SA519410672B1 - تركيبات إنسولين سريعة المفعول - Google Patents
تركيبات إنسولين سريعة المفعولInfo
- Publication number
- SA519410672B1 SA519410672B1 SA519410672A SA519410672A SA519410672B1 SA 519410672 B1 SA519410672 B1 SA 519410672B1 SA 519410672 A SA519410672 A SA 519410672A SA 519410672 A SA519410672 A SA 519410672A SA 519410672 B1 SA519410672 B1 SA 519410672B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- rapid
- acting insulin
- insulin compositions
- insulin
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940123452 Rapid-acting insulin Drugs 0.000 title 1
- 108010026951 Short-Acting Insulin Proteins 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
يتعلق الاختراع الحالي بتركيبة إنسولين insulin composition أو نظير إنسولين insulin analog تتسم بمفعول حركي دوائي pharmacokinetic action أسرع من الصيغ التجارية لمنتجات نظير الإنسولين سريعة بدء المفعول rapid-onset insulin analog products.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762513645P | 2017-06-01 | 2017-06-01 | |
PCT/US2018/035261 WO2018222787A1 (en) | 2017-06-01 | 2018-05-31 | Rapid-acting insulin compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
SA519410672B1 true SA519410672B1 (ar) | 2022-06-16 |
Family
ID=62779004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA519410672A SA519410672B1 (ar) | 2017-06-01 | 2019-11-28 | تركيبات إنسولين سريعة المفعول |
Country Status (25)
Country | Link |
---|---|
US (1) | US11207384B2 (ar) |
EP (1) | EP3630166B1 (ar) |
JP (1) | JP6920471B2 (ar) |
KR (2) | KR102342865B1 (ar) |
CN (1) | CN110662551B (ar) |
AU (1) | AU2018275545B2 (ar) |
BR (1) | BR112019022212A2 (ar) |
CA (1) | CA3065308C (ar) |
CL (1) | CL2019003336A1 (ar) |
CO (1) | CO2019013251A2 (ar) |
CR (1) | CR20190522A (ar) |
DO (1) | DOP2019000300A (ar) |
EA (1) | EA201992351A1 (ar) |
EC (1) | ECSP19085451A (ar) |
ES (1) | ES2912162T3 (ar) |
IL (1) | IL270975B2 (ar) |
JO (1) | JOP20190277B1 (ar) |
MA (1) | MA50496A (ar) |
MX (1) | MX2019014195A (ar) |
NZ (1) | NZ758298A (ar) |
PE (1) | PE20200017A1 (ar) |
PH (1) | PH12019502677A1 (ar) |
SA (1) | SA519410672B1 (ar) |
UA (1) | UA126450C2 (ar) |
WO (1) | WO2018222787A1 (ar) |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0018609B1 (de) | 1979-04-30 | 1983-09-21 | Hoechst Aktiengesellschaft | Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung |
FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
AU612141B2 (en) | 1987-02-25 | 1991-07-04 | Novo Nordisk A/S | Novel insulin derivatives |
US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
JPH04502465A (ja) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
US5547942A (en) | 1994-01-04 | 1996-08-20 | Rapaport; Eliezer | Method of treatment of diabetes mellitus by administration of adenosine 5'-t |
US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
AUPO066096A0 (en) | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
DE69924232D1 (de) | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
ATE220917T1 (de) | 1999-01-26 | 2002-08-15 | Lilly Co Eli | Monodisperse formulierungen, die hexamere acylierte insulinanaloge enthalten |
RU2300367C2 (ru) | 1999-11-15 | 2007-06-10 | Ханамарадди Т. ГАНГАЛ | Жидкий лечебный состав для внутривенного введения, содержащий декстрозу и инсулин |
US7084126B1 (en) | 2000-05-01 | 2006-08-01 | Healthpartners Research Foundation | Methods and compositions for enhancing cellular function through protection of tissue components |
US20020141946A1 (en) | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
DE10351594A1 (de) * | 2003-11-05 | 2005-06-16 | Tecpharma Licensing Ag | Vorrichtung für die Verabreichung eines injizierbaren Produkts |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
PT2319500E (pt) | 2004-03-12 | 2013-01-23 | Biodel Inc | Composições de distribuição de fármacos de actuação rápida |
US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
US20070086952A1 (en) | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
AU2008259768B2 (en) | 2007-06-05 | 2013-08-29 | Paka Pulmonary Pharmaceuticals, Inc. | Compositions for delivering medicaments into the lungs, uses thereof |
ES2744384T3 (es) | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
US20120094902A1 (en) | 2009-03-27 | 2012-04-19 | Adocia | Fast-acting insulin formulation |
FR2943538B1 (fr) | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
CA2805031A1 (en) | 2010-07-07 | 2012-01-12 | Biodel, Inc. | Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of insulin |
US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
AU2012271361B2 (en) | 2011-06-17 | 2017-03-02 | Halozyme, Inc. | Continuous subcutaneous insulin infusion methods with a hyaluronan degrading enzyme |
US20130231281A1 (en) | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
MX361727B (es) | 2011-12-30 | 2018-12-14 | Halozyme Inc | Variantes de polipeptido ph20, formulaciones y usos de las mismas. |
US9399065B2 (en) | 2012-04-16 | 2016-07-26 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin |
US9381247B2 (en) | 2012-04-16 | 2016-07-05 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
EA034393B1 (ru) | 2012-11-13 | 2020-02-03 | Адосиа | Состав инсулина быстрого действия, содержащий замещенное анионное соединение |
US20150065423A1 (en) | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations |
KR102351111B1 (ko) | 2014-01-13 | 2022-01-14 | 써멀린 다이어비티즈, 엘엘씨 | 초속효성 인슐린 제형 및 약제학적 전달 시스템 |
WO2015120457A1 (en) | 2014-02-10 | 2015-08-13 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
JO3624B1 (ar) | 2014-05-08 | 2020-08-27 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
US9795678B2 (en) * | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
AR102869A1 (es) * | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
US20180221385A1 (en) | 2015-07-28 | 2018-08-09 | Societe De Commercialisation Des Produits De La Recherche Appliquee Socpra Sciences Sante Et | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
JO3749B1 (ar) | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
US11247996B2 (en) | 2016-07-29 | 2022-02-15 | University Of Massachusetts | Small molecule inhibitors for transcription factors |
GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
-
2018
- 2018-05-31 EA EA201992351A patent/EA201992351A1/ru unknown
- 2018-05-31 IL IL270975A patent/IL270975B2/en unknown
- 2018-05-31 WO PCT/US2018/035261 patent/WO2018222787A1/en active Application Filing
- 2018-05-31 CA CA3065308A patent/CA3065308C/en active Active
- 2018-05-31 JP JP2019564109A patent/JP6920471B2/ja active Active
- 2018-05-31 JO JOP/2019/0277A patent/JOP20190277B1/ar active
- 2018-05-31 BR BR112019022212-0A patent/BR112019022212A2/pt unknown
- 2018-05-31 MX MX2019014195A patent/MX2019014195A/es unknown
- 2018-05-31 KR KR1020217026363A patent/KR102342865B1/ko active IP Right Grant
- 2018-05-31 US US16/615,894 patent/US11207384B2/en active Active
- 2018-05-31 AU AU2018275545A patent/AU2018275545B2/en active Active
- 2018-05-31 EP EP18735017.8A patent/EP3630166B1/en active Active
- 2018-05-31 CR CR20190522A patent/CR20190522A/es unknown
- 2018-05-31 UA UAA201911304A patent/UA126450C2/uk unknown
- 2018-05-31 NZ NZ758298A patent/NZ758298A/en unknown
- 2018-05-31 MA MA050496A patent/MA50496A/fr unknown
- 2018-05-31 CN CN201880035963.1A patent/CN110662551B/zh active Active
- 2018-05-31 KR KR1020197035033A patent/KR20190140048A/ko active Application Filing
- 2018-05-31 PE PE2019002463A patent/PE20200017A1/es unknown
- 2018-05-31 ES ES18735017T patent/ES2912162T3/es active Active
-
2019
- 2019-11-20 CL CL2019003336A patent/CL2019003336A1/es unknown
- 2019-11-26 CO CONC2019/0013251A patent/CO2019013251A2/es unknown
- 2019-11-27 PH PH12019502677A patent/PH12019502677A1/en unknown
- 2019-11-28 SA SA519410672A patent/SA519410672B1/ar unknown
- 2019-11-29 EC ECSENADI201985451A patent/ECSP19085451A/es unknown
- 2019-11-29 DO DO2019000300A patent/DOP2019000300A/es unknown
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