RU95110767A - Днк, кодирующая гликопротеин человеческого происхождения - Google Patents

Днк, кодирующая гликопротеин человеческого происхождения

Info

Publication number
RU95110767A
RU95110767A RU95110767/13A RU95110767A RU95110767A RU 95110767 A RU95110767 A RU 95110767A RU 95110767/13 A RU95110767/13 A RU 95110767/13A RU 95110767 A RU95110767 A RU 95110767A RU 95110767 A RU95110767 A RU 95110767A
Authority
RU
Russia
Prior art keywords
activity
dna sequence
growth
glycoprotein
dna encoding
Prior art date
Application number
RU95110767/13A
Other languages
English (en)
Other versions
RU2113480C1 (ru
Inventor
Кандзи Хагасио
Jp]
Синдзиро Митсуда
Нобуюки Сима
Ясухару Итагаки
Масая Нагао
Original Assignee
Сноу Брэнд Милк Продактс Ко.
Сноу Брэнд Милк Продактс Ко., Лтд.
Лтд. (Jp)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26340889&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU95110767(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Сноу Брэнд Милк Продактс Ко., Сноу Брэнд Милк Продактс Ко., Лтд., Лтд. (Jp) filed Critical Сноу Брэнд Милк Продактс Ко.
Publication of RU95110767A publication Critical patent/RU95110767A/ru
Application granted granted Critical
Publication of RU2113480C1 publication Critical patent/RU2113480C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Подучена ДНК последовательность, кодирующая новый гликопротеин, обладающий противоопухолевой активностью, активностью по индуцированию дифференциации клеток лейкемии, активностью по усилению клеточной иммунологии, активностью по стимулированию роста клеток эндотелия сосудов, а также активностью по стимулированию роста генатоцитов.

Claims (1)

  1. Подучена ДНК последовательность, кодирующая новый гликопротеин, обладающий противоопухолевой активностью, активностью по индуцированию дифференциации клеток лейкемии, активностью по усилению клеточной иммунологии, активностью по стимулированию роста клеток эндотелия сосудов, а также активностью по стимулированию роста генатоцитов.
RU95110767A 1989-03-10 1990-03-09 Фрагмент к днк, кодирующий гликопротеин tcf-ii RU2113480C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5863189 1989-03-10
JP58631/1989 1989-03-10
JP669290 1990-01-16
JP6692/1990 1990-01-16

Publications (2)

Publication Number Publication Date
RU95110767A true RU95110767A (ru) 1997-06-10
RU2113480C1 RU2113480C1 (ru) 1998-06-20

Family

ID=26340889

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95110767A RU2113480C1 (ru) 1989-03-10 1990-03-09 Фрагмент к днк, кодирующий гликопротеин tcf-ii

Country Status (17)

Country Link
US (2) US5587359A (ru)
EP (1) EP0462277B1 (ru)
JP (1) JPH0768272B1 (ru)
KR (1) KR960009054B1 (ru)
AT (1) ATE123498T1 (ru)
AU (1) AU629314B2 (ru)
CA (1) CA2049017C (ru)
DE (1) DE69019962T2 (ru)
DK (1) DK0462277T3 (ru)
ES (1) ES2075199T3 (ru)
FI (1) FI102681B1 (ru)
HU (2) HU212513B (ru)
IE (1) IE64005B1 (ru)
NO (1) NO180796C (ru)
NZ (1) NZ232813A (ru)
RU (1) RU2113480C1 (ru)
WO (1) WO1990010651A1 (ru)

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EP0461560B1 (en) * 1990-06-11 1998-11-18 Toshikazu Nakamura Recombinant human hepatocyte growth factor and method for production thereof
EP0539590B1 (en) * 1990-07-13 1999-03-31 Snow Brand Milk Products Co., Ltd. Plasmid containing dna which codes for the amino acid sequence of tcf-ii, transformed cell, and production of physiologically active substance by using the same
JP3438888B2 (ja) * 1990-09-14 2003-08-18 アメリカ合衆国 非分裂促進競合性ｈｇｆ拮抗剤
US5821223A (en) * 1990-09-14 1998-10-13 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen
JP3200609B2 (ja) * 1990-12-28 2001-08-20 敏一 中村 上皮細胞増殖促進剤
JPH0597A (ja) * 1991-06-21 1993-01-08 Snow Brand Milk Prod Co Ltd 新規抗ｔｃｆ−ｉｉモノクローナル抗体及びそれを用いるｔｃｆ−ｉｉの測定方法
JP3634359B2 (ja) * 1992-07-16 2005-03-30 第一製薬株式会社 Ｔｃｆ−▲ｉｉ▼を有効成分とする血液凝固正常化剤
DE69314586T2 (de) * 1992-07-16 1998-02-19 Snow Brand Milk Prod Co Ltd Arzneimittelzusammensetzung enthaltend TCF-II
AU5716594A (en) * 1992-12-28 1994-07-19 Snow Brand Milk Products Co., Ltd. Modified TCF
JP3552240B2 (ja) * 1993-02-23 2004-08-11 第一製薬株式会社 高濃度ｔｃｆ製剤
US5837676A (en) * 1993-10-18 1998-11-17 Long Island Jewish Medical Center Use of scatter factor to enhance angiogenesis
JP2747979B2 (ja) * 1994-08-19 1998-05-06 雪印乳業株式会社 ヒト由来の糖蛋白質からなる生理活性因子を有効成分とする医薬
NZ298141A (en) * 1994-12-27 2000-12-22 Snow Brand Milk Products Co Ltd Treating lipid metabolism disorder using TCF-II
DE69531673T2 (de) * 1994-12-27 2004-07-08 Daiichi Pharmaceutical Co., Ltd. Tcf mutante
JP3927248B2 (ja) * 1995-07-11 2007-06-06 第一製薬株式会社 Ｈｇｆ凍結乾燥製剤
AU4027601A (en) * 1995-07-11 2001-07-26 Snow Brand Milk Products Co., Ltd. Lyophilized HGF preparations
JP4006058B2 (ja) 1997-03-11 2007-11-14 第一三共株式会社 多臓器不全予防及び／又は治療剤
CA2253629A1 (en) 1997-03-14 1998-09-24 Snow Brand Milk Products Co., Ltd. Agent for preventing and/or treating cachexia
JPH1129493A (ja) * 1997-07-14 1999-02-02 Snow Brand Milk Prod Co Ltd 放射線障害予防及び／又は治療剤
JPH11269091A (ja) * 1998-03-19 1999-10-05 Snow Brand Milk Prod Co Ltd 敗血症予防及び／又は治療剤
CN1352087A (zh) * 2000-11-02 2002-06-05 上海博德基因开发有限公司 一种新的多肽——人糖蛋白42和编码这种多肽的多核苷酸
KR100562824B1 (ko) * 2002-03-20 2006-03-23 주식회사 바이로메드 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
US7563810B2 (en) 2002-11-06 2009-07-21 Celgene Corporation Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases
CN100417412C (zh) * 2003-03-28 2008-09-10 威海赛洛金药业有限公司 促肝细胞生长素注射液及制备方法和应用
JP4728807B2 (ja) * 2003-09-03 2011-07-20 敏一 中村 ヒト組換えｈｇｆを含有する皮膚潰瘍予防治癒剤
RU2520817C2 (ru) * 2006-01-25 2014-06-27 Октафарма Аг Очистка и применение фактора, способствующего заживлению ран
US20100124782A1 (en) * 2007-04-28 2010-05-20 Applied Cell Biotechnologies, Inc. Composition For Repairing Defect In Skin Or Gingival Soft Tissue And Method Of Culturing Autologous Fibroblasts
US20090202606A1 (en) * 2008-01-25 2009-08-13 Viromed Co., Ltd. Treatment and Prevention of Cardiac Conditions Using Two or More Isoforms of Hepatocyte Growth Factor
MX2010010993A (es) * 2008-04-09 2010-11-05 Viromed Co Ltd Formulaciones liofilizadas de adn para expresion mejorada de adn de plasmido.
BR112016008267A2 (pt) 2013-10-22 2017-10-03 Viromed Co Ltd Composição para prevenir ou tratar esclerose lateral amiotrófica usando duas ou mais isoformas de fator de crescimento de hepatócito
SG11201608583YA (en) 2014-04-28 2016-11-29 Eisai R&D Man Co Ltd Lyophilized formulation of hgf
WO2016039163A1 (ja) 2014-09-10 2016-03-17 クリングルファーマ株式会社 神経疾患の治療に適したｈｇｆ製剤
KR102275262B1 (ko) 2016-03-17 2021-07-12 에자이 알앤드디 매니지먼트 가부시키가이샤 활성 간세포 성장 인자(hgf)를 생성하는 방법
AU2019305221A1 (en) 2018-07-19 2021-02-18 Helixmith Co., Ltd. Lyophilized pharmaceutical compositions for naked DNA gene therapy
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JPS58148826A (ja) * 1982-02-26 1983-09-05 Mochida Pharmaceut Co Ltd 糖蛋白質および腫瘍治療剤
JP2564486B2 (ja) * 1986-07-14 1996-12-18 修治 橋本 肝細胞増殖因子
US5037644A (en) * 1986-10-27 1991-08-06 Cetus Corporation Pharmaceutical compositions of recombinant interleukin-2 and formulation processes
DE3643182A1 (de) * 1986-12-18 1988-06-30 Behringwerke Ag Arzneimittel enthaltend das gewebeprotein pp4, verfahren zur herstellung von pp4 und zu seiner pasteurisierung sowie die verwendung von pp4
JPS6410998A (en) * 1986-12-22 1989-01-13 Green Cross Corp Tumor cell inhibitory factor
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EP0539590B1 (en) * 1990-07-13 1999-03-31 Snow Brand Milk Products Co., Ltd. Plasmid containing dna which codes for the amino acid sequence of tcf-ii, transformed cell, and production of physiologically active substance by using the same

Also Published As

Publication number Publication date
US5587359A (en) 1996-12-24
NO913546L (no) 1991-11-11
CA2049017C (en) 1998-10-27
FI914234A0 (fi) 1991-09-09
NZ232813A (en) 1992-08-26
FI102681B (fi) 1999-01-29
EP0462277A1 (en) 1991-12-27
FI102681B1 (fi) 1999-01-29
NO180796B (no) 1997-03-17
AU5177490A (en) 1990-10-09
WO1990010651A1 (fr) 1990-09-20
KR960009054B1 (ko) 1996-07-10
HU212513B (en) 1996-07-29
IE64005B1 (en) 1995-06-28
AU629314B2 (en) 1992-10-01
CA2049017A1 (en) 1990-09-11
JPH0768272B1 (ru) 1995-07-26
NO180796C (no) 1997-06-25
NO913546D0 (no) 1991-09-09
DE69019962T2 (de) 1995-11-23
ES2075199T3 (es) 1995-10-01
US6333309B1 (en) 2001-12-25
DE69019962D1 (de) 1995-07-13
EP0462277B1 (en) 1995-06-07
KR920701256A (ko) 1992-08-11
DK0462277T3 (da) 1995-10-30
HU902330D0 (en) 1991-12-30
RU2113480C1 (ru) 1998-06-20
IE900863L (en) 1990-09-10
HUT58797A (en) 1992-03-30
ATE123498T1 (de) 1995-06-15
HU211229A9 (en) 1995-11-28
EP0462277A4 (en) 1992-08-12

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Effective date: 20090714