RU94046310A - Эфиры никотиновой кислоты, способ их получения, способ получения промежуточных соединений, фармацевтическая композиция и способ лечения - Google Patents
Эфиры никотиновой кислоты, способ их получения, способ получения промежуточных соединений, фармацевтическая композиция и способ леченияInfo
- Publication number
- RU94046310A RU94046310A RU94046310/04A RU94046310A RU94046310A RU 94046310 A RU94046310 A RU 94046310A RU 94046310/04 A RU94046310/04 A RU 94046310/04A RU 94046310 A RU94046310 A RU 94046310A RU 94046310 A RU94046310 A RU 94046310A
- Authority
- RU
- Russia
- Prior art keywords
- synthesis
- compounds
- saturated
- electron
- carbon atoms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Описываются новые соединения формулы (П), где R выбран из насыщенных или ненасыщенных алкилов, насыщенных и ненасыщенных циклоалкилов, гетероциклических соединений или из групп (а) или (b) где G представляет углерод или азот; m равно 0 - 10; где R, Rи Rявляются одинаковыми или различными и выбраны из водорода, галоида, алкила, содержащего 1 - 5 атомов углерода, электронодонорных групп таких как, алкокси, содержащих 1 - 5 атомов углерода, или гидрокси, электроноакцепторных групп, выбранных из циано, нитро, фторалкила и их фармакологически активных солей. Новые соединения могут быть использованы для лечения расстройств центральной нервной системы.
Claims (1)
- Описываются новые соединения формулы (П), где R выбран из насыщенных или ненасыщенных алкилов, насыщенных и ненасыщенных циклоалкилов, гетероциклических соединений или из групп (а) или (b) где G представляет углерод или азот; m равно 0 - 10; где R1, R2 и R3 являются одинаковыми или различными и выбраны из водорода, галоида, алкила, содержащего 1 - 5 атомов углерода, электронодонорных групп таких как, алкокси, содержащих 1 - 5 атомов углерода, или гидрокси, электроноакцепторных групп, выбранных из циано, нитро, фторалкила и их фармакологически активных солей. Новые соединения могут быть использованы для лечения расстройств центральной нервной системы.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9201956A SE9201956D0 (sv) | 1992-06-25 | 1992-06-25 | Novel nicotinicacid esters |
| SE9201956-1 | 1992-06-25 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU94046310A true RU94046310A (ru) | 1996-10-27 |
| RU2127732C1 RU2127732C1 (ru) | 1999-03-20 |
Family
ID=20386602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU94046310A RU2127732C1 (ru) | 1992-06-25 | 1993-06-23 | Эфиры бис-фенилпиперазинникотиновой кислоты, способ их получения (варианты), фармацевтическая композиция и способ лечения расстройств центральной нервной системы |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5658910A (ru) |
| EP (2) | EP0673368B1 (ru) |
| JP (1) | JP3306827B2 (ru) |
| KR (1) | KR100302216B1 (ru) |
| CN (1) | CN1085981C (ru) |
| AT (2) | ATE209634T1 (ru) |
| AU (1) | AU681346B2 (ru) |
| BG (1) | BG62000B1 (ru) |
| CA (1) | CA2139112C (ru) |
| CZ (1) | CZ281975B6 (ru) |
| DE (2) | DE69331234T2 (ru) |
| DK (1) | DK0673368T3 (ru) |
| EE (1) | EE03122B1 (ru) |
| ES (1) | ES2169044T3 (ru) |
| FI (1) | FI107151B (ru) |
| HU (2) | HU220613B1 (ru) |
| IL (1) | IL106135A (ru) |
| NO (1) | NO302945B1 (ru) |
| NZ (1) | NZ253823A (ru) |
| PH (1) | PH31417A (ru) |
| PT (1) | PT673368E (ru) |
| RO (1) | RO115725B1 (ru) |
| RU (1) | RU2127732C1 (ru) |
| SE (1) | SE9201956D0 (ru) |
| SK (1) | SK279393B6 (ru) |
| WO (1) | WO1994000434A1 (ru) |
| ZA (1) | ZA934596B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| JP4533534B2 (ja) | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | グリコーゲンシンターゼキナーゼ３のインヒビター |
| US7045519B2 (en) | 1998-06-19 | 2006-05-16 | Chiron Corporation | Inhibitors of glycogen synthase kinase 3 |
| BR112020022790A2 (pt) * | 2018-05-09 | 2021-02-02 | Lg Chem, Ltd | novo composto que exibe atividade inibitória de enteropeptidase |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8701375D0 (sv) * | 1987-04-02 | 1987-04-02 | Leo Ab | Novel pyridyl- and pyrimidyl derivatives |
| SE9201239D0 (sv) * | 1992-04-21 | 1992-04-21 | Kabi Pharmacia Ab | Agents for treating substance abuse disorders |
| SE9202265D0 (sv) * | 1992-07-31 | 1992-07-31 | Kabi Pharmacia Ab | Novel- pyridyl and pyrimidylpiperazine derivatives |
-
1992
- 1992-06-25 SE SE9201956A patent/SE9201956D0/xx unknown
-
1993
- 1993-06-23 AT AT93915075T patent/ATE209634T1/de not_active IP Right Cessation
- 1993-06-23 DK DK93915075T patent/DK0673368T3/da active
- 1993-06-23 NZ NZ253823A patent/NZ253823A/en not_active IP Right Cessation
- 1993-06-23 DE DE69331234T patent/DE69331234T2/de not_active Expired - Fee Related
- 1993-06-23 PT PT93915075T patent/PT673368E/pt unknown
- 1993-06-23 JP JP50226894A patent/JP3306827B2/ja not_active Expired - Fee Related
- 1993-06-23 SK SK1585-94A patent/SK279393B6/sk not_active IP Right Cessation
- 1993-06-23 HU HU9403786A patent/HU220613B1/hu not_active IP Right Cessation
- 1993-06-23 KR KR1019940704643A patent/KR100302216B1/ko not_active IP Right Cessation
- 1993-06-23 AU AU45193/93A patent/AU681346B2/en not_active Ceased
- 1993-06-23 US US08/362,475 patent/US5658910A/en not_active Expired - Lifetime
- 1993-06-23 ES ES93915075T patent/ES2169044T3/es not_active Expired - Lifetime
- 1993-06-23 EP EP93915075A patent/EP0673368B1/en not_active Expired - Lifetime
- 1993-06-23 WO PCT/SE1993/000565 patent/WO1994000434A1/en active IP Right Grant
- 1993-06-23 EP EP01108668A patent/EP1120410B1/en not_active Expired - Lifetime
- 1993-06-23 AT AT01108668T patent/ATE278671T1/de not_active IP Right Cessation
- 1993-06-23 RO RO94-02087A patent/RO115725B1/ro unknown
- 1993-06-23 CA CA002139112A patent/CA2139112C/en not_active Expired - Fee Related
- 1993-06-23 DE DE69333655T patent/DE69333655D1/de not_active Expired - Lifetime
- 1993-06-23 RU RU94046310A patent/RU2127732C1/ru not_active IP Right Cessation
- 1993-06-23 CZ CZ943274A patent/CZ281975B6/cs not_active IP Right Cessation
- 1993-06-24 IL IL10613593A patent/IL106135A/en not_active IP Right Cessation
- 1993-06-25 CN CN93116250A patent/CN1085981C/zh not_active Expired - Fee Related
- 1993-06-25 ZA ZA934596A patent/ZA934596B/xx unknown
-
1994
- 1994-11-17 EE EE9400400A patent/EE03122B1/xx not_active IP Right Cessation
- 1994-12-22 BG BG99289A patent/BG62000B1/bg unknown
- 1994-12-23 NO NO945022A patent/NO302945B1/no not_active IP Right Cessation
- 1994-12-23 FI FI946085A patent/FI107151B/fi active
-
1995
- 1995-05-23 HU HU95P/P00139P patent/HU210875A9/hu unknown
-
1998
- 1998-06-24 PH PH4640898A patent/PH31417A/en unknown
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| TH17758A (th) | สารเคมี |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20100624 |