CA3034875C - Combination therapies for the treatment of hepatocellular carcinoma - Google Patents

Combination therapies for the treatment of hepatocellular carcinoma Download PDF

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Publication number
CA3034875C
CA3034875C CA3034875A CA3034875A CA3034875C CA 3034875 C CA3034875 C CA 3034875C CA 3034875 A CA3034875 A CA 3034875A CA 3034875 A CA3034875 A CA 3034875A CA 3034875 C CA3034875 C CA 3034875C
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CA
Canada
Prior art keywords
pharmaceutically acceptable
acceptable salt
inhibitor
cdk
pyrimidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3034875A
Other languages
English (en)
French (fr)
Other versions
CA3034875A1 (en
Inventor
Anand SELVARAJ
Peter Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
Original Assignee
Eisai R&D Management Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of CA3034875A1 publication Critical patent/CA3034875A1/en
Application granted granted Critical
Publication of CA3034875C publication Critical patent/CA3034875C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3034875A 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma Active CA3034875C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662378455P 2016-08-23 2016-08-23
US62/378,455 2016-08-23
PCT/US2017/048183 WO2018039324A1 (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Publications (2)

Publication Number Publication Date
CA3034875A1 CA3034875A1 (en) 2018-03-01
CA3034875C true CA3034875C (en) 2024-05-28

Family

ID=59772765

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034875A Active CA3034875C (en) 2016-08-23 2017-08-23 Combination therapies for the treatment of hepatocellular carcinoma

Country Status (14)

Country Link
US (1) US20190175598A1 (enExample)
EP (1) EP3503923B1 (enExample)
JP (1) JP7190425B2 (enExample)
KR (1) KR102466192B1 (enExample)
CN (1) CN109803684B (enExample)
AU (1) AU2017315357B2 (enExample)
BR (1) BR112019003722A2 (enExample)
CA (1) CA3034875C (enExample)
ES (1) ES2966469T3 (enExample)
IL (1) IL264950B2 (enExample)
MX (1) MX2019002115A (enExample)
RU (1) RU2769251C2 (enExample)
SG (1) SG11201901472TA (enExample)
WO (1) WO2018039324A1 (enExample)

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WO2019136451A1 (en) 2018-01-08 2019-07-11 G1 Therapeutics, Inc. G1t38 superior dosage regimes
ES2968899T3 (es) 2018-05-14 2024-05-14 Pfizer Formulación de la solución oral
TW202128174A (zh) * 2019-10-09 2021-08-01 美商G1治療公司 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療
JP2023533903A (ja) * 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｆｇｆｒ４阻害剤の経口製剤によるがんの治療方法
KR20250003965A (ko) 2022-05-30 2025-01-07 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 암 치료용 약학적 조합 및 약학적 조성물
CN120417928A (zh) * 2023-11-30 2025-08-01 石药集团中奇制药技术（石家庄）有限公司 联合治疗肿瘤的药物

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Also Published As

Publication number Publication date
KR20190040996A (ko) 2019-04-19
JP2019528302A (ja) 2019-10-10
KR102466192B1 (ko) 2022-11-14
IL264950B1 (en) 2023-09-01
ES2966469T3 (es) 2024-04-22
IL264950B2 (en) 2024-01-01
WO2018039324A1 (en) 2018-03-01
CA3034875A1 (en) 2018-03-01
CN109803684B (zh) 2022-08-23
AU2017315357A1 (en) 2019-02-28
EP3503923B1 (en) 2023-10-04
AU2017315357B2 (en) 2022-12-01
RU2019108259A (ru) 2020-09-25
BR112019003722A2 (pt) 2019-05-28
CN109803684A (zh) 2019-05-24
SG11201901472TA (en) 2019-03-28
MX2019002115A (es) 2019-07-08
US20190175598A1 (en) 2019-06-13
JP7190425B2 (ja) 2022-12-15
RU2019108259A3 (enExample) 2020-11-24
IL264950A (en) 2019-05-30
EP3503923A1 (en) 2019-07-03
RU2769251C2 (ru) 2022-03-29

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