RU2674266C2 - Усовершенствованное устройство и способ тестирования на беременность - Google Patents
Усовершенствованное устройство и способ тестирования на беременность Download PDFInfo
- Publication number
- RU2674266C2 RU2674266C2 RU2016116771A RU2016116771A RU2674266C2 RU 2674266 C2 RU2674266 C2 RU 2674266C2 RU 2016116771 A RU2016116771 A RU 2016116771A RU 2016116771 A RU2016116771 A RU 2016116771A RU 2674266 C2 RU2674266 C2 RU 2674266C2
- Authority
- RU
- Russia
- Prior art keywords
- analysis
- hcg
- fsh
- sample
- subject
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 20
- 238000009597 pregnancy test Methods 0.000 title description 21
- 238000004458 analytical method Methods 0.000 claims abstract description 237
- 238000012360 testing method Methods 0.000 claims abstract description 147
- 230000035935 pregnancy Effects 0.000 claims abstract description 69
- 238000003556 assay Methods 0.000 claims abstract description 61
- 150000003146 progesterones Chemical class 0.000 claims abstract description 61
- 238000005259 measurement Methods 0.000 claims abstract description 20
- 230000035945 sensitivity Effects 0.000 claims abstract description 20
- 238000004422 calculation algorithm Methods 0.000 claims abstract description 11
- ZFFFJLDTCLJDHL-JQYCEVDMSA-N Pregnanediol-3-glucuronide Chemical compound O([C@H]1C[C@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H](O)C)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ZFFFJLDTCLJDHL-JQYCEVDMSA-N 0.000 claims description 71
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims description 61
- 239000012491 analyte Substances 0.000 claims description 60
- 229960003387 progesterone Drugs 0.000 claims description 30
- 239000000186 progesterone Substances 0.000 claims description 30
- 238000005206 flow analysis Methods 0.000 claims description 23
- YWYQTGBBEZQBGO-UHFFFAOYSA-N UC1011 Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(O)C)C1(C)CC2 YWYQTGBBEZQBGO-UHFFFAOYSA-N 0.000 claims description 6
- YWYQTGBBEZQBGO-BERLURQNSA-N Pregnanediol Chemical group C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](O)C)[C@@]2(C)CC1 YWYQTGBBEZQBGO-BERLURQNSA-N 0.000 claims description 5
- 238000012544 monitoring process Methods 0.000 claims description 5
- 238000003239 susceptibility assay Methods 0.000 claims description 4
- 238000012790 confirmation Methods 0.000 claims description 3
- 229930182480 glucuronide Natural products 0.000 claims description 3
- 150000008134 glucuronides Chemical class 0.000 claims description 2
- 230000037361 pathway Effects 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract 1
- 108010062540 Chorionic Gonadotropin Proteins 0.000 description 165
- 102000011022 Chorionic Gonadotropin Human genes 0.000 description 165
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 165
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 103
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 103
- 229940028334 follicle stimulating hormone Drugs 0.000 description 103
- 238000001514 detection method Methods 0.000 description 62
- 239000003153 chemical reaction reagent Substances 0.000 description 50
- 239000008279 sol Substances 0.000 description 49
- 230000027455 binding Effects 0.000 description 46
- 239000000243 solution Substances 0.000 description 45
- 210000002700 urine Anatomy 0.000 description 41
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 31
- 239000010931 gold Substances 0.000 description 30
- 229910052737 gold Inorganic materials 0.000 description 30
- 239000000020 Nitrocellulose Substances 0.000 description 19
- 229920001220 nitrocellulos Polymers 0.000 description 19
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 18
- 239000000463 material Substances 0.000 description 17
- 239000000872 buffer Substances 0.000 description 16
- 229940092253 ovalbumin Drugs 0.000 description 16
- 239000002245 particle Substances 0.000 description 14
- 238000006243 chemical reaction Methods 0.000 description 13
- 239000011152 fibreglass Substances 0.000 description 13
- -1 chromogens Substances 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
- 102000011632 Caseins Human genes 0.000 description 11
- 108010076119 Caseins Proteins 0.000 description 11
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 10
- 239000004372 Polyvinyl alcohol Substances 0.000 description 10
- 229920002451 polyvinyl alcohol Polymers 0.000 description 10
- 239000006228 supernatant Substances 0.000 description 10
- 239000002207 metabolite Substances 0.000 description 9
- 235000021247 β-casein Nutrition 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000002274 desiccant Substances 0.000 description 8
- 239000012530 fluid Substances 0.000 description 8
- 230000009245 menopause Effects 0.000 description 8
- 102000011923 Thyrotropin Human genes 0.000 description 7
- 108010061174 Thyrotropin Proteins 0.000 description 7
- 239000002250 absorbent Substances 0.000 description 7
- 230000002745 absorbent Effects 0.000 description 7
- 230000000903 blocking effect Effects 0.000 description 7
- 239000011888 foil Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- 229920003023 plastic Polymers 0.000 description 7
- 239000004033 plastic Substances 0.000 description 7
- 239000011541 reaction mixture Substances 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 238000009825 accumulation Methods 0.000 description 6
- 230000008021 deposition Effects 0.000 description 6
- 235000018102 proteins Nutrition 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 108010058846 Ovalbumin Proteins 0.000 description 5
- 229940088597 hormone Drugs 0.000 description 5
- 239000005556 hormone Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 238000004040 coloring Methods 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000005520 cutting process Methods 0.000 description 4
- 238000003018 immunoassay Methods 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000016087 ovulation Effects 0.000 description 4
- 230000027758 ovulation cycle Effects 0.000 description 4
- 239000012536 storage buffer Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000000007 visual effect Effects 0.000 description 4
- 239000011534 wash buffer Substances 0.000 description 4
- UWCBNAVPISMFJZ-GFCCVEGCSA-N 2-[2-[(2r)-3-(tert-butylamino)-2-hydroxypropoxy]phenoxy]-n-methylacetamide Chemical group CNC(=O)COC1=CC=CC=C1OC[C@H](O)CNC(C)(C)C UWCBNAVPISMFJZ-GFCCVEGCSA-N 0.000 description 3
- AURFZBICLPNKBZ-YZRLXODZSA-N 3alpha-hydroxy-5beta-pregnan-20-one Chemical compound C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)C)[C@@]2(C)CC1 AURFZBICLPNKBZ-YZRLXODZSA-N 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 3
- 239000004793 Polystyrene Substances 0.000 description 3
- AURFZBICLPNKBZ-UHFFFAOYSA-N Pregnanolone Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(=O)C)C1(C)CC2 AURFZBICLPNKBZ-UHFFFAOYSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 238000004364 calculation method Methods 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 3
- 230000002860 competitive effect Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 230000005906 menstruation Effects 0.000 description 3
- 229920001155 polypropylene Polymers 0.000 description 3
- 229920002223 polystyrene Polymers 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
- 238000011144 upstream manufacturing Methods 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical group N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010062767 Hypophysitis Diseases 0.000 description 2
- 102000004576 Placental Lactogen Human genes 0.000 description 2
- 108010003044 Placental Lactogen Proteins 0.000 description 2
- 239000000381 Placental Lactogen Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 229940096437 Protein S Drugs 0.000 description 2
- 102000006382 Ribonucleases Human genes 0.000 description 2
- 108010083644 Ribonucleases Proteins 0.000 description 2
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 238000002835 absorbance Methods 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 239000000427 antigen Substances 0.000 description 2
- 102000036639 antigens Human genes 0.000 description 2
- 108091007433 antigens Proteins 0.000 description 2
- 238000013096 assay test Methods 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000005018 casein Substances 0.000 description 2
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 2
- 235000021240 caseins Nutrition 0.000 description 2
- 229920002678 cellulose Chemical class 0.000 description 2
- 239000001913 cellulose Chemical class 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 229950007402 eltanolone Drugs 0.000 description 2
- 210000003754 fetus Anatomy 0.000 description 2
- 239000012634 fragment Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000003365 glass fiber Substances 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 238000013383 initial experiment Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 239000004973 liquid crystal related substance Substances 0.000 description 2
- 210000001161 mammalian embryo Anatomy 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002923 metal particle Substances 0.000 description 2
- 239000000178 monomer Substances 0.000 description 2
- 239000006199 nebulizer Substances 0.000 description 2
- 230000001817 pituitary effect Effects 0.000 description 2
- 210000003635 pituitary gland Anatomy 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 229920000515 polycarbonate Polymers 0.000 description 2
- 239000004417 polycarbonate Substances 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 229910052709 silver Inorganic materials 0.000 description 2
- 239000004332 silver Substances 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 230000009870 specific binding Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 230000002485 urinary effect Effects 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- CXCHEKCRJQRVNG-UHFFFAOYSA-N 2,2,2-trifluoroethanesulfonyl chloride Chemical compound FC(F)(F)CS(Cl)(=O)=O CXCHEKCRJQRVNG-UHFFFAOYSA-N 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 108090001008 Avidin Chemical group 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 108020004635 Complementary DNA Chemical group 0.000 description 1
- 102100031673 Corneodesmosin Human genes 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 102000003864 Human Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010082302 Human Follicle Stimulating Hormone Proteins 0.000 description 1
- 108090001090 Lectins Chemical group 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 102000009151 Luteinizing Hormone Human genes 0.000 description 1
- 108010073521 Luteinizing Hormone Proteins 0.000 description 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 108010039918 Polylysine Proteins 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- 102000003743 Relaxin Human genes 0.000 description 1
- 108090000103 Relaxin Proteins 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 108010031318 Vitronectin Proteins 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 229920006221 acetate fiber Chemical class 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 102000035824 beta Subunit Follicle Stimulating Hormone Human genes 0.000 description 1
- 108010081485 beta Subunit Follicle Stimulating Hormone Proteins 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 244000309464 bull Species 0.000 description 1
- 150000001720 carbohydrates Chemical group 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000011852 carbon nanoparticle Substances 0.000 description 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- POIUWJQBRNEFGX-XAMSXPGMSA-N cathelicidin Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(O)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(C)C)C1=CC=CC=C1 POIUWJQBRNEFGX-XAMSXPGMSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- PBAYDYUZOSNJGU-UHFFFAOYSA-N chelidonic acid Natural products OC(=O)C1=CC(=O)C=C(C(O)=O)O1 PBAYDYUZOSNJGU-UHFFFAOYSA-N 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 229920001577 copolymer Polymers 0.000 description 1
- 210000004246 corpus luteum Anatomy 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- ATDGTVJJHBUTRL-UHFFFAOYSA-N cyanogen bromide Chemical compound BrC#N ATDGTVJJHBUTRL-UHFFFAOYSA-N 0.000 description 1
- 238000010252 digital analysis Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000004696 endometrium Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000002532 enzyme inhibitor Substances 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 230000008217 follicular development Effects 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 229940014259 gelatin Drugs 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000003100 immobilizing effect Effects 0.000 description 1
- 229940027941 immunoglobulin g Drugs 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 238000003698 laser cutting Methods 0.000 description 1
- 238000012125 lateral flow test Methods 0.000 description 1
- 239000002523 lectin Chemical group 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 230000029849 luteinization Effects 0.000 description 1
- 229940040129 luteinizing hormone Drugs 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 239000000693 micelle Substances 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 229910052755 nonmetal Inorganic materials 0.000 description 1
- 150000002843 nonmetals Chemical class 0.000 description 1
- 230000009871 nonspecific binding Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 210000001672 ovary Anatomy 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- MTZWHHIREPJPTG-UHFFFAOYSA-N phorone Chemical compound CC(C)=CC(=O)C=C(C)C MTZWHHIREPJPTG-UHFFFAOYSA-N 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229920000083 poly(allylamine) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000656 polylysine Polymers 0.000 description 1
- 239000003505 polymerization initiator Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 150000003127 pregnanediols Chemical class 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- QSHGUCSTWRSQAF-FJSLEGQWSA-N s-peptide Chemical compound C([C@@H](C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C1=CC=C(OS(O)(=O)=O)C=C1 QSHGUCSTWRSQAF-FJSLEGQWSA-N 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 238000010206 sensitivity analysis Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 229910052714 tellurium Inorganic materials 0.000 description 1
- PORWMNRCUJJQNO-UHFFFAOYSA-N tellurium atom Chemical compound [Te] PORWMNRCUJJQNO-UHFFFAOYSA-N 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 238000003466 welding Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/689—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to pregnancy or the gonads
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/743—Steroid hormones
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
- G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/575—Hormones
- G01N2333/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1317458.6A GB201317458D0 (en) | 2013-10-02 | 2013-10-02 | Improved pregnancy test device and method |
| GB1317458.6 | 2013-10-02 | ||
| PCT/GB2014/052960 WO2015049508A1 (en) | 2013-10-02 | 2014-10-01 | Improved pregnancy test device and method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018142294A Division RU2018142294A (ru) | 2013-10-02 | 2014-10-01 | Усовершенствованное устройство и способ тестирования на беременность |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2016116771A RU2016116771A (ru) | 2017-11-13 |
| RU2016116771A3 RU2016116771A3 (enExample) | 2018-03-05 |
| RU2674266C2 true RU2674266C2 (ru) | 2018-12-06 |
Family
ID=49585194
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018142294A RU2018142294A (ru) | 2013-10-02 | 2014-10-01 | Усовершенствованное устройство и способ тестирования на беременность |
| RU2016116771A RU2674266C2 (ru) | 2013-10-02 | 2014-10-01 | Усовершенствованное устройство и способ тестирования на беременность |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018142294A RU2018142294A (ru) | 2013-10-02 | 2014-10-01 | Усовершенствованное устройство и способ тестирования на беременность |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US10228377B2 (enExample) |
| EP (1) | EP3052944B1 (enExample) |
| JP (2) | JP6675976B2 (enExample) |
| CN (1) | CN105765388B (enExample) |
| AU (2) | AU2014330913B2 (enExample) |
| BR (1) | BR112016007106A2 (enExample) |
| CA (1) | CA2922890C (enExample) |
| GB (1) | GB201317458D0 (enExample) |
| MX (2) | MX369321B (enExample) |
| RU (2) | RU2018142294A (enExample) |
| WO (1) | WO2015049508A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10890590B2 (en) | 2012-09-27 | 2021-01-12 | Ellume Limited | Diagnostic devices and methods |
| GB201317458D0 (en) | 2013-10-02 | 2013-11-13 | Spd Swiss Prec Diagnostics Gmbh | Improved pregnancy test device and method |
| TWM503197U (zh) * | 2014-12-31 | 2015-06-21 | Yonglin Yonglin Biotech Corp | 生理檢測裝置 |
| WO2016115608A1 (en) * | 2015-01-22 | 2016-07-28 | Ellume Pty Ltd | Diagnostic devices and methods for mitigating hook effect and use thereof |
| CN108139410A (zh) * | 2015-04-02 | 2018-06-08 | 瑞士斯保德精密诊断有限公司 | 改进的怀孕测试装置及方法 |
| JP6595818B2 (ja) * | 2015-06-30 | 2019-10-23 | 田中貴金属工業株式会社 | 免疫クロマト分析装置及び免疫クロマト分析方法 |
| CN105572395B (zh) * | 2015-10-30 | 2018-03-27 | 杭州康永生物技术有限公司 | 一种测试电子笔 |
| EP3335638A1 (en) * | 2016-12-13 | 2018-06-20 | Colorimetrix GmbH | Method and device for estimation of ovulation date |
| US11029321B2 (en) | 2017-02-17 | 2021-06-08 | MFB Fertility, Inc. | Method of evaluating corpus luteum function by recurrently evaluating progesterone non-serum bodily fluids on multiple days |
| US11061026B2 (en) | 2017-02-17 | 2021-07-13 | MFB Fertility, Inc. | System of evaluating corpus luteum function by recurrently evaluating progesterone non-serum bodily fluids on multiple days |
| US20240058805A1 (en) * | 2017-02-17 | 2024-02-22 | MFB Fertility, Inc. | Systems and methods for tracking progesterone |
| US12282029B2 (en) | 2017-05-08 | 2025-04-22 | MPB Fertility, Inc. | Portable diagnostic system for ovulation cycle monitoring |
| US11131665B1 (en) | 2018-08-22 | 2021-09-28 | MFB Fertility, Inc. | Method for evaluating urine of a subject to estimate the fertile window |
| CN106932598A (zh) * | 2017-03-24 | 2017-07-07 | 南通伊仕生物技术股份有限公司 | Hcg周期检测试剂盒及其制备方法 |
| WO2018199849A1 (en) * | 2017-04-28 | 2018-11-01 | Singapore Health Services Pte. Ltd. | Characteristic metabolites in miscarriages |
| CH713752B1 (fr) * | 2017-05-24 | 2019-06-14 | Palma Group S A | Méthode d'identification d'écarts à la norme d'indices de l'urine. |
| JP2019113425A (ja) * | 2017-12-25 | 2019-07-11 | Ｂｌｕｅ Ｉｎｄｕｓｔｒｉｅｓ株式会社 | イムノクロマトアッセイ用検査カートリッジ及び検査装置 |
| EP3731751B1 (en) * | 2017-12-28 | 2024-06-19 | MFB Fertility, Inc. | Systems and methods for tracking progesterone |
| KR102086141B1 (ko) * | 2017-12-28 | 2020-04-29 | 주식회사 수젠텍 | 진단기, 진단용 디바이스 및 진단 방법 |
| CN108387749A (zh) * | 2018-03-07 | 2018-08-10 | 广州浩强生物科技有限公司 | 一种或受孕的检测方法及检测笔 |
| CN108459167A (zh) * | 2018-03-16 | 2018-08-28 | 江苏维尔生物科技有限公司 | 一种用于人体尿液中β-HCG、PDG定量检测的试剂盒及其制备方法 |
| USD903897S1 (en) | 2019-01-17 | 2020-12-01 | Jamond Blake | Dual indicator light pregnancy testing device |
| CN112740035A (zh) * | 2018-07-27 | 2021-04-30 | 卢莫斯诊断Ip股份有限公司 | 侧流测定设备和使用方法 |
| US12181465B2 (en) | 2018-08-22 | 2024-12-31 | MFB Fertility, Inc. | Method for evaluating urine of a subject to estimate the fertile window by evaluating for the presence of analytes of estrogen and progesterone |
| CN109324181B (zh) * | 2018-10-22 | 2021-10-08 | 河北特温特生物科技发展有限公司 | 一种免疫层析用封闭剂组合物、用途、及免疫层析试剂盒的制备方法 |
| GB201905090D0 (en) * | 2019-04-10 | 2019-05-22 | Spd Swiss Prec Diagnostics Gmbh | Assay device |
| CA3135278A1 (en) | 2019-04-28 | 2020-11-05 | Visby Medical, Inc. | Molecular diagnostic devices with digital detection capability and wireless connectivity |
| KR102843656B1 (ko) * | 2019-06-14 | 2025-08-08 | 드라발 홀딩 에이비 | 측방 유동 테스트 결과의 유효성을 결정하기 위한 시스템 |
| CN111141917A (zh) * | 2019-12-19 | 2020-05-12 | 云奥生物科技(常州)有限公司 | 孕酮和β-hCG的二联层析检测卡及其制备方法和检测方法 |
| EP3859316A1 (en) * | 2020-01-31 | 2021-08-04 | Midge Medical GmbH | Testing device for lateral flow assay |
| JP7596077B2 (ja) * | 2020-04-07 | 2024-12-09 | ロート製薬株式会社 | 検体検査支援装置、方法およびプログラム、 |
| EP4136449A1 (de) | 2020-04-16 | 2023-02-22 | Senova Gesellschaft für Biowissenschaft und Technik mbH | Lateral flow assay |
| IT202000009154A1 (it) | 2020-04-27 | 2021-10-27 | Zenares S R L | Dispositivo di auto-test monouso con funzionalità di auto-certificazione e kit contenente il medesimo |
| US20210387187A1 (en) | 2020-05-27 | 2021-12-16 | University Of Warwick | Flow device |
| KR102534911B1 (ko) * | 2020-10-23 | 2023-05-19 | 한국기술교육대학교 산학협력단 | 임신 진단용 스캐너 및 이를 이용한 임신 진단결과 표시 방법 |
| GB2617503A (en) * | 2020-12-08 | 2023-10-11 | Akur Venkatesan Varun | Dynamic monitoring of E3G, LH, PDG, FSH levels in female subjects to predict health conditions |
| CN112698027B (zh) * | 2020-12-14 | 2022-04-01 | 广东唯实生物技术有限公司 | 一种半抗原免疫层析检测试剂 |
| US11921076B1 (en) | 2021-02-28 | 2024-03-05 | Uchenna Chukwu | Methods and devices for COVID-19 testing using urine samples |
| US12385901B2 (en) | 2021-02-28 | 2025-08-12 | Uchenna Chukwu | Methods and devices for COVID-19 testing using urine samples |
| GB202103200D0 (en) | 2021-03-08 | 2021-04-21 | Terasom S R O | Lung Cancer diagnosis |
| CN215727712U (zh) * | 2021-04-08 | 2022-02-01 | 雅培诊断产品(上海)有限公司 | 早孕检测笔壳和早孕检测笔 |
| EP4444185A1 (en) * | 2021-12-09 | 2024-10-16 | Koninklijke Philips N.V. | Estimating a gestational age of a target fetus |
| USD1023336S1 (en) * | 2023-02-16 | 2024-04-16 | Andon Health Co., Ltd. | Instrument and utensil for medical or laboratory diagnosis |
| WO2025010175A2 (en) * | 2023-07-04 | 2025-01-09 | Yates Bridger | Pregnancy test apparatus with affirmation display and method |
| DE102023213285A1 (de) * | 2023-12-22 | 2025-06-26 | Robert Bosch Gesellschaft mit beschränkter Haftung | Vorrichtung und Verfahren zur Analyse einer Hormon-Konzentration |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0075193A1 (en) * | 1981-09-23 | 1983-03-30 | Northwestern University | Method of pregnanediol glucuronide detection and indicator strip for use therein |
| GB2335983A (en) * | 1998-04-02 | 1999-10-06 | Unilever Plc | Estimating time of maximum fertility |
| US20060019404A1 (en) * | 1998-05-06 | 2006-01-26 | Blatt Joel M | Quantitative assay with extended dynamic range |
| US7090802B1 (en) * | 2002-09-05 | 2006-08-15 | Phenogenomics Corporation | Sampling assembly for simultaneously testing a liquid biological sample for a plurality of hormones and method thereof |
| US20100129935A1 (en) * | 2008-11-25 | 2010-05-27 | Sarah Daniel Maddison | Pregnancy testing method |
| RU2398235C2 (ru) * | 2005-08-31 | 2010-08-27 | Эгомедикаль Технологиз Аг | Тест-система с использованием элементов неэнзиматического распознавания анализируемого вещества |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0560410B1 (en) | 1987-04-27 | 2002-10-02 | Inverness Medical Switzerland GmbH | A test device for performing specific binding assays |
| US5663054A (en) * | 1995-03-03 | 1997-09-02 | Abbott Laboratories | Determination of steroids by competitive immunoassay |
| US5786220A (en) * | 1995-04-28 | 1998-07-28 | Quidel Corporation | Assays and devices for distinguishing between normal and abnormal pregnancy |
| US5679584A (en) | 1995-05-03 | 1997-10-21 | Mileaf; Daryl Sunny | Method for chemical detection |
| AU702209B2 (en) | 1996-07-16 | 1999-02-18 | Roche Diagnostics Gmbh | Analytical system with means for detecting too small sample volumes |
| DE19639227B4 (de) | 1996-09-24 | 2006-11-23 | Lre Technology Partner Gmbh | Verfahren und Vorrichtung zur Blutzuckermessung |
| US6194222B1 (en) | 1998-01-05 | 2001-02-27 | Biosite Diagnostics, Inc. | Methods for monitoring the status of assays and immunoassays |
| GB9807134D0 (en) | 1998-04-02 | 1998-06-03 | Unilever Plc | Test methods devices and test kits |
| GB2394547B (en) * | 2001-09-18 | 2005-09-21 | Inverness Medical Switzerland | Improvements in or relating to detection of impaired fertility |
| JP3717158B2 (ja) | 2001-11-09 | 2005-11-16 | 本田技研工業株式会社 | 油圧バルブ |
| WO2003058245A1 (en) | 2002-01-09 | 2003-07-17 | Inverness Medical Switzerland Gmbh | Liquid sample assay device |
| DE10211818B4 (de) | 2002-03-16 | 2006-07-06 | peS Gesellschaft für medizinische Diagnose-Systeme mbH | Verfahren zur quantitativen Bestimmung mehrerer Analyten |
| US7700372B2 (en) * | 2002-10-08 | 2010-04-20 | Tara Nylese | Portable diagnostic device and method for determining temporal variations in concentrations |
| DE60304603T2 (de) * | 2002-11-25 | 2007-02-15 | Octapharma Ag | Plasma-albumin fraktion mit vermindertem prekallikrein |
| CA2468014C (en) | 2003-06-04 | 2016-03-22 | Inverness Medical Switzerland Gmbh | Flow sensing for determination of assay results |
| DE602004019315D1 (de) * | 2003-06-04 | 2009-03-19 | Inverness Medical Switzerland | Optische Anordnung für ein Assay-Lesegerät |
| US7239394B2 (en) | 2003-06-04 | 2007-07-03 | Inverness Medical Switzerland Gmbh | Early determination of assay results |
| US7572639B2 (en) | 2004-06-03 | 2009-08-11 | Stc.Unm | Method and apparatus for predicting pregnancy outcome |
| ATE499607T1 (de) | 2005-08-31 | 2011-03-15 | Egomedical Technologies Ag | Analytentestsystem unter verwendung nichtenzymatischer analytenerkennungselemente |
| GB0717043D0 (en) * | 2007-04-10 | 2007-10-10 | Inverness Medical Switzerland | Assay device |
| GB0706906D0 (en) * | 2007-04-10 | 2007-05-16 | Inverness Medical Switzerland | Assay device |
| AU2008207371B2 (en) | 2007-09-01 | 2014-05-22 | Abbott Rapid Diagnostics International Unlimited Company | Assay device with shared zones |
| GB0717045D0 (en) * | 2007-09-01 | 2007-10-10 | Inverness Medical Switzerland | Assay device with shared zones |
| GB2460660B (en) * | 2008-06-04 | 2013-05-22 | Alere Switzerland Gmbh | Assay reader device & method for measuring hCG |
| GB0820999D0 (en) | 2008-11-17 | 2008-12-24 | Menon Johansson Anatole S | Pregnancy testing |
| US20120106464A1 (en) | 2010-10-27 | 2012-05-03 | The Hong Kong University Of Science And Technology | Spectrum sharing with implicit power control in cognitive radio networks |
| US9638704B2 (en) | 2010-11-24 | 2017-05-02 | Spd Swiss Precision Diagnostics Gmbh | Assay device |
| US9939385B2 (en) | 2011-09-09 | 2018-04-10 | Church & Dwight Co., Inc. | Systems, methods, and test kits for analyte variation detection |
| US9588113B2 (en) * | 2012-02-22 | 2017-03-07 | Church & Dwight Co., Inc. | Methods for electronic analyte assaying |
| GB201209664D0 (en) | 2012-05-30 | 2012-07-11 | Spd Swiss Prec Diagnostics Gmbh | Assay device |
| CA2924217A1 (en) | 2012-09-27 | 2014-04-03 | Ellume Pty Ltd | Diagnostic devices and methods |
| GB201317458D0 (en) | 2013-10-02 | 2013-11-13 | Spd Swiss Prec Diagnostics Gmbh | Improved pregnancy test device and method |
| CN108139410A (zh) * | 2015-04-02 | 2018-06-08 | 瑞士斯保德精密诊断有限公司 | 改进的怀孕测试装置及方法 |
-
2013
- 2013-10-02 GB GBGB1317458.6A patent/GB201317458D0/en not_active Ceased
-
2014
- 2014-10-01 JP JP2016515950A patent/JP6675976B2/ja not_active Expired - Fee Related
- 2014-10-01 AU AU2014330913A patent/AU2014330913B2/en not_active Ceased
- 2014-10-01 BR BR112016007106A patent/BR112016007106A2/pt not_active IP Right Cessation
- 2014-10-01 WO PCT/GB2014/052960 patent/WO2015049508A1/en not_active Ceased
- 2014-10-01 EP EP14789347.3A patent/EP3052944B1/en not_active Not-in-force
- 2014-10-01 RU RU2018142294A patent/RU2018142294A/ru not_active Application Discontinuation
- 2014-10-01 CN CN201480054650.2A patent/CN105765388B/zh not_active Expired - Fee Related
- 2014-10-01 RU RU2016116771A patent/RU2674266C2/ru active
- 2014-10-01 MX MX2016003914A patent/MX369321B/es active IP Right Grant
- 2014-10-01 CA CA2922890A patent/CA2922890C/en active Active
- 2014-10-01 MX MX2019013205A patent/MX390227B/es unknown
- 2014-10-02 US US14/505,083 patent/US10228377B2/en not_active Expired - Fee Related
-
2018
- 2018-09-14 JP JP2018172737A patent/JP2019023647A/ja active Pending
-
2019
- 2019-03-07 US US16/295,809 patent/US11099199B2/en active Active
- 2019-12-24 AU AU2019284096A patent/AU2019284096B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0075193A1 (en) * | 1981-09-23 | 1983-03-30 | Northwestern University | Method of pregnanediol glucuronide detection and indicator strip for use therein |
| GB2335983A (en) * | 1998-04-02 | 1999-10-06 | Unilever Plc | Estimating time of maximum fertility |
| US20060019404A1 (en) * | 1998-05-06 | 2006-01-26 | Blatt Joel M | Quantitative assay with extended dynamic range |
| US7090802B1 (en) * | 2002-09-05 | 2006-08-15 | Phenogenomics Corporation | Sampling assembly for simultaneously testing a liquid biological sample for a plurality of hormones and method thereof |
| RU2398235C2 (ru) * | 2005-08-31 | 2010-08-27 | Эгомедикаль Технологиз Аг | Тест-система с использованием элементов неэнзиматического распознавания анализируемого вещества |
| US20100129935A1 (en) * | 2008-11-25 | 2010-05-27 | Sarah Daniel Maddison | Pregnancy testing method |
Also Published As
| Publication number | Publication date |
|---|---|
| US10228377B2 (en) | 2019-03-12 |
| MX2019013205A (es) | 2020-01-21 |
| AU2014330913B2 (en) | 2020-01-30 |
| US20150094227A1 (en) | 2015-04-02 |
| RU2018142294A3 (enExample) | 2019-09-03 |
| US11099199B2 (en) | 2021-08-24 |
| RU2018142294A (ru) | 2018-12-10 |
| US20190204334A1 (en) | 2019-07-04 |
| RU2016116771A3 (enExample) | 2018-03-05 |
| RU2016116771A (ru) | 2017-11-13 |
| AU2014330913A1 (en) | 2016-04-07 |
| JP2016532077A (ja) | 2016-10-13 |
| EP3052944A1 (en) | 2016-08-10 |
| WO2015049508A1 (en) | 2015-04-09 |
| BR112016007106A2 (pt) | 2017-08-01 |
| JP6675976B2 (ja) | 2020-04-08 |
| CA2922890C (en) | 2022-03-01 |
| JP2019023647A (ja) | 2019-02-14 |
| MX369321B (es) | 2019-11-04 |
| CA2922890A1 (en) | 2015-04-09 |
| MX390227B (es) | 2025-03-20 |
| EP3052944B1 (en) | 2019-08-14 |
| MX2016003914A (es) | 2016-10-21 |
| CN105765388A (zh) | 2016-07-13 |
| CN105765388B (zh) | 2018-04-20 |
| GB201317458D0 (en) | 2013-11-13 |
| AU2019284096A1 (en) | 2020-01-23 |
| AU2019284096B2 (en) | 2020-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2674266C2 (ru) | Усовершенствованное устройство и способ тестирования на беременность | |
| US10794920B2 (en) | Pregnancy test device and method | |
| JP7267211B2 (ja) | 高濃度の分析物等、分析物を測定するための用量反応曲線の減少信号部分を使用したサンドイッチ型アッセイ | |
| CN113227791B (zh) | 具有多个检查线的妊娠诊断用免疫色谱条及包含其的妊娠诊断试剂盒 | |
| US8278109B2 (en) | Hyperglycosylated hCG detection device | |
| US20190187154A1 (en) | Biomedical measuring devices, systems, and methods for measuring peptide concentration to monitor a condition | |
| EP3248001B1 (en) | Diagnostic devices and methods for mitigating hook effect and use thereof | |
| KR20160108695A (ko) | 이종 검사선을 구비한 임신진단용 면역크로마토그래피 스트립 및 이를 구비한 임신 진단 키트 | |
| AU2024259892A1 (en) | Assay device | |
| KR102473036B1 (ko) | 베타 코어 단편 hCG를 표지자로 하는 자궁 외 임신 진단 장치 | |
| HK1226814A1 (en) | Improved pregnancy test device and method |