RU2615509C2 - Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота - Google Patents

Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота Download PDF

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RU2615509C2
RU2615509C2 RU2014123567A RU2014123567A RU2615509C2 RU 2615509 C2 RU2615509 C2 RU 2615509C2 RU 2014123567 A RU2014123567 A RU 2014123567A RU 2014123567 A RU2014123567 A RU 2014123567A RU 2615509 C2 RU2615509 C2 RU 2615509C2
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Russia
Prior art keywords
crystals
temperature
dihydroquinoline
fluoroethyl
oxo
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RU2014123567A
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English (en)
Russian (ru)
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RU2014123567A (ru
Inventor
Итиро АРАЯ
Акинори ГОТО
Ватару МИНАГАВА
Кеико ФУНАДА
Мунеки НАГАО
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Керин Фармасьютикал Ко., Лтд.
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Application filed by Керин Фармасьютикал Ко., Лтд. filed Critical Керин Фармасьютикал Ко., Лтд.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2014123567A 2011-11-10 2012-11-09 Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота RU2615509C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011246209 2011-11-10
JP2011-246209 2011-11-10
JP2012-071739 2012-03-27
JP2012071739 2012-03-27
PCT/JP2012/007195 WO2013069297A1 (ja) 2011-11-10 2012-11-09 ７－｛（３s、４s）－３－［（シクロプロピルアミノ)メチル］－４－フルオロピロリジン－1－イル｝－６－フルオロ－１－（２－フルオロエチル）－８－メトキシ－４－オキソ－１、４－ジヒドロキノリン－３－カルボン酸の結晶

Related Child Applications (1)

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RU2017109814A Division RU2017109814A (ru) 2011-11-10 2012-11-09 Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота

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RU2014123567A RU2014123567A (ru) 2015-12-20
RU2615509C2 true RU2615509C2 (ru) 2017-04-05

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RU2014123567A RU2615509C2 (ru) 2011-11-10 2012-11-09 Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота
RU2017109814A RU2017109814A (ru) 2011-11-10 2012-11-09 Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота

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RU2017109814A RU2017109814A (ru) 2011-11-10 2012-11-09 Кристаллическая 7-{ (3s,4s)-3-[(циклопропиламино)метил]-4-фторпирролидин-1-ил} -6-фтор-1-(2-фторэтил)-8-метокси-4-оксо-1,4-дигидрохинолин-3-карбоновая кислота

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US (3) US9090587B2 (enExample)
EP (2) EP3112359B1 (enExample)
JP (4) JP5871948B2 (enExample)
KR (2) KR102162208B1 (enExample)
CN (2) CN104945375B (enExample)
AU (1) AU2016273899B2 (enExample)
BR (1) BR112014010765B1 (enExample)
CA (1) CA2855022C (enExample)
ES (2) ES2621664T3 (enExample)
IN (1) IN2014DN03277A (enExample)
MX (1) MX375073B (enExample)
NZ (1) NZ623808A (enExample)
RU (2) RU2615509C2 (enExample)
SA (1) SA112330992B1 (enExample)
SG (2) SG10201608167UA (enExample)
TW (1) TWI547492B (enExample)
WO (1) WO2013069297A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12594418B2 (en) 2011-03-10 2026-04-07 Electrocore, Inc. Devices and methods for nerve stimulation
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
CN105338982B (zh) 2013-04-25 2017-10-10 杏林制药株式会社 固体药用组合物
JP6349306B2 (ja) * 2013-04-25 2018-06-27 杏林製薬株式会社 錠剤
US9687453B2 (en) 2013-04-25 2017-06-27 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
JP6018334B2 (ja) * 2014-10-23 2016-11-02 杏林製薬株式会社 固形医薬組成物
EP3210608A4 (en) * 2014-10-23 2018-06-20 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
MX380385B (es) 2015-03-13 2025-03-12 Kyorin Seiyaku Kk Agente para el tratamiento de infeccion respiratoria.
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
JP6031217B1 (ja) 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
WO2016195014A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
MY200429A (en) 2017-06-16 2023-12-26 Kyorin Seiyaku Kk Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess
CA3067188A1 (en) 2017-06-16 2018-12-20 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130932C1 (ru) * 1993-08-27 1999-05-27 Хокурику Сеяку Ко., ЛТД Производные 5-амино-8-метил-7-пирролидинилхинолин-3-карбоновой кислоты, способы их получения, фармацевтическая композиция, способ лечения, промежуточный продукт
EP1666477A1 (en) * 2003-09-10 2006-06-07 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) q uinolonecarboxylic acid derivative

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1158846A (zh) * 1995-05-09 1997-09-10 昆山市康壮达兽药厂 盐酸氟哌酸的合成工艺
WO2003014732A1 (en) 2001-08-10 2003-02-20 Symyx Technologies, Inc. Apparatuses and methods for creating and testing pre-formulations and systems for same
AU2002236267A1 (en) * 2002-03-08 2003-09-22 Daiichi Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivative
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2130932C1 (ru) * 1993-08-27 1999-05-27 Хокурику Сеяку Ко., ЛТД Производные 5-амино-8-метил-7-пирролидинилхинолин-3-карбоновой кислоты, способы их получения, фармацевтическая композиция, способ лечения, промежуточный продукт
EP1666477A1 (en) * 2003-09-10 2006-06-07 Kyorin Pharmaceutical Co., Ltd. 7-(4-substituted 3- cyclopropylaminomethyl-1- pyrrolidinyl) q uinolonecarboxylic acid derivative

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MX375073B (es) 2025-03-06
CN104945375B (zh) 2017-07-04
BR112014010765B1 (pt) 2020-07-14
BR112014010765A2 (pt) 2017-06-13
AU2012337206B2 (en) 2016-09-15
EP3112359A1 (en) 2017-01-04
EP2778159A4 (en) 2015-06-03
JP6514069B2 (ja) 2019-05-15
CN104945375A (zh) 2015-09-30
ES2621664T3 (es) 2017-07-04
JP2016027045A (ja) 2016-02-18
US20150284361A1 (en) 2015-10-08
TWI547492B (zh) 2016-09-01
WO2013069297A1 (ja) 2013-05-16
KR102162208B1 (ko) 2020-10-06
AU2012337206A8 (en) 2016-09-22
CN103930414B (zh) 2016-01-20
CN103930414A (zh) 2014-07-16
US20140288310A1 (en) 2014-09-25
USRE47785E1 (en) 2019-12-31
RU2014123567A (ru) 2015-12-20
JP5871948B2 (ja) 2016-03-01
JP2018158949A (ja) 2018-10-11
JPWO2013069297A1 (ja) 2015-04-02
CA2855022A1 (en) 2013-05-16
AU2012337206A1 (en) 2014-05-22
AU2016273899A1 (en) 2017-01-12
ES2747303T3 (es) 2020-03-10
KR20190065456A (ko) 2019-06-11
EP3112359B1 (en) 2019-08-21
RU2017109814A (ru) 2019-01-23
SG11201401817TA (en) 2014-08-28
AU2016273899B2 (en) 2017-07-27
TW201332991A (zh) 2013-08-16
SA112330992B1 (ar) 2015-09-13
KR20140098074A (ko) 2014-08-07
US9090587B2 (en) 2015-07-28
JP2017160243A (ja) 2017-09-14
NZ623808A (en) 2015-07-31
RU2017109814A3 (enExample) 2020-04-08
IN2014DN03277A (enExample) 2015-05-22
US9328089B2 (en) 2016-05-03
CA2855022C (en) 2019-05-07
EP2778159A1 (en) 2014-09-17
SG10201608167UA (en) 2016-11-29
JP6818719B2 (ja) 2021-01-20
JP6349435B2 (ja) 2018-06-27
EP2778159B1 (en) 2017-03-01

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