RU2766146C2 - Низкомолекулярные активаторы амфк - Google Patents

Низкомолекулярные активаторы амфк Download PDF

Info

Publication number
RU2766146C2
RU2766146C2 RU2019113149A RU2019113149A RU2766146C2 RU 2766146 C2 RU2766146 C2 RU 2766146C2 RU 2019113149 A RU2019113149 A RU 2019113149A RU 2019113149 A RU2019113149 A RU 2019113149A RU 2766146 C2 RU2766146 C2 RU 2766146C2
Authority
RU
Russia
Prior art keywords
formula
substituted
compound
unsubstituted
pharmaceutically acceptable
Prior art date
Application number
RU2019113149A
Other languages
English (en)
Russian (ru)
Other versions
RU2019113149A3 (OSRAM
RU2019113149A (ru
Inventor
Бэйбэй ЧЭНЬ
Рама К. МАЛЛАМПАЛЛИ
Юань Лю
Original Assignee
Юниверсити Оф Питтсбург - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн
Дзе Юнайтед Стэйтс Эз Репрезентед Бай Дзе Дипартмент Оф Ветеранс Афэрс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Юниверсити Оф Питтсбург - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн, Дзе Юнайтед Стэйтс Эз Репрезентед Бай Дзе Дипартмент Оф Ветеранс Афэрс filed Critical Юниверсити Оф Питтсбург - Оф Дзе Коммонвелт Систем Оф Хайер Эдьюкейшн
Publication of RU2019113149A publication Critical patent/RU2019113149A/ru
Publication of RU2019113149A3 publication Critical patent/RU2019113149A3/ru
Application granted granted Critical
Publication of RU2766146C2 publication Critical patent/RU2766146C2/ru

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/18—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with hydroxy groups and at least two amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • C07D311/84—Xanthenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 9
    • C07D311/88—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
RU2019113149A 2016-10-05 2017-10-04 Низкомолекулярные активаторы амфк RU2766146C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662404592P 2016-10-05 2016-10-05
US62/404,592 2016-10-05
PCT/US2017/055109 WO2018067685A1 (en) 2016-10-05 2017-10-04 Small molecule ampk activators

Publications (3)

Publication Number Publication Date
RU2019113149A RU2019113149A (ru) 2020-11-06
RU2019113149A3 RU2019113149A3 (OSRAM) 2021-02-03
RU2766146C2 true RU2766146C2 (ru) 2022-02-08

Family

ID=61832129

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2019113149A RU2766146C2 (ru) 2016-10-05 2017-10-04 Низкомолекулярные активаторы амфк

Country Status (8)

Country Link
US (2) US11040935B2 (OSRAM)
EP (1) EP3522877B1 (OSRAM)
JP (1) JP7034152B2 (OSRAM)
KR (1) KR20190096949A (OSRAM)
CN (1) CN110035745B (OSRAM)
AU (1) AU2017340403B2 (OSRAM)
RU (1) RU2766146C2 (OSRAM)
WO (1) WO2018067685A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators
WO2021050538A1 (en) * 2019-09-10 2021-03-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing level of phosphorylated ampk protein
CN111925345B (zh) * 2020-08-21 2023-09-29 上海科利生物医药有限公司 一种手性2-氨甲基四氢呋喃的制备方法
EP4479366A2 (en) * 2022-02-15 2024-12-25 The Children's Medical Center Corporation Compositions and methods relating to atp/p2x7r signaling inhibition

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110472A (en) * 1975-10-23 1978-08-29 Bayer Aktiengesellschaft Derivatives of 1-(disubstituted phenoxy)-3-amino-2-hydroxypropanes
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
WO2002006210A1 (en) * 2000-07-17 2002-01-24 Wyeth Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
WO2002006248A2 (en) * 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
WO2007118041A1 (en) * 2006-04-07 2007-10-18 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2008015558A2 (en) * 2006-08-04 2008-02-07 Universita' Degli Studi Di Bari Beta-3 receptor ligands and their use in therapy
WO2008142454A1 (en) * 2007-05-22 2008-11-27 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders
RU2416409C2 (ru) * 2005-08-18 2011-04-20 Мерк Патент Гмбх Применение производных тиенопиридона в качестве активаторов амфк и фармацевтические композиции, которые их содержат

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726653A (en) * 1980-05-09 1982-02-12 Ciba Geigy Ag Substituted phenyl ether
US4410472A (en) 1982-01-15 1983-10-18 Aluminum Company Of America Method for making spherical binderless pellets
US4552960A (en) 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
DE4017019A1 (de) 1990-05-26 1991-11-28 Hoechst Ag Verwendung von substituierten ss-hydroxyethylaminen als potente hemmstoffe der exoenzyme von pilzen
TW205034B (OSRAM) * 1990-09-13 1993-05-01 Pola Kasei Kogyo Kk
EP0533056A3 (en) 1991-09-14 1993-06-16 Hoechst Aktiengesellschaft Substituted aminopropanes, process for their preparation and their use as antimycotic agents
JP2003501352A (ja) 1999-05-27 2003-01-14 ３−ディメンショナル ファーマシューティカルズ， インコーポレイテッド プロテアーゼ阻害剤としてのオキサザ複素環
AUPQ841300A0 (en) * 2000-06-27 2000-07-20 Fujisawa Pharmaceutical Co., Ltd. New aminoalcohol derivatives
AR035605A1 (es) 2000-12-11 2004-06-16 Bayer Corp Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
JP4583752B2 (ja) 2001-06-05 2010-11-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｆ２ｏにより架橋した、アキシアルに置換されたシクロヘキサン誘導体
EP1426370A4 (en) 2001-09-13 2009-12-23 Nisshin Pharma Inc PROPANOLAMINE DERIVATIVE WITH 1,4-BENZODIOXANE CORE
US20030158195A1 (en) 2001-12-21 2003-08-21 Cywin Charles L. 1,6 naphthyridines useful as inhibitors of SYK kinase
AU2003226094A1 (en) 2002-03-27 2003-10-13 Smithkline Beecham Corporation Compounds and methods
WO2010003084A2 (en) * 2008-07-02 2010-01-07 Memory Pharmaceuticals Corporation Phosphodiesterase 4 inhibitors
US20100279997A1 (en) 2009-05-04 2010-11-04 Lindsay Burns Barbier Analgesic that binds filamin a
DK2882428T3 (en) 2012-07-13 2019-04-15 Pain Therapeutics Inc PROCEDURE TO INHIBIT TAU PHOSPHORIZATION
EP2872899B1 (en) 2012-07-13 2018-07-11 Pain Therapeutics, Inc. Alzheimer's disease assay in a living patient
TW201444552A (zh) * 2013-03-15 2014-12-01 Chien-Hung Chen 一種包含ａｍｐｋ激活劑及血清素活性製劑之醫藥組合物及其用途
US9433604B2 (en) 2013-10-08 2016-09-06 Pain Therapeutics Inc. Method for inhibiting growth of cancer cells
US11040935B2 (en) 2016-10-05 2021-06-22 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule AMPK activators

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110472A (en) * 1975-10-23 1978-08-29 Bayer Aktiengesellschaft Derivatives of 1-(disubstituted phenoxy)-3-amino-2-hydroxypropanes
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
WO2002006210A1 (en) * 2000-07-17 2002-01-24 Wyeth Phenyl amino squarate and thiadiazole dioxide beta-3 adrenergic receptor agonists
WO2002006248A2 (en) * 2000-07-17 2002-01-24 3-Dimensional Pharmaceuticals, Inc. Cyclic oxyguanidine pyrazinones as protease inhibitors
RU2416409C2 (ru) * 2005-08-18 2011-04-20 Мерк Патент Гмбх Применение производных тиенопиридона в качестве активаторов амфк и фармацевтические композиции, которые их содержат
WO2007118041A1 (en) * 2006-04-07 2007-10-18 Boehringer Ingelheim International Gmbh Compounds which modulate the cb2 receptor
WO2008015558A2 (en) * 2006-08-04 2008-02-07 Universita' Degli Studi Di Bari Beta-3 receptor ligands and their use in therapy
WO2008142454A1 (en) * 2007-05-22 2008-11-27 Prosidion Limited Bicyclic aryl and heteroaryl compounds for the treatment of metabolic disorders

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
I.CEPANEC et al., Calcium trifluoromethanesulfonate-catalysed aminolysisof epoxides, TETRAHEDRON, 2003, V.59, pp.2435-2439, doi: 10.1016/S0040-4020(03)00292-8. *
J.T.Q.TANAKA et al., Potent Plasmodium falciparum gametocytocidal activity of lead anti-malaria chemotype, diaminonaphthoquinones, identified in an anti-malaria compound screen, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, V.59, N.3, pp.1389-1397, doi: 10.1128/AAC.01930-13. *
K.REDDY et al., Lewis Acid Mediated Nucleophilic Ring-Opening of 1-Benzhydryl Azetidine-3-ol with Aryl Alcohols: A Formal Synthesis of Carvedilol, ASIAN JOURNAL OF CHEMISTRY, 2012, V.24, N.8, p.3468-3472. *
R. ZINDELL et al., Morpholine containing CB2 selective agonists, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, V.19, N.6, p.1604-1609, doi: 10.1016/J.BMCL.2009.02.033. *
S.A.GAREA et al., Synthesis and characterization of new nanocomposites based on epoxy resins and organophilic clays, POLYMER INTERNATIONAL, 2007, V.56, N.9, pp.1106-1114, doi:10.1002/pi.2242. *
T.IMMEDIATA and A.R.DAY, β-Naphthyl derivatives of ethanolamine and N-substituted ethanolamines, THE JOURNAL OF ORGANIC CHEMISTRY, 1940, V.5, N.5, pp.512-527, doi:10.1021/jo01211a005. *
T.Q.TANAKA et al., Potent Plasmodium falciparum gametocytocidal activity of lead anti-malaria chemotype, diaminonaphthoquinones, identified in an anti-malaria compound screen, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, V.59, N.3, pp.1389-1397, doi: 10.1128/AAC.01930-13. *
Y.M.BEASLEY et. al., Analgesics. Part I. Some aryloxypropanolamines, JOURNAL OF PHARMACY AND PHARMACOLOGY, 1958, V.10, N.1, pp.47-59, doi:10.1111/j.2042-7158.1958.tb10272.x. *
Y.M.BEASLEY et. al., Analgesics. Part I. Some aryloxypropanolamines, JOURNAL OF PHARMACY AND PHARMACOLOGY, 1958, V.10, N.1, pp.47-59, doi:10.1111/j.2042-7158.1958.tb10272.x. K.REDDY et al., Lewis Acid Mediated Nucleophilic Ring-Opening of 1-Benzhydryl Azetidine-3-ol with Aryl Alcohols: A Formal Synthesis of Carvedilol, ASIAN JOURNAL OF CHEMISTRY, 2012, V.24, N.8, p.3468-3472. I.CEPANEC et al., Calcium trifluoromethanesulfonate-catalysed aminolysisof epoxides, TETRAHEDRON, 2003, V.59, pp.2435-2439, doi: 10.1016/S0040-4020(03)00292-8. S.A.GAREA et al., Synthesis and characterization of new nanocomposites based on epoxy resins and organophilic clays, POLYMER INTERNATIONAL, 2007, V.56, N.9, pp.1106-1114, doi:10.1002/pi.2242. T.IMMEDIATA and A.R.DAY, β-Naphthyl derivatives of ethanolamine and N-substituted ethanolamines, THE JOURNAL OF ORGANIC CHEMISTRY, 1940, V.5, N.5, pp.512-527, doi:10.1021/jo01211a005. *

Also Published As

Publication number Publication date
US11673853B2 (en) 2023-06-13
EP3522877B1 (en) 2023-12-06
WO2018067685A1 (en) 2018-04-12
CN110035745A (zh) 2019-07-19
EP3522877A4 (en) 2019-11-06
CA3039368A1 (en) 2018-04-12
AU2017340403A1 (en) 2019-05-02
BR112019006830A2 (pt) 2019-07-16
RU2019113149A3 (OSRAM) 2021-02-03
US11040935B2 (en) 2021-06-22
CN110035745B (zh) 2022-04-29
RU2019113149A (ru) 2020-11-06
US20200062693A1 (en) 2020-02-27
AU2017340403B2 (en) 2022-03-17
JP7034152B2 (ja) 2022-03-11
JP2019534883A (ja) 2019-12-05
EP3522877A1 (en) 2019-08-14
US20220153685A1 (en) 2022-05-19
KR20190096949A (ko) 2019-08-20

Similar Documents

Publication Publication Date Title
AU2007245625B2 (en) N- ( 2-thiazolyl) -amide derivatives as GSK-3 inhibitors
US11673853B2 (en) Small molecule AMPK activators
ES2986581T3 (es) Antagonistas del receptor muscarínico de acetilcolina M4
AU2006278829B2 (en) GSK-3 inhibitors
US20240317724A1 (en) 3,4-methylenedioxymethamphetamine and related psychedelics and uses thereof
JP2021503443A (ja) ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
EP3697781B1 (en) Antagonists of the muscarinic acetylcholine receptor m4
JP2021513519A (ja) ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
CN102361853A (zh) 甲苯胺磺酰胺及其用途
JP2020530451A (ja) ムスカリン性アセチルコリン受容体ｍ４のアンタゴニスト
SA520412533B1 (ar) تثبيط قناة الأيون المحتملة للمستقبل العابر a1
US8765941B2 (en) Aniline derivative having anti-RNA viral activity
CA3225747A1 (en) Spirocyclic pyridine-1,5-diones exhibiting mnk inhibition and their method of use
CA3228265A1 (en) Methods of treating migraine with mnk inhibitors
US20100069443A1 (en) Compound with benzamide skeleton having cyclooxygenase-1 (cox-1)-selective inhibitory activity
CA3039368C (en) Small molecule ampk activators
US20240132458A1 (en) Nlrp3 inflammasome small-molecule inhibitor for treatment of alzheimer's disease
JP6843845B2 (ja) １，４−ジ−（４−メチルチオフェニル）−３−フタロイルアゼチジン−２−オンおよびその誘導体
US10174001B2 (en) Crystals of 5-cyclopropyl-2-((1-(3-fluorobenzyl)-1H-indol-5-yl)amino)nicotinic acid
BR112019006830B1 (pt) COMPOSTOS QUE INTERROMPEM A INTERAÇÃO ENTRE Fbxo48 E AMPK FOSFORILADA E COMPOSIÇÃO FARMACÊUTICA QUE OS COMPREENDE
KR101461554B1 (ko) α,β-불포화 락톤 유도체 및 그의 용도
KR101936054B1 (ko) 항염증 활성을 가지는 6-페녹시피리미딘 유도체, 이의 제조방법 및 이를 활성성분으로 하는 약학 조성물
KR20170088882A (ko) 이환식 함질소 방향족 헤테로환 아미드 화합물을 유효 성분으로 하는 의약 조성물