RU2617942C2 - БИСПЕЦИФИЧЕСКОЕ ОДНОЦЕПОЧЕЧНОЕ АНТИТЕЛО К PSMAxCD3 С МЕЖВИДОВОЙ СПЕЦИФИЧНОСТЬЮ - Google Patents

БИСПЕЦИФИЧЕСКОЕ ОДНОЦЕПОЧЕЧНОЕ АНТИТЕЛО К PSMAxCD3 С МЕЖВИДОВОЙ СПЕЦИФИЧНОСТЬЮ Download PDF

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RU2617942C2
RU2617942C2 RU2012143519A RU2012143519A RU2617942C2 RU 2617942 C2 RU2617942 C2 RU 2617942C2 RU 2012143519 A RU2012143519 A RU 2012143519A RU 2012143519 A RU2012143519 A RU 2012143519A RU 2617942 C2 RU2617942 C2 RU 2617942C2
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seq
cdr
presented
bispecific single
single chain
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RU2012143519A
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RU2012143519A (ru
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Петер КУФЕР
Тобиас Раум
Роман КИШЕЛЬ
Ральф ЛУТТЕРБЮЗЕ
Патрик ГОФМАН
Дорис РАУ
Сузанне МАНГОЛЬД
Маттиас КЛИНГЕР
Эвелине ШАЛЛЕР
Сузанне ХАУСМАН
Петра ФЛУР
Карола ШТАЙГЕР
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Эмджин Рисеч (Мюних) ГмбХ
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

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RU2012143519A 2010-04-01 2011-04-01 БИСПЕЦИФИЧЕСКОЕ ОДНОЦЕПОЧЕЧНОЕ АНТИТЕЛО К PSMAxCD3 С МЕЖВИДОВОЙ СПЕЦИФИЧНОСТЬЮ RU2617942C2 (ru)

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US32005210P 2010-04-01 2010-04-01
US61/320,052 2010-04-01
PCT/EP2011/055104 WO2011121110A1 (en) 2010-04-01 2011-04-01 CROSS-SPECIES-SPECIFIC PSMAxCD3 BISPECIFIC SINGLE CHAIN ANTIBODY

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RU2012143519A RU2012143519A (ru) 2014-05-10
RU2617942C2 true RU2617942C2 (ru) 2017-04-28

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KR (1) KR101799922B1 (enExample)
CN (2) CN107090044A (enExample)
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AU (1) AU2011234443B2 (enExample)
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CA (1) CA2793139C (enExample)
IL (1) IL222197A0 (enExample)
MX (1) MX348360B (enExample)
NZ (1) NZ602209A (enExample)
RU (1) RU2617942C2 (enExample)
SG (1) SG183937A1 (enExample)
TW (1) TWI653333B (enExample)
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