RU2717545C2 - Комбинации противоглистных агентов и способы их применения - Google Patents

Комбинации противоглистных агентов и способы их применения Download PDF

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Publication number
RU2717545C2
RU2717545C2 RU2017138118A RU2017138118A RU2717545C2 RU 2717545 C2 RU2717545 C2 RU 2717545C2 RU 2017138118 A RU2017138118 A RU 2017138118A RU 2017138118 A RU2017138118 A RU 2017138118A RU 2717545 C2 RU2717545 C2 RU 2717545C2
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Russia
Prior art keywords
spp
macrocyclic lactone
dirofilaria immitis
resistant
ivermectin
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RU2017138118A
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English (en)
Russian (ru)
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RU2017138118A (ru
RU2017138118A3 (https=
Inventor
Бренда БОНДЕЗЕН
Лэнс ХЭММЕРЛЭНД
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Мериал, Инк.
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Publication of RU2017138118A publication Critical patent/RU2017138118A/ru
Publication of RU2017138118A3 publication Critical patent/RU2017138118A3/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15Depsipeptides; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2017138118A 2015-04-02 2016-04-01 Комбинации противоглистных агентов и способы их применения RU2717545C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562142304P 2015-04-02 2015-04-02
US62/142,304 2015-04-02
PCT/US2016/025714 WO2016161369A1 (en) 2015-04-02 2016-04-01 Anthelmintic combinations and methods of use thereof

Publications (3)

Publication Number Publication Date
RU2017138118A RU2017138118A (ru) 2019-05-06
RU2017138118A3 RU2017138118A3 (https=) 2019-07-24
RU2717545C2 true RU2717545C2 (ru) 2020-03-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2017138118A RU2717545C2 (ru) 2015-04-02 2016-04-01 Комбинации противоглистных агентов и способы их применения

Country Status (18)

Country Link
US (1) US10993988B2 (https=)
EP (1) EP3277303B1 (https=)
JP (1) JP6899330B2 (https=)
KR (1) KR20170132330A (https=)
CN (1) CN107567334A (https=)
AU (1) AU2016244022A1 (https=)
BR (1) BR112017020975A2 (https=)
CA (1) CA2981489A1 (https=)
CL (1) CL2017002474A1 (https=)
CO (1) CO2017011284A2 (https=)
ES (1) ES2851345T3 (https=)
IL (1) IL254783B (https=)
MX (1) MX381319B (https=)
MY (1) MY187835A (https=)
PH (1) PH12017501806A1 (https=)
RU (1) RU2717545C2 (https=)
SG (1) SG11201708008TA (https=)
WO (1) WO2016161369A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
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RU2747149C1 (ru) * 2017-11-29 2021-04-28 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды

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EP3541789A1 (en) * 2016-11-16 2019-09-25 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
PT3579696T (pt) * 2017-02-08 2023-07-19 Boehringer Ingelheim Animal Health Usa Inc Modelo in vivo para infeção por vermes parasitários e métodos para avaliação de compostos antiparasíticos, que incluem compostos ativos contra a dirofilariose canina
BR112020010291A2 (pt) 2017-11-23 2020-11-17 Ceva Sante Animale composição contendo moxidectina para tratamento de infestações de parasitas
AR116524A1 (es) * 2018-10-04 2021-05-19 Elanco Tiergesundheit Ag Potenciación de tratamiento de helmintos
EP4208157A1 (en) 2020-09-04 2023-07-12 Elanco Us Inc. Palatable formulations
GB202100635D0 (en) * 2021-01-18 2021-03-03 Liverpool School Tropical Medicine Compounds and methods for treating or preventing dirofilaria infection in a mammal
US11999742B2 (en) 2021-11-01 2024-06-04 Boehringer Ingelheim Vetmedica Gmbh Substituted pyrrolo[1,2-b]pyridazines as anthelmintics

Citations (3)

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US6159932A (en) * 1995-06-02 2000-12-12 Bayer Aktiengesellschaft Endoparasiticidal compositions
US20110046072A1 (en) * 2008-05-07 2011-02-24 Bayer Animal Health Gmbh Solid pharmaceutical formulation with delayed release
RU2452180C2 (ru) * 2010-08-31 2012-06-10 Общество с ограниченной ответственностью "Научно-внедренческое предприятие "Астрафарм" Комплексная антипаразитарная композиция

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US4134973A (en) 1977-04-11 1979-01-16 Merck & Co., Inc. Carbohydrate derivatives of milbemycin and processes therefor
GB9300883D0 (en) 1993-01-18 1993-03-10 Pfizer Ltd Antiparasitic agents
US20030129680A1 (en) 2001-10-31 2003-07-10 O'connor Thomas Patrick Multi-analyte assay device
US20070042354A1 (en) 2005-08-19 2007-02-22 Engelhard Eric K Detecting pathogens in companion animals
ES2367332T3 (es) * 2007-02-21 2011-11-02 Pfizer Limited Agentes antiparasitarios de benzofurano.
JP4734656B2 (ja) 2007-03-30 2011-07-27 国立大学法人群馬大学 Pf1022類の製造法
US8809268B2 (en) 2008-10-29 2014-08-19 The Regents Of The University Of California Combination therapy to combat helminth resistance
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AU2010101389C4 (en) 2010-12-08 2017-03-02 Jurox Pty Ltd Anthelmintic formulation
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US6159932A (en) * 1995-06-02 2000-12-12 Bayer Aktiengesellschaft Endoparasiticidal compositions
US20110046072A1 (en) * 2008-05-07 2011-02-24 Bayer Animal Health Gmbh Solid pharmaceutical formulation with delayed release
RU2452180C2 (ru) * 2010-08-31 2012-06-10 Общество с ограниченной ответственностью "Научно-внедренческое предприятие "Астрафарм" Комплексная антипаразитарная композиция

Non-Patent Citations (1)

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HARDER A ET AL, "Cyclooctadepsipeptides-an anthelmintically active class of compounds exhibiting a novel mode of action"// INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, ELSEVIER SCIENCE, AMSTERDAM, NL, (20030901), vol. 22, no. 3, pages 318 - 331. *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2747149C1 (ru) * 2017-11-29 2021-04-28 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды
RU2747149C9 (ru) * 2017-11-29 2021-06-29 ЗОЕТИС СЕРВИСИЗ ЭлЭлСи Анти-эндопаразитарные депсипептиды

Also Published As

Publication number Publication date
MY187835A (en) 2021-10-26
IL254783A0 (en) 2017-12-31
CA2981489A1 (en) 2016-10-06
EP3277303A1 (en) 2018-02-07
CL2017002474A1 (es) 2018-03-23
PH12017501806A1 (en) 2018-04-11
CN107567334A (zh) 2018-01-09
BR112017020975A2 (pt) 2018-07-10
CO2017011284A2 (es) 2018-01-31
MX2017012510A (es) 2018-01-30
MX381319B (es) 2025-03-12
SG11201708008TA (en) 2017-10-30
JP2018510195A (ja) 2018-04-12
ES2851345T3 (es) 2021-09-06
IL254783B (en) 2020-11-30
US20170020955A1 (en) 2017-01-26
JP6899330B2 (ja) 2021-07-07
RU2017138118A (ru) 2019-05-06
US10993988B2 (en) 2021-05-04
RU2017138118A3 (https=) 2019-07-24
WO2016161369A1 (en) 2016-10-06
AU2016244022A1 (en) 2017-10-26
KR20170132330A (ko) 2017-12-01
EP3277303B1 (en) 2020-12-02

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