RU2698796C2 - Икотиниб-содержащие местнодействующие накожные фармацевтические композиции и их применения - Google Patents

Икотиниб-содержащие местнодействующие накожные фармацевтические композиции и их применения Download PDF

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Publication number
RU2698796C2
RU2698796C2 RU2016118063A RU2016118063A RU2698796C2 RU 2698796 C2 RU2698796 C2 RU 2698796C2 RU 2016118063 A RU2016118063 A RU 2016118063A RU 2016118063 A RU2016118063 A RU 2016118063A RU 2698796 C2 RU2698796 C2 RU 2698796C2
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Prior art keywords
pharmaceutical composition
composition according
group
icotinib
weight
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RU2016118063A
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English (en)
Russian (ru)
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RU2016118063A (ru
Inventor
Иньсян ВАН
Шуцзюнь ВАН
Яньпин ВАН
Шаоцзин ХУ
Юньянь ХУ
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Бетта Фармасьютикалз Ко., Лтд
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2016118063A 2013-10-11 2014-10-11 Икотиниб-содержащие местнодействующие накожные фармацевтические композиции и их применения RU2698796C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2013/085042 2013-10-11
CN2013085042 2013-10-11
PCT/CN2014/088344 WO2015051763A1 (zh) 2013-10-11 2014-10-11 一种含埃克替尼的皮肤外用药物组合物及其应用

Publications (2)

Publication Number Publication Date
RU2016118063A RU2016118063A (ru) 2017-11-16
RU2698796C2 true RU2698796C2 (ru) 2019-08-30

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016118063A RU2698796C2 (ru) 2013-10-11 2014-10-11 Икотиниб-содержащие местнодействующие накожные фармацевтические композиции и их применения

Country Status (13)

Country Link
US (2) US20160235757A1 (https=)
EP (1) EP3056206A4 (https=)
JP (1) JP6463745B2 (https=)
AU (1) AU2014334222B2 (https=)
BR (1) BR112016007627A2 (https=)
CA (1) CA2926874C (https=)
HK (1) HK1213813A1 (https=)
IL (1) IL245015A0 (https=)
NZ (1) NZ718802A (https=)
RU (1) RU2698796C2 (https=)
SG (1) SG11201602826VA (https=)
TW (1) TWI630921B (https=)
WO (1) WO2015051763A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102270538B1 (ko) * 2013-06-09 2021-06-29 베타 파머수티컬 컴퍼니 리미티드 이코티닙 포스페이트의 신규한 다형체 형태 및 이의 용도
WO2022022434A1 (zh) * 2020-07-27 2022-02-03 杭州和正医药有限公司 含托法替尼药学上可接受的盐的药物组合物、制剂及应用
CN116829152A (zh) * 2021-02-02 2023-09-29 贝达药业股份有限公司 埃克替尼在非小细胞肺癌术后辅助治疗中的应用
CN116492293A (zh) * 2022-01-25 2023-07-28 杭州和正医药有限公司 一种含托法替尼的局部用药的药物组合物、制剂及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090156485A1 (en) * 2005-11-24 2009-06-18 Base Se Method for coupling keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
US20110182882A1 (en) * 2008-07-08 2011-07-28 Beta Pharma, Inc. Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof
WO2012001403A1 (en) * 2010-06-29 2012-01-05 Edko Pazarlama Tanitim Ticaret Limited Sirketi Topical pharmaceutical composition comprising flurbiprofen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2909284B1 (fr) * 2006-11-30 2012-09-21 Galderma Sa Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien
MX2013004296A (es) * 2010-10-21 2013-09-26 Cadila Healthcare Ltd Composiciones farmaceuticas topicas que contienen gotas de tamaño nanometrico para el tratamiento de soriasis.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090156485A1 (en) * 2005-11-24 2009-06-18 Base Se Method for coupling keratin-binding polypeptides with effector molecules which support carboxylic groups or sulfonic acid groups
US20110182882A1 (en) * 2008-07-08 2011-07-28 Beta Pharma, Inc. Icotinib Hydrochloride, Synthesis, Crystalline Forms, Pharmaceutical Compositions, and Uses Thereof
WO2012001403A1 (en) * 2010-06-29 2012-01-05 Edko Pazarlama Tanitim Ticaret Limited Sirketi Topical pharmaceutical composition comprising flurbiprofen

Also Published As

Publication number Publication date
EP3056206A4 (en) 2017-07-05
SG11201602826VA (en) 2016-05-30
JP6463745B2 (ja) 2019-02-06
IL245015A0 (en) 2016-05-31
WO2015051763A1 (zh) 2015-04-16
AU2014334222B2 (en) 2017-03-09
CA2926874A1 (en) 2015-04-16
CA2926874C (en) 2018-12-11
US20190321369A1 (en) 2019-10-24
AU2014334222A1 (en) 2016-05-05
NZ718802A (en) 2017-09-29
EP3056206A1 (en) 2016-08-17
TW201513894A (zh) 2015-04-16
RU2016118063A (ru) 2017-11-16
BR112016007627A2 (pt) 2017-08-01
JP2016532659A (ja) 2016-10-20
TWI630921B (zh) 2018-08-01
US20160235757A1 (en) 2016-08-18
HK1213813A1 (zh) 2016-07-15

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FA92 Acknowledgement of application withdrawn (lack of supplementary materials submitted)

Effective date: 20180110

FZ9A Application not withdrawn (correction of the notice of withdrawal)

Effective date: 20181130

MM4A The patent is invalid due to non-payment of fees

Effective date: 20201012