RU95112451A - Фенилэтил- и фенилпропиаминовые соединения, способ их получения, фармацевтическая композиция и способ лечения - Google Patents

Фенилэтил- и фенилпропиаминовые соединения, способ их получения, фармацевтическая композиция и способ лечения

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Publication number
RU95112451A
RU95112451A RU95112451/04A RU95112451A RU95112451A RU 95112451 A RU95112451 A RU 95112451A RU 95112451/04 A RU95112451/04 A RU 95112451/04A RU 95112451 A RU95112451 A RU 95112451A RU 95112451 A RU95112451 A RU 95112451A
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Russia
Prior art keywords
treatment
phenylethyl
production
pharmaceutical composition
formula
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RU95112451/04A
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English (en)
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RU2133735C1 (ru
Inventor
Бенгтссон Стефан
Se]
Хелльберг Свен
Мохелль Нина
Жанг Лиан
Халльнемо Герд
Fi]
Джексон Дейвид
Ульфф Бенгт
Cn]
Au]
Original Assignee
Астра Актиеболаг (SE)
Астра Актиеболаг
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Publication of RU95112451A publication Critical patent/RU95112451A/ru
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Publication of RU2133735C1 publication Critical patent/RU2133735C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • C07D207/408—Radicals containing only hydrogen and carbon atoms attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/62—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/44—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing eight carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Luminescent Compositions (AREA)

Abstract

Предложены соединения общей формулы Iв которой Z представляет собой насыщенную или ненасыщенную углеродную цепь с 3 - 6 атомами углерода, m является числом 2 или 3, Rпредставляет собой атом водорода или C-алкил нормального или разветвленного строения, R, Rи Rвыбраны из следующих групп: Н, ОН, OR, галогена, СOR, CN, CF, NO, NH, COCH, OSOCF, OSOCH, CONRRи OCOR, R представляет собой радикал формулы 123и 4в которой R, R, R, R, R, W, nи nимеют значения, указанные в формуле изобретения, способы их получения, фармацевтические препараты, содержащие их, и применение соединений для лечения психиатрических нарушений.

Claims (1)

  1. Предложены соединения общей формулы I
    Figure 00000001

    в которой Z представляет собой насыщенную или ненасыщенную углеродную цепь с 3 - 6 атомами углерода, m является числом 2 или 3, R1 представляет собой атом водорода или C1- 4-алкил нормального или разветвленного строения, R2, R3 и R13 выбраны из следующих групп: Н, ОН, OR14, галогена, СO2R9, CN, CF3, NO2, NH2, COCH3, OSO2CF3, OSO2CH3, CONR10R11 и OCOR12, R представляет собой радикал формулы 1
    Figure 00000002
    2
    Figure 00000003
    3
    Figure 00000004
    и 4
    Figure 00000005

    в которой R4, R5, R6, R7, R8, W, n3 и n4 имеют значения, указанные в формуле изобретения, способы их получения, фармацевтические препараты, содержащие их, и применение соединений для лечения психиатрических нарушений.
RU95112451A 1993-10-07 1994-09-16 Фенилэтил- и фенилпропиламиновые соединения, способ их получения и фармацевтический препарат RU2133735C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9303274A SE9303274D0 (sv) 1993-10-07 1993-10-07 Novel phenylethyl and phenylproplamines
SE9303274-6 1993-10-07
PCT/SE1994/000860 WO1995009835A1 (en) 1993-10-07 1994-09-16 Novel phenylethyl and phenylpropylamines

Publications (2)

Publication Number Publication Date
RU95112451A true RU95112451A (ru) 1997-04-20
RU2133735C1 RU2133735C1 (ru) 1999-07-27

Family

ID=20391336

Family Applications (1)

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RU95112451A RU2133735C1 (ru) 1993-10-07 1994-09-16 Фенилэтил- и фенилпропиламиновые соединения, способ их получения и фармацевтический препарат

Country Status (31)

Country Link
US (1) US5693630A (ru)
EP (1) EP0672032B1 (ru)
JP (1) JPH08504835A (ru)
KR (1) KR950704236A (ru)
CN (1) CN1048718C (ru)
AT (1) ATE161823T1 (ru)
AU (1) AU680303B2 (ru)
BR (1) BR9405632A (ru)
CA (1) CA2150005A1 (ru)
CZ (1) CZ148595A3 (ru)
DE (1) DE69407751T2 (ru)
DK (1) DK0672032T3 (ru)
EE (1) EE03214B1 (ru)
ES (1) ES2111959T3 (ru)
FI (1) FI952772A0 (ru)
GR (1) GR3026484T3 (ru)
HU (1) HUT73774A (ru)
IL (1) IL111133A (ru)
IS (1) IS4204A (ru)
LT (1) LT3920B (ru)
LV (1) LV10862B (ru)
NO (1) NO305947B1 (ru)
NZ (1) NZ274273A (ru)
PL (1) PL179011B1 (ru)
RU (1) RU2133735C1 (ru)
SE (1) SE9303274D0 (ru)
SI (1) SI9420007A (ru)
SK (1) SK67295A3 (ru)
TW (1) TW338036B (ru)
WO (1) WO1995009835A1 (ru)
ZA (1) ZA947209B (ru)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60114413T2 (de) 2000-05-25 2006-07-27 F. Hoffmann-La Roche Ag Substituierte 1-aminoalkyl-lactame und deren verwendung als muscarinrezeptor-antagonisten
DE60215203T2 (de) 2001-09-12 2007-10-18 Merck Patent Gmbh VERWENDUNG VON AMINOMETHYL CHROMANEN ZUR BEHANDLUNG DER NEBENWIRKUNGEN VON NEUROLEPTIkA
IL147953A (en) 2002-02-01 2008-04-13 Meir Bialer Derivatives and pharmaceutical compositions of n-hydroxymethyl tetramethylcyclopropyl-
IL157751A0 (en) 2003-02-28 2004-03-28 Yissum Res Dev Co New amide derivatives of 2,2,3,3-tetramethylcyclopropane carboxylic acid, a method for their synthesis and pharmaceutical compositions containing them
IL156203A0 (en) * 2003-05-29 2003-12-23 Yissum Res Dev Co Use of 2,2,3,3, tetramethylcyclopropane carboxylic acid derivatives for treating psychiatric disorders

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR7644E (fr) 1903-08-11 1907-09-17 Chappee Et Fils Soc Nouveau système d'assainissement des villes
DE1518375A1 (de) * 1965-06-08 1969-08-14 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen 2-Amino-halogenbenzylaminen
FR7644M (ru) * 1968-06-24 1970-02-02
US4021558A (en) * 1973-09-08 1977-05-03 Boehringer Ingelheim Gmbh 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
AT330777B (de) * 1973-09-08 1976-07-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
DE2345423A1 (de) * 1973-09-08 1975-03-20 Thomae Gmbh Dr K Neue substituierte phenylaethylaminderivate, deren saeureadditionssalze, diese enthaltende arzneimittel sowie verfahren zu deren herstellung
JPS5414956A (en) * 1977-07-04 1979-02-03 Sumitomo Chem Co Ltd Novel 3-amino-4-homoisotwistan derivative
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
FR2608157B1 (fr) * 1986-12-11 1989-09-08 Roussel Uclaf Nouveaux derives de l'azaspirodecane, leurs sels, procede de preparation, application a titre de medicaments et compositions les renfermant et intermediaires
NO170790C (no) 1986-12-12 1992-12-02 Ceraver Fremgangsmaate for fremstilling av lynavleder

Also Published As

Publication number Publication date
CN1115575A (zh) 1996-01-24
NZ274273A (en) 1996-10-28
DE69407751T2 (de) 1998-04-16
CZ148595A3 (en) 1996-01-17
SE9303274D0 (sv) 1993-10-07
DE69407751D1 (de) 1998-02-12
ES2111959T3 (es) 1998-03-16
ATE161823T1 (de) 1998-01-15
TW338036B (en) 1998-08-11
KR950704236A (ko) 1995-11-17
AU7825694A (en) 1995-05-01
FI952772A (fi) 1995-06-06
HU9501643D0 (en) 1995-08-28
PL179011B1 (pl) 2000-07-31
FI952772A0 (fi) 1995-06-06
RU2133735C1 (ru) 1999-07-27
NO952232D0 (no) 1995-06-06
US5693630A (en) 1997-12-02
NO952232L (no) 1995-07-18
DK0672032T3 (da) 1998-05-04
CA2150005A1 (en) 1995-04-13
LT95059A (en) 1995-10-25
IL111133A0 (en) 1994-12-29
CN1048718C (zh) 2000-01-26
LV10862A (lv) 1995-10-20
NO305947B1 (no) 1999-08-23
LV10862B (en) 1996-08-20
GR3026484T3 (en) 1998-06-30
IL111133A (en) 1998-12-27
BR9405632A (pt) 1999-05-25
EE03214B1 (et) 1999-08-16
LT3920B (en) 1996-04-25
ZA947209B (en) 1995-07-07
IS4204A (is) 1995-04-08
SK67295A3 (en) 1996-09-04
SI9420007A (en) 1996-04-30
WO1995009835A1 (en) 1995-04-13
PL309189A1 (en) 1995-09-18
HUT73774A (en) 1996-09-30
JPH08504835A (ja) 1996-05-28
AU680303B2 (en) 1997-07-24
EP0672032B1 (en) 1998-01-07
EP0672032A1 (en) 1995-09-20

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