum g-52 och kenda sisomicin genom odling av en mikroorganism benemnd micromonospora zionensis
CA760421A (en) Antibiotic produced by streptomyces verticillus
AU426655B2 (en) New antibiotic and its preparation by culture of streptomyces
FR1547388A (fr) Nouvel antibiotique et sa préparation par culture d'un streptomyces
SE399907B (sv) Framstellning av en kend forening bl a benemnd bicyklomycin och antibiotikum nr 5879 genom odling av en ny mikroorganism benemnd streptomyces aizunensis deponerad som ferm-p no 1501
CA532613A (en) Isolation of antibiotic produced by streptomyces aureofaciens
CA728110A (en) Antibiotic by streptomyces bluensis
CA745181A (en) Manufacture of 1-cyano-1,3-butadiene
CA818462A (en) Antibiotic production of coumermycin by streptomyces rishiriensis
FR1499875A (fr) Nouveaux antibiotiques obtenus par culture de streptomyces caelestis et leurs procédés de préparation
FR2351659A1 (fr) Nouveaux composes antibiotiques, leurs preparations et leurs applications