RU2621732C2 - Замещенные пиримидинилпирролы, активные в качестве ингибиторов киназы - Google Patents

Замещенные пиримидинилпирролы, активные в качестве ингибиторов киназы Download PDF

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RU2621732C2
RU2621732C2 RU2013151174A RU2013151174A RU2621732C2 RU 2621732 C2 RU2621732 C2 RU 2621732C2 RU 2013151174 A RU2013151174 A RU 2013151174A RU 2013151174 A RU2013151174 A RU 2013151174A RU 2621732 C2 RU2621732 C2 RU 2621732C2
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formula
compound
pyrrole
carboxamide
aminopyrimidin
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RU2013151174A
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Russian (ru)
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RU2013151174A (ru
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Мария Габриелла Браска
Тициано Бандьера
Джей Аарон Бертран
Паола НЬОККИ
Данило МИРИЦЦИ
Марчелла Нези
Акилле Панцери
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НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
RU2013151174A 2011-04-19 2012-04-05 Замещенные пиримидинилпирролы, активные в качестве ингибиторов киназы RU2621732C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11162960.6 2011-04-19
EP11162960 2011-04-19
PCT/EP2012/056266 WO2012143248A1 (en) 2011-04-19 2012-04-05 Substituted pyrimidinyl-pyrroles active as kinase inhibitors

Publications (2)

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RU2013151174A RU2013151174A (ru) 2015-05-27
RU2621732C2 true RU2621732C2 (ru) 2017-06-07

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RU2013151174A RU2621732C2 (ru) 2011-04-19 2012-04-05 Замещенные пиримидинилпирролы, активные в качестве ингибиторов киназы

Country Status (8)

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US (1) US9283224B2 (OSRAM)
EP (1) EP2699564B1 (OSRAM)
JP (1) JP5970537B2 (OSRAM)
CN (1) CN103502241B (OSRAM)
BR (1) BR112013026137B1 (OSRAM)
ES (1) ES2616458T3 (OSRAM)
RU (1) RU2621732C2 (OSRAM)
WO (1) WO2012143248A1 (OSRAM)

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JP5970537B2 (ja) 2016-08-17
WO2012143248A1 (en) 2012-10-26
US20140155421A1 (en) 2014-06-05
CN103502241B (zh) 2016-03-23
CN103502241A (zh) 2014-01-08
RU2013151174A (ru) 2015-05-27
EP2699564B1 (en) 2016-12-14
US9283224B2 (en) 2016-03-15
BR112013026137B1 (pt) 2020-12-01
ES2616458T3 (es) 2017-06-13
BR112013026137A2 (pt) 2017-10-24
JP2014516360A (ja) 2014-07-10
HK1187905A1 (zh) 2014-04-17
BR112013026137A8 (pt) 2018-01-30
EP2699564A1 (en) 2014-02-26

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