RU2695358C2 - Соединения для предотвращения и лечения нейродегенеративных заболеваний и боли - Google Patents
Соединения для предотвращения и лечения нейродегенеративных заболеваний и боли Download PDFInfo
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- RU2695358C2 RU2695358C2 RU2016118282A RU2016118282A RU2695358C2 RU 2695358 C2 RU2695358 C2 RU 2695358C2 RU 2016118282 A RU2016118282 A RU 2016118282A RU 2016118282 A RU2016118282 A RU 2016118282A RU 2695358 C2 RU2695358 C2 RU 2695358C2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361894699P | 2013-10-23 | 2013-10-23 | |
| US61/894,699 | 2013-10-23 | ||
| PCT/US2014/061734 WO2015061426A1 (en) | 2013-10-23 | 2014-10-22 | Compounds for use in prevention and treatment of neurodegenerative diseases and pain |
Publications (3)
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| RU2016118282A RU2016118282A (ru) | 2017-11-28 |
| RU2016118282A3 RU2016118282A3 (enExample) | 2018-06-18 |
| RU2695358C2 true RU2695358C2 (ru) | 2019-07-23 |
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| RU2016118282A RU2695358C2 (ru) | 2013-10-23 | 2014-10-22 | Соединения для предотвращения и лечения нейродегенеративных заболеваний и боли |
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| US (1) | US10301348B2 (enExample) |
| EP (1) | EP3060566B1 (enExample) |
| JP (1) | JP6534997B2 (enExample) |
| KR (1) | KR102313314B1 (enExample) |
| CN (1) | CN106414456B (enExample) |
| AU (1) | AU2014340114B2 (enExample) |
| BR (1) | BR112016008901B1 (enExample) |
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| WO (1) | WO2015061426A1 (enExample) |
| ZA (1) | ZA201603118B (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10675293B2 (en) * | 2015-05-29 | 2020-06-09 | The Board Of Trustees Of The Leland Stanford Junior University | Nucleoside agents for the reduction of the deleterious activity of extended nucleotide repeat containing genes |
| US11753432B2 (en) | 2017-01-27 | 2023-09-12 | Academia Sinica | Compound with analgesic effect for use in prevention and treatment of pain |
| AU2023219172A1 (en) * | 2022-02-10 | 2024-08-08 | Academia Sinica | Method of treating spinal cord injury and composition for use therein |
| JP2025520975A (ja) * | 2022-07-07 | 2025-07-03 | 中央研究院 | 統合失調症を治療する方法及びそれにおける使用のための組成物 |
| EP4642452A1 (en) * | 2022-12-29 | 2025-11-05 | Academia Sinica | Method of treating sleep disruptions and composition for use therein |
| WO2024196760A1 (en) * | 2023-03-17 | 2024-09-26 | Academia Sinica | Method of treating tuberous sclerosis complex or epilepsy and composition for use therein |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988003148A2 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Heteroaromatic derivatives of adenoside |
| EA012703B1 (ru) * | 2002-08-21 | 2009-12-30 | Глэксо Груп Лимитед | Производные пиримидина и их применение в качестве модуляторов cb2 |
| US20120295863A1 (en) * | 2009-11-13 | 2012-11-22 | Yun-Lian Lin | Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases |
| WO2013120078A1 (en) * | 2012-02-11 | 2013-08-15 | Academia Sinica | Methods and compositions for treating pain |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034381A (en) * | 1988-01-07 | 1991-07-23 | Ciba-Geigy Corporation | 2-(substituted amino) adenosines as antihypertensives |
| DK0550631T3 (da) * | 1990-09-25 | 1997-01-20 | Rhone Poulenc Rorer Int | Forbindelser med blodtrykssænkende virkning og virkning mod iskæmi |
| US5561134A (en) * | 1990-09-25 | 1996-10-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties |
| CN102812033B (zh) * | 2009-12-10 | 2015-11-25 | 中国医学科学院药物研究所 | N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途 |
| CA2897675C (en) | 2012-02-09 | 2017-07-18 | Brandbumps, Llc | Decorative detectable warning panel having improved grip |
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2014
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- 2014-10-22 KR KR1020167013624A patent/KR102313314B1/ko active Active
- 2014-10-22 RU RU2016118282A patent/RU2695358C2/ru active
- 2014-10-22 CN CN201480058727.3A patent/CN106414456B/zh active Active
- 2014-10-22 WO PCT/US2014/061734 patent/WO2015061426A1/en not_active Ceased
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- 2014-10-22 AU AU2014340114A patent/AU2014340114B2/en active Active
- 2014-10-22 US US15/031,711 patent/US10301348B2/en active Active
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2016
- 2016-04-13 IL IL245103A patent/IL245103B/en active IP Right Grant
- 2016-05-10 ZA ZA2016/03118A patent/ZA201603118B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988003148A2 (en) * | 1986-10-31 | 1988-05-05 | Warner-Lambert Company | Heteroaromatic derivatives of adenoside |
| EA012703B1 (ru) * | 2002-08-21 | 2009-12-30 | Глэксо Груп Лимитед | Производные пиримидина и их применение в качестве модуляторов cb2 |
| US20120295863A1 (en) * | 2009-11-13 | 2012-11-22 | Yun-Lian Lin | Dual-Action Compounds Targeting Adenosine A2A Receptor and Adenosine Transporter for Prevention and Treatment of Neurodegenerative Diseases |
| WO2013120078A1 (en) * | 2012-02-11 | 2013-08-15 | Academia Sinica | Methods and compositions for treating pain |
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| Chemical book on line, CAS RN 214759-22-5 (2008 г) и 79387-71-6 (2010 г). * |
| Wang J. et al, Journal of medicinal chemistry, 19.04.2007, vol. 50, No 8, 1828-1839. GONCALVES N et al, Annals of Neurology, 2013, vol. 73, No5, 655-666. * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX367707B (es) | 2019-09-03 |
| JP6534997B2 (ja) | 2019-06-26 |
| CN106414456B (zh) | 2018-12-14 |
| MX2016005174A (es) | 2016-08-11 |
| NZ719740A (en) | 2021-02-26 |
| IL245103A0 (en) | 2016-06-30 |
| RU2016118282A3 (enExample) | 2018-06-18 |
| KR20160086852A (ko) | 2016-07-20 |
| US20160264613A1 (en) | 2016-09-15 |
| RU2016118282A (ru) | 2017-11-28 |
| CA2927699C (en) | 2022-07-05 |
| BR112016008901A2 (pt) | 2020-05-12 |
| BR112016008901B1 (pt) | 2022-08-23 |
| JP2016535019A (ja) | 2016-11-10 |
| US10301348B2 (en) | 2019-05-28 |
| CN106414456A (zh) | 2017-02-15 |
| CA2927699A1 (en) | 2015-04-30 |
| EP3060566A1 (en) | 2016-08-31 |
| ZA201603118B (en) | 2019-04-24 |
| EP3060566A4 (en) | 2017-06-14 |
| IL245103B (en) | 2019-02-28 |
| EP3060566B1 (en) | 2018-09-05 |
| WO2015061426A1 (en) | 2015-04-30 |
| AU2014340114A1 (en) | 2016-05-26 |
| KR102313314B1 (ko) | 2021-10-19 |
| SG11201603063WA (en) | 2016-05-30 |
| AU2014340114B2 (en) | 2018-10-18 |
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