RU2770039C2 - Вдыхаемые составы на основе никотина и способы их получения и применения - Google Patents

Вдыхаемые составы на основе никотина и способы их получения и применения Download PDF

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Publication number
RU2770039C2
RU2770039C2 RU2019128062A RU2019128062A RU2770039C2 RU 2770039 C2 RU2770039 C2 RU 2770039C2 RU 2019128062 A RU2019128062 A RU 2019128062A RU 2019128062 A RU2019128062 A RU 2019128062A RU 2770039 C2 RU2770039 C2 RU 2770039C2
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RU
Russia
Prior art keywords
nicotine
particles
microns
composition
sugar
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RU2019128062A
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English (en)
Russian (ru)
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RU2019128062A3 (de
RU2019128062A (ru
Inventor
Алекс Стенцлер
Ноэ ЦАМЕЛЬ
Артур СЛУТСКИ
Стивен ЭЛЛИС
Стив Хэн
Original Assignee
Филип Моррис Продактс С.А.
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Priority claimed from US15/452,133 external-priority patent/US10149844B2/en
Application filed by Филип Моррис Продактс С.А. filed Critical Филип Моррис Продактс С.А.
Publication of RU2019128062A publication Critical patent/RU2019128062A/ru
Publication of RU2019128062A3 publication Critical patent/RU2019128062A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Addiction (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2019128062A 2017-03-07 2018-03-07 Вдыхаемые составы на основе никотина и способы их получения и применения RU2770039C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/452,133 2017-03-07
US15/452,133 US10149844B2 (en) 2015-09-16 2017-03-07 Inhalable nicotine formulations, and methods of making and using thereof
PCT/IB2018/051482 WO2018163085A1 (en) 2017-03-07 2018-03-07 Inhalable nicotine formulations, and methods of making and using thereof

Publications (3)

Publication Number Publication Date
RU2019128062A RU2019128062A (ru) 2021-04-07
RU2019128062A3 RU2019128062A3 (de) 2021-05-21
RU2770039C2 true RU2770039C2 (ru) 2022-04-14

Family

ID=61731727

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019128062A RU2770039C2 (ru) 2017-03-07 2018-03-07 Вдыхаемые составы на основе никотина и способы их получения и применения

Country Status (9)

Country Link
EP (1) EP3592352A1 (de)
JP (1) JP2020510002A (de)
KR (1) KR20190126772A (de)
CN (1) CN110300588A (de)
CA (1) CA3048677A1 (de)
IL (1) IL268458A (de)
MX (1) MX2019010263A (de)
RU (1) RU2770039C2 (de)
WO (1) WO2018163085A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2965397T3 (es) * 2019-11-14 2024-04-15 Philip Morris Products Sa Formulación mejorada de polvo seco con sabor a tabaco
WO2022049486A1 (en) * 2020-09-03 2022-03-10 Philip Morris Products S.A. Freeze dried low hygroscopicity active powder compositions
CN112841709B (zh) * 2021-01-20 2022-11-25 深圳市艾普生物科技有限公司 一种尼古丁盐的制备方法及应用
CN113880802A (zh) * 2021-11-09 2022-01-04 深圳萨特瓦生物科技有限公司 酒石酸-尼古丁盐及其制备方法与应用、无水酒石酸晶体的制备方法
WO2024091005A1 (ko) * 2022-10-27 2024-05-02 주식회사 케이티앤지 기침 억제제를 함유한 건조 분말 흡입기용 스틱 및 이를 포함한 건조 분말 흡입기

Citations (5)

* Cited by examiner, † Cited by third party
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WO2001085137A2 (en) * 2000-05-10 2001-11-15 Inhale Therapeutic Systems, Inc. Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
RU2275900C2 (ru) * 2000-06-09 2006-05-10 Адвансд Инхалейшен Рисёч, Инк. Способ высокоэффективной доставки аэрозоля с большой терапевтической массой
EA200870118A1 (ru) * 2005-12-28 2009-02-27 Филип Моррис Продактс С.А. Устройство для доставки аэрозольного порошка
RU2497507C2 (ru) * 2005-10-21 2013-11-10 Эратек С.Р.Л. Ингаляционные фармацевтические композиции в форме сухих порошков, растворов или суспензий, полученных из них, и способ их получения
US20150283070A1 (en) * 2014-04-08 2015-10-08 Sansa Corporation (Barbados) Inc. Nicotine Formulations and Methods of Making the Same

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WO1993017663A1 (en) * 1992-03-10 1993-09-16 Fisons Plc Pharmaceutical inhalation compositions
GB9827145D0 (en) * 1998-12-09 1999-02-03 Co Ordinated Drug Dev Improvements in or relating to powders
US6586008B1 (en) * 1999-08-25 2003-07-01 Advanced Inhalation Research, Inc. Use of simple amino acids to form porous particles during spray drying
TWI283182B (en) * 2000-08-07 2007-07-01 Nektar Therapeutics Inhalable spray dried 4-helix bundle protein powders having minimized aggregation
WO2003024396A2 (en) * 2001-09-17 2003-03-27 Glaxo Group Limited Dry powder medicament formulations
ITMI20012174A1 (it) * 2001-10-18 2003-04-18 Univ Parma Polvere per somministrazione nasale di farmaci
GB0425758D0 (en) * 2004-11-23 2004-12-22 Vectura Ltd Preparation of pharmaceutical compositions
GB0523576D0 (en) * 2005-11-18 2005-12-28 Theradeas Ltd Drug composition and its use in therapy
WO2008069970A2 (en) * 2006-12-01 2008-06-12 Aradigm Corporation Nicotine formulations, kits and systems and methods for their use
US20140294969A1 (en) * 2011-08-01 2014-10-02 Monash University Method and formulation for inhalation
FR3035826B1 (fr) * 2015-05-07 2018-11-16 Saint-Gobain Glass France Vitrage de vehicule comprenant une platine pour la fixation de plusieurs accessoires, platine et procede de fixation.
US9585835B1 (en) * 2015-09-16 2017-03-07 Sansa Corporation (Barbados) Inc. Inhalable nicotine formulations and methods of making and using the same
CN105770862B (zh) * 2016-04-22 2022-01-11 北京三元基因药业股份有限公司 干扰素的干粉吸入剂
UA126853C2 (uk) * 2016-06-30 2023-02-15 Філіп Морріс Продактс С.А. Нікотиновмісні частинки

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001085137A2 (en) * 2000-05-10 2001-11-15 Inhale Therapeutic Systems, Inc. Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
RU2275900C2 (ru) * 2000-06-09 2006-05-10 Адвансд Инхалейшен Рисёч, Инк. Способ высокоэффективной доставки аэрозоля с большой терапевтической массой
RU2497507C2 (ru) * 2005-10-21 2013-11-10 Эратек С.Р.Л. Ингаляционные фармацевтические композиции в форме сухих порошков, растворов или суспензий, полученных из них, и способ их получения
EA200870118A1 (ru) * 2005-12-28 2009-02-27 Филип Моррис Продактс С.А. Устройство для доставки аэрозольного порошка
US20150283070A1 (en) * 2014-04-08 2015-10-08 Sansa Corporation (Barbados) Inc. Nicotine Formulations and Methods of Making the Same

Also Published As

Publication number Publication date
RU2019128062A3 (de) 2021-05-21
WO2018163085A1 (en) 2018-09-13
IL268458A (en) 2019-09-26
KR20190126772A (ko) 2019-11-12
CN110300588A (zh) 2019-10-01
MX2019010263A (es) 2019-10-09
RU2019128062A (ru) 2021-04-07
EP3592352A1 (de) 2020-01-15
JP2020510002A (ja) 2020-04-02
CA3048677A1 (en) 2018-09-13

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