JP6279104B2 - 質量分析によるタモキシフェンおよびその代謝産物の定量化 - Google Patents

質量分析によるタモキシフェンおよびその代謝産物の定量化 Download PDF

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JP6279104B2
JP6279104B2 JP2016567654A JP2016567654A JP6279104B2 JP 6279104 B2 JP6279104 B2 JP 6279104B2 JP 2016567654 A JP2016567654 A JP 2016567654A JP 2016567654 A JP2016567654 A JP 2016567654A JP 6279104 B2 JP6279104 B2 JP 6279104B2
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tamoxifen
hydroxy tamoxifen
desmethyl
detecting
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JP2017516104A5 (enExample
JP2017516104A (ja
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クラーク，ニゲル
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クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド
クエスト ダイアグノスティックス インヴェストメンツ インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/15—Medicinal preparations ; Physical properties thereof, e.g. dissolubility
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/17—Nitrogen containing
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ecology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2016567654A 2014-05-12 2015-05-12 質量分析によるタモキシフェンおよびその代謝産物の定量化 Active JP6279104B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992214P 2014-05-12 2014-05-12
US61/992,214 2014-05-12
PCT/US2015/030419 WO2015175561A1 (en) 2014-05-12 2015-05-12 Quantitation of tamoxifen and metabolites thereof by mass spectrometry

Related Child Applications (1)

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JP2018004851A Division JP6821610B2 (ja) 2014-05-12 2018-01-16 質量分析によるタモキシフェンおよびその代謝産物の定量化

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JP2017516104A JP2017516104A (ja) 2017-06-15
JP2017516104A5 JP2017516104A5 (enExample) 2017-07-27
JP6279104B2 true JP6279104B2 (ja) 2018-02-14

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JP2016567654A Active JP6279104B2 (ja) 2014-05-12 2015-05-12 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2018004851A Active JP6821610B2 (ja) 2014-05-12 2018-01-16 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2021000689A Pending JP2021073450A (ja) 2014-05-12 2021-01-06 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2023080724A Pending JP2023109874A (ja) 2014-05-12 2023-05-16 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2025018885A Pending JP2025081382A (ja) 2014-05-12 2025-02-07 質量分析によるタモキシフェンおよびその代謝産物の定量化

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JP2021000689A Pending JP2021073450A (ja) 2014-05-12 2021-01-06 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2023080724A Pending JP2023109874A (ja) 2014-05-12 2023-05-16 質量分析によるタモキシフェンおよびその代謝産物の定量化
JP2025018885A Pending JP2025081382A (ja) 2014-05-12 2025-02-07 質量分析によるタモキシフェンおよびその代謝産物の定量化

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US (6) US9459267B2 (enExample)
EP (2) EP4220178A3 (enExample)
JP (5) JP6279104B2 (enExample)
CN (2) CN110044998B (enExample)
AU (6) AU2015259294A1 (enExample)
BR (1) BR112016026459B1 (enExample)
CA (1) CA2948823C (enExample)
SA (1) SA516380291B1 (enExample)
WO (1) WO2015175561A1 (enExample)

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CN105159539B (zh) * 2015-09-10 2018-06-01 京东方科技集团股份有限公司 可穿戴设备的触控响应方法、装置及可穿戴设备
US12055518B2 (en) 2019-10-10 2024-08-06 Regeneron Pharmaceuticals, Inc. Liquid chromatography-mass spectrometry (LC-MS) methods for analyzing ampholyte lot variation
IL295038A (en) 2020-01-31 2022-09-01 Regeneron Pharma Use of liquid chromatography and mass spectrometry to characterize oligonucleotides
US12105102B2 (en) 2022-03-30 2024-10-01 University Of Utah Research Foundation Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2

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US5605798A (en) 1993-01-07 1997-02-25 Sequenom, Inc. DNA diagnostic based on mass spectrometry
DK0700521T3 (da) 1993-05-28 2003-09-29 Baylor College Medicine Fremgangsmåde og massespektrometer til desorption og ionisering af analysander
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US9459267B2 (en) 2016-10-04
CA2948823A1 (en) 2015-11-19
US9835606B2 (en) 2017-12-05
JP2018077253A (ja) 2018-05-17
AU2022202628A1 (en) 2022-05-12
BR112016026459B1 (pt) 2022-09-27
EP3143392B1 (en) 2023-02-22
US11428682B2 (en) 2022-08-30
US10830746B2 (en) 2020-11-10
AU2023204389A1 (en) 2023-07-27
US20230114103A1 (en) 2023-04-13
AU2018275011A1 (en) 2019-01-03
AU2022202628B2 (en) 2023-06-08
US11835505B2 (en) 2023-12-05
US20210055277A1 (en) 2021-02-25
US20170023537A1 (en) 2017-01-26
WO2015175561A1 (en) 2015-11-19
US12270803B2 (en) 2025-04-08
US20150323513A1 (en) 2015-11-12
EP3143392A4 (en) 2017-11-15
CN110044998B (zh) 2021-12-14
AU2015259294A1 (en) 2016-12-01
EP3143392A1 (en) 2017-03-22
JP2021073450A (ja) 2021-05-13
BR112016026459A2 (enExample) 2017-08-15
US20240060950A1 (en) 2024-02-22
JP2023109874A (ja) 2023-08-08
US20190212317A1 (en) 2019-07-11
AU2020239700B2 (en) 2022-01-27
AU2020239700A1 (en) 2020-10-15
JP2017516104A (ja) 2017-06-15
CN110044998A (zh) 2019-07-23
EP4220178A2 (en) 2023-08-02
AU2023204389B2 (en) 2025-05-22
JP2025081382A (ja) 2025-05-27
EP4220178A3 (en) 2023-08-16
CN106537139A (zh) 2017-03-22
CA2948823C (en) 2020-09-22
JP6821610B2 (ja) 2021-01-27
CN106537139B (zh) 2019-04-16
SA516380291B1 (ar) 2020-04-13
AU2024227191A1 (en) 2024-10-31

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