CA2855022C - 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal - Google Patents

7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal Download PDF

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Publication number
CA2855022C
CA2855022C CA2855022A CA2855022A CA2855022C CA 2855022 C CA2855022 C CA 2855022C CA 2855022 A CA2855022 A CA 2855022A CA 2855022 A CA2855022 A CA 2855022A CA 2855022 C CA2855022 C CA 2855022C
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CA
Canada
Prior art keywords
crystals
hydrochloride salt
methoxy
oxo
fluoroethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2855022A
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English (en)
French (fr)
Other versions
CA2855022A1 (en
Inventor
Ichiro Araya
Akinori Goto
Wataru Minagawa
Keiko Funada
Muneki Nagao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
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Kyorin Pharmaceutical Co Ltd
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48289529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2855022(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of CA2855022A1 publication Critical patent/CA2855022A1/en
Application granted granted Critical
Publication of CA2855022C publication Critical patent/CA2855022C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2855022A 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal Expired - Fee Related CA2855022C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2011246209 2011-11-10
JP2011-246209 2011-11-10
JP2012071739 2012-03-27
JP2012-071739 2012-03-27
PCT/JP2012/007195 WO2013069297A1 (ja) 2011-11-10 2012-11-09 ７－｛（３s、４s）－３－［（シクロプロピルアミノ)メチル］－４－フルオロピロリジン－1－イル｝－６－フルオロ－１－（２－フルオロエチル）－８－メトキシ－４－オキソ－１、４－ジヒドロキノリン－３－カルボン酸の結晶

Publications (2)

Publication Number Publication Date
CA2855022A1 CA2855022A1 (en) 2013-05-16
CA2855022C true CA2855022C (en) 2019-05-07

Family

ID=48289529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2855022A Expired - Fee Related CA2855022C (en) 2011-11-10 2012-11-09 7-{(3s,4s)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid crystal

Country Status (17)

Country Link
US (3) US9090587B2 (enExample)
EP (2) EP2778159B1 (enExample)
JP (4) JP5871948B2 (enExample)
KR (2) KR102162208B1 (enExample)
CN (2) CN103930414B (enExample)
AU (1) AU2016273899B2 (enExample)
BR (1) BR112014010765B1 (enExample)
CA (1) CA2855022C (enExample)
ES (2) ES2747303T3 (enExample)
IN (1) IN2014DN03277A (enExample)
MX (1) MX375073B (enExample)
NZ (1) NZ623808A (enExample)
RU (2) RU2615509C2 (enExample)
SA (1) SA112330992B1 (enExample)
SG (2) SG11201401817TA (enExample)
TW (1) TWI547492B (enExample)
WO (1) WO2013069297A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي
JP5651812B1 (ja) * 2013-04-25 2015-01-14 杏林製薬株式会社 固形医薬組成物
JP5700740B1 (ja) * 2013-04-25 2015-04-15 杏林製薬株式会社 固形医薬組成物
JP6349306B2 (ja) * 2013-04-25 2018-06-27 杏林製薬株式会社 錠剤
GB201402071D0 (en) 2014-02-07 2014-03-26 Galapagos Nv Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
US20170246160A1 (en) * 2014-10-23 2017-08-31 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
JP6018334B2 (ja) * 2014-10-23 2016-11-02 杏林製薬株式会社 固形医薬組成物
JP6077725B1 (ja) * 2015-03-13 2017-02-08 杏林製薬株式会社 呼吸器感染症治療剤
CA2988092A1 (en) 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous liquid formulation
CA2987879A1 (en) 2015-06-02 2016-12-08 Kyorin Pharmaceutical Co., Ltd. Aqueous drug
US10206917B2 (en) * 2015-06-02 2019-02-19 Kyorin Pharmaceutical Co., Ltd. Aqueous drug
MX2019014931A (es) 2017-06-16 2020-02-13 Kyorin Seiyaku Kk Agente terapeutico para neumonia por aspiracion, supuracion pulmonar, o absceso pulmonar.
CN116549446A (zh) * 2017-06-16 2023-08-08 杏林制药株式会社 吸入性肺炎、肺化脓或肺脓肿的治疗剂
GB201808575D0 (en) 2018-05-24 2018-07-11 Galapagos Nv Methods for the treatment of psoriatic arthrits

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA944369B (en) * 1993-08-27 1995-02-13 Hokuriku Seuyaku Co Ltd 5-amino-8-methyl-7-pyrrolidinylquinoline-3-carboxylic acid derivative
CN1158846A (zh) * 1995-05-09 1997-09-10 昆山市康壮达兽药厂 盐酸氟哌酸的合成工艺
US20030124028A1 (en) * 2001-08-10 2003-07-03 Carlson Eric D. Apparatuses and methods for creating and testing pre-formulations and systems for same
JPWO2003076428A1 (ja) * 2002-03-08 2005-07-07 第一製薬株式会社 キノロンカルボン酸誘導体
DK1666477T3 (da) 2003-09-10 2013-07-29 Kyorin Seiyaku Kk 7-(4-trisubstitueret 3-cyclopropylaminomethyl-1- pyrrolidinyl)-quinoloncarboxylsyre-derivat
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
SA112330992B1 (ar) * 2011-11-10 2015-09-13 كيورين فارماسوتيكال كو.، ليمتد صورة متبلرة من 7-{(s4، s3)-3-[(سيكلو بروبيل أمينو) ميثيل]-4-فلورو بيروليدين-1-يل}-6-فلورو-1-(2-فلورو إيثيل)- 8-ميثوكسي-4-أوكسو-1، 4-داي هيدرو كينولين-3- حمض كربوكسيلي

Also Published As

Publication number Publication date
NZ623808A (en) 2015-07-31
RU2615509C2 (ru) 2017-04-05
JP2018158949A (ja) 2018-10-11
CA2855022A1 (en) 2013-05-16
JP5871948B2 (ja) 2016-03-01
AU2016273899B2 (en) 2017-07-27
ES2747303T3 (es) 2020-03-10
US9328089B2 (en) 2016-05-03
JP6349435B2 (ja) 2018-06-27
AU2012337206A8 (en) 2016-09-22
AU2016273899A1 (en) 2017-01-12
RU2017109814A (ru) 2019-01-23
KR20190065456A (ko) 2019-06-11
RU2014123567A (ru) 2015-12-20
BR112014010765B1 (pt) 2020-07-14
TWI547492B (zh) 2016-09-01
EP3112359B1 (en) 2019-08-21
EP2778159B1 (en) 2017-03-01
US20150284361A1 (en) 2015-10-08
ES2621664T3 (es) 2017-07-04
USRE47785E1 (en) 2019-12-31
CN103930414B (zh) 2016-01-20
AU2012337206A1 (en) 2014-05-22
CN104945375B (zh) 2017-07-04
CN103930414A (zh) 2014-07-16
EP2778159A1 (en) 2014-09-17
AU2012337206B2 (en) 2016-09-15
TW201332991A (zh) 2013-08-16
US9090587B2 (en) 2015-07-28
EP3112359A1 (en) 2017-01-04
BR112014010765A2 (pt) 2017-06-13
JP6514069B2 (ja) 2019-05-15
CN104945375A (zh) 2015-09-30
JP2017160243A (ja) 2017-09-14
WO2013069297A1 (ja) 2013-05-16
SG10201608167UA (en) 2016-11-29
EP2778159A4 (en) 2015-06-03
SG11201401817TA (en) 2014-08-28
SA112330992B1 (ar) 2015-09-13
KR102162208B1 (ko) 2020-10-06
KR20140098074A (ko) 2014-08-07
JP6818719B2 (ja) 2021-01-20
JPWO2013069297A1 (ja) 2015-04-02
IN2014DN03277A (enExample) 2015-05-22
US20140288310A1 (en) 2014-09-25
JP2016027045A (ja) 2016-02-18
RU2017109814A3 (enExample) 2020-04-08
MX375073B (es) 2025-03-06

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