RU95103100A - Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения - Google Patents

Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения

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Publication number
RU95103100A
RU95103100A RU95103100/04A RU95103100A RU95103100A RU 95103100 A RU95103100 A RU 95103100A RU 95103100/04 A RU95103100/04 A RU 95103100/04A RU 95103100 A RU95103100 A RU 95103100A RU 95103100 A RU95103100 A RU 95103100A
Authority
RU
Russia
Prior art keywords
inhibitors
treatment
cell adhesion
glycolipids
pharmaceutical composition
Prior art date
Application number
RU95103100/04A
Other languages
English (en)
Russian (ru)
Inventor
Мартел Элейн
Ca]
Банвилль Жак
А.Аруффо Алехандро
Mx]
Original Assignee
Бристоль-Мейерз Сквибб Компани (US)
Бристоль-Мейерз Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристоль-Мейерз Сквибб Компани (US), Бристоль-Мейерз Сквибб Компани filed Critical Бристоль-Мейерз Сквибб Компани (US)
Publication of RU95103100A publication Critical patent/RU95103100A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU95103100/04A 1994-03-04 1995-03-03 Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения RU95103100A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20592894A 1994-03-04 1994-03-04
US205,928 1994-03-04

Publications (1)

Publication Number Publication Date
RU95103100A true RU95103100A (ru) 1997-03-20

Family

ID=22764246

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95103100/04A RU95103100A (ru) 1994-03-04 1995-03-03 Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения

Country Status (15)

Country Link
US (1) US5663151A (enExample)
EP (1) EP0671407A2 (enExample)
JP (1) JPH0841093A (enExample)
KR (1) KR950032258A (enExample)
CN (1) CN1112122A (enExample)
AU (1) AU1360595A (enExample)
CA (1) CA2142154A1 (enExample)
CZ (1) CZ49895A3 (enExample)
FI (1) FI951001L (enExample)
HU (1) HUT70404A (enExample)
IL (1) IL112756A0 (enExample)
NO (1) NO950763L (enExample)
PL (1) PL307524A1 (enExample)
RU (1) RU95103100A (enExample)
ZA (1) ZA95937B (enExample)

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WO1997043296A1 (en) 1996-05-16 1997-11-20 Nissin Food Products Co., Ltd. Novel compounds having antiviral activity
US5700458A (en) 1996-09-20 1997-12-23 Geltex Pharmaceuticals Inc. Acid-functionalized saccharides as polyvalent anti-infectives
DE19700774A1 (de) * 1997-01-13 1998-07-16 Hoechst Ag Antiadhäsive Sulfatid-Mimetika
PL213644B1 (pl) * 2001-11-21 2013-04-30 H:S Rigshospitalet Zastosowanie glikozydów mono- i diacyloglicerolu do wytwarzania leku do leczenia, lagodzenia lub profilaktyki stanów zapalnych
WO2003097658A2 (en) * 2002-05-16 2003-11-27 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
EP1539251A4 (en) * 2002-07-03 2009-02-25 Glycomimetics Inc COMPOSITIONS AND METHODS FOR DIAGNOSIS AND THERAPY OF MEDICAL DISEASES WITH ANGIOGENESIS
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
DE602004011272T2 (de) * 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
US20050187171A1 (en) * 2003-11-19 2005-08-25 Glycomimetics, Inc. Glycomimetic antagonists for both E-and P-selectins
US7481080B2 (en) * 2004-07-01 2009-01-27 General Electric Company Clothes washer braking method and apparatus
DE102004036213B4 (de) * 2004-07-26 2011-02-24 Johannes-Gutenberg-Universität Mainz Nichtglykosidische und nichtpeptidische Selektininhibitoren, deren Herstellung und pharmazeutische Zusammensetzungen
US7534434B2 (en) * 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
US7923013B2 (en) 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
DK1928892T3 (da) * 2005-08-09 2012-01-30 Glycomimetics Inc Glycomimetiske inhibitorer af PA-IL-lectin PA-IIL-lectin eller begge lectiner fra pseudomonas
ES2397850T3 (es) 2005-09-02 2013-03-11 Glycomimetics, Inc. Inhibidores de pan-selectina heterobifuncionales
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
WO2008060378A2 (en) 2006-10-12 2008-05-22 Glycomimetics, Inc. Glycomimetic replacements for hexoses and n-acetyl hexosamines
EP2457573A1 (en) * 2007-02-09 2012-05-30 GlycoMimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and N-Acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
CA2704201C (en) 2007-10-16 2015-06-30 Progen Pharmaceuticals Limited Novel sulfated oligosaccharide derivatives
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
AU2009257536B2 (en) * 2008-06-13 2015-07-02 Glycomimetics, Inc. Treatment of cancers of the blood using selected glycomimetic compounds
CN102421441B (zh) * 2009-05-01 2015-04-01 糖模拟物有限公司 E-选择蛋白和cxcr4趋化因子受体的异双功能抑制剂
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
CN104039805B (zh) 2011-12-22 2016-11-16 糖模拟物有限公司 E-选择蛋白拮抗剂化合物、组合物及使用方法
SI2928476T1 (en) 2012-12-07 2018-06-29 Glycomimetics, Inc. COMPONENTS, INSTALLATIONS AND PROCEDURES OF THE APPLICATION OF E-SELECTINE OF ANTAGONISTS FOR THE MOBILIZATION OF HEMATOPOETIC CELLS
JP6689854B2 (ja) 2014-12-03 2020-04-28 グリコミメティクス， インコーポレイテッド Ｅ−セレクチンおよびｃｘｃｒ４ケモカイン受容体のヘテロ二官能性阻害剤
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
WO2017151708A1 (en) 2016-03-02 2017-09-08 Glycomimetics, Inc. Methods for the treatment and/or prevention of cardiovescular disease by inhibition of e-selectin
WO2018031445A1 (en) 2016-08-08 2018-02-15 Glycomimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4
KR102653723B1 (ko) 2016-10-07 2024-04-01 글리코미메틱스, 인크. 매우 강력한 다량체성 e-셀렉틴 길항물질
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
US11712446B2 (en) 2017-11-30 2023-08-01 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
BR112020013198A2 (pt) 2017-12-29 2020-12-01 Glycomimetics, Inc. inibidores heterobifuncionais de e-selectina e galectina-3
US11707474B2 (en) 2018-03-05 2023-07-25 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3

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GB1164388A (en) * 1966-06-14 1969-09-17 Shionogi & Co Crystalline Sulfur-Containing Glycolipid and the Production Thereof.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
EP0212400B1 (de) * 1985-08-13 1992-01-02 Solco Basel AG Neues Verfahren zur Herstellung von Sphingosinderivaten
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
JPH0317020A (ja) * 1989-06-14 1991-01-25 Nippon Koutai Kenkyusho:Kk 抗ｈｉｖ剤
JP3096305B2 (ja) * 1990-07-17 2000-10-10 ボード オブ リージェンツ オブ ザ ユニバーシティ オブ オクラホマ Ｇｍｐ―１４０に対する糖タンパク質リガンド
DK84691D0 (da) * 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
WO1993005803A1 (en) * 1991-09-25 1993-04-01 Genetics Institute, Inc. Anti-inflammatory selectin inhibitors
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors

Also Published As

Publication number Publication date
KR950032258A (ko) 1995-12-20
FI951001A0 (fi) 1995-03-03
NO950763D0 (no) 1995-02-28
ZA95937B (en) 1996-08-06
CZ49895A3 (en) 1995-12-13
JPH0841093A (ja) 1996-02-13
US5663151A (en) 1997-09-02
HU9500655D0 (en) 1995-04-28
EP0671407A3 (enExample) 1995-10-25
PL307524A1 (en) 1995-09-18
CA2142154A1 (en) 1995-09-05
FI951001A7 (fi) 1995-09-05
FI951001L (fi) 1995-09-05
AU1360595A (en) 1995-09-14
IL112756A0 (en) 1995-05-26
NO950763L (no) 1995-09-05
HUT70404A (en) 1995-10-30
CN1112122A (zh) 1995-11-22
EP0671407A2 (en) 1995-09-13

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