SA517381158B1 - تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمر - Google Patents
تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمرInfo
- Publication number
- SA517381158B1 SA517381158B1 SA517381158A SA517381158A SA517381158B1 SA 517381158 B1 SA517381158 B1 SA 517381158B1 SA 517381158 A SA517381158 A SA 517381158A SA 517381158 A SA517381158 A SA 517381158A SA 517381158 B1 SA517381158 B1 SA 517381158B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- continuous flow
- carboxylation reaction
- reaction
- flow carboxylation
- aryl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/242—Tubular reactors in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/24—Stationary reactors without moving elements inside
- B01J19/2415—Tubular reactors
- B01J19/243—Tubular reactors spirally, concentrically or zigzag wound
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00049—Controlling or regulating processes
- B01J2219/00051—Controlling the temperature
- B01J2219/00074—Controlling the temperature by indirect heating or cooling employing heat exchange fluids
- B01J2219/00087—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor
- B01J2219/00099—Controlling the temperature by indirect heating or cooling employing heat exchange fluids with heat exchange elements outside the reactor the reactor being immersed in the heat exchange medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/02—Apparatus characterised by their chemically-resistant properties
- B01J2219/025—Apparatus characterised by their chemically-resistant properties characterised by the construction materials of the reactor vessel proper
- B01J2219/0277—Metal based
- B01J2219/0286—Steel
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/24—Stationary reactors without moving elements inside
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462055286P | 2014-09-25 | 2014-09-25 | |
| PCT/US2015/052320 WO2016049509A1 (en) | 2014-09-25 | 2015-09-25 | Continuous flow carboxylation reaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA517381158B1 true SA517381158B1 (ar) | 2021-05-23 |
Family
ID=55582084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA517381158A SA517381158B1 (ar) | 2014-09-25 | 2017-03-22 | تفاعل إضافة مجموعة الكربوكسيل بتدفق مستمر |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US9725413B2 (enExample) |
| EP (1) | EP3197454B1 (enExample) |
| JP (2) | JP6754356B2 (enExample) |
| CN (1) | CN106714801B (enExample) |
| AU (1) | AU2015320349B2 (enExample) |
| BR (1) | BR112017005856A2 (enExample) |
| CA (1) | CA2960392A1 (enExample) |
| ES (1) | ES2857730T3 (enExample) |
| HU (1) | HUE053118T2 (enExample) |
| IL (2) | IL250958B (enExample) |
| MX (1) | MX365010B (enExample) |
| PL (1) | PL3197454T3 (enExample) |
| PT (1) | PT3197454T (enExample) |
| SA (1) | SA517381158B1 (enExample) |
| WO (1) | WO2016049509A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106714801B (zh) | 2014-09-25 | 2021-04-06 | 诺华股份有限公司 | 连续流羧基化反应 |
| CN110831938B (zh) * | 2017-06-30 | 2023-08-01 | 台湾神隆股份有限公司 | 用于制备立他司特和其中间体的方法 |
| JPWO2019026425A1 (ja) * | 2017-07-31 | 2020-05-28 | 株式会社カネカ | フロー式リアクター |
| HUE059090T2 (hu) * | 2017-11-14 | 2022-10-28 | Albemarle Germany Gmbh | Szerves lítium eljárás folyamatos áramlási körülmények között |
| CN109384717A (zh) * | 2018-10-29 | 2019-02-26 | 广安凯特制药有限公司 | 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酸盐酸盐水合物及其制备方法和用途 |
| CN110724098A (zh) * | 2019-11-13 | 2020-01-24 | 成都福柯斯医药技术有限公司 | 一种5,7-二氯-1,2,3,4-四氢异喹啉-6-羧酸盐酸盐的合成方法 |
| CN113845478B (zh) * | 2020-12-18 | 2023-11-21 | 四川大学 | 一种中间体及其制备方法和应用 |
| CN113277942B (zh) * | 2021-05-25 | 2024-05-03 | 都创(上海)医药开发有限公司 | 一种基于微通道反应技术快速制备5-氯-2-氟-4-(三氟甲基)苯甲酸的方法 |
| CN116239532B (zh) * | 2022-12-19 | 2023-11-07 | 浙江博崤生物制药有限公司 | 一种二氯四氢异喹啉羧酸的中间体及其制备方法和应用 |
| CN115872929B (zh) * | 2022-12-27 | 2024-12-03 | 山东金城柯瑞化学有限公司 | 芳基类化合物连续羧基化反应制备立他司特中间体的方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7767856B2 (en) * | 2007-01-25 | 2010-08-03 | Xerox Corporation | System and method for producing arylamine compounds |
| CN101450300A (zh) * | 2007-12-05 | 2009-06-10 | 海南大学 | 连续流微反应器及其制备和应用 |
| US8378105B2 (en) * | 2009-10-21 | 2013-02-19 | Sarcode Bioscience Inc. | Crystalline pharmaceutical and methods of preparation and use thereof |
| WO2013086585A1 (en) * | 2011-12-14 | 2013-06-20 | Commonwealth Scientific And Industrial Research Organisation | Raft polymers |
| EP2877465A4 (en) | 2012-07-25 | 2016-05-11 | Sarcode Bioscience Inc | LFA-1 HEMMER AND POLYMORPH THEREOF |
| CN106714801B (zh) * | 2014-09-25 | 2021-04-06 | 诺华股份有限公司 | 连续流羧基化反应 |
-
2015
- 2015-09-25 CN CN201580050837.XA patent/CN106714801B/zh active Active
- 2015-09-25 MX MX2017003505A patent/MX365010B/es active IP Right Grant
- 2015-09-25 BR BR112017005856A patent/BR112017005856A2/pt not_active Application Discontinuation
- 2015-09-25 PT PT158448464T patent/PT3197454T/pt unknown
- 2015-09-25 HU HUE15844846A patent/HUE053118T2/hu unknown
- 2015-09-25 CA CA2960392A patent/CA2960392A1/en not_active Abandoned
- 2015-09-25 PL PL15844846T patent/PL3197454T3/pl unknown
- 2015-09-25 AU AU2015320349A patent/AU2015320349B2/en active Active
- 2015-09-25 WO PCT/US2015/052320 patent/WO2016049509A1/en not_active Ceased
- 2015-09-25 US US14/866,085 patent/US9725413B2/en active Active
- 2015-09-25 ES ES15844846T patent/ES2857730T3/es active Active
- 2015-09-25 EP EP15844846.4A patent/EP3197454B1/en active Active
- 2015-09-25 JP JP2017516101A patent/JP6754356B2/ja active Active
-
2017
- 2017-03-06 IL IL250958A patent/IL250958B/en active IP Right Grant
- 2017-03-22 SA SA517381158A patent/SA517381158B1/ar unknown
- 2017-06-28 US US15/635,632 patent/US10273212B2/en active Active
-
2019
- 2019-04-09 US US16/378,868 patent/US10899715B2/en active Active
- 2019-08-01 IL IL268432A patent/IL268432B/en active IP Right Grant
- 2019-10-16 JP JP2019189312A patent/JP2020045341A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015320349B2 (en) | 2020-03-12 |
| US20160090361A1 (en) | 2016-03-31 |
| PT3197454T (pt) | 2021-03-04 |
| MX365010B (es) | 2019-05-20 |
| MX2017003505A (es) | 2017-07-28 |
| ES2857730T3 (es) | 2021-09-29 |
| JP2020045341A (ja) | 2020-03-26 |
| EP3197454A4 (en) | 2018-02-21 |
| IL250958A0 (en) | 2017-04-30 |
| HUE053118T2 (hu) | 2021-06-28 |
| CN106714801B (zh) | 2021-04-06 |
| JP6754356B2 (ja) | 2020-09-09 |
| IL268432A (en) | 2019-09-26 |
| IL268432B (en) | 2020-08-31 |
| WO2016049509A1 (en) | 2016-03-31 |
| IL250958B (en) | 2019-08-29 |
| JP2017530125A (ja) | 2017-10-12 |
| PL3197454T3 (pl) | 2021-06-14 |
| US20190300485A1 (en) | 2019-10-03 |
| CA2960392A1 (en) | 2016-03-31 |
| BR112017005856A2 (pt) | 2017-12-19 |
| CN106714801A (zh) | 2017-05-24 |
| US10273212B2 (en) | 2019-04-30 |
| US9725413B2 (en) | 2017-08-08 |
| AU2015320349A1 (en) | 2017-03-23 |
| EP3197454B1 (en) | 2021-01-06 |
| US10899715B2 (en) | 2021-01-26 |
| US20180118689A1 (en) | 2018-05-03 |
| EP3197454A1 (en) | 2017-08-02 |
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