RU95103100A - Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения - Google Patents

Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения

Info

Publication number
RU95103100A
RU95103100A RU95103100/04A RU95103100A RU95103100A RU 95103100 A RU95103100 A RU 95103100A RU 95103100/04 A RU95103100/04 A RU 95103100/04A RU 95103100 A RU95103100 A RU 95103100A RU 95103100 A RU95103100 A RU 95103100A
Authority
RU
Russia
Prior art keywords
inhibitors
treatment
cell adhesion
glycolipids
pharmaceutical composition
Prior art date
Application number
RU95103100/04A
Other languages
English (en)
Russian (ru)
Inventor
Мартел Элейн
Ca]
Банвилль Жак
А.Аруффо Алехандро
Mx]
Original Assignee
Бристоль-Мейерз Сквибб Компани (US)
Бристоль-Мейерз Сквибб Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бристоль-Мейерз Сквибб Компани (US), Бристоль-Мейерз Сквибб Компани filed Critical Бристоль-Мейерз Сквибб Компани (US)
Publication of RU95103100A publication Critical patent/RU95103100A/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
RU95103100/04A 1994-03-04 1995-03-03 Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения RU95103100A (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20592894A 1994-03-04 1994-03-04
US205,928 1994-03-04

Publications (1)

Publication Number Publication Date
RU95103100A true RU95103100A (ru) 1997-03-20

Family

ID=22764246

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95103100/04A RU95103100A (ru) 1994-03-04 1995-03-03 Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения

Country Status (15)

Country Link
US (1) US5663151A (cg-RX-API-DMAC7.html)
EP (1) EP0671407A2 (cg-RX-API-DMAC7.html)
JP (1) JPH0841093A (cg-RX-API-DMAC7.html)
KR (1) KR950032258A (cg-RX-API-DMAC7.html)
CN (1) CN1112122A (cg-RX-API-DMAC7.html)
AU (1) AU1360595A (cg-RX-API-DMAC7.html)
CA (1) CA2142154A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ49895A3 (cg-RX-API-DMAC7.html)
FI (1) FI951001L (cg-RX-API-DMAC7.html)
HU (1) HUT70404A (cg-RX-API-DMAC7.html)
IL (1) IL112756A0 (cg-RX-API-DMAC7.html)
NO (1) NO950763L (cg-RX-API-DMAC7.html)
PL (1) PL307524A1 (cg-RX-API-DMAC7.html)
RU (1) RU95103100A (cg-RX-API-DMAC7.html)
ZA (1) ZA95937B (cg-RX-API-DMAC7.html)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU737680C (en) * 1996-05-16 2002-05-02 Nissin Foods Holdings Co., Ltd. Novel compounds having antiviral activity
US5700458A (en) 1996-09-20 1997-12-23 Geltex Pharmaceuticals Inc. Acid-functionalized saccharides as polyvalent anti-infectives
DE19700774A1 (de) * 1997-01-13 1998-07-16 Hoechst Ag Antiadhäsive Sulfatid-Mimetika
JP4716655B2 (ja) * 2001-11-21 2011-07-06 ユニバーシティ・オブ・オーフース 抗炎症剤としてのモノ−およびジアシルグリセロールのグリコシドの使用
US7060685B2 (en) * 2002-05-16 2006-06-13 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
JP2006502986A (ja) * 2002-07-03 2006-01-26 グリコミメティクス， インコーポレイテッド 新脈管形成に関与する医学的状態の診断および治療のための組成物および方法
US20040219158A1 (en) * 2003-05-02 2004-11-04 Glycomimetics, Inc. Compositions and methods for diagnosis and therapy of medical conditions involving infection with pseudomonas bacteria
US20050187171A1 (en) * 2003-11-19 2005-08-25 Glycomimetics, Inc. Glycomimetic antagonists for both E-and P-selectins
WO2005051920A2 (en) * 2003-11-19 2005-06-09 Glycomimetics, Inc. Specific antagonist for both e- and p-selectins
US7481080B2 (en) * 2004-07-01 2009-01-27 General Electric Company Clothes washer braking method and apparatus
DE102004036213B4 (de) * 2004-07-26 2011-02-24 Johannes-Gutenberg-Universität Mainz Nichtglykosidische und nichtpeptidische Selektininhibitoren, deren Herstellung und pharmazeutische Zusammensetzungen
AU2005322027B2 (en) * 2004-12-28 2013-09-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NK Tcells
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
US20090036386A1 (en) * 2005-05-25 2009-02-05 Glycomimetics, Inc Heterobifunctional compounds for selectin inhibition
AU2006280101B2 (en) * 2005-08-09 2012-06-28 Glycomimetics, Inc. Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
EP2264043B1 (en) * 2005-09-02 2017-11-08 GlycoMimetics, Inc. Heterobifunctional pan-selectin inhibitors
WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
JP5298020B2 (ja) 2006-10-12 2013-09-25 グリコミメティクス， インコーポレイテッド ヘキソースおよびｎ−アセチルヘキソサミンの糖模倣体置換
WO2008100453A1 (en) * 2007-02-09 2008-08-21 Glycomimetics, Inc. Methods of use of glycomimetics with replacements for hexoses and n-acetyl hexosamines
US8039442B2 (en) 2007-07-18 2011-10-18 Glycomimetics, Inc. Compounds and methods for treatment of sickle cell disease or complications associated therewith
US8828952B2 (en) 2007-10-16 2014-09-09 Progen Pharmaceuticals Limited Sulfated oligosaccharide derivatives
US8895510B2 (en) * 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
CN102088983B (zh) * 2008-06-13 2013-01-30 糖模拟物有限公司 利用选择的糖模拟化合物的血液癌症的治疗
US8410066B2 (en) * 2009-05-01 2013-04-02 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
WO2012037034A1 (en) 2010-09-14 2012-03-22 Glycomimetics, Inc. E-selectin antagonists
WO2013096926A1 (en) 2011-12-22 2013-06-27 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
ES2668045T3 (es) 2012-12-07 2018-05-16 Glycomimetics, Inc. Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas
US10519181B2 (en) 2014-12-03 2019-12-31 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
EP3405473A1 (en) 2016-01-22 2018-11-28 GlycoMimetics, Inc. Glycomimetic inhibitors of pa-il and pa-iil lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
EP3522931A1 (en) 2016-10-07 2019-08-14 GlycoMimetics, Inc. Highly potent multimeric e-selectin antagonists
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
EP3717013A1 (en) 2017-11-30 2020-10-07 GlycoMimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
CA3085356A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
AU2019230013A1 (en) 2018-03-05 2020-09-10 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
WO2020139962A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1164388A (en) * 1966-06-14 1969-09-17 Shionogi & Co Crystalline Sulfur-Containing Glycolipid and the Production Thereof.
EP0146810A3 (de) * 1983-12-05 1987-05-13 Solco Basel AG Verfahren zur Herstellung von Sphingosinderivaten
DE3683214D1 (de) * 1985-08-13 1992-02-13 Solco Basel Ag Neues verfahren zur herstellung von sphingosinderivaten.
IT1235162B (it) * 1988-12-02 1992-06-22 Fidia Farmaceutici Derivati di lisosfingolipidi
JPH0317020A (ja) * 1989-06-14 1991-01-25 Nippon Koutai Kenkyusho:Kk 抗ｈｉｖ剤
EP0544815A1 (en) * 1990-07-17 1993-06-09 The Board Of Regents Of The University Of Oklahoma Peptides from the GMP-140 lectinbindingdomain and selectin binding ligands on carbonhydrates
DK84691D0 (da) * 1991-05-07 1991-05-07 Karsten Buschard Visse glycolipider og specifikke catchere for disse til anvendelse ved profylaxe eller terapi af diabetes, og/eller dermed forbundne komplikationer samt anvendelse af saadanne glycolipider til detektion af oe-celle-antistoffer (ica) i et individ og anvendelse af saadanne catchere til detektion af langerhans-oe-celler i pancreas-praeparater
WO1993005803A1 (en) * 1991-09-25 1993-04-01 Genetics Institute, Inc. Anti-inflammatory selectin inhibitors
US5326752A (en) * 1991-11-27 1994-07-05 Glycomed Incorporated Substituted lactose and lactosamine derivatives as cell adhesion inhibitors

Also Published As

Publication number Publication date
FI951001A7 (fi) 1995-09-05
CA2142154A1 (en) 1995-09-05
NO950763D0 (no) 1995-02-28
HUT70404A (en) 1995-10-30
FI951001A0 (fi) 1995-03-03
HU9500655D0 (en) 1995-04-28
NO950763L (no) 1995-09-05
EP0671407A3 (cg-RX-API-DMAC7.html) 1995-10-25
AU1360595A (en) 1995-09-14
FI951001L (fi) 1995-09-05
JPH0841093A (ja) 1996-02-13
EP0671407A2 (en) 1995-09-13
CN1112122A (zh) 1995-11-22
US5663151A (en) 1997-09-02
KR950032258A (ko) 1995-12-20
ZA95937B (en) 1996-08-06
IL112756A0 (en) 1995-05-26
PL307524A1 (en) 1995-09-18
CZ49895A3 (en) 1995-12-13

Similar Documents

Publication Publication Date Title
RU95103100A (ru) Сульфатированные производные альфа - гликолипидов, используемые в качестве ингибиторов клеточной адгезии, фармацевтическая композиция, способы лечения
EA200100766A1 (ru) Хинолин-2-он замещенные гетероарильные производные, используемые в качестве противоопухолевых агентов
AU553419B2 (en) New deiphosphonic acid derivatives
RU94040390A (ru) Производные виниленазаиндола, способ их получения, фармацевтическая композиция
EA200500174A1 (ru) Новые производные бензимидазола, полезные в качестве антипролиферативных агентов
KR940014293A (ko) 아이오드화 아로일옥시 에스테르
KR930019637A (ko) 비페닐설포닐우레아 또는 비페닐설포닐우레탄 측쇄를 갖는 이미다졸 유도체, 이의 제조방법 및 용도
ES534959A0 (es) Procedimiento para la preparacion de derivados de oligoglucosido
ATE270271T1 (de) Sulfonamidhydroxamate
RU95103099A (ru) Сульфатированные производные бета - гликолипидов, содержащий их фармацевтический препарат и способ лечения
PT982305E (pt) Novos derivados do indano-1-ol proceso para a sua preparacao e as composicoes farmaceuticas que os contem
ES8205224A1 (es) Un procedimiento para la preparacion de acidos 1-carbadetiapen-2-em-3-carboxilios 6-1-y 2-sustituidos.
DE3568424D1 (en) Acetylenic phenoxypropanol derivatives and pharmaceutical compositions for the treatment of hypertension
ES8603406A1 (es) Un procedimiento para producir derivados de acilindol
OA09114A (fr) Nouveaux dérivés hétéroarotinoïdes, leurs procédés de préparation et les compositions pharceutiques qui les contiennent.
ES8801637A1 (es) Un procedimiento para la preparacion de benzimidazoles.
PL334088A1 (en) Novel derivatives of n-benzenesulphonyl-l-proline, methods of obtaining them and pharmaceutic agents
ES472591A1 (es) Procedimiento para la obtencion de derivados de 1-fenileta- nolamina
DE2963605D1 (en) Substituted 2-phenylamino-2-imidazolines, their acid addition salts, pharmaceutical compositions containing them and process for their preparation
HUP9901030A2 (hu) Helyettesített N-metil-N-(4-(4-(1H-benzimidazol-2-il)-amino)-piperidin-1-il)-2-(aril)-butil)-benzamid-származékok, a vegyületeket tartalmazó gyógyászati készítmények és alkalmazásuk
IT1191109B (it) Derivati di acidi aminopiridincarbossilici,loro metodo di sintesi e composizioni farmaceutiche che li contengono
ES556048A0 (es) Un procedimiento para la preparacion de un derivado de tiazolidina.
DE3481059D1 (de) Neue 11-piperazinyl-5h-imidazo(2,1-c)(1,4)benzodiazepine, verfahren zu ihrer herstellung und zwischenprodukte und erstere enthaltende arzneimittel.
RU95120590A (ru) Новые производные эритромицина, метод их получения, фармацевтическая композиция на их основе и промежуточные соединения синтеза
DE69105108D1 (de) Substituierte N-[Phenyl-(thioxomethyl)]-morpholinderivate, Verfahren zu ihrer Herstellung, diese enthaltende Zusammensetzung und ihre Verwendung.