RU2637945C2 - Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы - Google Patents
Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы Download PDFInfo
- Publication number
- RU2637945C2 RU2637945C2 RU2014148316A RU2014148316A RU2637945C2 RU 2637945 C2 RU2637945 C2 RU 2637945C2 RU 2014148316 A RU2014148316 A RU 2014148316A RU 2014148316 A RU2014148316 A RU 2014148316A RU 2637945 C2 RU2637945 C2 RU 2637945C2
- Authority
- RU
- Russia
- Prior art keywords
- phenyl
- ethyl
- oxide
- difluoromethoxy
- carbonyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170714 | 2012-06-04 | ||
| EP12170714.5 | 2012-06-04 | ||
| PCT/EP2013/060915 WO2013182451A1 (en) | 2012-06-04 | 2013-05-28 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014148316A RU2014148316A (ru) | 2016-07-27 |
| RU2637945C2 true RU2637945C2 (ru) | 2017-12-08 |
Family
ID=48670496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014148316A RU2637945C2 (ru) | 2012-06-04 | 2013-05-28 | Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9440954B2 (enExample) |
| EP (1) | EP2855450B1 (enExample) |
| KR (1) | KR20150022789A (enExample) |
| CN (1) | CN104334542A (enExample) |
| AR (1) | AR091261A1 (enExample) |
| BR (1) | BR112014029642A2 (enExample) |
| CA (1) | CA2875421A1 (enExample) |
| HK (1) | HK1205116A1 (enExample) |
| IN (1) | IN2014DN10239A (enExample) |
| RU (1) | RU2637945C2 (enExample) |
| WO (1) | WO2013182451A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| US20130005716A1 (en) | 2011-06-06 | 2013-01-03 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| WO2013045280A1 (en) | 2011-09-26 | 2013-04-04 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| CA2893663A1 (en) | 2012-12-05 | 2014-06-12 | Chiesi Farmaceutici S.P.A. | Phenylethylpyridine derivatives as pde4-inhibitors |
| TWI628166B (zh) | 2012-12-05 | 2018-07-01 | 吉斯藥品公司 | 作為磷酸二酯酶抑制劑之１－苯基－２－吡啶基烷基醇衍生物 |
| BR112015012949A2 (pt) | 2012-12-05 | 2017-07-11 | Chiesi Farm Spa | composto, composição farmaceutica, uso de um composto, dispositivo inalatório e kit |
| TR201807181T4 (tr) | 2012-12-05 | 2018-06-21 | Chiesi Farm Spa | Pde-4 i̇nhi̇bi̇törleri̇ ve muskari̇ni̇k reseptör antagoni̇stleri̇ olarak feni̇leti̇lpi̇ri̇di̇n türevleri̇ |
| AR104822A1 (es) * | 2015-06-01 | 2017-08-16 | Chiesi Farm Spa | Derivado de aminoésteres |
| TW201710254A (zh) * | 2015-06-01 | 2017-03-16 | 吉斯藥品公司 | 胺基酯衍生物 |
| IL283608B2 (en) | 2019-01-08 | 2025-06-01 | Kyorin Pharmaceutical Co Ltd Co Number 0100 01 01479 | 15-PGDH inhibitor |
| JP7532385B2 (ja) | 2019-01-31 | 2024-08-13 | 杏林製薬株式会社 | １５－ｐｇｄｈ阻害薬 |
| CN116082670B (zh) * | 2023-04-11 | 2023-06-27 | 中国人民解放军军事科学院军事医学研究院 | 一种含有季膦盐的声响应假性共轭聚合物纳米颗粒的制备方法及其在抗菌领域的应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080015226A1 (en) * | 2006-07-14 | 2008-01-17 | Chiesi Farmaceutici S.P.A.. | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors |
| WO2009018909A2 (en) * | 2007-08-08 | 2009-02-12 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| RU2009135810A (ru) * | 2007-02-28 | 2011-04-10 | Лео Фарма А/С (Dk) | Новые ингибиторы фосфодиэстераз |
| EA019113B1 (ru) * | 2009-02-06 | 2014-01-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | (1-фенил-2-пиридин-4-ил)этиловые эфиры бензойной кислоты в качестве ингибиторов фосфодиэстеразы 4 (pde4) |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69333688T2 (de) | 1992-07-28 | 2005-11-03 | Aventis Pharma Ltd., West Malling | Inhibitoren von c-amp phosphodiesterase |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| EP1634606A1 (en) | 2003-03-31 | 2006-03-15 | Kyowa Hakko Kogyo Co., Ltd. | Drug for airway administration |
| EP2070913A1 (en) | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
| EP2110375A1 (en) * | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class |
| US20130005716A1 (en) | 2011-06-06 | 2013-01-03 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| WO2013045280A1 (en) | 2011-09-26 | 2013-04-04 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| BR112014009471A2 (pt) | 2011-10-21 | 2017-04-18 | Chiesi Farm Spa | compostos, combinação de um composto, composição farmacêutica, uso de um composto, dispositivo e kit |
-
2013
- 2013-05-28 KR KR20147033409A patent/KR20150022789A/ko not_active Withdrawn
- 2013-05-28 CN CN201380029435.2A patent/CN104334542A/zh active Pending
- 2013-05-28 HK HK15105703.0A patent/HK1205116A1/xx unknown
- 2013-05-28 BR BR112014029642A patent/BR112014029642A2/pt not_active IP Right Cessation
- 2013-05-28 RU RU2014148316A patent/RU2637945C2/ru active
- 2013-05-28 CA CA2875421A patent/CA2875421A1/en not_active Abandoned
- 2013-05-28 WO PCT/EP2013/060915 patent/WO2013182451A1/en not_active Ceased
- 2013-05-28 EP EP13730498.6A patent/EP2855450B1/en active Active
- 2013-05-28 IN IN10239DEN2014 patent/IN2014DN10239A/en unknown
- 2013-06-03 AR ARP130101959 patent/AR091261A1/es unknown
- 2013-06-04 US US13/909,222 patent/US9440954B2/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080015226A1 (en) * | 2006-07-14 | 2008-01-17 | Chiesi Farmaceutici S.P.A.. | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors |
| RU2009135810A (ru) * | 2007-02-28 | 2011-04-10 | Лео Фарма А/С (Dk) | Новые ингибиторы фосфодиэстераз |
| WO2009018909A2 (en) * | 2007-08-08 | 2009-02-12 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| WO2009018909A3 (en) * | 2007-08-08 | 2009-05-14 | Chiesi Farma Spa | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| EA019113B1 (ru) * | 2009-02-06 | 2014-01-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | (1-фенил-2-пиридин-4-ил)этиловые эфиры бензойной кислоты в качестве ингибиторов фосфодиэстеразы 4 (pde4) |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2855450B1 (en) | 2016-07-06 |
| WO2013182451A9 (en) | 2014-02-06 |
| US20130324501A1 (en) | 2013-12-05 |
| AR091261A1 (es) | 2015-01-21 |
| IN2014DN10239A (enExample) | 2015-08-07 |
| RU2014148316A (ru) | 2016-07-27 |
| HK1205116A1 (en) | 2015-12-11 |
| US9440954B2 (en) | 2016-09-13 |
| EP2855450A1 (en) | 2015-04-08 |
| KR20150022789A (ko) | 2015-03-04 |
| WO2013182451A1 (en) | 2013-12-12 |
| CA2875421A1 (en) | 2013-12-12 |
| CN104334542A (zh) | 2015-02-04 |
| BR112014029642A2 (pt) | 2017-06-27 |
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