CA2855022C - 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal - Google Patents

7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal Download PDF

Info

Publication number
CA2855022C
CA2855022C CA2855022A CA2855022A CA2855022C CA 2855022 C CA2855022 C CA 2855022C CA 2855022 A CA2855022 A CA 2855022A CA 2855022 A CA2855022 A CA 2855022A CA 2855022 C CA2855022 C CA 2855022C
Authority
CA
Canada
Prior art keywords
crystals
hydrochloride salt
methoxy
oxo
fluoroethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2855022A
Other languages
English (en)
French (fr)
Other versions
CA2855022A1 (en
Inventor
Ichiro Araya
Akinori Goto
Wataru Minagawa
Keiko Funada
Muneki Nagao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2855022(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of CA2855022A1 publication Critical patent/CA2855022A1/en
Application granted granted Critical
Publication of CA2855022C publication Critical patent/CA2855022C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2855022A 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal Expired - Fee Related CA2855022C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011246209 2011-11-10
JP2011-246209 2011-11-10
JP2012-071739 2012-03-27
JP2012071739 2012-03-27
PCT/JP2012/007195 WO2013069297A1 (ja) 2011-11-10 2012-11-09 ７－｛（３s、４s）－３－［（シクロプロピルアミノ)メチル］－４－フルオロピロリジン－1－イル｝－６－フルオロ－１－（２－フルオロエチル）－８－メトキシ－４－オキソ－１、４－ジヒドロキノリン－３－カルボン酸の結晶

Publications (2)

Publication Number Publication Date
CA2855022A1 CA2855022A1 (en) 2013-05-16
CA2855022C true CA2855022C (en) 2019-05-07

Family

ID=48289529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2855022A Expired - Fee Related CA2855022C (en) 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal

Country Status (17)

Country Link
US (3) US9090587B2 (enExample)
EP (2) EP3112359B1 (enExample)
JP (4) JP5871948B2 (enExample)
KR (2) KR102162208B1 (enExample)
CN (2) CN104945375B (enExample)
AU (1) AU2016273899B2 (enExample)
BR (1) BR112014010765B1 (enExample)
CA (1) CA2855022C (enExample)
ES (2) ES2621664T3 (enExample)
IN (1) IN2014DN03277A (enExample)
MX (1) MX375073B (enExample)
NZ (1) NZ623808A (enExample)
RU (2) RU2615509C2 (enExample)
SA (1) SA112330992B1 (enExample)
SG (2) SG10201608167UA (enExample)
TW (1) TWI547492B (enExample)
WO (1) WO2013069297A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12594418B2 (en) 2011-03-10 2026-04-07 Electrocore, Inc. Devices and methods for nerve stimulation
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
CN105338982B (zh) 2013-04-25 2017-10-10 杏林制药株式会社 固体药用组合物
JP6349306B2 (ja) * 2013-04-25 2018-06-27 杏林製薬株式会社 錠剤
US9687453B2 (en) 2013-04-25 2017-06-27 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
GB201402071D0 (en) * 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
JP6018334B2 (ja) * 2014-10-23 2016-11-02 杏林製薬株式会社 固形医薬組成物
EP3210608A4 (en) * 2014-10-23 2018-06-20 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
MX380385B (es) 2015-03-13 2025-03-12 Kyorin Seiyaku Kk Agente para el tratamiento de infeccion respiratoria.
WO2016195020A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
JP6031217B1 (ja) 2015-06-02 2016-11-24 杏林製薬株式会社 水性液剤
WO2016195014A1 (ja) * 2015-06-02 2016-12-08 杏林製薬株式会社 水性液剤
MY200429A (en) 2017-06-16 2023-12-26 Kyorin Seiyaku Kk Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess
CA3067188A1 (en) 2017-06-16 2018-12-20 Kyorin Pharmaceutical Co., Ltd. Therapeutic agent for aspiration pneumonia, lung suppuration, or lung abscess
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA944369B (en) * 1993-08-27 1995-02-13 Hokuriku Seuyaku Co Ltd 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
CN1158846A (zh) * 1995-05-09 1997-09-10 昆山市康壮达兽药厂 盐酸氟哌酸的合成工艺
WO2003014732A1 (en) 2001-08-10 2003-02-20 Symyx Technologies, Inc. Apparatuses and methods for creating and testing pre-formulations and systems for same
AU2002236267A1 (en) * 2002-03-08 2003-09-22 Daiichi Pharmaceutical Co., Ltd. Quinolonecarboxylic acid derivative
PL1666477T3 (pl) 2003-09-10 2013-11-29 Kyorin Seiyaku Kk Pochodna kwasu 7-(4-podstawionego-3-cyklopropyloaminometylo-1- pirolidynylo)chinolonokarboksylowego
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي

Also Published As

Publication number Publication date
MX375073B (es) 2025-03-06
CN104945375B (zh) 2017-07-04
BR112014010765B1 (pt) 2020-07-14
BR112014010765A2 (pt) 2017-06-13
AU2012337206B2 (en) 2016-09-15
EP3112359A1 (en) 2017-01-04
EP2778159A4 (en) 2015-06-03
JP6514069B2 (ja) 2019-05-15
CN104945375A (zh) 2015-09-30
ES2621664T3 (es) 2017-07-04
JP2016027045A (ja) 2016-02-18
US20150284361A1 (en) 2015-10-08
TWI547492B (zh) 2016-09-01
WO2013069297A1 (ja) 2013-05-16
KR102162208B1 (ko) 2020-10-06
AU2012337206A8 (en) 2016-09-22
CN103930414B (zh) 2016-01-20
RU2615509C2 (ru) 2017-04-05
CN103930414A (zh) 2014-07-16
US20140288310A1 (en) 2014-09-25
USRE47785E1 (en) 2019-12-31
RU2014123567A (ru) 2015-12-20
JP5871948B2 (ja) 2016-03-01
JP2018158949A (ja) 2018-10-11
JPWO2013069297A1 (ja) 2015-04-02
CA2855022A1 (en) 2013-05-16
AU2012337206A1 (en) 2014-05-22
AU2016273899A1 (en) 2017-01-12
ES2747303T3 (es) 2020-03-10
KR20190065456A (ko) 2019-06-11
EP3112359B1 (en) 2019-08-21
RU2017109814A (ru) 2019-01-23
SG11201401817TA (en) 2014-08-28
AU2016273899B2 (en) 2017-07-27
TW201332991A (zh) 2013-08-16
SA112330992B1 (ar) 2015-09-13
KR20140098074A (ko) 2014-08-07
US9090587B2 (en) 2015-07-28
JP2017160243A (ja) 2017-09-14
NZ623808A (en) 2015-07-31
RU2017109814A3 (enExample) 2020-04-08
IN2014DN03277A (enExample) 2015-05-22
US9328089B2 (en) 2016-05-03
EP2778159A1 (en) 2014-09-17
SG10201608167UA (en) 2016-11-29
JP6818719B2 (ja) 2021-01-20
JP6349435B2 (ja) 2018-06-27
EP2778159B1 (en) 2017-03-01

Similar Documents

Publication Publication Date Title
USRE47785E1 (en) 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal
CN114728899A (zh) 新型三苯基化合物盐
BR112020015509A2 (pt) macrociclos como moduladores de regulador da condutância transmembrana da fibrose cística, composições farmacêuticas dos mesmos, sua utilização no tratamento da fibrose cística, e processo para sua produção
AU2019295790A1 (en) Inhibiting creb binding protein (CBP)
KR20100103427A (ko) 아연 분말을 이용한 메로페넴의 개선된 제조방법
AU2017341999B2 (en) Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof
WO2011153221A1 (en) Solid state forms of ixabepilone
KR101763106B1 (ko) 보르테조밉(Bortezomib)의 신규한 결정형 및 그의 제조방법
AU2012337206B8 (en) 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal
ES2861062T3 (es) Procedimiento de purificación de un derivado de benzopirano, forma cristalina del mismo, y procedimiento de preparación de la forma cristalina
JP2025524904A (ja) ダプロデュスタットおよびその共結晶を調整するための方法
MX2014005007A (es) Cristal del acido 7-{(3s,4s)-3-[(ciclopropilamino)metil]-4-fluorop irrolidin-1-il}-6-fluoro-1-(fluoroetil)-8-metoxi-4-oxo-1,4-dihidr oquinolin-3-carboxilico.

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20170629

MKLA Lapsed

Effective date: 20211109