SA516370789B1 - نظام معالجة بالغاز لغريسة خلية - Google Patents

نظام معالجة بالغاز لغريسة خلية

Info

Publication number
SA516370789B1
SA516370789B1 SA516370789A SA516370789A SA516370789B1 SA 516370789 B1 SA516370789 B1 SA 516370789B1 SA 516370789 A SA516370789 A SA 516370789A SA 516370789 A SA516370789 A SA 516370789A SA 516370789 B1 SA516370789 B1 SA 516370789B1
Authority
SA
Saudi Arabia
Prior art keywords
gas
subsystem
gas generator
cell containment
implantable
Prior art date
Application number
SA516370789A
Other languages
English (en)
Inventor
ستون سيمون
باباس كليرشوس
تيمبلمان ليندا
Original Assignee
جينير، انك.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by جينير، انك. filed Critical جينير، انك.
Publication of SA516370789B1 publication Critical patent/SA516370789B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M2005/006—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests for gases, e.g. CO2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/02—Gases
    • A61M2202/0208—Oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/75—General characteristics of the apparatus with filters
    • A61M2205/7536—General characteristics of the apparatus with filters allowing gas passage, but preventing liquid passage, e.g. liquophobic, hydrophobic, water-repellent membranes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E60/00—Enabling technologies; Technologies with a potential or indirect contribution to GHG emissions mitigation
    • Y02E60/30—Hydrogen technology
    • Y02E60/36—Hydrogen production from non-carbon containing sources, e.g. by water electrolysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
  • Prostheses (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع الحالي بنظام لمعالجة بالغاز لغرائس خلوية. ويعزز النظام بقاء الغرائس الخلوية وعملها، وبصفة خاصة تلك التي تتسم بكثافة خلوية مرتفعة، للاستخدام في الطب البشري أو البيطري. ويستخدم النظام نظام فرعي لمولد غاز كهروكيميائي مصغر يقوم باستمرار بتزويد الأكسجين و/ أو الهيدروجين إلى الخلايا داخل نظام فرعي لاحتواء الخلايا قابل للغرس والعزل المناعي لتسهيل بقاء الخلية وعملها بكثافة خلوية مرتفعة مع تقليل حجم الغريسة الإجمالي. ويتم تزويد نظام احتواء الخلية الفرعي بسمات للسماح بتوصيل الغاز عبر أنابيب مسامية أو حجيرات غاز داخلية منفذة للغاز فقط داخل نظام فرعي لاحتواء خلية قابلة للغرس. وعلاوة على ذلك، يتضمن نظام مولد الغاز الفرعي مكونات تسمح بالوصول إلى الماء للتحلل الكهربي أثناء زرعها، وبالتالي تعزيز قابلية الغرس على المدى الطويل لنظام مولد الغاز الفرعي. ومن بين استخدامات النظام غريسة جزيرية بنكرياسية (أو نظير الجزيرة البنكرياسية) لعلاج السكري من النوع 1 (T1D) والتي يمكن اعتبارها بنكرياس حيوي اصطناعي.
SA516370789A 2013-09-24 2016-03-22 نظام معالجة بالغاز لغريسة خلية SA516370789B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361881654P 2013-09-24 2013-09-24
PCT/US2014/057295 WO2015048184A1 (en) 2013-09-24 2014-09-24 System for gas treatment of a cell implant

Publications (1)

Publication Number Publication Date
SA516370789B1 true SA516370789B1 (ar) 2020-03-04

Family

ID=52744433

Family Applications (1)

Application Number Title Priority Date Filing Date
SA516370789A SA516370789B1 (ar) 2013-09-24 2016-03-22 نظام معالجة بالغاز لغريسة خلية

Country Status (13)

Country Link
US (3) US10231817B2 (ar)
EP (1) EP3049020B1 (ar)
JP (1) JP6749239B2 (ar)
KR (1) KR102323291B1 (ar)
CN (2) CN110101485B (ar)
AU (1) AU2014326794B2 (ar)
BR (1) BR112016006378A2 (ar)
CA (2) CA3059017C (ar)
IL (1) IL244714B (ar)
MX (1) MX2016003615A (ar)
SA (1) SA516370789B1 (ar)
SG (1) SG11201602232UA (ar)
WO (1) WO2015048184A1 (ar)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10091985B2 (en) 2009-06-18 2018-10-09 Giner, Inc. Perfusing an organ with an in situ generated gas
MX2012002440A (es) 2009-08-28 2012-06-19 Sernova Corp Metodos y dispositivos para el transplante de celulas.
MX2017012982A (es) 2015-04-10 2018-07-06 Univ Jefferson Metodos y composiciones para tratar el cancer e incrementar la inmunidad terapeutica reduciendo selectivamente los monocitos m2 inmunomoduladores.
WO2017175065A2 (en) * 2016-04-04 2017-10-12 Beta-O2 Technologies Ltd. Implantable device for implantation of cells having anti-inflammatory and vascularization capabilities and methods of making thereof
WO2018067813A1 (en) 2016-10-05 2018-04-12 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for augmenting immune system responses
AU2017396753B2 (en) 2016-11-03 2021-04-29 Arizona Board Of Regents On Behalf Of The University Of Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
KR20190106996A (ko) * 2016-11-03 2019-09-18 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 외부 산소 전달을 수반 또는 비-수반하는 산소 센서가 구비된 캡슐화 장치 시스템
WO2018144099A1 (en) * 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
AU2017366791B2 (en) * 2016-11-03 2021-01-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and implantable devices for enhancing blood glucose regulation
USD824042S1 (en) * 2016-11-10 2018-07-24 Viacyte, Inc. Perforated cell encapsulation device
AU2017361260B2 (en) * 2016-11-15 2023-06-08 Giner, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
WO2018093940A1 (en) * 2016-11-15 2018-05-24 Giner, Inc. Self-regulating electrolytic gas generator and implant system comprising the same
CN110832068A (zh) 2017-03-09 2020-02-21 托马斯杰弗逊大学 使用反义分子治疗癌症的方法和组合物
EP3398558A1 (en) * 2017-05-02 2018-11-07 Carlo Andretta In body perfusion system
WO2018204867A1 (en) * 2017-05-04 2018-11-08 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
IL308120B1 (en) 2017-06-14 2024-08-01 Vertex Pharma Devices and methods for drug administration
EP3687499A4 (en) * 2017-09-29 2021-06-30 Semma Therapeutics, Inc. CELL HOUSING DEVICE
JP2019097442A (ja) * 2017-11-30 2019-06-24 株式会社日立製作所 免疫隔離デバイス
FR3075831B1 (fr) * 2017-12-22 2020-11-13 Univ Grenoble Alpes Dispositif implantable de production d'hydrogene
CA3089583A1 (en) * 2018-01-24 2019-08-01 Thomas Jefferson University Biodiffusion chamber
EP3810250A4 (en) * 2018-05-14 2022-07-13 Giner Life Sciences, Inc. SYSTEM AND METHOD FOR CONTROLLING OXYGEN SUPPLY TO IMPLANT CELLS
WO2019222704A1 (en) 2018-05-17 2019-11-21 Giner Life Sciences, Inc. Electrolytic gas generator with combined lead and gas port terminals
US11963862B2 (en) * 2018-08-22 2024-04-23 Boston Scientific Scimed, Inc. Cell encapsulation device including a porous tube
US20210401564A1 (en) * 2018-09-24 2021-12-30 Arizona Board Regents On Behalf Of The University Of Arizona Methods and systems for implantable medical devices and vascularization membranes
WO2020206157A1 (en) * 2019-04-03 2020-10-08 Vertex Pharmaceuticals Incorporated Multicompartment macroencapsulation devices
WO2021202975A1 (en) * 2020-04-03 2021-10-07 The Brigham And Women's Hospital, Inc. Implantable cell macroencapsulation device and method of manufacture and use
CA3196876A1 (en) 2020-10-30 2022-05-05 Klearchos Papas Methods and systems for encapsulation devices for housing cells and agents
US20220152369A1 (en) * 2020-11-18 2022-05-19 Giner Life Sciences, Inc. Wearable system and method for gas delivery to exterior surface of an eye
WO2023282968A1 (en) * 2021-07-06 2023-01-12 Massachusetts Institute Of Technology Bioelectronic devices to support transplanted cells in vivo for encapsulated cell therapies
WO2023107698A1 (en) * 2021-12-09 2023-06-15 Encellin, Inc. Methods and devices for pre-vascularization of implantation sites and/or cell encapsulation devices
WO2023205302A2 (en) * 2022-04-20 2023-10-26 Northwestern University Oxygen generation system and applications thereof

Family Cites Families (129)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US150995A (en) 1874-05-19 Improvement ifs
US3005943A (en) 1957-04-10 1961-10-24 Electric Storage Battery Co Sealed storage cell using liquid electrolyte
US3453086A (en) 1965-10-12 1969-07-01 Gen Electric Self-regulating gas generator
US3373057A (en) 1965-10-24 1968-03-12 Texas Instruments Inc Battery having an automatic circuit breaker therein
US3783868A (en) 1971-05-06 1974-01-08 Gulf Oil Corp Percutaneous implant
US3933526A (en) 1974-09-09 1976-01-20 Motorola, Inc. Housing for battery cell with protection for pressure and temperature
US4057479A (en) 1976-02-26 1977-11-08 Billings Energy Research Corporation Solid polymer electrolyte cell construction
US4385093A (en) 1980-11-06 1983-05-24 W. L. Gore & Associates, Inc. Multi-component, highly porous, high strength PTFE article and method for manufacturing same
US4648391A (en) 1985-11-18 1987-03-10 Carbomedics, Inc. Stabilizer for percutaneous medical devices
ATE65159T1 (de) 1986-10-23 1991-08-15 Ciba Geigy Ag Bekaempfung von ektoparasiten.
DE3853278T2 (de) 1988-02-29 1995-07-13 Du Pont Vorrichtung für das Liefern von Substanzen in Zellen und Gewebe auf eine nichtletale Weise.
US4925732A (en) 1988-07-27 1990-05-15 W. L. Gore & Associates, Inc. Breathable flexible laminates adhered by a breathable adhesive
US5011472A (en) 1988-09-06 1991-04-30 Brown University Research Foundation Implantable delivery system for biological factors
US5344454A (en) 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
CA2070816A1 (en) 1990-10-31 1992-05-01 James H. Brauker Close vascularization implant material
US5713888A (en) 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5264276A (en) 1992-04-06 1993-11-23 W. L. Gore & Associates, Inc. Chemically protective laminate
DE4227066A1 (de) 1992-08-16 1994-02-17 Bernhard Josef Dr Med Hering Langerhans'sche Inseln in reiner Form
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
US5362622A (en) 1993-03-11 1994-11-08 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation apparatus
US5356771A (en) 1993-03-11 1994-10-18 Board Of Regents, The University Of Texas System Combined perfusion and oxygenation organ preservation apparatus
DE4342728A1 (de) 1993-12-15 1995-06-22 Thomae Gmbh Dr K Verfahren, Apparate und Perfusionslösungen zur Konservierung explantierter Organe
US5586438A (en) 1995-03-27 1996-12-24 Organ, Inc. Portable device for preserving organs by static storage or perfusion
US5788682A (en) 1995-04-28 1998-08-04 Maget; Henri J.R. Apparatus and method for controlling oxygen concentration in the vicinity of a wound
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
GB9606452D0 (en) 1996-03-27 1996-06-05 Sandoz Ltd Organic compounds
WO1997042953A1 (en) 1996-05-10 1997-11-20 Novartis Ag Use of brequinar and derivatives in chronic rejection of allografts and xenotransplantation
US5965433A (en) 1996-05-29 1999-10-12 Trans D.A.T.A. Service, Inc. Portable perfusion/oxygenation module having mechanically linked dual pumps and mechanically actuated flow control for pulsatile cycling of oxygenated perfusate
EP1208847B8 (en) 1996-07-30 2007-02-14 Novartis AG Pharmaceutical compositions for the treatment of transplant rejection, as well as autoimmune or inflammatory conditions
US5951538A (en) 1997-08-07 1999-09-14 Ceramatec, Inc. Gas generating device for delivering beneficial agents to a body cavity
US6368592B1 (en) 1998-07-17 2002-04-09 Massachusetts Institute Of Technology Method of delivering oxygen to cells by electrolyzing water
US6673594B1 (en) 1998-09-29 2004-01-06 Organ Recovery Systems Apparatus and method for maintaining and/or restoring viability of organs
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US6171368B1 (en) 1998-11-06 2001-01-09 Med-E-Cell Gas extraction from closed containers
US20040213768A1 (en) 1999-04-30 2004-10-28 Elliott Robert Bartlett Preparation for biotransplantation and xenotransplantion and uses thereof
ATE474590T1 (de) 1999-05-10 2010-08-15 Paolo Brenner Kombination von immunsuppressiven substanzen zur behandlung oder vorbeugung von transplantat abstossungen
US6413238B1 (en) 1999-09-17 2002-07-02 Baxter International Inc Fluid dispenser with stabilized fluid flow
US8012500B2 (en) 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
IL134009A (en) 2000-01-12 2011-07-31 Bo2 Technologies Ltd Transplant device
US6268592B1 (en) * 2000-01-18 2001-07-31 Tsann Kuen Usa, Inc. Electric grill plate appliance for tortilla cuisine
US6492103B1 (en) 2000-01-31 2002-12-10 Organ Recovery Systems, Inc. System for organ and tissue preservation and hypothermic blood substitution
EP1146117B1 (en) 2000-04-12 2008-01-23 Beta-Cell N.V. A method for producing preparations of mature and immature pancreatic endocrine cells, the cell preparation and its use for treatment of diabetes mellitus
WO2001093908A1 (en) 2000-06-02 2001-12-13 Regents Of The University Of Minnesota Immunotherapeutic method to prevent islet cell rejection
US6824915B1 (en) 2000-06-12 2004-11-30 The Gillette Company Air managing systems and methods for gas depolarized power supplies utilizing a diaphragm
USD453828S1 (en) 2000-08-25 2002-02-19 Organ Recovery Systems, Inc. Organ perfusion apparatus
DE10045683C2 (de) 2000-09-15 2002-09-05 Draegerwerk Ag Elektrochemischer Sauerstoffkonzentrator
US6475716B1 (en) 2001-03-06 2002-11-05 Biobank Co., Ltd. Method for preserving mammalian organs
US20030008192A1 (en) 2001-04-10 2003-01-09 Freund Michael S. Actuatable and reversible pressure generation based on fuel cell operation
US20030031652A1 (en) 2001-04-16 2003-02-13 Bernhard Hering Systems and methods for inducing mixed chimerism
US6677150B2 (en) 2001-09-14 2004-01-13 Organ Transport Systems, Inc. Organ preservation apparatus and methods
US7073005B1 (en) 2002-01-17 2006-07-04 Juniper Networks, Inc. Multiple concurrent dequeue arbiters
US20030207161A1 (en) 2002-05-01 2003-11-06 Ali Rusta-Sallehy Hydrogen production and water recovery system for a fuel cell
US7572622B2 (en) 2002-08-14 2009-08-11 Transmedic, Inc. Heart preservation chamber
US8721515B2 (en) 2003-01-31 2014-05-13 L-Vad Technology, Inc. Rigid body aortic blood pump implant
CN1438313A (zh) * 2003-03-08 2003-08-27 浙江大学医学院附属第二医院 微囊化功能细胞的制备方法
US7504201B2 (en) 2004-04-05 2009-03-17 Organ Recovery Systems Method for perfusing an organ and for isolating cells from the organ
BRPI0510550A (pt) 2004-05-03 2007-11-20 Ams Res Corp implante cirúrgico, kit cirúrgico, método para formar ou montar um implante cirúrgico, molde de inserção, aparelho, e, método para produzir um implante cirúrgico
US8034102B2 (en) * 2004-07-19 2011-10-11 Coroneo, Inc. Aortic annuloplasty ring
US8298813B2 (en) 2004-09-23 2012-10-30 Dennis Holman Method for preparing an expanded product for fermentation
IL311989A (en) 2004-10-07 2024-06-01 Transmedics Inc Methods and systems for extracorporeal organ treatment
EP1809101B1 (en) 2004-11-12 2016-11-02 Organoflush B.V. Composition for cold preservation and perfusion of organs
US20060182722A1 (en) 2005-02-11 2006-08-17 Hering Bernhard J Methods and materials for isolating isogenic islet cells
NZ539491A (en) 2005-04-15 2008-04-30 Living Cell Products Pty Ltd Swine population and uses thereof
NL1028848C2 (nl) 2005-04-22 2006-10-24 Doorzand Airdrive B V Inrichting voor het transporteren van een orgaan.
WO2006122169A2 (en) * 2005-05-10 2006-11-16 Ogenix Corporation Novel portable electrochemical devices for dual action wound healing
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US20090209031A1 (en) 2006-01-26 2009-08-20 Tyco Healthcare Group Lp Medical device package
CA2646674A1 (en) 2006-04-20 2007-11-01 Fred Hutchinson Cancer Research Center Use of chalcogenides for treating shock and other adverse conditions
TW200806392A (en) 2006-06-20 2008-02-01 Lynntech Inc Microcartridge hydrogen generator
US20100028398A1 (en) 2006-11-21 2010-02-04 Living Cell Technologies Limited Cell implantation to prevent and/or treat hearing loss
AU2007200990B8 (en) 2006-11-21 2011-05-12 Living Cell Technologies Limited Cell Implantation To Prevent and/or Treat Hearing Loss
ES2659988T3 (es) * 2006-11-28 2018-03-20 Beta O2 Technologies Ltd. Suministro de oxígeno para el transplante celular y la vascularización
WO2008079997A2 (en) * 2006-12-22 2008-07-03 Medtronic, Inc. Implantable device, angiogenesis mechanism and methods
MX2009008294A (es) 2007-02-02 2010-03-18 Univ Miami Dispositivos implantables hibridos terapeuticos.
US20080245672A1 (en) 2007-04-03 2008-10-09 New Sky Energy, Inc. Electrochemical methods to generate hydrogen and sequester carbon dioxide
US8083821B2 (en) 2007-04-13 2011-12-27 Giner, Inc. System for modifying the atmosphere within an enclosed space and incubator system including the same
WO2009023409A1 (en) 2007-07-24 2009-02-19 Rovcal, Inc. On-demand hydrogen gas generation device with pressure-regulating switch
US8821431B2 (en) * 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
US8110283B2 (en) 2007-09-28 2012-02-07 General Electric Company Article and associated method
US8287506B2 (en) 2007-10-26 2012-10-16 Electrochemical Oxygen Concepts, Inc. Apparatus and methods for controlling tissue oxygenation for wound healing and promoting tissue viability
US10750738B2 (en) 2008-01-31 2020-08-25 Transmedics, Inc. Systems and methods for ex vivo lung care
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
DE102008045621A1 (de) 2008-09-03 2010-03-04 Novalung Gmbh Gastransfervorrichtung und Verwendung einer strukturierten Membran
WO2010049996A1 (ja) 2008-10-28 2010-05-06 株式会社レゾナンスクラブ 哺乳動物の臓器の保存方法
US20100108534A1 (en) 2008-10-30 2010-05-06 Mti Micro Fuel Cells, Inc. Electrochemical actuator
EP4176888A1 (en) 2008-11-14 2023-05-10 ViaCyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US8043271B2 (en) 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
WO2010091074A2 (en) 2009-02-03 2010-08-12 Purdue Research Foundation Method and apparatus for improving local hypoxicity for enhanced therapy
US20100209475A1 (en) * 2009-02-19 2010-08-19 Biomet Manufacturing Corp. Medical implants having a drug delivery coating
US10091985B2 (en) 2009-06-18 2018-10-09 Giner, Inc. Perfusing an organ with an in situ generated gas
US9357764B2 (en) 2009-06-18 2016-06-07 Giner, Inc. System for fluid perfusion of biological matter comprising tissue
IN2012DN00526A (ar) 2009-08-07 2015-08-28 Zeus Ind Products Inc
US8784389B2 (en) * 2009-08-31 2014-07-22 Beta-O2 Technologies Ltd. Oxygen supply for implantable medical device
WO2011038251A1 (en) 2009-09-25 2011-03-31 Board Of Regents, The University Of Texas System Fluidics based pulsatile perfusion preservation device and method
GB201002370D0 (en) 2010-02-12 2010-03-31 Renishaw Ireland Ltd Percutaneous drug delivery apparatus
KR101813300B1 (ko) 2010-04-08 2017-12-28 힐리오닉스 코포레이션 미세다공성 표면 층을 가지는 이식형 의료 장치 및 이에 대한 이물 반응을 감소시키는 방법
EP2571543B1 (en) 2010-05-11 2018-12-05 Allergan, Inc. Porous materials, methods of making and uses
JP5502615B2 (ja) 2010-06-23 2014-05-28 本田技研工業株式会社 燃料電池
WO2012115619A1 (en) 2011-02-21 2012-08-30 Viacyte, Inc. Loading system for an encapsulation device
WO2012130567A1 (en) 2011-03-29 2012-10-04 Beta-Cell Nv Method for encapsulated therapeutic products and uses thereof
DE102012112709B4 (de) * 2011-12-30 2022-09-08 Giner Life Sciences, Inc. System zur Fluidperfusion oder Persufflation von biologischem Material, welches Gewebe umfasst
WO2014138691A1 (en) 2013-03-07 2014-09-12 Viacyte, Inc. 3-dimensional large capacity cell encapsulation device assembly
WO2014171842A1 (en) 2013-04-19 2014-10-23 Living Cell Technologies New Zealand Limited Biocompatible encapsulation system
CN105555950B (zh) 2013-06-13 2021-03-05 奥尔吉尼西丝有限公司 细胞群体、转分化的方法及其使用方法
US20160228377A1 (en) 2013-09-19 2016-08-11 Beta-Cell Nv Method for the treatment of diabetes mellitus
EP3066468B1 (en) 2013-11-07 2023-03-29 Vrije Universiteit Brussel Screening assay for agents that influence beta cell number and/or phenotype
CN116059378A (zh) 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
RU2017143158A (ru) 2015-05-15 2019-06-17 Ливин Селл Текнолоджис Нью Зиланд Лимитед Лечение заболевания цнс с помощью инкапсулированных индуцируемых клеток сосудистого сплетения
WO2017160850A1 (en) 2016-03-14 2017-09-21 The Regents Of The University Of California Nanostraw devices and methods of fabricating and using the same
WO2017175065A2 (en) 2016-04-04 2017-10-12 Beta-O2 Technologies Ltd. Implantable device for implantation of cells having anti-inflammatory and vascularization capabilities and methods of making thereof
US20190119462A1 (en) 2016-06-14 2019-04-25 The Regents Of The University Of California Porous Polymer Scaffolds, and Methods of Making and Using the Same
KR20190017985A (ko) 2016-06-14 2019-02-20 리전츠 오브 더 유니버스티 오브 미네소타 질환을 치료하기 위한 유전적으로 변형된 세포, 조직, 및 장기
WO2018144099A1 (en) 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
KR20190106996A (ko) 2016-11-03 2019-09-18 아리조나 보드 오브 리전츠 온 비해프 오브 더 유니버시티 오브 아리조나 외부 산소 전달을 수반 또는 비-수반하는 산소 센서가 구비된 캡슐화 장치 시스템
AU2017396753B2 (en) 2016-11-03 2021-04-29 Arizona Board Of Regents On Behalf Of The University Of Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
AU2017366791B2 (en) 2016-11-03 2021-01-21 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and implantable devices for enhancing blood glucose regulation
WO2018093940A1 (en) 2016-11-15 2018-05-24 Giner, Inc. Self-regulating electrolytic gas generator and implant system comprising the same
AU2017361260B2 (en) 2016-11-15 2023-06-08 Giner, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
WO2018204867A1 (en) 2017-05-04 2018-11-08 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
WO2018207179A1 (en) 2017-05-08 2018-11-15 Orgenesis Ltd. Transdifferentiated cell populations and methods of use thereof
WO2018220623A1 (en) 2017-05-29 2018-12-06 Orgenesis Ltd. Compositions and methods for providing cell replacement therapy
US20200263196A1 (en) 2017-09-27 2020-08-20 Sigilon Therapeutics, Inc. Methods, compositions, and implantable elements comprising active cells
WO2019089993A1 (en) 2017-11-02 2019-05-09 Living Cell Technologies New Zealand Limited Pericyte protective agents for neurological disorders including neurodegenerative diseases, central nervous system diseases and others
WO2019089943A1 (en) 2017-11-06 2019-05-09 Theranova, Llc Methods and devices for delivering pancreatic islet function to a body
US11793622B2 (en) 2018-05-08 2023-10-24 Michael J. Dalton Artificial interstitium device
WO2019241562A1 (en) 2018-06-14 2019-12-19 University Of Miami Methods of implanting cells

Also Published As

Publication number Publication date
US10231817B2 (en) 2019-03-19
JP2016530980A (ja) 2016-10-06
BR112016006378A2 (pt) 2017-08-01
CA3059017C (en) 2021-05-25
JP6749239B2 (ja) 2020-09-02
CN110101485B (zh) 2021-07-06
CN110101485A (zh) 2019-08-09
US20190336267A1 (en) 2019-11-07
WO2015048184A1 (en) 2015-04-02
EP3049020B1 (en) 2022-06-15
EP3049020A1 (en) 2016-08-03
CA2924681A1 (en) 2015-04-02
IL244714A0 (en) 2016-04-21
SG11201602232UA (en) 2016-04-28
US12070383B2 (en) 2024-08-27
AU2014326794A1 (en) 2016-04-21
EP3049020A4 (en) 2017-07-26
KR102323291B1 (ko) 2021-11-05
CA3059017A1 (en) 2015-04-02
AU2014326794B2 (en) 2019-03-21
US20240189088A1 (en) 2024-06-13
KR20160060115A (ko) 2016-05-27
IL244714B (en) 2020-06-30
CN105792775B (zh) 2019-02-19
CN105792775A (zh) 2016-07-20
CA2924681C (en) 2019-12-31
US11701215B2 (en) 2023-07-18
US20150112247A1 (en) 2015-04-23
MX2016003615A (es) 2016-10-26

Similar Documents

Publication Publication Date Title
SA516370789B1 (ar) نظام معالجة بالغاز لغريسة خلية
MX2019005676A (es) Dispositivo percutáneo de difusión de gases adecuado para su uso con un implante subcutáneo.
SG10201805199RA (en) Methods and Uses for Ex Vivo Tissue Culture Systems
CA2817106A1 (en) Irradiation of red blood cells and anaerobic storage
NZ615383A (en) Methods and devices for cellular transplantation
MX2021007933A (es) Dispositivos de suministro de farmacos con un componente permeable al farmaco y metodos.
MX2012004881A (es) Metodos para reprogramar células y sus usos.
Fierz et al. Patients with oral tumors. Part 1: Prosthetic rehabilitation following tumor resection.
EP2600930A4 (en) INJECTION APPARATUS AND METHOD FOR DELIVERY OF MEDICAMENT
MX2018001556A (es) Membranas implantables de grafeno con baja citotoxicidad.
WO2008065660A3 (en) Oxygen supply for cell transplant and vascularization
EP4302736A3 (en) Ophthalmic implant for delivering therapeutic substances
MX2008011521A (es) Modulo de instalacion para la produccion y almacenamiento de producto de terapia celular.
RU2013110524A (ru) Лечение диабета при помощи панкреатических эндокринных клеток-предшественников
MX2009004640A (es) Estimulacion por litio de proliferacion de celula de tallo sanguinea de cordon y produccion de factor de crecimiento.
MX2017016925A (es) Sistema de infusion que se puede implantar.
MX2018002645A (es) Dispositivo de implantacion de pildora y kit de herramientas.
MX2020011884A (es) Metodo para la xeno-generacion libre de una poblacion de hmpc.
WO2006122551A8 (en) An implantable therapy system for treating a living being with an active factor
EA201591522A1 (ru) Лечение реакции трансплантат против хозяина у подвергаемых трансплантации пациентов
WO2014197798A3 (en) Transplantation device and method of use
Liu et al. Pancreas transplantation in the mouse
MX2018005566A (es) Dispositivo y metodo para el tratamiento de un implante oseo artificial con sangre.
Herrero et al. Live demonstration: A handheld bio-inspired artificial pancreas for treatment of diabetes
DK1778834T5 (da) Fremgangsmåder til anvendelse af regenerative celler i behandlingen af renale sygdomme og lidelser