RU2769251C2 - Комбинированная терапия для лечения гепатоцеллюлярной карциномы - Google Patents

Комбинированная терапия для лечения гепатоцеллюлярной карциномы Download PDF

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RU2769251C2
RU2769251C2 RU2019108259A RU2019108259A RU2769251C2 RU 2769251 C2 RU2769251 C2 RU 2769251C2 RU 2019108259 A RU2019108259 A RU 2019108259A RU 2019108259 A RU2019108259 A RU 2019108259A RU 2769251 C2 RU2769251 C2 RU 2769251C2
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pharmaceutically acceptable
amino
inhibitor
cdk
pyrimidin
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RU2019108259A
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Russian (ru)
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RU2019108259A (ru
RU2019108259A3 (enExample
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Ананд СЕЛВАРАДЖ
Питер Смит
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Эйсай Ар Энд Ди Менеджмент Ко., Лтд.
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2019108259A 2016-08-23 2017-08-23 Комбинированная терапия для лечения гепатоцеллюлярной карциномы RU2769251C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378455P 2016-08-23 2016-08-23
US62/378,455 2016-08-23
PCT/US2017/048183 WO2018039324A1 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Publications (3)

Publication Number Publication Date
RU2019108259A RU2019108259A (ru) 2020-09-25
RU2019108259A3 RU2019108259A3 (enExample) 2020-11-24
RU2769251C2 true RU2769251C2 (ru) 2022-03-29

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Country Link
US (1) US20190175598A1 (enExample)
EP (1) EP3503923B1 (enExample)
JP (1) JP7190425B2 (enExample)
KR (1) KR102466192B1 (enExample)
CN (1) CN109803684B (enExample)
AU (1) AU2017315357B2 (enExample)
BR (1) BR112019003722A2 (enExample)
CA (1) CA3034875C (enExample)
ES (1) ES2966469T3 (enExample)
IL (1) IL264950B2 (enExample)
MX (1) MX2019002115A (enExample)
RU (1) RU2769251C2 (enExample)
SG (1) SG11201901472TA (enExample)
WO (1) WO2018039324A1 (enExample)

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JP2021509680A (ja) 2018-01-08 2021-04-01 ジー1、セラピューティクス、インコーポレイテッドG1 Therapeutics, Inc. G1t38の優れた投与レジメン
WO2019220253A1 (en) * 2018-05-14 2019-11-21 Pfizer Inc. Oral solution formulation
TW202128174A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
WO2021230886A1 (en) * 2020-05-15 2021-11-18 Eisai R&D Management Co., Ltd. A method for treating cancer with an oral dosage form of an fgfr4 inhibitor
JP2025520303A (ja) 2022-05-30 2025-07-03 石▲薬▼集▲團▼中奇制▲薬▼技▲術▼(石家庄)有限公司 癌治療用の医薬組み合わせ物および医薬組成物
TW202523318A (zh) * 2023-11-30 2025-06-16 大陸商石藥集團中奇製藥技術(石家莊)有限公司 聯合治療腫瘤的藥物

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Also Published As

Publication number Publication date
EP3503923A1 (en) 2019-07-03
AU2017315357B2 (en) 2022-12-01
IL264950B1 (en) 2023-09-01
BR112019003722A2 (pt) 2019-05-28
CA3034875A1 (en) 2018-03-01
IL264950A (en) 2019-05-30
MX2019002115A (es) 2019-07-08
SG11201901472TA (en) 2019-03-28
AU2017315357A1 (en) 2019-02-28
EP3503923B1 (en) 2023-10-04
CA3034875C (en) 2024-05-28
US20190175598A1 (en) 2019-06-13
ES2966469T3 (es) 2024-04-22
KR102466192B1 (ko) 2022-11-14
RU2019108259A (ru) 2020-09-25
JP2019528302A (ja) 2019-10-10
RU2019108259A3 (enExample) 2020-11-24
CN109803684B (zh) 2022-08-23
CN109803684A (zh) 2019-05-24
WO2018039324A1 (en) 2018-03-01
JP7190425B2 (ja) 2022-12-15
KR20190040996A (ko) 2019-04-19
IL264950B2 (en) 2024-01-01

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