SA516380291B1 - الحساب الكمي لتاموكسيفين ونواتج أيضه بواسطة القياس الطيفي الكتلي - Google Patents
الحساب الكمي لتاموكسيفين ونواتج أيضه بواسطة القياس الطيفي الكتلي Download PDFInfo
- Publication number
- SA516380291B1 SA516380291B1 SA516380291A SA516380291A SA516380291B1 SA 516380291 B1 SA516380291 B1 SA 516380291B1 SA 516380291 A SA516380291 A SA 516380291A SA 516380291 A SA516380291 A SA 516380291A SA 516380291 B1 SA516380291 B1 SA 516380291B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- tamoxifen
- mass spectrometry
- norendoxifen
- amount
- sample
- Prior art date
Links
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 title claims abstract 19
- 238000004949 mass spectrometry Methods 0.000 title claims abstract 10
- 239000002207 metabolite Substances 0.000 title claims abstract 9
- 229960001603 tamoxifen Drugs 0.000 title claims abstract 8
- 238000000034 method Methods 0.000 claims abstract 33
- YCQBLTPGQSYLHD-VHXPQNKSSA-N Norendoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN)=CC=1)/C1=CC=C(O)C=C1 YCQBLTPGQSYLHD-VHXPQNKSSA-N 0.000 claims abstract 9
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims 6
- 150000002500 ions Chemical class 0.000 claims 5
- 238000000746 purification Methods 0.000 claims 5
- 238000001514 detection method Methods 0.000 claims 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims 4
- 238000004811 liquid chromatography Methods 0.000 claims 4
- MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 claims 3
- -1 norendoxifen ions Chemical class 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- KLPBCGLMGLFHNY-OCOZRVBESA-N 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)\C1=CC=CC=C1 KLPBCGLMGLFHNY-OCOZRVBESA-N 0.000 claims 2
- 238000000451 chemical ionisation Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 230000006920 protein precipitation Effects 0.000 claims 2
- 238000011002 quantification Methods 0.000 claims 2
- 238000004885 tandem mass spectrometry Methods 0.000 claims 2
- 241000196324 Embryophyta Species 0.000 claims 1
- NYDCDZSEEAUOHN-IZHYLOQSSA-N N-Desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=CC=C1 NYDCDZSEEAUOHN-IZHYLOQSSA-N 0.000 claims 1
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 238000002474 experimental method Methods 0.000 claims 1
- 239000011800 void material Substances 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0031—Step by step routines describing the use of the apparatus
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/17—Nitrogen containing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Ecology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992214P | 2014-05-12 | 2014-05-12 | |
| PCT/US2015/030419 WO2015175561A1 (en) | 2014-05-12 | 2015-05-12 | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SA516380291B1 true SA516380291B1 (ar) | 2020-04-13 |
Family
ID=54367635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SA516380291A SA516380291B1 (ar) | 2014-05-12 | 2016-11-13 | الحساب الكمي لتاموكسيفين ونواتج أيضه بواسطة القياس الطيفي الكتلي |
Country Status (9)
| Country | Link |
|---|---|
| US (6) | US9459267B2 (enExample) |
| EP (2) | EP3143392B1 (enExample) |
| JP (5) | JP6279104B2 (enExample) |
| CN (2) | CN106537139B (enExample) |
| AU (6) | AU2015259294A1 (enExample) |
| BR (1) | BR112016026459B1 (enExample) |
| CA (1) | CA2948823C (enExample) |
| SA (1) | SA516380291B1 (enExample) |
| WO (1) | WO2015175561A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2384437B1 (en) * | 2008-12-24 | 2018-12-12 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for pregnenolone and 17-hydroxypregnenolone |
| US9459267B2 (en) | 2014-05-12 | 2016-10-04 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
| CN105159539B (zh) * | 2015-09-10 | 2018-06-01 | 京东方科技集团股份有限公司 | 可穿戴设备的触控响应方法、装置及可穿戴设备 |
| BR112022006749A2 (pt) | 2019-10-10 | 2022-06-28 | Regeneron Pharma | Método para identificar uma composição de anfólito de teste com atividade adequada |
| KR20220136376A (ko) | 2020-01-31 | 2022-10-07 | 리제너론 파마슈티칼스 인코포레이티드 | 올리고뉴클레오티드의 특성을 분석하기 위한 액체 크로마토그래피 및 질량 분광분석의 용도 |
| US12105102B2 (en) | 2022-03-30 | 2024-10-01 | University Of Utah Research Foundation | Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5119827A (en) * | 1990-09-05 | 1992-06-09 | Board Of Regents, The University Of Texas System | Mechanisms of antiestrogen resistance in breast cancer |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| EP1347493A3 (en) | 1993-05-28 | 2005-11-23 | Baylor College Of Medicine | Method and apparatus for desorption and ionization of analytes |
| IES66994B2 (en) * | 1995-12-08 | 1996-02-21 | Bunskellig Limited | A process for analysing a fluid |
| GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| AU2463299A (en) | 1998-01-23 | 1999-08-09 | Analytica Of Branford, Inc. | Mass spectrometry from surfaces |
| CN1871517A (zh) * | 2002-02-19 | 2006-11-29 | 免疫公司 | 快速有效分离循环癌细胞的方法和试剂 |
| EP1572171B1 (en) * | 2002-12-18 | 2009-04-22 | Laboratoires Besins International | Reduction of breast density with 4-hydroxy tamoxifen |
| NZ542499A (en) * | 2003-04-01 | 2008-10-31 | Besins Int Lab | Prevention and treatment of breast cancer with 4-hydroxy tamoxifen |
| WO2005064344A1 (ja) * | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 脂質代謝異常症の予測方法 |
| MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| US20060105045A1 (en) * | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Cyclodextrin solubilizers for liquid and semi-solid formulations |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| US8017403B2 (en) * | 2007-06-14 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Mass spectrometry method for measuring vitamin B6 in body fluid |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US8916385B2 (en) * | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
| US7834313B2 (en) | 2008-08-08 | 2010-11-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
| EP3301446B1 (en) * | 2009-02-11 | 2020-04-15 | Caris MPI, Inc. | Molecular profiling of tumors |
| US20110081675A1 (en) * | 2009-10-06 | 2011-04-07 | Wisconsin Alumni Research Foundation | Metabolic Biomarkers Of Drug-Induced Cardiotoxicity |
| WO2012119010A2 (en) * | 2011-03-01 | 2012-09-07 | Indiana University Research And Technology Corporation | Materials for inhibiting aromatase and method of using the same to diagnose, treat and monitor breast cancer |
| WO2012167126A1 (en) * | 2011-06-03 | 2012-12-06 | Purdue Research Foundation | Ion generation using modified wetted porous materials |
| CN104203961B (zh) * | 2012-03-05 | 2017-05-17 | 泽维尔大学 | 作为用于治疗乳腺癌的基于硼的4‑羟基他莫昔芬和因多昔芬前药 |
| WO2014014279A1 (ko) * | 2012-07-17 | 2014-01-23 | 서울대학교 산학협력단 | 질량 스펙트럼의 재현성 향상 방법 및 이를 이용한 정량 분석 방법 |
| CN103494787B (zh) * | 2013-07-22 | 2014-10-29 | 南通广泰生化制品有限公司 | 枸橼酸他莫昔芬滴丸 |
| US9459267B2 (en) * | 2014-05-12 | 2016-10-04 | Quest Diagnostics Investments Incorporated | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
-
2015
- 2015-05-12 US US14/710,311 patent/US9459267B2/en active Active
- 2015-05-12 BR BR112016026459-2A patent/BR112016026459B1/pt active IP Right Grant
- 2015-05-12 AU AU2015259294A patent/AU2015259294A1/en not_active Abandoned
- 2015-05-12 JP JP2016567654A patent/JP6279104B2/ja active Active
- 2015-05-12 CN CN201580037630.9A patent/CN106537139B/zh active Active
- 2015-05-12 WO PCT/US2015/030419 patent/WO2015175561A1/en not_active Ceased
- 2015-05-12 EP EP15793289.8A patent/EP3143392B1/en active Active
- 2015-05-12 CN CN201910220665.6A patent/CN110044998B/zh active Active
- 2015-05-12 CA CA2948823A patent/CA2948823C/en active Active
- 2015-05-12 EP EP23157017.7A patent/EP4220178A3/en active Pending
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2016
- 2016-10-03 US US15/284,248 patent/US9835606B2/en active Active
- 2016-11-13 SA SA516380291A patent/SA516380291B1/ar unknown
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2017
- 2017-12-04 US US15/830,812 patent/US10830746B2/en active Active
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2018
- 2018-01-16 JP JP2018004851A patent/JP6821610B2/ja active Active
- 2018-12-07 AU AU2018275011A patent/AU2018275011A1/en not_active Abandoned
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2020
- 2020-09-23 AU AU2020239700A patent/AU2020239700B2/en active Active
- 2020-11-09 US US17/093,472 patent/US11428682B2/en active Active
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2021
- 2021-01-06 JP JP2021000689A patent/JP2021073450A/ja active Pending
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2022
- 2022-04-20 AU AU2022202628A patent/AU2022202628B2/en active Active
- 2022-08-23 US US17/893,950 patent/US11835505B2/en active Active
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2023
- 2023-05-16 JP JP2023080724A patent/JP2023109874A/ja active Pending
- 2023-07-07 AU AU2023204389A patent/AU2023204389B2/en active Active
- 2023-10-25 US US18/494,030 patent/US12270803B2/en active Active
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2024
- 2024-10-09 AU AU2024227191A patent/AU2024227191A1/en active Pending
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2025
- 2025-02-07 JP JP2025018885A patent/JP2025081382A/ja active Pending
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