JP2017516104A5 - - Google Patents
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- Publication number
- JP2017516104A5 JP2017516104A5 JP2016567654A JP2016567654A JP2017516104A5 JP 2017516104 A5 JP2017516104 A5 JP 2017516104A5 JP 2016567654 A JP2016567654 A JP 2016567654A JP 2016567654 A JP2016567654 A JP 2016567654A JP 2017516104 A5 JP2017516104 A5 JP 2017516104A5
- Authority
- JP
- Japan
- Prior art keywords
- mass spectrometry
- amount
- norendoxifene
- tamoxifen
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 34
- 239000002207 metabolite Substances 0.000 claims 9
- 238000004949 mass spectrometry Methods 0.000 claims 8
- 150000002500 ions Chemical class 0.000 claims 7
- NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 claims 6
- 238000000746 purification Methods 0.000 claims 6
- MHJBZVSGOZTKRH-IZHYLOQSSA-N 4-Hydroxy-N-desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=C(O)C=C1 MHJBZVSGOZTKRH-IZHYLOQSSA-N 0.000 claims 5
- DODQJNMQWMSYGS-QPLCGJKRSA-N 4-[(z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 DODQJNMQWMSYGS-QPLCGJKRSA-N 0.000 claims 4
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims 4
- 238000004128 high performance liquid chromatography Methods 0.000 claims 4
- 238000004811 liquid chromatography Methods 0.000 claims 4
- 229960001603 tamoxifen Drugs 0.000 claims 3
- KLPBCGLMGLFHNY-OCOZRVBESA-N 4-[(E)-1-[4-[2-(methylamino)ethoxy]phenyl]-1-phenylbut-1-en-2-yl]phenol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)\C1=CC=CC=C1 KLPBCGLMGLFHNY-OCOZRVBESA-N 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 238000001914 filtration Methods 0.000 claims 2
- 230000006920 protein precipitation Effects 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 238000004885 tandem mass spectrometry Methods 0.000 claims 2
- NYDCDZSEEAUOHN-IZHYLOQSSA-N N-Desmethyltamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCNC)=CC=1)/C1=CC=CC=C1 NYDCDZSEEAUOHN-IZHYLOQSSA-N 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461992214P | 2014-05-12 | 2014-05-12 | |
| US61/992,214 | 2014-05-12 | ||
| PCT/US2015/030419 WO2015175561A1 (en) | 2014-05-12 | 2015-05-12 | Quantitation of tamoxifen and metabolites thereof by mass spectrometry |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018004851A Division JP6821610B2 (ja) | 2014-05-12 | 2018-01-16 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017516104A JP2017516104A (ja) | 2017-06-15 |
| JP2017516104A5 true JP2017516104A5 (enExample) | 2017-07-27 |
| JP6279104B2 JP6279104B2 (ja) | 2018-02-14 |
Family
ID=54367635
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016567654A Active JP6279104B2 (ja) | 2014-05-12 | 2015-05-12 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2018004851A Active JP6821610B2 (ja) | 2014-05-12 | 2018-01-16 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2021000689A Pending JP2021073450A (ja) | 2014-05-12 | 2021-01-06 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2023080724A Pending JP2023109874A (ja) | 2014-05-12 | 2023-05-16 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2025018885A Active JP7884626B2 (ja) | 2014-05-12 | 2025-02-07 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018004851A Active JP6821610B2 (ja) | 2014-05-12 | 2018-01-16 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2021000689A Pending JP2021073450A (ja) | 2014-05-12 | 2021-01-06 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2023080724A Pending JP2023109874A (ja) | 2014-05-12 | 2023-05-16 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
| JP2025018885A Active JP7884626B2 (ja) | 2014-05-12 | 2025-02-07 | 質量分析によるタモキシフェンおよびその代謝産物の定量化 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US9459267B2 (enExample) |
| EP (2) | EP3143392B1 (enExample) |
| JP (5) | JP6279104B2 (enExample) |
| CN (2) | CN110044998B (enExample) |
| AU (6) | AU2015259294A1 (enExample) |
| BR (1) | BR112016026459B1 (enExample) |
| CA (1) | CA2948823C (enExample) |
| SA (1) | SA516380291B1 (enExample) |
| WO (1) | WO2015175561A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4718073A3 (en) * | 2008-12-24 | 2026-07-29 | Quest Diagnostics Investments LLC | Mass spectrometry assay for congenital adrenal hyperplasia |
| CN110044998B (zh) * | 2014-05-12 | 2021-12-14 | 奎斯特诊断投资公司 | 通过质谱法定量他莫昔芬及其代谢物 |
| CN105159539B (zh) * | 2015-09-10 | 2018-06-01 | 京东方科技集团股份有限公司 | 可穿戴设备的触控响应方法、装置及可穿戴设备 |
| CA3153535A1 (en) | 2019-10-10 | 2021-04-15 | Rachel MULLEN | Liquid chromatography-mass spectrometry (lc-ms) methods for analyzing ampholyte lot variation |
| EP4097256A1 (en) | 2020-01-31 | 2022-12-07 | Regeneron Pharmaceuticals, Inc. | Use of liquid chromatography and mass spectrometry to characterize oligonucleotides |
| US12105102B2 (en) | 2022-03-30 | 2024-10-01 | University Of Utah Research Foundation | Methods for quantifying insulin-like growth factor-1 and insulin-like growth factor-2 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5119827A (en) * | 1990-09-05 | 1992-06-09 | Board Of Regents, The University Of Texas System | Mechanisms of antiestrogen resistance in breast cancer |
| US5605798A (en) | 1993-01-07 | 1997-02-25 | Sequenom, Inc. | DNA diagnostic based on mass spectrometry |
| PT700521E (pt) | 1993-05-28 | 2003-10-31 | Baylor College Medicine | Metodo e espectrometro de massa para dessorcao e ionizacao de analitos |
| IES950928A2 (en) * | 1995-12-08 | 1996-02-21 | Bunskellig Limited | "A process for analysing a fluid" |
| GB9717926D0 (en) | 1997-08-22 | 1997-10-29 | Micromass Ltd | Methods and apparatus for tandem mass spectrometry |
| JP2002502086A (ja) | 1998-01-23 | 2002-01-22 | アナリティカ オブ ブランフォード インコーポレーテッド | 表面からの質量分光測定 |
| CN1871517A (zh) * | 2002-02-19 | 2006-11-29 | 免疫公司 | 快速有效分离循环癌细胞的方法和试剂 |
| EP2050443B1 (en) * | 2002-12-18 | 2017-05-24 | Besins Healthcare Luxembourg SARL | Reduction of breast density with 4-hydroxy tamoxifen |
| CA2519980C (en) | 2003-04-01 | 2012-04-10 | Laboratoires Besins International | Prevention and treatment of breast cancer with 4-hydroxy tamoxifen |
| WO2005064344A1 (ja) * | 2003-12-26 | 2005-07-14 | Takeda Pharmaceutical Company Limited | 脂質代謝異常症の予測方法 |
| MY145634A (en) * | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| US20060105045A1 (en) * | 2004-11-08 | 2006-05-18 | Buchanan Charles M | Cyclodextrin solubilizers for liquid and semi-solid formulations |
| US20090291134A1 (en) * | 2006-11-21 | 2009-11-26 | Jina Pharmaceuticals, Inc. | Endoxifen methods and compositions in the treatment of psychiatric and neurodegenerative diseases |
| US8017403B2 (en) * | 2007-06-14 | 2011-09-13 | Quest Diagnostics Investments Incorporated | Mass spectrometry method for measuring vitamin B6 in body fluid |
| US20090134325A1 (en) * | 2007-11-27 | 2009-05-28 | Goldman Mildred M | Methods for detecting estradiol by mass spectrometry |
| US8916385B2 (en) * | 2007-12-13 | 2014-12-23 | Quest Diagnostics Investments, Inc. | Methods for detecting estrone by mass spectrometry |
| US7834313B2 (en) | 2008-08-08 | 2010-11-16 | Quest Diagnostics Investments Incorporated | Mass spectrometry assay for plasma-renin |
| IL313131A (en) * | 2009-02-11 | 2024-07-01 | Caris Mpi Inc | Molecular characterization of tumors |
| US20110081675A1 (en) * | 2009-10-06 | 2011-04-07 | Wisconsin Alumni Research Foundation | Metabolic Biomarkers Of Drug-Induced Cardiotoxicity |
| WO2012119010A2 (en) * | 2011-03-01 | 2012-09-07 | Indiana University Research And Technology Corporation | Materials for inhibiting aromatase and method of using the same to diagnose, treat and monitor breast cancer |
| WO2012167126A1 (en) | 2011-06-03 | 2012-12-06 | Purdue Research Foundation | Ion generation using modified wetted porous materials |
| WO2013134230A1 (en) * | 2012-03-05 | 2013-09-12 | Xavier University | Boron-based 4-hydroxytamoxifen and endoxifen prodrugs as treatment for breast cancer |
| JP6216786B2 (ja) * | 2012-07-17 | 2017-10-18 | ソウル大学校産学協力団Ｓｎｕ Ｒ＆Ｄｂ Ｆｏｕｎｄａｔｉｏｎ | 質量スペクトルの再現性向上方法およびこれを用いた定量分析方法 |
| CN103494787B (zh) * | 2013-07-22 | 2014-10-29 | 南通广泰生化制品有限公司 | 枸橼酸他莫昔芬滴丸 |
| CN110044998B (zh) * | 2014-05-12 | 2021-12-14 | 奎斯特诊断投资公司 | 通过质谱法定量他莫昔芬及其代谢物 |
-
2015
- 2015-05-12 CN CN201910220665.6A patent/CN110044998B/zh active Active
- 2015-05-12 EP EP15793289.8A patent/EP3143392B1/en active Active
- 2015-05-12 EP EP23157017.7A patent/EP4220178A3/en active Pending
- 2015-05-12 AU AU2015259294A patent/AU2015259294A1/en not_active Abandoned
- 2015-05-12 US US14/710,311 patent/US9459267B2/en active Active
- 2015-05-12 CA CA2948823A patent/CA2948823C/en active Active
- 2015-05-12 WO PCT/US2015/030419 patent/WO2015175561A1/en not_active Ceased
- 2015-05-12 BR BR112016026459-2A patent/BR112016026459B1/pt active IP Right Grant
- 2015-05-12 CN CN201580037630.9A patent/CN106537139B/zh active Active
- 2015-05-12 JP JP2016567654A patent/JP6279104B2/ja active Active
-
2016
- 2016-10-03 US US15/284,248 patent/US9835606B2/en active Active
- 2016-11-13 SA SA516380291A patent/SA516380291B1/ar unknown
-
2017
- 2017-12-04 US US15/830,812 patent/US10830746B2/en active Active
-
2018
- 2018-01-16 JP JP2018004851A patent/JP6821610B2/ja active Active
- 2018-12-07 AU AU2018275011A patent/AU2018275011A1/en not_active Abandoned
-
2020
- 2020-09-23 AU AU2020239700A patent/AU2020239700B2/en active Active
- 2020-11-09 US US17/093,472 patent/US11428682B2/en active Active
-
2021
- 2021-01-06 JP JP2021000689A patent/JP2021073450A/ja active Pending
-
2022
- 2022-04-20 AU AU2022202628A patent/AU2022202628B2/en active Active
- 2022-08-23 US US17/893,950 patent/US11835505B2/en active Active
-
2023
- 2023-05-16 JP JP2023080724A patent/JP2023109874A/ja active Pending
- 2023-07-07 AU AU2023204389A patent/AU2023204389B2/en active Active
- 2023-10-25 US US18/494,030 patent/US12270803B2/en active Active
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2024
- 2024-10-09 AU AU2024227191A patent/AU2024227191B2/en active Active
-
2025
- 2025-02-07 JP JP2025018885A patent/JP7884626B2/ja active Active
- 2025-03-07 US US19/074,121 patent/US20260118337A1/en active Pending
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