RU2707126C2 - МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ - Google Patents

МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ Download PDF

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RU2707126C2
RU2707126C2 RU2015137158A RU2015137158A RU2707126C2 RU 2707126 C2 RU2707126 C2 RU 2707126C2 RU 2015137158 A RU2015137158 A RU 2015137158A RU 2015137158 A RU2015137158 A RU 2015137158A RU 2707126 C2 RU2707126 C2 RU 2707126C2
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mutein
leu
ser
thr
sequence
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RU2015137158A3 (OSRAM
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Арне Скерра
Михаэла ГЕБАУЭР
Доминик ХИНЦ
Забине РАУТ
Габриэле МАЧИНЕР
Мартин ХЮЛЬСМЕЙЕР
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Пирис Аг
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00041—Use of virus, viral particle or viral elements as a vector

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RU2015137158A 2009-12-07 2010-12-07 МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ RU2707126C2 (ru)

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US26709809P 2009-12-07 2009-12-07
US61/267,098 2009-12-07

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RU2012128586/10A Division RU2564125C2 (ru) 2009-12-07 2010-12-07 Мутеины липокалина 2 человека (lcn2, hngal) с аффинностью для определенной мишени

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RU2019132267A Division RU2804336C2 (ru) 2019-10-11 МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ

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RU2015137158A RU2015137158A (ru) 2018-12-25
RU2015137158A3 RU2015137158A3 (OSRAM) 2018-12-25
RU2707126C2 true RU2707126C2 (ru) 2019-11-22

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RU2015137158A RU2707126C2 (ru) 2009-12-07 2010-12-07 МУТЕИНЫ ЛИПОКАЛИНА 2 ЧЕЛОВЕКА (Lcn2, hNGAL) С АФФИННОСТЬЮ ДЛЯ ОПРЕДЕЛЕННОЙ МИШЕНИ
RU2012128586/10A RU2564125C2 (ru) 2009-12-07 2010-12-07 Мутеины липокалина 2 человека (lcn2, hngal) с аффинностью для определенной мишени

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US (3) US9549968B2 (OSRAM)
EP (3) EP2510357B1 (OSRAM)
JP (5) JP5913120B2 (OSRAM)
KR (2) KR101842076B1 (OSRAM)
CN (1) CN102770764B (OSRAM)
AU (1) AU2010329995B2 (OSRAM)
BR (1) BR112012013662B1 (OSRAM)
CA (1) CA2779562C (OSRAM)
DK (2) DK2510357T3 (OSRAM)
RU (2) RU2707126C2 (OSRAM)
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EP2510357A2 (en) 2012-10-17
KR20180031081A (ko) 2018-03-27
WO2011069992A3 (en) 2011-08-11
JP7482544B2 (ja) 2024-05-14
JP2021006024A (ja) 2021-01-21
CN102770764B (zh) 2016-04-20
US10618941B2 (en) 2020-04-14
BR112012013662A2 (pt) 2020-11-03
DK2510357T3 (en) 2016-07-18
AU2010329995B2 (en) 2015-09-17
EP2990798B1 (en) 2019-09-25
US20170114109A1 (en) 2017-04-27
WO2011069992A2 (en) 2011-06-16
JP2013512683A (ja) 2013-04-18
KR20120117815A (ko) 2012-10-24
US20200308237A1 (en) 2020-10-01
EP3660510A2 (en) 2020-06-03
EP2510357B1 (en) 2016-03-30
RU2015137158A (ru) 2018-12-25
EP2990798A1 (en) 2016-03-02
CN102770764A (zh) 2012-11-07
US9549968B2 (en) 2017-01-24
JP5913120B2 (ja) 2016-05-11
RU2564125C2 (ru) 2015-09-27
KR101842076B1 (ko) 2018-03-27
SG10201408073XA (en) 2015-01-29
RU2015137158A3 (OSRAM) 2018-12-25
CA2779562C (en) 2019-12-31
US11827681B2 (en) 2023-11-28
BR112012013662B1 (pt) 2022-08-02
JP2016105709A (ja) 2016-06-16
CA2779562A1 (en) 2011-06-16
AU2010329995A1 (en) 2012-05-10
KR101974044B1 (ko) 2019-04-30
JP2018148914A (ja) 2018-09-27
DK2990798T3 (da) 2019-12-02
RU2012128586A (ru) 2014-01-20
EP3660510A3 (en) 2020-07-08
US20130079286A1 (en) 2013-03-28
JP6346159B2 (ja) 2018-06-20
JP2022160410A (ja) 2022-10-19

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