RU95114528A - Аминопроизводные, способ получения, фармацевтическая композиция способ лечения - Google Patents
Аминопроизводные, способ получения, фармацевтическая композиция способ леченияInfo
- Publication number
- RU95114528A RU95114528A RU95114528/04A RU95114528A RU95114528A RU 95114528 A RU95114528 A RU 95114528A RU 95114528/04 A RU95114528/04 A RU 95114528/04A RU 95114528 A RU95114528 A RU 95114528A RU 95114528 A RU95114528 A RU 95114528A
- Authority
- RU
- Russia
- Prior art keywords
- ris
- substituted
- hydrogen
- halogen
- alkyl
- Prior art date
Links
- FOQYDURHXZVLFT-UHFFFAOYSA-N 2-phenyl-2-pyridin-2-ylethanethioamide Chemical compound C=1C=CC=NC=1C(C(=S)N)C1=CC=CC=C1 FOQYDURHXZVLFT-UHFFFAOYSA-N 0.000 title 1
- -1 nitro- Chemical class 0.000 claims abstract 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract 6
- 125000000217 alkyl group Chemical group 0.000 claims abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 4
- 125000005843 halogen group Chemical group 0.000 claims abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 3
- 229920006395 saturated elastomer Polymers 0.000 claims abstract 3
- 102100021022 Gastrin Human genes 0.000 claims abstract 2
- 108010052343 Gastrins Proteins 0.000 claims abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract 2
- 125000003545 alkoxy group Chemical class 0.000 claims abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 claims abstract 2
- 125000002947 alkylene group Chemical group 0.000 claims abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract 2
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 claims abstract 2
- 150000002367 halogens Chemical class 0.000 claims abstract 2
- 125000005842 heteroatom Chemical group 0.000 claims abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 2
- 125000001715 oxadiazolyl group Chemical group 0.000 claims abstract 2
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 2
- 239000001301 oxygen Substances 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000001424 substituent group Chemical group 0.000 claims abstract 2
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 2
- 239000011593 sulfur Substances 0.000 claims abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929225492A GB9225492D0 (en) | 1992-12-05 | 1992-12-05 | Amine derivatives |
| GB9225492.9 | 1992-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU95114528A true RU95114528A (ru) | 1997-06-10 |
Family
ID=10726205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95114528/04A RU95114528A (ru) | 1992-12-05 | 1993-12-02 | Аминопроизводные, способ получения, фармацевтическая композиция способ лечения |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5569654A (OSRAM) |
| EP (1) | EP0672037B1 (OSRAM) |
| JP (1) | JPH08504200A (OSRAM) |
| KR (1) | KR950704270A (OSRAM) |
| CN (1) | CN1093085A (OSRAM) |
| AT (1) | ATE168102T1 (OSRAM) |
| AU (1) | AU688295B2 (OSRAM) |
| BG (1) | BG99696A (OSRAM) |
| BR (1) | BR9307580A (OSRAM) |
| CA (1) | CA2150461A1 (OSRAM) |
| CZ (1) | CZ138495A3 (OSRAM) |
| DE (1) | DE69319614D1 (OSRAM) |
| EC (1) | ECSP941085A (OSRAM) |
| FI (1) | FI952709A7 (OSRAM) |
| GB (1) | GB9225492D0 (OSRAM) |
| HU (1) | HUT71339A (OSRAM) |
| IL (1) | IL107869A (OSRAM) |
| MX (1) | MX9307654A (OSRAM) |
| NO (1) | NO952208L (OSRAM) |
| NZ (1) | NZ258874A (OSRAM) |
| OA (1) | OA10161A (OSRAM) |
| PE (1) | PE54294A1 (OSRAM) |
| PL (1) | PL309281A1 (OSRAM) |
| RO (1) | RO114446B1 (OSRAM) |
| RU (1) | RU95114528A (OSRAM) |
| SK (1) | SK74195A3 (OSRAM) |
| TW (1) | TW237450B (OSRAM) |
| WO (1) | WO1994013648A1 (OSRAM) |
| ZA (1) | ZA939068B (OSRAM) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9314981D0 (en) * | 1993-07-20 | 1993-09-01 | Glaxo Spa | Chemical compounds |
| US5428157A (en) * | 1993-11-22 | 1995-06-27 | Merck & Co., Inc. | 3-acylaminobenzodiazepines |
| JPH09511998A (ja) * | 1994-04-15 | 1997-12-02 | グラクソ、ウェルカム、インコーポレーテッド | １，４ − ベンゾジアゼピン化合物を用いたコレシストキニンアゴニスト活性の誘導方法 |
| US5807876A (en) * | 1996-04-23 | 1998-09-15 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme |
| AUPO284396A0 (en) * | 1996-10-08 | 1996-10-31 | Fujisawa Pharmaceutical Co., Ltd. | Benzodiazepine derivatives |
| US6194435B1 (en) | 1996-10-11 | 2001-02-27 | Cor Therapeutics, Inc. | Lactams as selective factor Xa inhibitors |
| US6262047B1 (en) | 1996-10-11 | 2001-07-17 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6063794A (en) | 1996-10-11 | 2000-05-16 | Cor Therapeutics Inc. | Selective factor Xa inhibitors |
| US6369080B2 (en) | 1996-10-11 | 2002-04-09 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| NZ500354A (en) | 1997-04-14 | 2001-11-30 | Cor Therapeutics Inc | Cyclic diaza compounds as selective factor Xa inhibitors for treating thrombotic related disorders |
| WO1998046627A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | SELECTIVE FACTOR Xa INHIBITORS |
| CA2285685A1 (en) | 1997-04-14 | 1998-10-22 | Cor Therapeutics, Inc. | Selective factor xa inhibitors |
| US6218382B1 (en) | 1997-08-11 | 2001-04-17 | Cor Therapeutics, Inc | Selective factor Xa inhibitors |
| US6228854B1 (en) | 1997-08-11 | 2001-05-08 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6333321B1 (en) * | 1997-08-11 | 2001-12-25 | Cor Therapeutics, Inc. | Selective factor Xa inhibitors |
| US6100254A (en) * | 1997-10-10 | 2000-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of protein tyrosine kinases |
| US20080058424A1 (en) * | 2002-05-23 | 2008-03-06 | Cephalon, Inc. | Novel pharmaceutical formulations of modafinil |
| MXPA03010705A (es) * | 2001-05-25 | 2004-05-27 | Cephalon Inc | Formulaciones farmaceuticas solidas que comprenden modafinil. |
| US7229644B2 (en) * | 2002-05-23 | 2007-06-12 | Cephalon, Inc. | Pharmaceutical formulations of modafinil |
| US20040116532A1 (en) | 2002-09-13 | 2004-06-17 | Craig Heacock | Pharmaceutical formulations of modafinil |
| JP2008523071A (ja) * | 2004-12-07 | 2008-07-03 | ルーカス ファーマシューティカルズ， インコーポレイテッド | Ｍａｐキナーゼの尿素インヒビター |
| WO2006062984A2 (en) * | 2004-12-07 | 2006-06-15 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| EP1973408A2 (en) * | 2006-01-04 | 2008-10-01 | Locus Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| GB201414116D0 (en) * | 2014-08-08 | 2014-09-24 | Trio Medicines Ltd | Benzodiazepine derivatives |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2032226A1 (en) * | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepine analogs |
| CA2068355A1 (en) * | 1991-05-14 | 1992-11-15 | Mark S. Chambers | Benzodiazephine derivatives, compositions containing them and their use in therapy |
| GB9201180D0 (en) * | 1992-01-21 | 1992-03-11 | Glaxo Group Ltd | Chemical compounds |
-
1992
- 1992-12-05 GB GB929225492A patent/GB9225492D0/en active Pending
-
1993
- 1993-12-01 TW TW082110143A patent/TW237450B/zh active
- 1993-12-02 AU AU56948/94A patent/AU688295B2/en not_active Ceased
- 1993-12-02 DE DE69319614T patent/DE69319614D1/de not_active Expired - Lifetime
- 1993-12-02 AT AT94902658T patent/ATE168102T1/de not_active IP Right Cessation
- 1993-12-02 EP EP94902658A patent/EP0672037B1/en not_active Expired - Lifetime
- 1993-12-02 NZ NZ258874A patent/NZ258874A/en unknown
- 1993-12-02 SK SK741-95A patent/SK74195A3/sk unknown
- 1993-12-02 PL PL93309281A patent/PL309281A1/xx unknown
- 1993-12-02 BR BR9307580A patent/BR9307580A/pt not_active Application Discontinuation
- 1993-12-02 JP JP6513738A patent/JPH08504200A/ja active Pending
- 1993-12-02 US US08/446,728 patent/US5569654A/en not_active Expired - Fee Related
- 1993-12-02 KR KR1019950702269A patent/KR950704270A/ko not_active Withdrawn
- 1993-12-02 RO RO95-01064A patent/RO114446B1/ro unknown
- 1993-12-02 WO PCT/EP1993/003381 patent/WO1994013648A1/en not_active Ceased
- 1993-12-02 CA CA002150461A patent/CA2150461A1/en not_active Abandoned
- 1993-12-02 HU HU9501622A patent/HUT71339A/hu unknown
- 1993-12-02 CZ CZ951384A patent/CZ138495A3/cs unknown
- 1993-12-02 RU RU95114528/04A patent/RU95114528A/ru unknown
- 1993-12-03 ZA ZA939068A patent/ZA939068B/xx unknown
- 1993-12-03 IL IL10786993A patent/IL107869A/en active IP Right Review Request
- 1993-12-03 MX MX9307654A patent/MX9307654A/es not_active IP Right Cessation
- 1993-12-04 CN CN93120779A patent/CN1093085A/zh active Pending
-
1994
- 1994-05-11 EC EC1994001085A patent/ECSP941085A/es unknown
- 1994-06-01 PE PE1994243670A patent/PE54294A1/es not_active Application Discontinuation
-
1995
- 1995-05-30 OA OA60669A patent/OA10161A/en unknown
- 1995-06-02 BG BG99696A patent/BG99696A/bg unknown
- 1995-06-02 FI FI952709A patent/FI952709A7/fi not_active Application Discontinuation
- 1995-06-02 NO NO952208A patent/NO952208L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5694894A (en) | 1994-07-04 |
| SK74195A3 (en) | 1995-11-08 |
| WO1994013648A1 (en) | 1994-06-23 |
| PL309281A1 (en) | 1995-10-02 |
| HUT71339A (en) | 1995-11-28 |
| IL107869A (en) | 1998-10-30 |
| HU9501622D0 (en) | 1995-08-28 |
| NZ258874A (en) | 1996-09-25 |
| RO114446B1 (ro) | 1999-04-30 |
| BG99696A (bg) | 1996-01-31 |
| US5569654A (en) | 1996-10-29 |
| ATE168102T1 (de) | 1998-07-15 |
| TW237450B (OSRAM) | 1995-01-01 |
| CN1093085A (zh) | 1994-10-05 |
| ZA939068B (en) | 1994-08-09 |
| GB9225492D0 (en) | 1993-01-27 |
| NO952208L (no) | 1995-08-02 |
| AU688295B2 (en) | 1998-03-12 |
| CA2150461A1 (en) | 1994-06-23 |
| JPH08504200A (ja) | 1996-05-07 |
| DE69319614D1 (de) | 1998-08-13 |
| KR950704270A (ko) | 1995-11-17 |
| EP0672037B1 (en) | 1998-07-08 |
| OA10161A (en) | 1996-12-18 |
| FI952709A7 (fi) | 1995-08-01 |
| BR9307580A (pt) | 1999-06-29 |
| NO952208D0 (no) | 1995-06-02 |
| EP0672037A1 (en) | 1995-09-20 |
| IL107869A0 (en) | 1994-04-12 |
| CZ138495A3 (en) | 1995-12-13 |
| ECSP941085A (es) | 1994-12-15 |
| PE54294A1 (es) | 1995-01-06 |
| FI952709A0 (fi) | 1995-06-02 |
| MX9307654A (es) | 1994-06-30 |
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