SG11201909977PA - Characteristic metabolites in miscarriages - Google Patents

Characteristic metabolites in miscarriages

Info

Publication number
SG11201909977PA
SG11201909977PA SG11201909977PA SG11201909977PA SG 11201909977P A SG11201909977P A SG 11201909977PA SG 11201909977P A SG11201909977P A SG 11201909977PA SG 11201909977P A SG11201909977P A SG 11201909977PA
Authority
SG
Singapore
Prior art keywords
singapore
international
nanyang
pte
tan
Prior art date
Application number
Inventor
Thiam Chye Tan
Chee Wai Ku
Nguan Soon Tan
zhen wei Tan
Original Assignee
Singapore Health Serv Pte Ltd
Univ Nanyang Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Singapore Health Serv Pte Ltd, Univ Nanyang Tech filed Critical Singapore Health Serv Pte Ltd
Publication of SG11201909977PA publication Critical patent/SG11201909977PA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743—Steroid hormones
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/36—Gynecology or obstetrics
    • G01N2800/368—Pregnancy complicated by disease or abnormalities of pregnancy, e.g. preeclampsia, preterm labour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/493—Physical analysis of biological material of liquid biological material urine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 01 November 2018 (01.11.2018) WIPO I PCT mu °million °nolo mooloin moilmioluo oimIE (10) International Publication Number WO 2018/199849 Al (51) International Patent Classification: GO1N 33/74 (2006.01) GO1N 33/493 (2006.01) (21) International Application Number: PCT/SG2018/050208 (22) International Filing Date: 30 April 2018 (30.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201703502T 28 April 2017 (28.04.2017) SG (71) Applicants: SINGAPORE HEALTH SERVICES PTE. LTD. [SG/SG]; 31 Third Hospital Avenue, #03-03, Bowyer Block C, Singapore 168753 (SG). NANYANG TECH- NOLOGICAL UNIVERSITY [SG/SG]; 50 Nanyang Av- enue, Singapore 639798 (SG). (72) Inventors: TAN, Thiam Chye; c/o KK Women's and Children's Hospital Pte. Ltd., 100 Bukit Timah Road, Sin- gapore 229899 (SG). KU, Chee Wai; c/o KK Women's and Children's Hospital Pte. Ltd., 100 Bukit Timah Road, Singapore 229899 (SG). TAN, Nguan Soon; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). TAN, Zhen Wei; c/o Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (SG). (74) Agent: SPRUSON & FERGUSON (ASIA) PTE LTD; P.O. Box 1531, Robinson Road Post Office, Singapore 903031 (SG). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: CHARACTERISTIC METABOLITES IN MISCARRIAGES (57) : Disclosed herein are methods of identifying the risk of a miscarriage in a subject comprising detecting and measuring the concentration of at least one metabolite in a sample obtained from the subject. Specifically, an increase in concentration of tetrahy- drocortisone, and a decrease in concentration of propionylcarnitine, isovalerylcarnitine, 3- methylglutarylcarnitine, hexanoylcarnitine or 3a,20a-dihydroxy-5[3-pregnane-3-glucuronide in a serum or a urine sample are associated with spontaneous miscarriage in first trimester pregnancy. Also disclosed herein are kits for determining the risk of a miscarriage in a subject.
SG11201909977P 2017-04-28 2018-04-30 Characteristic metabolites in miscarriages SG11201909977PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201703502T 2017-04-28
PCT/SG2018/050208 WO2018199849A1 (en) 2017-04-28 2018-04-30 Characteristic metabolites in miscarriages

Publications (1)

Publication Number Publication Date
SG11201909977PA true SG11201909977PA (en) 2019-11-28

Family

ID=63917738

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909977P SG11201909977PA (en) 2017-04-28 2018-04-30 Characteristic metabolites in miscarriages

Country Status (3)

Country Link
CN (1) CN110785664A (en)
SG (1) SG11201909977PA (en)
WO (1) WO2018199849A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5786220A (en) * 1995-04-28 1998-07-28 Quidel Corporation Assays and devices for distinguishing between normal and abnormal pregnancy
US20140221236A1 (en) * 2013-02-01 2014-08-07 Kristi S. Borowski Metabolomic markers for preterm birth
US20150090010A1 (en) * 2013-09-27 2015-04-02 Chang Gung University Method for diagnosing heart failure
GB201317458D0 (en) * 2013-10-02 2013-11-13 Spd Swiss Prec Diagnostics Gmbh Improved pregnancy test device and method

Also Published As

Publication number Publication date
CN110785664A (en) 2020-02-11
WO2018199849A1 (en) 2018-11-01

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