DE69319614D1 - 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren - Google Patents

1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren

Info

Publication number
DE69319614D1
DE69319614D1 DE69319614T DE69319614T DE69319614D1 DE 69319614 D1 DE69319614 D1 DE 69319614D1 DE 69319614 T DE69319614 T DE 69319614T DE 69319614 T DE69319614 T DE 69319614T DE 69319614 D1 DE69319614 D1 DE 69319614D1
Authority
DE
Germany
Prior art keywords
4alkyl
pct
optionally substituted
halogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69319614T
Other languages
English (en)
Inventor
Duncan Robert Armour
Philip Charles Box
Pritom Shah
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of DE69319614D1 publication Critical patent/DE69319614D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69319614T 1992-12-05 1993-12-02 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren Expired - Lifetime DE69319614D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929225492A GB9225492D0 (en) 1992-12-05 1992-12-05 Amine derivatives
PCT/EP1993/003381 WO1994013648A1 (en) 1992-12-05 1993-12-02 1,4-benzodiazepine derivatives and their use as cck-modulators

Publications (1)

Publication Number Publication Date
DE69319614D1 true DE69319614D1 (de) 1998-08-13

Family

ID=10726205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69319614T Expired - Lifetime DE69319614D1 (de) 1992-12-05 1993-12-02 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren

Country Status (29)

Country Link
US (1) US5569654A (de)
EP (1) EP0672037B1 (de)
JP (1) JPH08504200A (de)
KR (1) KR950704270A (de)
CN (1) CN1093085A (de)
AT (1) ATE168102T1 (de)
AU (1) AU688295B2 (de)
BG (1) BG99696A (de)
BR (1) BR9307580A (de)
CA (1) CA2150461A1 (de)
CZ (1) CZ138495A3 (de)
DE (1) DE69319614D1 (de)
EC (1) ECSP941085A (de)
FI (1) FI952709A (de)
GB (1) GB9225492D0 (de)
HU (1) HUT71339A (de)
IL (1) IL107869A (de)
MX (1) MX9307654A (de)
NO (1) NO952208L (de)
NZ (1) NZ258874A (de)
OA (1) OA10161A (de)
PE (1) PE54294A1 (de)
PL (1) PL309281A1 (de)
RO (1) RO114446B1 (de)
RU (1) RU95114528A (de)
SK (1) SK74195A3 (de)
TW (1) TW237450B (de)
WO (1) WO1994013648A1 (de)
ZA (1) ZA939068B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9314981D0 (en) * 1993-07-20 1993-09-01 Glaxo Spa Chemical compounds
US5428157A (en) * 1993-11-22 1995-06-27 Merck & Co., Inc. 3-acylaminobenzodiazepines
AU2446295A (en) * 1994-04-15 1995-11-10 Glaxo Inc. A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds
US5807876A (en) * 1996-04-23 1998-09-15 Vertex Pharmaceuticals Incorporated Inhibitors of IMPDH enzyme
AUPO284396A0 (en) * 1996-10-08 1996-10-31 Fujisawa Pharmaceutical Co., Ltd. Benzodiazepine derivatives
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
CA2285335A1 (en) 1997-04-14 1998-10-22 Cor Therapeutics, Inc. Selective factor xa inhibitors
NZ500352A (en) 1997-04-14 2001-10-26 Cor Therapeutics Inc Cyclic diaza selective factor Xa inhibitors
AU6896298A (en) 1997-04-14 1998-11-11 Cor Therapeutics, Inc. Selective factor xa inhibitors
US6333321B1 (en) * 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6100254A (en) * 1997-10-10 2000-08-08 Board Of Regents, The University Of Texas System Inhibitors of protein tyrosine kinases
US20080058424A1 (en) * 2002-05-23 2008-03-06 Cephalon, Inc. Novel pharmaceutical formulations of modafinil
MXPA03010705A (es) * 2001-05-25 2004-05-27 Cephalon Inc Formulaciones farmaceuticas solidas que comprenden modafinil.
US7229644B2 (en) * 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US20040116532A1 (en) * 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
EP1828169A2 (de) * 2004-12-07 2007-09-05 Locus Pharmaceuticals, Inc. Harnstoffinhibitoren von map-kinasen
WO2006062984A2 (en) * 2004-12-07 2006-06-15 Locus Pharmaceuticals, Inc. Inhibitors of protein kinases
JP2009522363A (ja) * 2006-01-04 2009-06-11 ローカス ファーマシューティカルズ、インク． プロテインキナーゼの阻害剤
GB201414116D0 (en) * 2014-08-08 2014-09-24 Trio Medicines Ltd Benzodiazepine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2032226A1 (en) * 1989-12-18 1991-06-19 Mark G. Bock Benzodiazepine analogs
CA2068355A1 (en) * 1991-05-14 1992-11-15 Mark S. Chambers Benzodiazephine derivatives, compositions containing them and their use in therapy
GEP20001968B (en) * 1992-01-21 2000-03-05 Glaxo Spa Arilthio Compounds as Antibacterial and Antiviral Agents

Also Published As

Publication number Publication date
RU95114528A (ru) 1997-06-10
CZ138495A3 (en) 1995-12-13
SK74195A3 (en) 1995-11-08
KR950704270A (ko) 1995-11-17
TW237450B (de) 1995-01-01
RO114446B1 (ro) 1999-04-30
EP0672037B1 (de) 1998-07-08
HUT71339A (en) 1995-11-28
FI952709A0 (fi) 1995-06-02
HU9501622D0 (en) 1995-08-28
IL107869A (en) 1998-10-30
PE54294A1 (es) 1995-01-06
MX9307654A (es) 1994-06-30
US5569654A (en) 1996-10-29
ECSP941085A (es) 1994-12-15
IL107869A0 (en) 1994-04-12
NO952208D0 (no) 1995-06-02
ZA939068B (en) 1994-08-09
BG99696A (bg) 1996-01-31
PL309281A1 (en) 1995-10-02
AU688295B2 (en) 1998-03-12
CN1093085A (zh) 1994-10-05
FI952709A (fi) 1995-08-01
JPH08504200A (ja) 1996-05-07
OA10161A (en) 1996-12-18
NZ258874A (en) 1996-09-25
WO1994013648A1 (en) 1994-06-23
BR9307580A (pt) 1999-06-29
EP0672037A1 (de) 1995-09-20
CA2150461A1 (en) 1994-06-23
AU5694894A (en) 1994-07-04
ATE168102T1 (de) 1998-07-15
GB9225492D0 (en) 1993-01-27
NO952208L (no) 1995-08-02

Similar Documents

Publication Publication Date Title
DE69319614D1 (de) 1,4-benzodiazepinderivate und ihre verwendung als cck-modulatoren
CO4970780A1 (es) Nuevos compuestos heterociclicos de piridazina
NZ336302A (en) Quinoline and quinazoline compounds useful in therapy, particularly in the treatment of benign prostatic hyperplasia
NZ503076A (en) 6,7-asymmetrically disubstituted quinoxalinecarboxylic acid derivatives and addition salts thereof, with antagonism against amino acid receptors (particularly AMPA receptor) and processes for their preparation
ATE156804T1 (de) Ethanolamin-derivate mit sympathomimetischer und anti-pollakiuria wirkung
BG97221A (bg) Ортозаместени бифениламидини и бифенилизанидини и съдържащите ги антидиабетични или хипогликемични средства
DK0759027T3 (da) Bicykliske amidinderivater som inhibitorer af nitrogenoxidsynthetase
ATE168672T1 (de) Indol-piperazin-derivate als selektive liganden der 5ht1d und 5ht1b receptoren verwendbar als arzneimittel
ATE172193T1 (de) Piperazinderivate
DK0875506T3 (da) Quinolin- og quinazolin-forbindelser, som er anvendelige til behandling
DE69520279D1 (de) Bibphenylamid-derivate als 5-ht1d-antagonisten
CO5540322A2 (es) Nuevos derivados heterociclicos que comprenden un anillo de tetrahidroisoquinolina y uso farmaceutico de los mismos
ATE152442T1 (de) Substituierte arylalkylaminobenzyl- aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel
DK1220848T3 (da) N-arylmethylthioanilid-forbindelser, som er nyttige til inhibition af replikationen af HIV
ATE172454T1 (de) Pyridazinon derivate mit pharmazeutischer wirkung
ATE259359T1 (de) Benzoxazol-derivate zur verwendung als integrin- inhibitoren
ATE191465T1 (de) Carbamoylcarbonsäureamide
NZ337749A (en) Benzimidazole derivative and their use in allergy-related disease
DE69627346D1 (de) 4-aryl-thio-pyridin-2(1h)-onen, diese enthaltende arzneimittel und ihre anwendungen bei der behandlung von mit hiv zusammenhängenden krankheiten
ES2010089A6 (es) Procedimiento para la obtencion de n-oxidos de gamma-carbolina antipsicoticos.
TH15971A (th) อนุพันธ์ของแอมีน
BG96022A (bg) 2-(2'метил-3',4'-тризаместени бензол)-1,3- циклохександиони, метод за борба срещу нежелана растителност и хербициден състав, използващ тези съединения
ES2120885A1 (es) Nuevas tienopirimidonas con actividad antifungica.
ECSP920821A (es) Composiciones heterocyclicas

Legal Events

Date Code Title Description
8332 No legal effect for de