RU2582392C2 - Композиции и способы для нехирургического лечения птоза - Google Patents
Композиции и способы для нехирургического лечения птоза Download PDFInfo
- Publication number
- RU2582392C2 RU2582392C2 RU2013142602/15A RU2013142602A RU2582392C2 RU 2582392 C2 RU2582392 C2 RU 2582392C2 RU 2013142602/15 A RU2013142602/15 A RU 2013142602/15A RU 2013142602 A RU2013142602 A RU 2013142602A RU 2582392 C2 RU2582392 C2 RU 2582392C2
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- Russia
- Prior art keywords
- oxymetazoline
- eye
- phenylephrine
- subject
- pharmaceutical composition
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- B65D47/00—Closures with filling and discharging, or with discharging, devices
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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| US13/218,584 | 2011-08-26 | ||
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| PCT/US2012/026496 WO2012118704A1 (en) | 2011-03-03 | 2012-02-24 | Compositions and methods for non-surgical treatment of ptosis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| MX357635B (es) | 2011-09-20 | 2018-07-17 | Allergan Inc | Composiciones y metodos para el tratamiento de presbicia, hipermetropia leve, y astigmatismo irregular. |
| BR112015027984A2 (pt) * | 2013-05-06 | 2017-09-05 | Allergan Inc | Agonistas alfa adrenérgicos para o tratamento de lesão de tecido |
| CA2869060A1 (en) * | 2014-07-28 | 2016-01-28 | Queen's University At Kingston | Dosage forms and methods for diagnosing sympathetic nervous system dysfunction |
| US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
| WO2017132410A1 (en) * | 2016-01-26 | 2017-08-03 | Frank Litvack | Compositions and uses of alpha-adrenergic agents |
| CN106726115B (zh) * | 2016-12-22 | 2023-01-20 | 上海交通大学医学院附属第九人民医院 | 一种眼睑功能矫正器 |
| CN106938039A (zh) * | 2017-03-29 | 2017-07-11 | 卢仁华 | 眼睑下垂的治疗药物 |
| WO2019204401A1 (en) * | 2018-04-19 | 2019-10-24 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| CN108635434A (zh) * | 2018-06-24 | 2018-10-12 | 吴安相 | 一种治疗眼睑下垂的侗族中药配方 |
| AU2019390704A1 (en) * | 2018-11-26 | 2021-06-03 | Cellix Bio Private Limited | Ophthalmic compositions and methods for the treatment of skin diseases and eye diseases |
| US10814001B1 (en) * | 2019-05-06 | 2020-10-27 | Rvl Pharmaceuticals, Inc. | Oxymetazoline compositions |
| US20230218726A1 (en) * | 2020-04-23 | 2023-07-13 | Okogen, Inc. | Treatment of viral conjunctivitis |
| WO2022187306A1 (en) | 2021-03-03 | 2022-09-09 | Voom, Llc | Compositions and methods for treatment of blepharitis |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066675A (en) * | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
| WO2002026223A2 (en) * | 2000-09-29 | 2002-04-04 | Board Of Trustees Operating Michigan State University | Catecholamine pharmaceutical compositions and methods |
| RU2232154C2 (ru) * | 1999-06-10 | 2004-07-10 | Оллерган Инк. | Замещенные производные имидазола, способ введения фармацевтической композиции и способ лечения на основе этих соединений |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1117588B (de) | 1960-09-30 | 1961-11-23 | Merck Ag E | Verfahren zur Herstellung eines neuen Imidazolinderivates |
| US3670087A (en) * | 1970-10-16 | 1972-06-13 | Miles Lab | Method of lowering intraocular pressure |
| IE51421B1 (en) * | 1980-08-01 | 1986-12-24 | Smith & Nephew Ass | Ophthalmic compositions containing triamterene |
| US4407791A (en) | 1981-09-28 | 1983-10-04 | Alcon Laboratories, Inc. | Ophthalmic solutions |
| DE3227741A1 (de) | 1982-07-24 | 1984-01-26 | Hoechst Ag, 6230 Frankfurt | 1-phenyl-isochinolinderivate und verfahren zu ihrer herstellung |
| FR2549015B1 (fr) * | 1983-07-13 | 1986-06-13 | Oreal | Ensemble compte-gouttes |
| US5459133A (en) * | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| AU7081598A (en) * | 1997-04-24 | 1998-11-13 | Taisho Pharmaceutical Co., Ltd. | Eye drops |
| EP0903151A1 (en) * | 1997-09-22 | 1999-03-24 | ASTA Medica Aktiengesellschaft | Use of combinations comprising non-sedating antihistamines and alpha-adrenergic drugs for the topical treatment of rhinitis/conjunctivitis and cold, cold-like and/or flu symptoms |
| US5885550A (en) * | 1998-07-02 | 1999-03-23 | Vallier; Deandra K. | Ophthalmic whitening solution |
| US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
| US6572849B2 (en) * | 2000-09-20 | 2003-06-03 | Lee Shahinian, Jr. | Self-preserved antibacterial nasal, inhalable, and topical ophthalmic preparations and medications |
| US7780976B2 (en) * | 2002-05-30 | 2010-08-24 | Eye Care And Cure, Asia | Apparatus and method for delivering controlled quantities of one or more agents to the eye |
| JP2005533076A (ja) * | 2002-06-20 | 2005-11-04 | ノバルテイス・コンシユーマー・ヘルス・エス・アー | ムコ多糖及びプロピレングリコールを含む鼻用組成物 |
| US6806364B2 (en) | 2002-07-29 | 2004-10-19 | Ast Products, Inc. | Ophthalmic compositions |
| US20060177430A1 (en) * | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
| DE10337186A1 (de) * | 2003-08-13 | 2005-03-17 | Merck Patent Gmbh | Wässrige Wirkstoff-Lösung |
| US7812049B2 (en) | 2004-01-22 | 2010-10-12 | Vicept Therapeutics, Inc. | Method and therapeutic/cosmetic topical compositions for the treatment of rosacea and skin erythema using α1-adrenoceptor agonists |
| US7022740B2 (en) | 2004-04-29 | 2006-04-04 | Leonard Mackles | Lubricious ophthalmic solutions |
| US7618615B2 (en) * | 2004-08-13 | 2009-11-17 | Healthpartners Research Foundation | Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia |
| JP4942328B2 (ja) * | 2004-11-01 | 2012-05-30 | ロート製薬株式会社 | ビタミンｂ６類含有水性組成物 |
| US8758816B2 (en) | 2004-11-24 | 2014-06-24 | Meda Pharmaceuticals Inc. | Compositions comprising azelastine and methods of use thereof |
| JP4956981B2 (ja) * | 2005-01-05 | 2012-06-20 | 大正製薬株式会社 | オキシメタゾリン含有水性組成物 |
| KR101454674B1 (ko) | 2006-03-17 | 2014-10-27 | 존슨 앤드 존슨 비젼 케어, 인코포레이티드 | 산화에 불안정한 성분을 포함하는 안정화된 안과용 조성물 |
| JP2009535342A (ja) * | 2006-04-26 | 2009-10-01 | アーシエックス， インコーポレイテッド | 眼瞼腫脹の予防および処置のための組成物 |
| WO2008070185A2 (en) | 2006-12-06 | 2008-06-12 | The Trustees Of Columbia University In The City Of New York | Method of stabilizing human eye tissue by reaction with nitrite and related agents such as nitro compounds |
| AU2008325214A1 (en) * | 2007-11-08 | 2009-05-14 | Aciex Therapeutics, Inc. | Compositions for the treatment and prevention of eyelid swelling comprising an osmotically active ingredient and a vasoconstrictor |
| CA2755679C (en) * | 2009-03-17 | 2017-09-12 | Aciex Therapeutics, Inc. | Ophthalmic formulations of cetirizine and methods of use |
| MX2011013060A (es) | 2009-06-05 | 2012-02-28 | Aciex Therapeutics Inc | Formulaciones oftalmicas, metodos de preparacion y metodos para utilizarlas. |
| WO2012017077A1 (en) | 2010-08-06 | 2012-02-09 | Galderma Research & Development | Combination of compounds for treating or preventing skin diseases |
| JP6030067B2 (ja) | 2010-12-03 | 2016-11-24 | アラーガン、インコーポレイテッドＡｌｌｅｒｇａｎ，Ｉｎｃｏｒｐｏｒａｔｅｄ | 薬学的クリーム組成物および使用法 |
| BR112013020770A2 (pt) * | 2011-02-15 | 2019-08-27 | Allergan, Inc. | composições de creme farmacêutico de oximetazolina para tratamento de sintomas de rosácea |
| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| AU2013266067B2 (en) | 2012-05-25 | 2016-10-06 | Xlear, Inc. | Xylitol-based anti-mucosal compositions and related methods and compositions |
| UA119324C2 (uk) | 2013-04-02 | 2019-06-10 | Теміс Медікер Лімітед | Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні |
| MX379253B (es) | 2014-06-11 | 2025-03-11 | Epi Health Llc | Formulaciones de oximetazolina estabilizadas y sus usos. |
| HK1248570A1 (zh) | 2015-05-29 | 2018-10-19 | 西德奈克西斯公司 | D2o稳定化的药物制剂 |
| US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
| WO2017132410A1 (en) | 2016-01-26 | 2017-08-03 | Frank Litvack | Compositions and uses of alpha-adrenergic agents |
| US10814001B1 (en) * | 2019-05-06 | 2020-10-27 | Rvl Pharmaceuticals, Inc. | Oxymetazoline compositions |
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2011
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- 2011-10-11 US US13/270,577 patent/US8357714B2/en active Active
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2012
- 2012-02-24 HR HRP20192266TT patent/HRP20192266T1/hr unknown
- 2012-02-24 AU AU2012223615A patent/AU2012223615B2/en active Active
- 2012-02-24 PT PT127094217T patent/PT2680829T/pt unknown
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- 2012-02-24 BR BR112013022094A patent/BR112013022094A2/pt not_active Application Discontinuation
- 2012-02-24 CA CA2827285A patent/CA2827285C/en active Active
- 2012-02-24 RU RU2013142602/15A patent/RU2582392C2/ru active
- 2012-02-24 HU HUE12709421A patent/HUE046740T2/hu unknown
- 2012-02-24 EP EP19199263.5A patent/EP3653205A3/en active Pending
- 2012-02-24 SI SI201231705T patent/SI2680829T1/sl unknown
- 2012-02-24 WO PCT/US2012/026496 patent/WO2012118704A1/en not_active Ceased
- 2012-02-24 ES ES12709421T patent/ES2750123T3/es active Active
- 2012-02-24 EP EP12709421.7A patent/EP2680829B1/en active Active
- 2012-02-24 RS RS20191580A patent/RS59636B1/sr unknown
- 2012-02-24 SM SM20190718T patent/SMT201900718T1/it unknown
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- 2012-02-24 LT LTEP12709421.7T patent/LT2680829T/lt unknown
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2019
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2020
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2022
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6066675A (en) * | 1996-09-13 | 2000-05-23 | The Regents Of The University Of California | Method for treatment of retinal diseases |
| RU2232154C2 (ru) * | 1999-06-10 | 2004-07-10 | Оллерган Инк. | Замещенные производные имидазола, способ введения фармацевтической композиции и способ лечения на основе этих соединений |
| WO2002026223A2 (en) * | 2000-09-29 | 2002-04-04 | Board Of Trustees Operating Michigan State University | Catecholamine pharmaceutical compositions and methods |
Non-Patent Citations (1)
| Title |
|---|
| Yazici B et. all "Use of 0.5% apraclonidine solution in evaluation of blepharoptosis", Ophthal Plast Reconstr Surg. 2008 Jul-Aug;24(4):299-301, реферат. * |
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