RU2636552C2 - Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором - Google Patents

Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором Download PDF

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RU2636552C2
RU2636552C2 RU2013128895A RU2013128895A RU2636552C2 RU 2636552 C2 RU2636552 C2 RU 2636552C2 RU 2013128895 A RU2013128895 A RU 2013128895A RU 2013128895 A RU2013128895 A RU 2013128895A RU 2636552 C2 RU2636552 C2 RU 2636552C2
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seq
amino acid
terminal capping
capping module
acid residue
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Ханс Каспар БИНЦ
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Молекьюлер Партнерс Аг
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
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    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
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    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide
    • C07K2319/55Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide
    • C07K2319/60Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
RU2013128895A 2010-11-26 2011-11-25 Улучшенные n-терминальные кэппинг модули для сконструированных белков с анкириновым повтором RU2636552C2 (ru)

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EP10192711 2010-11-26
EP10192711.9 2010-11-26
PCT/EP2011/071084 WO2012069655A2 (en) 2010-11-26 2011-11-25 Improved n-terminal capping modules for designed ankyrin repeat proteins

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RU2013128895A RU2013128895A (ru) 2015-01-10
RU2636552C2 true RU2636552C2 (ru) 2017-11-23

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RU2013128896A RU2625882C2 (ru) 2010-11-26 2011-11-25 Сконструированные белки повторов, которые связываются с сывороточным альбумином

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US (5) US9284361B2 (enExample)
EP (3) EP2643348B1 (enExample)
JP (3) JP6105479B2 (enExample)
KR (3) KR101782790B1 (enExample)
CN (3) CN113278077A (enExample)
AU (2) AU2011333665B2 (enExample)
BR (3) BR112013012786B1 (enExample)
CA (2) CA2818969C (enExample)
DK (1) DK2643349T3 (enExample)
ES (2) ES2981441T3 (enExample)
PL (1) PL2643349T3 (enExample)
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