RU95114377A - 7-гало- и 7бета, 8бета -метано-таксолы, фармацевтическая композиция, промежуточные соединения, способы получения промежуточных соединений - Google Patents

7-гало- и 7бета, 8бета -метано-таксолы, фармацевтическая композиция, промежуточные соединения, способы получения промежуточных соединений

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Publication number
RU95114377A
RU95114377A RU95114377/04A RU95114377A RU95114377A RU 95114377 A RU95114377 A RU 95114377A RU 95114377/04 A RU95114377/04 A RU 95114377/04A RU 95114377 A RU95114377 A RU 95114377A RU 95114377 A RU95114377 A RU 95114377A
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intermediate compounds
cancer
taxoles
methano
halo
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RU95114377/04A
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RU2125996C1 (ru
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Б.Хестер Джэксон
Us]
А.Джонсон Рой
К.Келли Роберт
Г.Майди Элдон
И.Скалник Харви
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Дзе Апджон Компани (US)
Дзе Апджон Компани
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Настоящее изобретение относится к аналогам 7-дезокситаксола, имеющим формулу:Соединения формулы полезны для применения в случае некоторых видов рака, для которых показана активность таксола и которые включают рак яичников человека, рак груди, злокачественную меланому, а также рак легкого, рак желудка, рак толстой кишки, рак головы и шеи и лейкоз.

Claims (1)

  1. Настоящее изобретение относится к аналогам 7-дезокситаксола, имеющим формулу:
    Figure 00000001

    Соединения формулы полезны для применения в случае некоторых видов рака, для которых показана активность таксола и которые включают рак яичников человека, рак груди, злокачественную меланому, а также рак легкого, рак желудка, рак толстой кишки, рак головы и шеи и лейкоз.
RU95114377A 1992-12-15 1993-12-13 7-ГАЛО- И 7β, 8β-МЕТАНОТАКСОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ И СПОСОБЫ ПОЛУЧЕНИЯ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ RU2125996C1 (ru)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US08/013826 1992-02-02
US99057992A 1992-12-15 1992-12-15
US07/990579 1992-12-15
US1382693A 1993-02-02 1993-02-02
US7633793A 1993-06-11 1993-06-11
US08/076337 1993-06-11
US12297493A 1993-09-17 1993-09-17
US08/112974 1993-09-17

Publications (2)

Publication Number Publication Date
RU95114377A true RU95114377A (ru) 1997-06-10
RU2125996C1 RU2125996C1 (ru) 1999-02-10

Family

ID=27486333

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95114377A RU2125996C1 (ru) 1992-12-15 1993-12-13 7-ГАЛО- И 7β, 8β-МЕТАНОТАКСОЛЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ И СПОСОБЫ ПОЛУЧЕНИЯ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ

Country Status (26)

Country Link
US (1) US6911549B1 (ru)
EP (1) EP0674630B1 (ru)
JP (1) JP3441458B2 (ru)
KR (1) KR100317015B1 (ru)
CN (2) CN1062561C (ru)
AT (1) ATE226576T1 (ru)
AU (1) AU687027B2 (ru)
CA (1) CA2149021A1 (ru)
CZ (1) CZ291177B6 (ru)
DE (1) DE69332438T2 (ru)
DK (1) DK0674630T3 (ru)
ES (1) ES2187519T3 (ru)
FI (1) FI111633B (ru)
HU (1) HUT74447A (ru)
IL (1) IL107950A (ru)
LV (1) LV13023B (ru)
MX (1) MX9307777A (ru)
MY (1) MY116473A (ru)
NO (1) NO313801B1 (ru)
NZ (1) NZ259196A (ru)
PL (1) PL185042B1 (ru)
PT (1) PT674630E (ru)
RU (1) RU2125996C1 (ru)
SK (1) SK281897B6 (ru)
TW (1) TW389758B (ru)
WO (1) WO1994013655A1 (ru)

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Also Published As

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PT674630E (pt) 2003-03-31
SK281897B6 (sk) 2001-09-11
CN1062561C (zh) 2001-02-28
JP3441458B2 (ja) 2003-09-02
CZ291177B6 (cs) 2003-01-15
MX9307777A (es) 1994-07-29
CZ143795A3 (en) 1995-11-15
NO313801B1 (no) 2002-12-02
US6911549B1 (en) 2005-06-28
PL185042B1 (pl) 2003-02-28
CN1261072A (zh) 2000-07-26
RU2125996C1 (ru) 1999-02-10
PL309392A1 (en) 1995-10-02
NZ259196A (en) 1998-08-26
AU687027B2 (en) 1998-02-19
TW389758B (en) 2000-05-11
CA2149021A1 (en) 1994-06-23
HUT74447A (en) 1996-12-30
HU9501733D0 (en) 1995-08-28
FI952920A (fi) 1995-06-14
JPH08506568A (ja) 1996-07-16
ATE226576T1 (de) 2002-11-15
CN1095377A (zh) 1994-11-23
FI111633B (fi) 2003-08-29
KR100317015B1 (ko) 2002-06-22
SK78895A3 (en) 1995-12-06
IL107950A0 (en) 1994-04-12
WO1994013655A1 (en) 1994-06-23
ES2187519T3 (es) 2003-06-16
NO952351D0 (no) 1995-06-14
LV13023B (en) 2003-12-20
EP0674630A1 (en) 1995-10-04
DE69332438D1 (de) 2002-11-28
KR950704288A (ko) 1995-11-17
DE69332438T2 (de) 2003-06-18
AU5741194A (en) 1994-07-04
DK0674630T3 (da) 2003-02-24
FI952920A0 (fi) 1995-06-14
NO952351L (no) 1995-08-14
EP0674630B1 (en) 2002-10-23
IL107950A (en) 2001-04-30
MY116473A (en) 2004-02-28

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