CO2019013251A2 - Composiciones de insulina de rápida acción - Google Patents
Composiciones de insulina de rápida acciónInfo
- Publication number
- CO2019013251A2 CO2019013251A2 CONC2019/0013251A CO2019013251A CO2019013251A2 CO 2019013251 A2 CO2019013251 A2 CO 2019013251A2 CO 2019013251 A CO2019013251 A CO 2019013251A CO 2019013251 A2 CO2019013251 A2 CO 2019013251A2
- Authority
- CO
- Colombia
- Prior art keywords
- rapid
- acting insulin
- insulin compositions
- insulin
- compositions
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 229940123452 Rapid-acting insulin Drugs 0.000 title 1
- 108010026951 Short-Acting Insulin Proteins 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 239000004026 insulin derivative Substances 0.000 abstract 2
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
La invención es una composición de insulina o análogo de insulina que tiene una acción farmacocinética más rápida que las formulaciones comerciales de productos análogos de insulina de inicio rápido.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762513645P | 2017-06-01 | 2017-06-01 | |
| PCT/US2018/035261 WO2018222787A1 (en) | 2017-06-01 | 2018-05-31 | Rapid-acting insulin compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2019013251A2 true CO2019013251A2 (es) | 2020-01-17 |
Family
ID=62779004
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2019/0013251A CO2019013251A2 (es) | 2017-06-01 | 2019-11-26 | Composiciones de insulina de rápida acción |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11207384B2 (es) |
| EP (1) | EP3630166B1 (es) |
| JP (1) | JP6920471B2 (es) |
| KR (2) | KR20190140048A (es) |
| CN (1) | CN110662551B (es) |
| AU (1) | AU2018275545B2 (es) |
| BR (1) | BR112019022212A2 (es) |
| CA (1) | CA3065308C (es) |
| CL (1) | CL2019003336A1 (es) |
| CO (1) | CO2019013251A2 (es) |
| CR (1) | CR20190522A (es) |
| DO (1) | DOP2019000300A (es) |
| EA (1) | EA201992351A1 (es) |
| EC (1) | ECSP19085451A (es) |
| ES (1) | ES2912162T3 (es) |
| IL (1) | IL270975B2 (es) |
| JO (1) | JOP20190277B1 (es) |
| MA (1) | MA50496A (es) |
| MX (1) | MX2019014195A (es) |
| NZ (1) | NZ758298A (es) |
| PE (1) | PE20200017A1 (es) |
| PH (1) | PH12019502677A1 (es) |
| SA (1) | SA519410672B1 (es) |
| UA (1) | UA126450C2 (es) |
| WO (1) | WO2018222787A1 (es) |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3064888D1 (en) | 1979-04-30 | 1983-10-27 | Hoechst Ag | Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization |
| FI78616C (fi) | 1982-02-05 | 1989-09-11 | Novo Industri As | Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt. |
| PH25772A (en) | 1985-08-30 | 1991-10-18 | Novo Industri As | Insulin analogues, process for their preparation |
| DE10075034I1 (de) | 1987-02-25 | 2001-05-23 | Novo Nordisk As | Insulinderivate |
| JPH04502465A (ja) | 1988-12-23 | 1992-05-07 | ノボ ノルディスク アクティーゼルスカブ | ヒトインシュリン類似物質 |
| US5716927A (en) | 1988-12-23 | 1998-02-10 | Novo Nordisk A/S | Insulin analogs having a modified B-chain |
| US5547942A (en) | 1994-01-04 | 1996-08-20 | Rapaport; Eliezer | Method of treatment of diabetes mellitus by administration of adenosine 5'-t |
| US5474978A (en) | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
| US5866538A (en) | 1996-06-20 | 1999-02-02 | Novo Nordisk A/S | Insulin preparations containing NaCl |
| AUPO066096A0 (en) | 1996-06-26 | 1996-07-18 | Peptide Delivery Systems Pty Ltd | Oral delivery of peptides |
| DE69924232D1 (de) | 1998-01-09 | 2005-04-21 | Novo Nordisk As | Stabilisierte insulin-zubereitungen |
| JP2002535287A (ja) | 1999-01-26 | 2002-10-22 | イーライ・リリー・アンド・カンパニー | 単分散性６量体のアシル化されたインスリンアナログ製剤 |
| WO2001035943A2 (en) | 1999-11-15 | 2001-05-25 | Gangal Hanamaraddi T | Dextrose and insulin fluid formulation for intravenous infusion |
| US7084126B1 (en) | 2000-05-01 | 2006-08-01 | Healthpartners Research Foundation | Methods and compositions for enhancing cellular function through protection of tissue components |
| US20020141946A1 (en) | 2000-12-29 | 2002-10-03 | Advanced Inhalation Research, Inc. | Particles for inhalation having rapid release properties |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| DE10227232A1 (de) | 2002-06-18 | 2004-01-15 | Aventis Pharma Deutschland Gmbh | Saure Insulinzubereitungen mit verbesserter Stabilität |
| DE10351594A1 (de) * | 2003-11-05 | 2005-06-16 | Tecpharma Licensing Ag | Vorrichtung für die Verabreichung eines injizierbaren Produkts |
| US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
| ES2398318T3 (es) | 2004-03-12 | 2013-03-15 | Biodel, Inc. | Composiciones de suministro de fármacos de acción rápida |
| US8084420B2 (en) | 2005-09-29 | 2011-12-27 | Biodel Inc. | Rapid acting and long acting insulin combination formulations |
| US20070086952A1 (en) | 2005-09-29 | 2007-04-19 | Biodel, Inc. | Rapid Acting and Prolonged Acting Inhalable Insulin Preparations |
| CN101754747A (zh) | 2007-06-05 | 2010-06-23 | Paka肺部医药公司 | 用于向肺脏递送药物的方法以及组合物 |
| JP5552046B2 (ja) | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー／エス | インスリン誘導体を含有する薬学的製剤 |
| TWI394580B (zh) | 2008-04-28 | 2013-05-01 | Halozyme Inc | 超快起作用胰島素組成物 |
| US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
| FR2943538B1 (fr) | 2009-03-27 | 2011-05-20 | Adocia | Formulation a action rapide d'insuline recombinante humaine |
| US20120094902A1 (en) | 2009-03-27 | 2012-04-19 | Adocia | Fast-acting insulin formulation |
| CA2805031A1 (en) | 2010-07-07 | 2012-01-12 | Biodel, Inc. | Compositions and methods for modulating the pharmacokinetics and pharmacodynamics of insulin |
| US9993529B2 (en) | 2011-06-17 | 2018-06-12 | Halozyme, Inc. | Stable formulations of a hyaluronan-degrading enzyme |
| EA201400030A1 (ru) | 2011-06-17 | 2014-07-30 | Галозим, Инк. | Способ непрерывного подкожного введения инсулина с использованием фермента, разрушающего хиалуронан |
| US20130231281A1 (en) * | 2011-11-02 | 2013-09-05 | Adocia | Rapid acting insulin formulation comprising an oligosaccharide |
| RS59703B1 (sr) | 2011-12-30 | 2020-01-31 | Halozyme Inc | Varijante ph20 polipeptida, njihove formulacije i upotrebe |
| US9381247B2 (en) | 2012-04-16 | 2016-07-05 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and pharmacodynamics of insulin and insulin analogs, and injection site pain |
| US9399065B2 (en) | 2012-04-16 | 2016-07-26 | Biodel Inc. | Magnesium compositions for modulating the pharmacokinetics and injection site pain of insulin |
| CN104902922B (zh) | 2012-11-13 | 2017-12-12 | 阿道恰公司 | 包含经取代阴离子化合物的速效胰岛素制剂 |
| US20150065423A1 (en) | 2013-08-30 | 2015-03-05 | Perosphere, Inc. | Rapid acting injectable formulations |
| CA2936563A1 (en) | 2014-01-13 | 2015-07-16 | Thermalin Diabetes, Llc | Rapid action insulin formulations and pharmaceutical delivery systems |
| WO2015120457A1 (en) | 2014-02-10 | 2015-08-13 | Biodel Inc. | Stabilized ultra-rapid-acting insulin formulations |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| US9795678B2 (en) * | 2014-05-14 | 2017-10-24 | Adocia | Fast-acting insulin composition comprising a substituted anionic compound and a polyanionic compound |
| AR102869A1 (es) * | 2014-12-16 | 2017-03-29 | Lilly Co Eli | Composiciones de insulina de rápida acción |
| EP3328388B1 (en) | 2015-07-28 | 2023-12-27 | Eli Lilly and Company | A pharmaceutical preparation for improving absorption and postprandial hypoglycemic action of insulin |
| JO3749B1 (ar) * | 2015-08-27 | 2021-01-31 | Lilly Co Eli | تركيبات إنسولين سريعة المفعول |
| GB201607918D0 (en) | 2016-05-06 | 2016-06-22 | Arecor Ltd | Novel formulations |
| US11247996B2 (en) | 2016-07-29 | 2022-02-15 | University Of Massachusetts | Small molecule inhibitors for transcription factors |
| GB201707188D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
| GB201707189D0 (en) | 2017-05-05 | 2017-06-21 | Arecor Ltd | Novel formulations |
-
2018
- 2018-05-31 JO JOP/2019/0277A patent/JOP20190277B1/ar active
- 2018-05-31 EP EP18735017.8A patent/EP3630166B1/en active Active
- 2018-05-31 KR KR1020197035033A patent/KR20190140048A/ko active Application Filing
- 2018-05-31 MX MX2019014195A patent/MX2019014195A/es unknown
- 2018-05-31 AU AU2018275545A patent/AU2018275545B2/en active Active
- 2018-05-31 MA MA050496A patent/MA50496A/fr unknown
- 2018-05-31 IL IL270975A patent/IL270975B2/en unknown
- 2018-05-31 KR KR1020217026363A patent/KR102342865B1/ko active IP Right Grant
- 2018-05-31 WO PCT/US2018/035261 patent/WO2018222787A1/en active Application Filing
- 2018-05-31 CR CR20190522A patent/CR20190522A/es unknown
- 2018-05-31 NZ NZ758298A patent/NZ758298A/en unknown
- 2018-05-31 JP JP2019564109A patent/JP6920471B2/ja active Active
- 2018-05-31 BR BR112019022212-0A patent/BR112019022212A2/pt unknown
- 2018-05-31 EA EA201992351A patent/EA201992351A1/ru unknown
- 2018-05-31 CA CA3065308A patent/CA3065308C/en active Active
- 2018-05-31 PE PE2019002463A patent/PE20200017A1/es unknown
- 2018-05-31 US US16/615,894 patent/US11207384B2/en active Active
- 2018-05-31 UA UAA201911304A patent/UA126450C2/uk unknown
- 2018-05-31 ES ES18735017T patent/ES2912162T3/es active Active
- 2018-05-31 CN CN201880035963.1A patent/CN110662551B/zh active Active
-
2019
- 2019-11-20 CL CL2019003336A patent/CL2019003336A1/es unknown
- 2019-11-26 CO CONC2019/0013251A patent/CO2019013251A2/es unknown
- 2019-11-27 PH PH12019502677A patent/PH12019502677A1/en unknown
- 2019-11-28 SA SA519410672A patent/SA519410672B1/ar unknown
- 2019-11-29 EC ECSENADI201985451A patent/ECSP19085451A/es unknown
- 2019-11-29 DO DO2019000300A patent/DOP2019000300A/es unknown
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