RU92016231A - Тиазолидиновые соединения, способ их получения, фармацевтическая композиция и способ лечения - Google Patents
Тиазолидиновые соединения, способ их получения, фармацевтическая композиция и способ леченияInfo
- Publication number
- RU92016231A RU92016231A RU92016231/04A RU92016231A RU92016231A RU 92016231 A RU92016231 A RU 92016231A RU 92016231/04 A RU92016231/04 A RU 92016231/04A RU 92016231 A RU92016231 A RU 92016231A RU 92016231 A RU92016231 A RU 92016231A
- Authority
- RU
- Russia
- Prior art keywords
- hydrogen
- compounds
- alkyl
- tiazolidin
- treatment
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- DZLNHFMRPBPULJ-UHFFFAOYSA-N thioproline Chemical class OC(=O)C1CSCN1 DZLNHFMRPBPULJ-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- -1 pyridinecarbonyl Chemical group 0.000 claims 2
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 230000003178 anti-diabetic Effects 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Claims (1)
- Предложены соединения формулы
в которой R1 представляет алкил; R2 и R3 каждый представляет алкил или алкокси, или R2 и R3 вместе образуют необязательно замещенное бензольное кольцо, и, когда R2 и R3 вместе образуют указанное бензольное кольцо, R1 представляет водород, галоген или алкил; R4 и R5 представляют водород, или R4 и R5 вместе представляют одинарную углерод-углеродную связь; Y1 и Y2 каждый представляет водород, алкильную, ацильную или необязательно замещенную бензоильную, нафтоильную, пиридинкарбонильную или хинолинкарбонильную группу; W представляет одинарную связь или алкилен; и Z представляет водород или катион, обладающие ценными видами терапевтической и профилактической активности, включая противодиабетическую активность.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP34457191 | 1991-12-26 | ||
JP3-344571 | 1991-12-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92016231A true RU92016231A (ru) | 1995-05-20 |
RU2095354C1 RU2095354C1 (ru) | 1997-11-10 |
Family
ID=18370304
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU9292016231A RU2095354C1 (ru) | 1991-12-26 | 1992-12-25 | Тиазолидиновые соединения, способы их получения, способ снижения содержания сахара в крови у млекопитающих |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0549365B1 (ru) |
JP (1) | JP2833949B2 (ru) |
CN (1) | CN1032751C (ru) |
AT (1) | ATE126221T1 (ru) |
AU (1) | AU654223B2 (ru) |
CA (1) | CA2086277A1 (ru) |
CZ (1) | CZ389792A3 (ru) |
DE (1) | DE69204041T2 (ru) |
DK (1) | DK0549365T3 (ru) |
ES (1) | ES2078671T3 (ru) |
FI (1) | FI925849A (ru) |
GR (1) | GR3017632T3 (ru) |
HK (1) | HK196095A (ru) |
HU (1) | HU215450B (ru) |
IL (1) | IL104238A (ru) |
MX (1) | MX9207595A (ru) |
NO (1) | NO302471B1 (ru) |
NZ (1) | NZ245612A (ru) |
RU (1) | RU2095354C1 (ru) |
TW (1) | TW211007B (ru) |
ZA (1) | ZA9210021B (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
EP0783888A1 (en) | 1995-12-26 | 1997-07-16 | Sankyo Company Limited | Use of troglitazone and related thiazolidinediones in the manufacture of a medicament for the treatment and prophylaxis of osteoporosis |
US6331633B1 (en) * | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
EP1148054B1 (en) * | 2000-04-21 | 2005-11-23 | Pfizer Products Inc. | Thyroid receptor ligands |
US6620830B2 (en) | 2000-04-21 | 2003-09-16 | Pfizer, Inc. | Thyroid receptor ligands |
AU2001259130A1 (en) * | 2000-04-24 | 2001-11-07 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6680387B2 (en) | 2000-04-24 | 2004-01-20 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
US6768008B2 (en) | 2000-04-24 | 2004-07-27 | Aryx Therapeutics | Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis |
JP2003040877A (ja) * | 2001-07-24 | 2003-02-13 | Sumika Fine Chemicals Co Ltd | 5−[6−(2−フルオロベンジルオキシ)−2−ナフチル]メチル−2,4−チアゾリジンジオンの製造方法及びその精製方法 |
CN101454005B (zh) | 2006-03-16 | 2013-01-02 | 新陈代谢解决方案开发公司 | 用于治疗代谢性炎症介导的疾病的噻唑烷二酮类似物 |
CA2646149A1 (en) | 2006-03-16 | 2007-09-27 | Metabolic Solutions Development Company | Thiazolidinedione analogues for the treatment of hypertension and for lowering lipids |
US8304441B2 (en) | 2007-09-14 | 2012-11-06 | Metabolic Solutions Development Company, Llc | Thiazolidinedione analogues for the treatment of metabolic diseases |
ES2398313T3 (es) * | 2007-09-14 | 2013-03-15 | Metabolic Solutions Development Company Llc | 5-(4-(2-(3-metoxifenil)-2-oxoetoxi)bencil)tiazolidin-2,4-diona para uso en el tratamiento de la diabetes |
WO2011084453A1 (en) | 2009-12-15 | 2011-07-14 | Metabolic Solutions Development Company | Ppar-sparing thiazolidinedione salts for the treatment of metabolic diseases |
CA2796437C (en) * | 2010-04-19 | 2018-09-11 | Metabolic Solutions Development Company, Llc | Novel synthesis for thiazolidinedione compounds |
MX2012012095A (es) * | 2010-04-21 | 2012-12-17 | Metabolic Solutions Dev Co Llc | Analogos de tiazolidinadiona. |
ES2609837T3 (es) | 2010-08-10 | 2017-04-24 | Octeta Therapeutics, Llc | Nueva síntesis de compuestos de tiazolidindiona |
CN115433144B (zh) * | 2022-10-09 | 2023-09-19 | 燃点(南京)生物医药科技有限公司 | 一种脂肪酸酯类化合物及其制备方法和应用 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5522636A (en) * | 1978-08-04 | 1980-02-18 | Takeda Chem Ind Ltd | Thiazoliding derivative |
JPS6051189A (ja) * | 1983-08-30 | 1985-03-22 | Sankyo Co Ltd | チアゾリジン誘導体およびその製造法 |
JPH06779B2 (ja) * | 1985-06-10 | 1994-01-05 | 武田薬品工業株式会社 | チアゾリジオン誘導体およびそれを含んでなる医薬組成物 |
US5143930A (en) * | 1990-02-07 | 1992-09-01 | Sankyo Company, Limited | Thiazolidine derivatives with anti-diabetic activity, their preparation and their use |
NO302519B1 (no) * | 1991-12-26 | 1998-03-16 | Sankyo Co | Tiazolidinforbindelser som inneholder en kinongruppe, og farmasöytisk preparat |
-
1992
- 1992-12-22 NO NO924964A patent/NO302471B1/no unknown
- 1992-12-23 HU HUP9204130A patent/HU215450B/hu not_active IP Right Cessation
- 1992-12-23 ZA ZA9210021A patent/ZA9210021B/xx unknown
- 1992-12-23 NZ NZ245612A patent/NZ245612A/en unknown
- 1992-12-23 FI FI925849A patent/FI925849A/fi not_active Application Discontinuation
- 1992-12-24 TW TW081110354A patent/TW211007B/zh active
- 1992-12-24 EP EP92311813A patent/EP0549365B1/en not_active Expired - Lifetime
- 1992-12-24 DE DE69204041T patent/DE69204041T2/de not_active Expired - Fee Related
- 1992-12-24 AT AT92311813T patent/ATE126221T1/de not_active IP Right Cessation
- 1992-12-24 ES ES92311813T patent/ES2078671T3/es not_active Expired - Lifetime
- 1992-12-24 CA CA002086277A patent/CA2086277A1/en not_active Abandoned
- 1992-12-24 DK DK92311813.7T patent/DK0549365T3/da active
- 1992-12-24 AU AU30431/92A patent/AU654223B2/en not_active Ceased
- 1992-12-25 IL IL10423892A patent/IL104238A/en not_active IP Right Cessation
- 1992-12-25 JP JP4346122A patent/JP2833949B2/ja not_active Expired - Fee Related
- 1992-12-25 RU RU9292016231A patent/RU2095354C1/ru active
- 1992-12-26 CN CN92115234A patent/CN1032751C/zh not_active Expired - Fee Related
- 1992-12-28 MX MX9207595A patent/MX9207595A/es not_active IP Right Cessation
- 1992-12-28 CZ CS923897A patent/CZ389792A3/cs unknown
-
1995
- 1995-10-04 GR GR950402745T patent/GR3017632T3/el unknown
- 1995-12-28 HK HK196095A patent/HK196095A/xx not_active IP Right Cessation
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU92016231A (ru) | Тиазолидиновые соединения, способ их получения, фармацевтическая композиция и способ лечения | |
FI881103A0 (fi) | Menetelmä antidiabeettisena aineena käytettävien bensoksatsolijohdannaisten valmistamiseksi | |
RU93004970A (ru) | Производные циклоалкилзамещенного глутарамида, их применение, фармацевтическая композиция | |
RU93041055A (ru) | Новые 4-арилпиперазины и 4-арилпиперидины | |
NO871640D0 (no) | Fremgangsmaate for fremstilling av n-(2[-aminofenyl)-benzamidderivater. | |
IT1240360B (it) | Uso di un derivato dell'1alfa-idrossivitamina d per la preparazione di un medicamento per il trattamento dell' iperparatiroidismo | |
RU92016230A (ru) | Тиазолидиновые соединения, фармацевтическая композиция, способ лечения и способы получения соединений | |
ES2078671T3 (es) | Compuestos de tiazolidina, su preparacion y su utilizacion terapeutica. | |
IL82084A0 (en) | 1,4-diazepines,their preparation and pharmaceutical compositions containing them | |
SE8904298D0 (sv) | New compounds | |
ATE67495T1 (de) | 4-(1,2,5,6-tetrahydro-1-alkyl-3-pyridinyl)-2thiazolamine und 4-(hexahydro-1-alkyl-3pyridinyl)-2-thiazolamine. | |
ATE40987T1 (de) | Acetylenische phenoxypropanolderivate und pharmazeutische zusammensetzungen fuer die behandlung von bluthochdruck. | |
IT8922246A0 (it) | Procedimento di preparazione di 3-ciano-3,5,5'-trimetil-1-cicloesanone | |
RU93047049A (ru) | Новые производные фосфолипидов | |
EP0095451A3 (en) | Novel dihydropyridines | |
ES8403116A1 (es) | Procedimiento para la preparacion de pirido (1,4) benzodiazepinas. | |
KR900700484A (ko) | 1,4:3,6-디안히드로 헥시톨 잘산염의 아미노프로판올 유도체,그의 제법 및 약제로서의 그의 용도 | |
JPS6434963A (en) | Carbostyril derivative | |
IL95384A0 (en) | 1,3-oxazines,their preparation and pharmaceutical compositions containing them | |
IT8922129A0 (it) | Impiego dell'isosorbide 2-mononitrato per la preparazione di composizioni farmaceutiche atte al trattamento dell'angina pectoris | |
IT8047950A0 (it) | Composizioni farmaceutiche impiegabili per il trattamento dell'ipertensione | |
ES2039436T3 (es) | Un procedimiento para preparar una composicion farmaceutica. | |
RU93035827A (ru) | Производные тиадиазинона, способ их получения, фармацевтическая композиция, способ ее получения | |
CA2033975A1 (en) | Use of .beta.-receptor blocking agents | |
IT8848020A0 (it) | Anello per macchina di filatura |