RU2663803C2 - Лечение инфекций h. pylori с применением ингибиторов mtan - Google Patents

Лечение инфекций h. pylori с применением ингибиторов mtan Download PDF

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Publication number
RU2663803C2
RU2663803C2 RU2016136533A RU2016136533A RU2663803C2 RU 2663803 C2 RU2663803 C2 RU 2663803C2 RU 2016136533 A RU2016136533 A RU 2016136533A RU 2016136533 A RU2016136533 A RU 2016136533A RU 2663803 C2 RU2663803 C2 RU 2663803C2
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RU
Russia
Prior art keywords
pylori
mmol
amino
compound
nmr
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RU2016136533A
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English (en)
Russian (ru)
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RU2016136533A3 (enExample
RU2016136533A (ru
Inventor
Верн Л. ШРАММ
Кейт Клинч
Шивали Ашвин ГУЛАБ
Original Assignee
Альберт Эйнштейн Колледж Оф Медсин, Инк.
Виктория Линк Лимитед
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Publication of RU2016136533A publication Critical patent/RU2016136533A/ru
Publication of RU2016136533A3 publication Critical patent/RU2016136533A3/ru
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
RU2016136533A 2014-02-12 2015-02-06 Лечение инфекций h. pylori с применением ингибиторов mtan RU2663803C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461938755P 2014-02-12 2014-02-12
US61/938,755 2014-02-12
PCT/US2015/014778 WO2015123101A1 (en) 2014-02-12 2015-02-06 Treatment of h. pylori infections using mtan inhibitors

Publications (3)

Publication Number Publication Date
RU2016136533A RU2016136533A (ru) 2018-03-13
RU2016136533A3 RU2016136533A3 (enExample) 2018-06-06
RU2663803C2 true RU2663803C2 (ru) 2018-08-09

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ID=53800544

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016136533A RU2663803C2 (ru) 2014-02-12 2015-02-06 Лечение инфекций h. pylori с применением ингибиторов mtan

Country Status (12)

Country Link
US (2) US10118928B2 (enExample)
EP (1) EP3104707B1 (enExample)
JP (1) JP6512613B2 (enExample)
AU (1) AU2015217416B2 (enExample)
BR (1) BR112016019469B1 (enExample)
CA (1) CA2974916C (enExample)
HK (1) HK1232071A1 (enExample)
IL (1) IL247218B (enExample)
NZ (1) NZ724103A (enExample)
RU (1) RU2663803C2 (enExample)
SG (2) SG10201806381VA (enExample)
WO (1) WO2015123101A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
CN108794628A (zh) * 2018-05-28 2018-11-13 广东工业大学 一种抗幽门螺杆菌的卵黄抗体制备方法及应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2333208C2 (ru) * 2002-06-13 2008-09-10 Вертекс Фармасьютикалз Инкорпорейтед Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций
US20110046167A1 (en) * 2006-09-07 2011-02-24 Keith Clinch Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
US20130274220A1 (en) * 2010-11-29 2013-10-17 Industrial Research Limited Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase

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US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
US7553839B2 (en) 2002-08-21 2009-06-30 Industrial Research Limited 5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
WO2007016291A2 (en) 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
ES2362805T3 (es) 2006-09-07 2011-07-13 Industrial Research Limited Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
DK2114925T3 (da) 2006-12-22 2012-05-29 Ind Res Ltd Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer
WO2008115531A1 (en) * 2007-03-21 2008-09-25 Novacea, Inc. Prevention and treatment of infectious conditions with active vitamin d compounds or mimics thereof
WO2010033236A2 (en) * 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (ja) 2009-07-17 2016-02-16 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ ５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
US9522159B2 (en) 2012-09-11 2016-12-20 Albert Einstein College Of Medicine, Inc. Treatment and prevention of P. aeruginosa infections using coformycin analogs
WO2014073989A1 (en) 2012-11-12 2014-05-15 Callaghan Innovation Research Limited Salt and polymorphic forms of (3r,4s)-l-((4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4(methylthiomethyl)pyrodin-3-ol(mtdia)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2333208C2 (ru) * 2002-06-13 2008-09-10 Вертекс Фармасьютикалз Инкорпорейтед Производные 2-уреидо-6-гетероарил-3н-бензимидазол-6-карбоновой кислоты и родственные соединения в качестве ингибиторов гиразы и/или топоизомеразы iv для лечения бактериальных инфекций
US20110046167A1 (en) * 2006-09-07 2011-02-24 Keith Clinch Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
US20130274220A1 (en) * 2010-11-29 2013-10-17 Industrial Research Limited Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase

Also Published As

Publication number Publication date
CA2974916A1 (en) 2015-08-20
AU2015217416B2 (en) 2018-10-04
WO2015123101A1 (en) 2015-08-20
RU2016136533A3 (enExample) 2018-06-06
JP2017506238A (ja) 2017-03-02
US10118928B2 (en) 2018-11-06
IL247218A0 (en) 2016-09-29
NZ724103A (en) 2020-07-31
BR112016019469A2 (pt) 2018-07-24
SG10201806381VA (en) 2018-08-30
CA2974916C (en) 2022-05-31
US20190016730A1 (en) 2019-01-17
EP3104707A1 (en) 2016-12-21
AU2015217416A1 (en) 2016-09-29
US20170166571A1 (en) 2017-06-15
SG11201606595RA (en) 2016-09-29
EP3104707B1 (en) 2020-07-15
US10294233B2 (en) 2019-05-21
HK1232071A1 (zh) 2018-01-05
IL247218B (en) 2020-06-30
EP3104707A4 (en) 2017-12-13
BR112016019469B1 (pt) 2022-12-06
JP6512613B2 (ja) 2019-05-15
RU2016136533A (ru) 2018-03-13

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