SE0400886D0 - Process of purification - Google Patents

Process of purification

Info

Publication number
SE0400886D0
SE0400886D0 SE0400886A SE0400886A SE0400886D0 SE 0400886 D0 SE0400886 D0 SE 0400886D0 SE 0400886 A SE0400886 A SE 0400886A SE 0400886 A SE0400886 A SE 0400886A SE 0400886 D0 SE0400886 D0 SE 0400886D0
Authority
SE
Sweden
Prior art keywords
chromatography matrix
target compound
ionic polyether
peg
isolating
Prior art date
Application number
SE0400886A
Other languages
English (en)
Swedish (sv)
Inventor
James Van Alstine
Anders Ljungloef
Hamid Houshmand
Per-Mikael Aaberg
Original Assignee
Amersham Biosciences Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amersham Biosciences Ab filed Critical Amersham Biosciences Ab
Priority to SE0400886A priority Critical patent/SE0400886D0/xx
Publication of SE0400886D0 publication Critical patent/SE0400886D0/xx
Priority to AT05722292T priority patent/ATE485880T1/de
Priority to EP05722292A priority patent/EP1729867B1/fr
Priority to JP2007506111A priority patent/JP4831697B2/ja
Priority to CA002560012A priority patent/CA2560012A1/fr
Priority to PCT/SE2005/000467 priority patent/WO2005094960A1/fr
Priority to US10/594,187 priority patent/US20070213513A1/en
Priority to AU2005228834A priority patent/AU2005228834A1/en
Priority to DE602005024373T priority patent/DE602005024373D1/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/461—Flow patterns using more than one column with serial coupling of separation columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Peptides Or Proteins (AREA)
  • Polyethers (AREA)
SE0400886A 2004-04-02 2004-04-02 Process of purification SE0400886D0 (sv)

Priority Applications (9)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification
AT05722292T ATE485880T1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung
EP05722292A EP1729867B1 (fr) 2004-04-02 2005-03-31 Procede de purification chromatographique
JP2007506111A JP4831697B2 (ja) 2004-04-02 2005-03-31 精製方法
CA002560012A CA2560012A1 (fr) 2004-04-02 2005-03-31 Procede de purification chromatographique
PCT/SE2005/000467 WO2005094960A1 (fr) 2004-04-02 2005-03-31 Procede de purification chromatographique
US10/594,187 US20070213513A1 (en) 2004-04-02 2005-03-31 Method for Chromatographic Purification
AU2005228834A AU2005228834A1 (en) 2004-04-02 2005-03-31 A method for chromatographic purification
DE602005024373T DE602005024373D1 (de) 2004-04-02 2005-03-31 Verfahren zur chromatographischen reinigung

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Publications (1)

Publication Number Publication Date
SE0400886D0 true SE0400886D0 (sv) 2004-04-02

Family

ID=32173667

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0400886A SE0400886D0 (sv) 2004-04-02 2004-04-02 Process of purification

Country Status (9)

Country Link
US (1) US20070213513A1 (fr)
EP (1) EP1729867B1 (fr)
JP (1) JP4831697B2 (fr)
AT (1) ATE485880T1 (fr)
AU (1) AU2005228834A1 (fr)
CA (1) CA2560012A1 (fr)
DE (1) DE602005024373D1 (fr)
SE (1) SE0400886D0 (fr)
WO (1) WO2005094960A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201510384UA (en) 2006-09-13 2016-01-28 Abbvie Inc Cell culture improvements
US8911964B2 (en) 2006-09-13 2014-12-16 Abbvie Inc. Fed-batch method of making human anti-TNF-alpha antibody
WO2008156410A1 (fr) * 2007-06-19 2008-12-24 Ge Healthcare Bio-Sciences Ab Système bi-phasique polymérique et utilisation de celui-ci
US20110034672A1 (en) * 2008-01-18 2011-02-10 Roberto Falkenstein Purification of not-glycosylated polypeptides
US8372286B2 (en) * 2008-02-05 2013-02-12 Ge Healthcare Bio-Sciences Ab Method for production of separation media
FR2930780B1 (fr) * 2008-04-30 2010-08-20 Moet & Chandon Procede de degorgement de vins mousseux
CA2726823A1 (fr) * 2008-06-03 2009-12-10 Patrys Limited Procede de purification d'anticorps
WO2010048192A2 (fr) 2008-10-20 2010-04-29 Abbott Laboratories Inactivation virale pendant la purification d'anticorps
MX2011004200A (es) * 2008-10-20 2011-05-24 Abbott Lab Aislamento y purificacion de anticuerpos usando la cromatografia de afinidad de proteina a.
WO2012123488A1 (fr) 2011-03-16 2012-09-20 F. Hoffmann-La Roche Ag Chromatographie échangeuse d'ions à sélectivité améliorée pour séparation de monomères polypeptidiques, d'agrégats et de fragments par modulation de la phase mobile
DK2691411T3 (da) 2011-03-29 2020-05-11 Glaxosmithkline Llc Buffersystem til proteinoprensning
SG10201603931TA (en) * 2011-06-08 2016-07-28 Agency Science Tech & Res Purification Of Biological Products By Constrained Cohydration Chromatography
EP2682168A1 (fr) 2012-07-02 2014-01-08 Millipore Corporation Dispositif de tirage et métier à filer
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
EP3048109A4 (fr) * 2013-09-17 2017-04-19 Kaneka Corporation Nouveau procédé de purification d'anticorps et anticorps obtenu au moyen de ce procédé, nouveau procédé de purification d'anticorps à l'aide d'un échangeur de cations et anticorps obtenu au moyen de ce procédé
AR102198A1 (es) 2014-10-09 2017-02-08 Regeneron Pharma Proceso para reducir partículas subvisibles en una formulación farmacéutica
KR102369014B1 (ko) 2016-08-16 2022-03-02 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
KR20230119729A (ko) 2016-10-25 2023-08-16 리제너론 파아마슈티컬스, 인크. 크로마토그래피 데이터 분석을 위한 방법 및 시스템
BR112020005335A2 (pt) 2017-09-19 2020-09-24 Regeneron Pharmaceuticals, Inc. métodos para reduzir a formação de partículas e composições formadas pelos mesmos
CN108152104B (zh) * 2017-12-25 2020-08-11 上海微谱化工技术服务有限公司 超支化水性聚氨酯中二氧化硅填料的分离及定量方法
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
US11420916B2 (en) * 2018-06-08 2022-08-23 Board Of Regents, The University Of Texas System Systems and methods for separation of olefins from mixtures that contain reducing agents
US11884698B2 (en) 2018-07-02 2024-01-30 Regeneron Pharmaceuticals, Inc. Systems and methods for preparing a polypeptide from a mixture
CA3156648A1 (fr) * 2019-10-04 2021-04-08 Merck Patent Gmbh Elution d'anticorps monoclonaux dans une chromatographie d'affinite de proteine a

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3869436A (en) * 1971-06-01 1975-03-04 Statens Bakteriologiska Lab Method for fractionating plasma proteins using peg and ion-exchangers
EP0119767B1 (fr) * 1983-03-11 1990-11-22 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Procédé pour la détermination de ligands
US4683294A (en) * 1985-04-03 1987-07-28 Smith Kline Rit, S.A. Process for the extraction and purification of proteins from culture media producing them
EP0263072B1 (fr) * 1986-10-03 1994-03-23 Ciba-Geigy Ag Peptides analogues au lymphokine
US5151358A (en) * 1989-06-13 1992-09-29 Genencor International, Inc. Processes for the recovery of naturally produced chymosin
DE4321904B4 (de) * 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
US5443953A (en) * 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
US5561064A (en) * 1994-02-01 1996-10-01 Vical Incorporated Production of pharmaceutical-grade plasmid DNA
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
SE9503925D0 (sv) * 1995-11-07 1995-11-07 Pharmacia Biotech Ab Separationsmedium för IgG
AU3048797A (en) * 1996-10-22 1998-05-15 Chugai Seiyaku Kabushiki Kaisha Sepsis remedy comprising anti-il-8 antibody as active ingredient
AUPR110100A0 (en) * 2000-10-30 2000-11-23 Life Therapeutics Limited Improved separation of macromolecules
US7514078B2 (en) * 2001-06-01 2009-04-07 Cornell Research Foundation, Inc. Methods of treating prostate cancer with anti-prostate specific membrane antigen antibodies
US7998705B2 (en) * 2002-08-06 2011-08-16 FUJIFILM Diosynth Biotechnologies U.S.A., Inc Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
US20060275766A1 (en) * 2003-01-07 2006-12-07 Haurum John S Method for manufacturing recombinant polyclonal proteins

Also Published As

Publication number Publication date
JP2007530971A (ja) 2007-11-01
AU2005228834A1 (en) 2005-10-13
CA2560012A1 (fr) 2005-10-13
EP1729867A1 (fr) 2006-12-13
JP4831697B2 (ja) 2011-12-07
ATE485880T1 (de) 2010-11-15
DE602005024373D1 (de) 2010-12-09
EP1729867B1 (fr) 2010-10-27
US20070213513A1 (en) 2007-09-13
WO2005094960A1 (fr) 2005-10-13

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