RU93036551A - Способ получения ii-кето-стероидных производных - Google Patents
Способ получения ii-кето-стероидных производныхInfo
- Publication number
- RU93036551A RU93036551A RU93036551/04A RU93036551A RU93036551A RU 93036551 A RU93036551 A RU 93036551A RU 93036551/04 A RU93036551/04 A RU 93036551/04A RU 93036551 A RU93036551 A RU 93036551A RU 93036551 A RU93036551 A RU 93036551A
- Authority
- RU
- Russia
- Prior art keywords
- keto
- producing
- steroid derivatives
- radical
- ester
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title claims 2
- -1 alkyl radical Chemical class 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N Methyl radical Chemical compound [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 125000004432 carbon atoms Chemical group C* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 150000003944 halohydrins Chemical class 0.000 claims 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
Claims (1)
- Изобретение относится к новому способу получения II-кето-стероидных производных, заключающемуся в том, что соединение общей формулы
где R - атом водорода или остаток сложного эфира или простого эфира; R' - радикал метил или радикал -CH2OR", причем R" - остаток сложного эфира или простого эфира, одинаковый или различный с R, и циклы A' и B' - остаток:
где K' - защищающая группа формулы
где n - 2 или 3; линия пунктиром может быть второй связью; K" - радикал алкил с 1 - 8 атомами углерода или радикал алкил с 6 - 12 атомами, преобразуют в галогеногидрин общей формулы
где X - атом галогена; R, R', A' и B' определены выше, в присутствии спирта, и полученный продукт обрабатывают кислотой.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR929206773A FR2691968B1 (fr) | 1992-06-04 | 1992-06-04 | Nouveau procede de preparation d'un derive sterouide 11-ceto. |
| FR9206773 | 1992-06-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93036551A true RU93036551A (ru) | 1997-04-20 |
| RU2108340C1 RU2108340C1 (ru) | 1998-04-10 |
Family
ID=9430432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93036551A RU2108340C1 (ru) | 1992-06-04 | 1993-04-21 | Способ получения 11-кетостероидного производного |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5585482A (ru) |
| EP (1) | EP0573362B1 (ru) |
| JP (1) | JP3328377B2 (ru) |
| KR (1) | KR100274369B1 (ru) |
| CN (1) | CN1039646C (ru) |
| AT (1) | ATE144526T1 (ru) |
| CA (1) | CA2097678C (ru) |
| DE (1) | DE69305572T2 (ru) |
| DK (1) | DK0573362T3 (ru) |
| ES (1) | ES2093379T3 (ru) |
| FR (1) | FR2691968B1 (ru) |
| GR (1) | GR3021436T3 (ru) |
| HU (1) | HU216638B (ru) |
| MX (1) | MX9303139A (ru) |
| RU (1) | RU2108340C1 (ru) |
| ZA (1) | ZA933940B (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2700339B1 (fr) * | 1993-01-14 | 1995-03-03 | Roussel Uclaf | Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires. |
| US5909921A (en) * | 1997-04-11 | 1999-06-08 | Nesbeth; Roleto E. | Lift device and system for a pick-up truck cargo cover |
| EP1079859B1 (en) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| CN100428897C (zh) * | 2002-08-16 | 2008-10-29 | 浙江寿峰堂生物工程有限公司 | 抗疲劳改善亚健康的保健食品及其制备方法 |
| SI1889198T1 (sl) | 2005-04-28 | 2015-02-27 | Proteus Digital Health, Inc. | Farma-informacijski sistem |
| JP2009508494A (ja) | 2005-09-16 | 2009-03-05 | ラプトール ファーマシューティカル インコーポレイテッド | Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用 |
| DK2398500T3 (da) | 2009-02-20 | 2019-05-13 | 2 Bbb Medicines B V | Glutathion-baseret lægemiddelafgivelsessystem |
| ES2942923T3 (es) | 2009-05-06 | 2023-06-07 | Laboratory Skin Care Inc | Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas |
| CN103923145B (zh) * | 2014-04-16 | 2015-04-01 | 江苏远大仙乐药业有限公司 | 一种醋酸可的松重要中间体的制备方法 |
| CN106866765B (zh) * | 2016-12-12 | 2019-01-15 | 河南利华制药有限公司 | 一种醋酸可的松的制备方法 |
| CN107400153B (zh) * | 2017-04-23 | 2019-08-27 | 浙江仙琚制药股份有限公司 | 一种醋酸氢化可的松的制备方法 |
| CN108373492B (zh) * | 2018-04-20 | 2021-12-21 | 江苏远大仙乐药业有限公司 | 一种醋酸可的松的制备方法 |
| CN111333690B (zh) * | 2018-12-18 | 2021-10-08 | 奥锐特药业股份有限公司 | 一种9-卤代甾体激素化合物9-位脱卤的制备方法 |
| CN109942660B (zh) * | 2019-04-17 | 2020-06-12 | 河南利华制药有限公司 | 一锅烩制备醋酸可的松的方法 |
| CN110698528B (zh) * | 2019-11-19 | 2022-08-26 | 湖南新合新生物医药有限公司 | 甲基泼尼松龙中间体脱溴物及其制备方法 |
| CN113493484A (zh) * | 2020-04-02 | 2021-10-12 | 河南利华制药有限公司 | 一种甲基泼尼松及其中间体的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA536948A (en) * | 1957-02-05 | S. Fonken Gunther | 17.alpha.,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE | |
| US3057884A (en) * | 1961-07-24 | 1962-10-09 | Upjohn Co | Process for converting 11-hydroxy steroid compounds to corresponding keto derivatives |
| DE2950026C2 (de) * | 1979-12-10 | 1982-05-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 11-Ketosteroiden |
| EP0097328B1 (en) * | 1982-06-21 | 1987-08-26 | Dainippon Ink And Chemicals, Inc. | Process for preparation of steroids |
| FR2681069B1 (fr) * | 1991-09-06 | 1995-04-28 | Roussel Uclaf | Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires. |
-
1992
- 1992-06-04 FR FR929206773A patent/FR2691968B1/fr not_active Expired - Fee Related
-
1993
- 1993-04-21 RU RU93036551A patent/RU2108340C1/ru active
- 1993-05-27 MX MX9303139A patent/MX9303139A/es unknown
- 1993-05-31 KR KR1019930009652A patent/KR100274369B1/ko not_active IP Right Cessation
- 1993-06-03 AT AT93401419T patent/ATE144526T1/de active
- 1993-06-03 ES ES93401419T patent/ES2093379T3/es not_active Expired - Lifetime
- 1993-06-03 HU HU9301633A patent/HU216638B/hu unknown
- 1993-06-03 EP EP93401419A patent/EP0573362B1/fr not_active Expired - Lifetime
- 1993-06-03 CA CA002097678A patent/CA2097678C/fr not_active Expired - Lifetime
- 1993-06-03 DE DE69305572T patent/DE69305572T2/de not_active Expired - Lifetime
- 1993-06-03 DK DK93401419.2T patent/DK0573362T3/da active
- 1993-06-04 CN CN93106670A patent/CN1039646C/zh not_active Expired - Lifetime
- 1993-06-04 JP JP15819393A patent/JP3328377B2/ja not_active Expired - Lifetime
- 1993-06-04 ZA ZA933940A patent/ZA933940B/xx unknown
-
1995
- 1995-10-19 US US08/545,518 patent/US5585482A/en not_active Expired - Lifetime
-
1996
- 1996-10-24 GR GR950403164T patent/GR3021436T3/el unknown
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