RU2654068C1 - Бензоксазепиновые ингибиторы pi3 и способы применения - Google Patents
Бензоксазепиновые ингибиторы pi3 и способы применения Download PDFInfo
- Publication number
- RU2654068C1 RU2654068C1 RU2016105810A RU2016105810A RU2654068C1 RU 2654068 C1 RU2654068 C1 RU 2654068C1 RU 2016105810 A RU2016105810 A RU 2016105810A RU 2016105810 A RU2016105810 A RU 2016105810A RU 2654068 C1 RU2654068 C1 RU 2654068C1
- Authority
- RU
- Russia
- Prior art keywords
- mmol
- compound
- compounds
- mixture
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Rheumatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24638109P | 2009-09-28 | 2009-09-28 | |
| US61/246,381 | 2009-09-28 | ||
| US33068510P | 2010-05-03 | 2010-05-03 | |
| US61/330,685 | 2010-05-03 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012117398/04A Division RU2600927C2 (ru) | 2009-09-28 | 2010-09-27 | Бензоксазепиновые ингибиторы pi3k и способы применения |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2654068C1 true RU2654068C1 (ru) | 2018-05-16 |
Family
ID=43037239
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016105810A RU2654068C1 (ru) | 2009-09-28 | 2010-09-27 | Бензоксазепиновые ингибиторы pi3 и способы применения |
| RU2012117398/04A RU2600927C2 (ru) | 2009-09-28 | 2010-09-27 | Бензоксазепиновые ингибиторы pi3k и способы применения |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012117398/04A RU2600927C2 (ru) | 2009-09-28 | 2010-09-27 | Бензоксазепиновые ингибиторы pi3k и способы применения |
Country Status (31)
| Country | Link |
|---|---|
| US (7) | US8242104B2 (enExample) |
| EP (3) | EP2483278B1 (enExample) |
| JP (2) | JP5540101B2 (enExample) |
| KR (1) | KR101428346B1 (enExample) |
| CN (2) | CN102762576B (enExample) |
| AR (1) | AR078187A1 (enExample) |
| AU (1) | AU2010299816C1 (enExample) |
| BR (1) | BR112012006807A2 (enExample) |
| CA (1) | CA2772691C (enExample) |
| CL (1) | CL2012000754A1 (enExample) |
| CO (1) | CO6491026A2 (enExample) |
| CR (1) | CR20120121A (enExample) |
| DK (1) | DK2483278T3 (enExample) |
| EC (1) | ECSP12011755A (enExample) |
| ES (2) | ES2570569T3 (enExample) |
| HR (1) | HRP20140229T1 (enExample) |
| IL (2) | IL217558A (enExample) |
| MA (1) | MA33531B1 (enExample) |
| MX (1) | MX2012003591A (enExample) |
| MY (2) | MY160064A (enExample) |
| NZ (1) | NZ597833A (enExample) |
| PE (1) | PE20121025A1 (enExample) |
| PL (1) | PL2483278T3 (enExample) |
| PT (1) | PT2483278E (enExample) |
| RS (1) | RS53164B (enExample) |
| RU (2) | RU2654068C1 (enExample) |
| SG (1) | SG10201405049RA (enExample) |
| SI (1) | SI2483278T1 (enExample) |
| TW (1) | TWI423980B (enExample) |
| WO (1) | WO2011036280A1 (enExample) |
| ZA (1) | ZA201202199B (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2464645T1 (sl) | 2009-07-27 | 2017-10-30 | Gilead Sciences, Inc. | Zlite heterociklične spojine kot ionsko kanalni modulatorji |
| JP5546636B2 (ja) | 2009-09-28 | 2014-07-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾキセピンｐｉ３ｋ阻害剤化合物及び使用方法 |
| PL2483278T3 (pl) * | 2009-09-28 | 2014-05-30 | Hoffmann La Roche | Związki benzoksazepinowe stanowiące inhibitor pi3k i ich zastosowanie w leczeniu nowotworu |
| MX2012015096A (es) | 2010-07-02 | 2013-05-28 | Gilead Sciences Inc | Compuestos heterociclicos fusionados como moduladores del canal ion. |
| EP2688891B1 (en) * | 2011-03-21 | 2017-11-15 | F. Hoffmann-La Roche AG | Benzoxazepin compounds selective for pi3k p110 delta and methods of use |
| NZ716420A (en) | 2011-05-10 | 2017-05-26 | Gilead Sciences Inc | Fused heterocyclic compounds as sodium channel modulators |
| WO2012156379A1 (en) | 2011-05-13 | 2012-11-22 | Universität Zürich | PIK3/P110α INHIBITORS FOR PREVENTION OF RESTENOSIS BY APPLICATION AS AN IMPLANT COATING |
| NO3175985T3 (enExample) * | 2011-07-01 | 2018-04-28 | ||
| TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
| BR112014019209A2 (pt) * | 2012-02-17 | 2017-07-04 | Hoffmann La Roche | compostos tricíclicos e métodos de uso para os mesmos |
| EP2858666B1 (en) * | 2012-06-08 | 2019-09-04 | F.Hoffmann-La Roche Ag | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| KR102427777B1 (ko) | 2012-06-26 | 2022-08-01 | 델 마 파마슈티컬스 | 디안하이드로갈락티톨, 디아세틸디안하이드로갈락티톨, 디브로모둘시톨, 또는 그의 유사체 또는 유도체를 이용하여 유전학적 다형성이 있는 환자에 있어서 티로신-키나아제-억제제 내성 악성종양, ahi1 조절곤란 또는 돌연변이를 치료하는 방법 |
| CN102775395A (zh) * | 2012-07-12 | 2012-11-14 | 江苏七洲绿色化工股份有限公司 | 一种丙环唑的制备方法及丙环唑中间体 |
| IN2015DN00659A (enExample) * | 2012-08-07 | 2015-06-26 | Janssen Pharmaceutica Nv | |
| SG10201706760YA (en) | 2013-03-13 | 2017-10-30 | Hoffmann La Roche | Process for making benzoxazepin compounds |
| JP2016519684A (ja) | 2013-04-08 | 2016-07-07 | デニス エム ブラウン | 準最適に投与された薬物療法の有効性を改善するための及び／又は副作用を低減するための方法および組成物 |
| US9266903B2 (en) * | 2013-12-16 | 2016-02-23 | Genentech, Inc. | Polymorphs of 2-(4-(2-(1-isopropyl-3-methyl-1H-1,2,4-triazole-5-yl)-5,6-dihydrobenzo[F]imidazo [1,2-D][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide, methods of production, and pharmaceutical uses thereof |
| RU2016137122A (ru) | 2014-03-13 | 2018-04-18 | Ф. Хоффманн-Ля Рош Аг | Терапевтические комбинации с модуляторами рецепторов эстрогена |
| US10183934B2 (en) | 2015-02-02 | 2019-01-22 | Forma Therapeutics, Inc. | Bicyclic [4,6,0] hydroxamic acids as HDAC inhibitors |
| PL3292116T3 (pl) | 2015-02-02 | 2022-02-21 | Valo Health, Inc. | 3-arylo-4-amidobicykliczne kwasy [4,5,0]hydroksamowe jako inhibitory hdac |
| AR104068A1 (es) | 2015-03-26 | 2017-06-21 | Hoffmann La Roche | Combinaciones de un compuesto inhibidor de fosfoinosítido 3-cinasa y un compuesto inhibidor de cdk4/6 para el tratamiento del cáncer |
| US10351576B2 (en) * | 2015-04-30 | 2019-07-16 | Novartis Ag | Fused tricyclic pyrazole derivatives useful for farnesoid X receptors |
| JP6871919B2 (ja) | 2015-06-16 | 2021-05-19 | ナノファギックス エルエルシー | 薬物送達及びイメージング化学コンジュゲート、製剤及びその使用方法 |
| CN107635560A (zh) | 2015-06-29 | 2018-01-26 | 豪夫迈·罗氏有限公司 | 用他塞利昔布进行治疗的方法 |
| AU2016287463B2 (en) * | 2015-07-02 | 2020-07-02 | F. Hoffmann-La Roche Ag | Benzoxazepin oxazolidinone compounds and methods of use |
| JP6522807B2 (ja) * | 2015-07-02 | 2019-05-29 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾオキサゼピンオキサゾリジノン化合物及び使用方法 |
| US10065970B2 (en) | 2015-09-08 | 2018-09-04 | Genentech, Inc. | Tricyclic PI3K inhibitor compounds and methods of use |
| US9721369B2 (en) * | 2015-09-15 | 2017-08-01 | Facebook, Inc. | Systems and methods for utilizing multiple map portions from multiple map data sources |
| US10555935B2 (en) | 2016-06-17 | 2020-02-11 | Forma Therapeutics, Inc. | 2-spiro-5- and 6-hydroxamic acid indanes as HDAC inhibitors |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| CN109982999A (zh) | 2016-09-29 | 2019-07-05 | 拜耳作物科学股份公司 | 新的5-取代的咪唑基甲基衍生物 |
| HRP20230948T1 (hr) * | 2016-12-15 | 2023-11-24 | F. Hoffmann - La Roche Ag | Postupak za proizvodnju (s)-2-((2-((s)-4-(difluorometil)-2-oksooksazolidin-3-il)-5,6-dihidrobenzo[f]imidazo[1,2−d][1,4]oksazepin-9-il)amino) propanamida |
| US11077189B2 (en) | 2017-03-02 | 2021-08-03 | Genentech Inc. | Adjuvant treatment of HER2-positive breast cancer |
| EP3615541B1 (en) * | 2017-04-28 | 2025-03-19 | F. Hoffmann-La Roche AG | Polymorphs and solid forms of (s)-2-((2-((s)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide, and methods of production |
| IL274027B2 (en) * | 2017-10-26 | 2023-12-01 | Xynomic Pharmaceuticals Inc | Crystalline salts of a b-raf kinase inhibitor |
| MX2020012347A (es) * | 2018-05-30 | 2021-01-29 | Jiangsu Hansoh Pharmaceutical Group Co Ltd | Inhibidor que contiene derivado triciclico, metodo de preparacion del mismo y aplicacion del mismo. |
| CN111909157B (zh) * | 2019-05-07 | 2023-02-03 | 南京药石科技股份有限公司 | Ezh2抑制剂及其用途 |
| WO2021088839A1 (zh) * | 2019-11-04 | 2021-05-14 | 贝达药业股份有限公司 | 咪唑烷酮类化合物及其制备方法与应用 |
| WO2021088845A1 (zh) * | 2019-11-04 | 2021-05-14 | 贝达药业股份有限公司 | 咪唑烷酮类化合物及其制备方法与应用 |
| WO2021104146A1 (zh) * | 2019-11-25 | 2021-06-03 | 上海翰森生物医药科技有限公司 | 含三并环类衍生物的盐或晶型及其药物组合物 |
| CA3217763A1 (en) * | 2021-05-03 | 2022-11-10 | Bin Liu | Tricyclic ubiquitin specific protease 1 inhibitor and use thereof |
| AU2022275275A1 (en) * | 2021-05-13 | 2023-12-14 | Betta Pharmaceuticals Co., Ltd | Polymorph of imidazolidinone compound, preparation method therefor and use thereof |
| WO2022251567A1 (en) | 2021-05-28 | 2022-12-01 | Genentech, Inc. | Process for the preparation of benzoxazepin oxazolidinone compounds |
| CN120202205A (zh) * | 2022-11-17 | 2025-06-24 | 微境生物医药科技(上海)有限公司 | 三并环类PI3Kα抑制剂及其制备方法和医药用途 |
| CN116003280B (zh) * | 2022-12-30 | 2024-11-19 | 合肥工业大学 | 一种芳基甲酰胺类化合物的光化学合成方法 |
| WO2025082533A1 (zh) * | 2023-10-21 | 2025-04-24 | 上海轶诺药业有限公司 | 一种稠环化合物及其制备和应用 |
| WO2025237374A1 (zh) * | 2024-05-16 | 2025-11-20 | 微境生物医药科技(上海)有限公司 | PI3Kα抑制剂及其制备方法和医药用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2279434C2 (ru) * | 2001-06-11 | 2006-07-10 | Акцо Нобель Н.В. | Производные бензоксазепина, фармацевтическая композиция на их основе и их применение в качестве стимуляторов рецептора амра |
| WO2007141491A1 (en) * | 2006-06-02 | 2007-12-13 | Hammersmith Imanet Limited | Tricyclic oxazepines as in vivo imaging compounds |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| GB8504702D0 (en) | 1985-02-23 | 1985-03-27 | Zyma Sa | Tricyclic compounds |
| US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
| FR2677356B1 (fr) | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| ES2102195T3 (es) | 1992-12-28 | 1997-07-16 | Eisai Co Ltd | Derivados heterociclicos de acido carbonico que se fijan en receptores de retinoides. |
| AU678503B2 (en) * | 1993-09-24 | 1997-05-29 | Takeda Chemical Industries Ltd. | Condensed heterocyclic compounds and their use as squalene synthetase inhibitors |
| US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
| JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
| US5985799A (en) | 1995-11-17 | 1999-11-16 | E.I. Du Pont De Nemours And Company | Tricyclic herbicidal heterocycles |
| US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
| DE19908533A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908535A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| DE19908538A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Polycyclische 2-Amino-Thiazol Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen |
| DE19908537A1 (de) | 1999-02-26 | 2000-08-31 | Aventis Pharma Gmbh | Verwendung von polycyclischen 2-Amino-Thiazol Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas |
| US7273880B2 (en) | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| AU2001246494A1 (en) | 2000-03-03 | 2001-09-12 | Novartis Ag | Condensed thiazolamines and their use as neuropeptide y5 antagonists |
| MXPA03006950A (es) | 2001-02-02 | 2003-11-18 | Schering Corp | Ciclobuteno-1,2-dionas 3,4-disustituidas como antagonistas de receptor de quimiocina cxc. |
| US20040082602A1 (en) | 2002-07-19 | 2004-04-29 | Hagen Timothy J. | Substituted thiophene carboxamide compounds for the treatment of inflammation |
| WO2004069245A1 (en) * | 2003-02-07 | 2004-08-19 | Warner-Lambert Company Llc | Oxazolidinone derivates n-substituted by a tricyclic ring, for use as antibacterial agents |
| TW200510356A (en) * | 2003-08-01 | 2005-03-16 | Takeda Chemical Industries Ltd | Benzoxaepine compounds |
| US20050239767A1 (en) | 2003-10-28 | 2005-10-27 | Chan Michael K | Intermolecular SNAr of the heterocycle-activated nitro and fluoro groups-application in the synthesis of polyazamacrocyclic ligands |
| EP1765830B1 (en) * | 2004-07-01 | 2010-09-22 | Merck Sharp & Dohme Corp. | Mitotic kinesin inhibitors |
| CN101048418A (zh) | 2004-10-07 | 2007-10-03 | 贝林格尔·英格海姆国际有限公司 | Pi3－激酶 |
| AU2006302415B2 (en) | 2005-10-07 | 2012-09-13 | Exelixis, Inc. | Azetidines as MEK inhibitors for the treatment of proliferative diseases |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| US20070238718A1 (en) * | 2006-04-06 | 2007-10-11 | Matthias Grauert | Thiazolyl-dihydro-indazole |
| CA2659280A1 (en) * | 2006-07-28 | 2008-01-31 | Alcan Packaging Flexible France | Coextruded film with polylactic acid (pla) and ethylene vinyl acetate (eva) |
| ES2614931T3 (es) | 2006-08-04 | 2017-06-02 | Beth Israel Deaconess Medical Center | Inhibidores de la piruvato cinasa y métodos de tratamiento de enfermedad |
| US8779154B2 (en) | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| KR20150090281A (ko) * | 2006-12-29 | 2015-08-05 | 아비에 도이치란트 게엠베하 운트 콤파니 카게 | 카복스아미드 화합물 및 칼페인 억제제로서의 이의 용도 |
| WO2009038795A2 (en) | 2007-09-19 | 2009-03-26 | The Regents Of The University Of California | Positron emission tomography probes for imaging immune activation and selected cancers |
| TWI443102B (zh) * | 2008-03-31 | 2014-07-01 | Genentech Inc | 苯并哌喃及苯并氧呯ｐｉ３ｋ抑制劑化合物及其使用方法 |
| WO2010043676A1 (en) * | 2008-10-17 | 2010-04-22 | Boehringer Ingelheim International Gmbh | Tetra-aza-heterocycles as phosphatidylinositol-3-kinases (pi3-kinases) inhibitor |
| PL2483278T3 (pl) * | 2009-09-28 | 2014-05-30 | Hoffmann La Roche | Związki benzoksazepinowe stanowiące inhibitor pi3k i ich zastosowanie w leczeniu nowotworu |
| JP5546636B2 (ja) * | 2009-09-28 | 2014-07-09 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | ベンゾキセピンｐｉ３ｋ阻害剤化合物及び使用方法 |
-
2010
- 2010-09-27 PL PL10757213T patent/PL2483278T3/pl unknown
- 2010-09-27 MY MYPI2012000823A patent/MY160064A/en unknown
- 2010-09-27 AU AU2010299816A patent/AU2010299816C1/en active Active
- 2010-09-27 JP JP2012530282A patent/JP5540101B2/ja active Active
- 2010-09-27 SI SI201030536T patent/SI2483278T1/sl unknown
- 2010-09-27 HR HRP20140229AT patent/HRP20140229T1/hr unknown
- 2010-09-27 TW TW099132661A patent/TWI423980B/zh active
- 2010-09-27 PE PE2012000390A patent/PE20121025A1/es active IP Right Grant
- 2010-09-27 EP EP10757213.3A patent/EP2483278B1/en active Active
- 2010-09-27 CN CN201080053938.XA patent/CN102762576B/zh active Active
- 2010-09-27 MX MX2012003591A patent/MX2012003591A/es active IP Right Grant
- 2010-09-27 DK DK10757213.3T patent/DK2483278T3/da active
- 2010-09-27 RU RU2016105810A patent/RU2654068C1/ru active
- 2010-09-27 CA CA2772691A patent/CA2772691C/en active Active
- 2010-09-27 CN CN201510043641.XA patent/CN104744491B/zh active Active
- 2010-09-27 RS RS20140060A patent/RS53164B/sr unknown
- 2010-09-27 EP EP13193562.9A patent/EP2711368B1/en active Active
- 2010-09-27 MY MYPI2015002473A patent/MY184074A/en unknown
- 2010-09-27 KR KR1020127010974A patent/KR101428346B1/ko active Active
- 2010-09-27 ES ES13193562T patent/ES2570569T3/es active Active
- 2010-09-27 NZ NZ597833A patent/NZ597833A/en unknown
- 2010-09-27 ES ES10757213.3T patent/ES2444779T3/es active Active
- 2010-09-27 US US12/890,812 patent/US8242104B2/en active Active
- 2010-09-27 EP EP20140190276 patent/EP2845592A1/en not_active Withdrawn
- 2010-09-27 RU RU2012117398/04A patent/RU2600927C2/ru active
- 2010-09-27 AR ARP100103491A patent/AR078187A1/es unknown
- 2010-09-27 WO PCT/EP2010/064208 patent/WO2011036280A1/en not_active Ceased
- 2010-09-27 SG SG10201405049RA patent/SG10201405049RA/en unknown
- 2010-09-27 BR BR112012006807-5A patent/BR112012006807A2/pt not_active Application Discontinuation
- 2010-09-27 PT PT107572133T patent/PT2483278E/pt unknown
-
2012
- 2012-01-10 CO CO12002995A patent/CO6491026A2/es active IP Right Grant
- 2012-01-16 IL IL217558A patent/IL217558A/en active IP Right Grant
- 2012-02-15 MA MA34637A patent/MA33531B1/fr unknown
- 2012-03-13 CR CR20120121A patent/CR20120121A/es unknown
- 2012-03-26 ZA ZA2012/02199A patent/ZA201202199B/en unknown
- 2012-03-27 CL CL2012000754A patent/CL2012000754A1/es unknown
- 2012-03-28 EC ECSP12011755 patent/ECSP12011755A/es unknown
- 2012-05-22 US US13/477,587 patent/US8343955B2/en active Active
- 2012-11-20 US US13/681,763 patent/US8586574B2/en active Active
-
2013
- 2013-10-07 US US14/047,206 patent/US8785626B2/en active Active
- 2013-11-01 JP JP2013228826A patent/JP5625101B2/ja active Active
-
2014
- 2014-06-05 US US14/297,142 patent/US9198918B2/en active Active
-
2015
- 2015-05-28 IL IL239081A patent/IL239081B/en active IP Right Grant
- 2015-11-03 US US14/930,929 patent/US9546178B2/en active Active
-
2016
- 2016-12-05 US US15/368,937 patent/US9670228B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2279434C2 (ru) * | 2001-06-11 | 2006-07-10 | Акцо Нобель Н.В. | Производные бензоксазепина, фармацевтическая композиция на их основе и их применение в качестве стимуляторов рецептора амра |
| WO2007141491A1 (en) * | 2006-06-02 | 2007-12-13 | Hammersmith Imanet Limited | Tricyclic oxazepines as in vivo imaging compounds |
Non-Patent Citations (1)
| Title |
|---|
| Wang Q. et al. "A facial synthesis of the neutral [1,2,4]triazolo[3,2-d][1,5]benzoxazepines and their chalcogen-analogues" SYNTHETIC COMMUNICATIONS, vol.32, N9, 2007, 1327-1335. * |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2654068C1 (ru) | Бензоксазепиновые ингибиторы pi3 и способы применения | |
| RU2557658C2 (ru) | Бензоксепиновые ингибиторы pi3 и способы применения | |
| AU2015252149B2 (en) | Benzoxazepin PI3K inhibitor compounds and methods of use | |
| HK1211929B (en) | Benzoxazepin pi3k inhibitor compounds and methods of use | |
| HK1174629B (en) | Benzoxazepin pi3k inhibitor compounds and methods of use |