RU2018104707A - ИСПОЛЬЗОВАНИЕ МОЛЕКУЛЯРНЫХ МАРКЕРОВ IL-3, IL-33 и IL12ρ40 ДЛЯ ХАРАКТЕРИСТИКИ СТЕПЕНИ ТЯЖЕСТИ РЕСПИРАТОРНЫХ ИНФЕКЦИЙ, ВЫЗВАННЫХ РЕСПИРАТОРНО-СИНЦИТИАЛЬНЫМ ВИРУСОМ ЧЕЛОВЕКА И МЕТАПНЕВМОВИРУСОМ ЧЕЛОВЕКА - Google Patents

ИСПОЛЬЗОВАНИЕ МОЛЕКУЛЯРНЫХ МАРКЕРОВ IL-3, IL-33 и IL12ρ40 ДЛЯ ХАРАКТЕРИСТИКИ СТЕПЕНИ ТЯЖЕСТИ РЕСПИРАТОРНЫХ ИНФЕКЦИЙ, ВЫЗВАННЫХ РЕСПИРАТОРНО-СИНЦИТИАЛЬНЫМ ВИРУСОМ ЧЕЛОВЕКА И МЕТАПНЕВМОВИРУСОМ ЧЕЛОВЕКА Download PDF

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RU2018104707A
RU2018104707A RU2018104707A RU2018104707A RU2018104707A RU 2018104707 A RU2018104707 A RU 2018104707A RU 2018104707 A RU2018104707 A RU 2018104707A RU 2018104707 A RU2018104707 A RU 2018104707A RU 2018104707 A RU2018104707 A RU 2018104707A
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human
respiratory
il12ρ40
molecular markers
infections caused
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RU2018104707A
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RU2707549C2 (ru
RU2018104707A3 (ru
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Сусан Марсела БУЕНО РАМИРЕЗ
Хосе Пабло БЕРТРАНД НАВАРРЕТЕ
Маргарита Кам-Лем ЛАЙ РЕМОЛКОИ
ПАРРА Алексис Микес КАЛЛЕРГИС
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Понтифисиа Универсидад Католика Дэ Чиле
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Claims (6)

1. Применение молекулярных маркеров IL-3, IL-12p40 и IL-33, отличающееся тем, что они служат для прогнозирования рецидивирующей бронхиальной обструкции и астмы после бронхиолита, вызванных респираторно-синцитиальным вирусом человека (SRV).
2. Применение по п. 1, отличающееся тем, что одна из респираторных инфекций представлена бронхиолитом.
3. Способ прогнозирования рецидивирующей бронхиальной обструкции и астмы после бронхиолита, вызванных респираторно-синцитиальным вирусом человека (SRV), отличающийся тем, что он включает:
амплификацию и обнаружение с помощью молекулярно-биологической процедуры, например, PCR и ELISA, с использованием маркеров IL-3, IL-12p40 и IL-33;
подсчет сверхэкспрессии последовательности-мишени в дополнение к маркерам IL-3, IL-33 или IL-12p40;
соотношение на основании количественного определения полученной сверхэкспрессии и развития болезни, вызванной SRV: высокая вероятность развития бронхиальной обструкции, если концентрация в бронхоальвеолярных выделениях превышает 500 пг/мл IL-12p40 или IL-3; высокая вероятность развитие астмы, если концентрация в бронхоальвеолярных выделениях превышает 500 пг/мл IL-33.
RU2018104707A 2015-07-31 2016-07-25 ИСПОЛЬЗОВАНИЕ МОЛЕКУЛЯРНЫХ МАРКЕРОВ IL-3, IL-33 и IL12ρ40 ДЛЯ ХАРАКТЕРИСТИКИ СТЕПЕНИ ТЯЖЕСТИ РЕСПИРАТОРНЫХ ИНФЕКЦИЙ, ВЫЗВАННЫХ РЕСПИРАТОРНО-СИНЦИТИАЛЬНЫМ ВИРУСОМ ЧЕЛОВЕКА И МЕТАПНЕВМОВИРУСОМ ЧЕЛОВЕКА RU2707549C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CL201502153 2015-07-31
CL2015002153A CL2015002153A1 (es) 2015-07-31 2015-07-31 Uso de los marcadores moleculares il-3,il33 e il-12p40 para caracterizar la severidad de infecciones respiratorias por virus respiratorio sincicial y metapneumovirus humano
PCT/IB2016/054423 WO2017021814A1 (en) 2015-07-31 2016-07-25 Use of il-3, il-33, and il-12p40 for characterization of the respiratory infections by syncytial respiratory virus

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RU2018104707A true RU2018104707A (ru) 2019-08-28
RU2018104707A3 RU2018104707A3 (ru) 2019-08-28
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US (1) US11085080B2 (ru)
EP (1) EP3329019B1 (ru)
KR (1) KR102621463B1 (ru)
CN (1) CN108368556B (ru)
AR (1) AR105542A1 (ru)
BR (1) BR112018002140B1 (ru)
CA (1) CA2994252A1 (ru)
CL (1) CL2015002153A1 (ru)
CO (1) CO2018001917A2 (ru)
ES (1) ES2783859T3 (ru)
MX (1) MX2018001373A (ru)
PE (1) PE20180577A1 (ru)
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US20160168640A1 (en) 2014-11-10 2016-06-16 Genentech, Inc. Therapeutic and diagnostic methods for il-33-mediated disorders
AU2015346460A1 (en) 2014-11-10 2017-03-23 Genentech, Inc. Anti-interleukin-33 antibodies and uses thereof
PE20230252A1 (es) 2020-03-13 2023-02-07 Genentech Inc Anticuerpos anti-interleucina-33 y sus usos de estos
JP6960642B2 (ja) * 2020-04-16 2021-11-05 国立研究開発法人国立国際医療研究センター 呼吸器感染症の重症化の予測を補助する方法、バイオマーカーの測定値をモニタリングする方法、これらの方法に用いられる試薬キット、呼吸器感染症の重症化の予測を補助する装置およびコンピュータプログラム

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UY36819A (es) 2017-01-31
US20180327843A1 (en) 2018-11-15
ES2783859T3 (es) 2020-09-18
EP3329019B1 (en) 2020-01-01
KR20180028525A (ko) 2018-03-16
CL2015002153A1 (es) 2016-01-29
CA2994252A1 (en) 2017-02-09
RU2707549C2 (ru) 2019-11-27
EP3329019A4 (en) 2018-06-06
AR105542A1 (es) 2017-10-11
BR112018002140A2 (pt) 2018-09-11
RU2018104707A3 (ru) 2019-08-28
PT3329019T (pt) 2020-04-08
KR102621463B1 (ko) 2024-01-04
US11085080B2 (en) 2021-08-10
WO2017021814A1 (en) 2017-02-09
ZA201800940B (en) 2019-07-31
MX2018001373A (es) 2018-06-15
CN108368556B (zh) 2021-06-22
BR112018002140B1 (pt) 2024-01-23
EP3329019A1 (en) 2018-06-06
CN108368556A (zh) 2018-08-03
PE20180577A1 (es) 2018-04-04
CO2018001917A2 (es) 2018-05-10

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