RU2580294C2 - Применение расар в качестве молекулярного адъюванта для вакцин - Google Patents
Применение расар в качестве молекулярного адъюванта для вакцин Download PDFInfo
- Publication number
- RU2580294C2 RU2580294C2 RU2014111465/15A RU2014111465A RU2580294C2 RU 2580294 C2 RU2580294 C2 RU 2580294C2 RU 2014111465/15 A RU2014111465/15 A RU 2014111465/15A RU 2014111465 A RU2014111465 A RU 2014111465A RU 2580294 C2 RU2580294 C2 RU 2580294C2
- Authority
- RU
- Russia
- Prior art keywords
- pacap
- fish
- vaccine
- group
- peptide
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 55
- 239000002671 adjuvant Substances 0.000 title claims abstract description 31
- 101150060255 MZB1 gene Proteins 0.000 title 1
- 101100462550 Mus musculus Adcyap1 gene Proteins 0.000 title 1
- 241000251468 Actinopterygii Species 0.000 claims abstract description 78
- 239000000427 antigen Substances 0.000 claims abstract description 37
- 108091007433 antigens Proteins 0.000 claims abstract description 37
- 102000036639 antigens Human genes 0.000 claims abstract description 37
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 32
- 239000000203 mixture Substances 0.000 claims abstract description 19
- 230000028993 immune response Effects 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 15
- 241000700605 Viruses Species 0.000 claims abstract description 14
- 239000012678 infectious agent Substances 0.000 claims abstract description 11
- 230000003213 activating effect Effects 0.000 claims abstract description 10
- 230000001817 pituitary effect Effects 0.000 claims abstract description 10
- 108060000200 adenylate cyclase Proteins 0.000 claims abstract description 9
- 241000894006 Bacteria Species 0.000 claims abstract description 8
- 102000030621 adenylate cyclase Human genes 0.000 claims abstract description 8
- 230000001965 increasing effect Effects 0.000 claims abstract description 6
- 244000078703 ectoparasite Species 0.000 claims abstract description 4
- 230000006806 disease prevention Effects 0.000 claims abstract 5
- 238000002649 immunization Methods 0.000 claims description 24
- 230000003053 immunization Effects 0.000 claims description 21
- 238000007654 immersion Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000002299 complementary DNA Substances 0.000 claims description 8
- 239000007924 injection Substances 0.000 claims description 8
- 238000002347 injection Methods 0.000 claims description 8
- 238000003786 synthesis reaction Methods 0.000 claims description 7
- 108020004511 Recombinant DNA Proteins 0.000 claims description 6
- 230000037396 body weight Effects 0.000 claims description 6
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000002955 isolation Methods 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 20
- 208000015181 infectious disease Diseases 0.000 abstract description 18
- 230000002458 infectious effect Effects 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000002808 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 description 20
- 108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 description 20
- 239000002953 phosphate buffered saline Substances 0.000 description 19
- 108090000623 proteins and genes Proteins 0.000 description 19
- 108010058846 Ovalbumin Proteins 0.000 description 17
- 210000000265 leukocyte Anatomy 0.000 description 17
- 229940092253 ovalbumin Drugs 0.000 description 17
- 210000004027 cell Anatomy 0.000 description 16
- 230000014509 gene expression Effects 0.000 description 16
- 108010041986 DNA Vaccines Proteins 0.000 description 13
- 229940021995 DNA vaccine Drugs 0.000 description 13
- 241000277275 Oncorhynchus mykiss Species 0.000 description 13
- 102000005962 receptors Human genes 0.000 description 12
- 108020003175 receptors Proteins 0.000 description 12
- 241000607528 Aeromonas hydrophila Species 0.000 description 11
- 230000024932 T cell mediated immunity Effects 0.000 description 11
- 102000004127 Cytokines Human genes 0.000 description 10
- 108090000695 Cytokines Proteins 0.000 description 10
- 238000002474 experimental method Methods 0.000 description 10
- 241000252233 Cyprinus carpio Species 0.000 description 9
- 102000003812 Interleukin-15 Human genes 0.000 description 9
- 108090000172 Interleukin-15 Proteins 0.000 description 9
- 210000003734 kidney Anatomy 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 241000721191 Clarias gariepinus Species 0.000 description 8
- 101710154606 Hemagglutinin Proteins 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 8
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 8
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 8
- 101710176177 Protein A56 Proteins 0.000 description 8
- 238000011260 co-administration Methods 0.000 description 8
- 239000000185 hemagglutinin Substances 0.000 description 8
- 239000013642 negative control Substances 0.000 description 8
- 244000045947 parasite Species 0.000 description 8
- 210000005259 peripheral blood Anatomy 0.000 description 8
- 239000011886 peripheral blood Substances 0.000 description 8
- 238000003753 real-time PCR Methods 0.000 description 8
- 230000004083 survival effect Effects 0.000 description 8
- 238000002255 vaccination Methods 0.000 description 8
- 241000248482 Ichthyophthirius multifiliis Species 0.000 description 7
- 241000711825 Viral hemorrhagic septicemia virus Species 0.000 description 7
- 238000013518 transcription Methods 0.000 description 7
- 230000035897 transcription Effects 0.000 description 7
- 208000023275 Autoimmune disease Diseases 0.000 description 6
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- 241000710921 Infectious pancreatic necrosis virus Species 0.000 description 6
- 241000282887 Suidae Species 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000013612 plasmid Substances 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 230000004936 stimulating effect Effects 0.000 description 6
- 230000003612 virological effect Effects 0.000 description 6
- 108020004414 DNA Proteins 0.000 description 5
- 241000287828 Gallus gallus Species 0.000 description 5
- 102100037850 Interferon gamma Human genes 0.000 description 5
- 108010074328 Interferon-gamma Proteins 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 5
- 230000033228 biological regulation Effects 0.000 description 5
- 235000013330 chicken meat Nutrition 0.000 description 5
- 230000028996 humoral immune response Effects 0.000 description 5
- 210000000987 immune system Anatomy 0.000 description 5
- 229940027941 immunoglobulin g Drugs 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 244000052769 pathogen Species 0.000 description 5
- 230000004044 response Effects 0.000 description 5
- 235000015170 shellfish Nutrition 0.000 description 5
- 102100037907 High mobility group protein B1 Human genes 0.000 description 4
- 102000004889 Interleukin-6 Human genes 0.000 description 4
- 108090001005 Interleukin-6 Proteins 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 4
- 108090000189 Neuropeptides Proteins 0.000 description 4
- 102000055135 Vasoactive Intestinal Peptide Human genes 0.000 description 4
- 108010003205 Vasoactive Intestinal Peptide Proteins 0.000 description 4
- 230000000240 adjuvant effect Effects 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 230000002708 enhancing effect Effects 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 4
- 230000005764 inhibitory process Effects 0.000 description 4
- 229940100601 interleukin-6 Drugs 0.000 description 4
- 239000007927 intramuscular injection Substances 0.000 description 4
- 238000010255 intramuscular injection Methods 0.000 description 4
- VBUWHHLIZKOSMS-RIWXPGAOSA-N invicorp Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=C(O)C=C1 VBUWHHLIZKOSMS-RIWXPGAOSA-N 0.000 description 4
- 210000004698 lymphocyte Anatomy 0.000 description 4
- 108020004707 nucleic acids Proteins 0.000 description 4
- 102000039446 nucleic acids Human genes 0.000 description 4
- 150000007523 nucleic acids Chemical class 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 101100339431 Arabidopsis thaliana HMGB2 gene Proteins 0.000 description 3
- 241000271566 Aves Species 0.000 description 3
- 241001611004 Caligus rogercresseyi Species 0.000 description 3
- 102000003886 Glycoproteins Human genes 0.000 description 3
- 108090000288 Glycoproteins Proteins 0.000 description 3
- 108700010013 HMGB1 Proteins 0.000 description 3
- 101150021904 HMGB1 gene Proteins 0.000 description 3
- 241000252498 Ictalurus punctatus Species 0.000 description 3
- 102000003797 Neuropeptides Human genes 0.000 description 3
- 241000277289 Salmo salar Species 0.000 description 3
- 230000004913 activation Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000001886 ciliary effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 3
- 230000013632 homeostatic process Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 239000007928 intraperitoneal injection Substances 0.000 description 3
- 210000002540 macrophage Anatomy 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 102000008482 12E7 Antigen Human genes 0.000 description 2
- 108010020567 12E7 Antigen Proteins 0.000 description 2
- 102000019034 Chemokines Human genes 0.000 description 2
- 108010012236 Chemokines Proteins 0.000 description 2
- 208000011231 Crohn disease Diseases 0.000 description 2
- 241000252210 Cyprinidae Species 0.000 description 2
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 2
- 102000003814 Interleukin-10 Human genes 0.000 description 2
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 102000002508 Peptide Elongation Factors Human genes 0.000 description 2
- 108010068204 Peptide Elongation Factors Proteins 0.000 description 2
- 108010076039 Polyproteins Proteins 0.000 description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
- 102100037505 Secretin Human genes 0.000 description 2
- 108010086019 Secretin Proteins 0.000 description 2
- 206010040070 Septic Shock Diseases 0.000 description 2
- 210000000447 Th1 cell Anatomy 0.000 description 2
- 230000004523 agglutinating effect Effects 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 206010064097 avian influenza Diseases 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 241001233037 catfish Species 0.000 description 2
- 230000024245 cell differentiation Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000000139 costimulatory effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000010195 expression analysis Methods 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 229940076144 interleukin-10 Drugs 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 239000002858 neurotransmitter agent Substances 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000000902 placebo Substances 0.000 description 2
- 229940068196 placebo Drugs 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 206010039073 rheumatoid arthritis Diseases 0.000 description 2
- 229960002101 secretin Drugs 0.000 description 2
- OWMZNFCDEHGFEP-NFBCVYDUSA-N secretin human Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(N)=O)[C@@H](C)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)C1=CC=CC=C1 OWMZNFCDEHGFEP-NFBCVYDUSA-N 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 230000036303 septic shock Effects 0.000 description 2
- 230000000638 stimulation Effects 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- XULKGRJEOPRYTO-UHFFFAOYSA-N vip-pacap Chemical compound C=1C=C(O)C=CC=1CC(C(=O)NC(CC(C)C)C(=O)NC(C)C(=O)NC(C)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CCSC)NC(=O)C(CCC(N)=O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(N)=N)NC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(NC(=O)C(CC=1C=CC=CC=1)NC(=O)C(NC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CO)NC(=O)C(N)CC=1N=CNC=1)C(C)C)C(C)O)CC1=CC=C(O)C=C1 XULKGRJEOPRYTO-UHFFFAOYSA-N 0.000 description 2
- LOGFVTREOLYCPF-KXNHARMFSA-N (2s,3r)-2-[[(2r)-1-[(2s)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CCCCN LOGFVTREOLYCPF-KXNHARMFSA-N 0.000 description 1
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- YQNRVGJCPCNMKT-LFVJCYFKSA-N 2-[(e)-[[2-(4-benzylpiperazin-1-ium-1-yl)acetyl]hydrazinylidene]methyl]-6-prop-2-enylphenolate Chemical compound [O-]C1=C(CC=C)C=CC=C1\C=N\NC(=O)C[NH+]1CCN(CC=2C=CC=CC=2)CC1 YQNRVGJCPCNMKT-LFVJCYFKSA-N 0.000 description 1
- 208000009663 Acute Necrotizing Pancreatitis Diseases 0.000 description 1
- 241000272525 Anas platyrhynchos Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 241000710777 Classical swine fever virus Species 0.000 description 1
- 241000239250 Copepoda Species 0.000 description 1
- 235000005956 Cosmos caudatus Nutrition 0.000 description 1
- 244000293323 Cosmos caudatus Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 1
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 1
- 102000051325 Glucagon Human genes 0.000 description 1
- 108060003199 Glucagon Proteins 0.000 description 1
- 101000838335 Homo sapiens Dual specificity protein phosphatase 2 Proteins 0.000 description 1
- 101001025337 Homo sapiens High mobility group protein B1 Proteins 0.000 description 1
- 101001080401 Homo sapiens Proteasome assembly chaperone 1 Proteins 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002979 Influenza in Birds Diseases 0.000 description 1
- 102100034343 Integrase Human genes 0.000 description 1
- 102000003777 Interleukin-1 beta Human genes 0.000 description 1
- 108090000193 Interleukin-1 beta Proteins 0.000 description 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical class CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 108010025020 Nerve Growth Factor Proteins 0.000 description 1
- 102000007072 Nerve Growth Factors Human genes 0.000 description 1
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical class O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 1
- 101710163270 Nuclease Proteins 0.000 description 1
- 229960005552 PAC-1 Drugs 0.000 description 1
- 206010058096 Pancreatic necrosis Diseases 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 108010077524 Peptide Elongation Factor 1 Proteins 0.000 description 1
- 102000014743 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Human genes 0.000 description 1
- 108010064032 Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Proteins 0.000 description 1
- 102100027583 Proteasome assembly chaperone 1 Human genes 0.000 description 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 1
- 238000010818 SYBR green PCR Master Mix Methods 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 108010046722 Thrombospondin 1 Proteins 0.000 description 1
- 102100036034 Thrombospondin-1 Human genes 0.000 description 1
- 102000005737 Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Human genes 0.000 description 1
- 108010045627 Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptors Proteins 0.000 description 1
- 101150024766 VP1 gene Proteins 0.000 description 1
- 101900220844 Viral hemorrhagic septicemia virus Spike glycoprotein Proteins 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 208000038016 acute inflammation Diseases 0.000 description 1
- 230000006022 acute inflammation Effects 0.000 description 1
- 230000033289 adaptive immune response Effects 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000005875 antibody response Effects 0.000 description 1
- 230000030741 antigen processing and presentation Effects 0.000 description 1
- 230000006851 antioxidant defense Effects 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- 238000010804 cDNA synthesis Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000037976 chronic inflammation Diseases 0.000 description 1
- 230000006020 chronic inflammation Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 210000004443 dendritic cell Anatomy 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
- 229960004666 glucagon Drugs 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 231100000086 high toxicity Toxicity 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000028709 inflammatory response Effects 0.000 description 1
- 230000015788 innate immune response Effects 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 210000005210 lymphoid organ Anatomy 0.000 description 1
- 230000001589 lymphoproliferative effect Effects 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000003900 neurotrophic factor Substances 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- UFTCZKMBJOPXDM-XXFCQBPRSA-N pituitary adenylate cyclase-activating polypeptide Chemical compound C([C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(N)=O)C1=CN=CN1 UFTCZKMBJOPXDM-XXFCQBPRSA-N 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000000770 proinflammatory effect Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000019491 signal transduction Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 239000012646 vaccine adjuvant Substances 0.000 description 1
- 229940124931 vaccine adjuvant Drugs 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0003—Invertebrate antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/002—Protozoa antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/0208—Specific bacteria not otherwise provided for
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/205—Rhabdoviridae, e.g. rabies virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/04—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
- A61K2039/552—Veterinary vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
- C12N2720/00011—Details
- C12N2720/10011—Birnaviridae
- C12N2720/10034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/20011—Rhabdoviridae
- C12N2760/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24311—Pestivirus, e.g. bovine viral diarrhea virus
- C12N2770/24334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Tropical Medicine & Parasitology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2011-0167 | 2011-08-26 | ||
| CU2011000167A CU24075B1 (es) | 2011-08-26 | 2011-08-26 | Composición vacunal que comprende el péptido activador de la adenilato ciclasa de pituitaria como adyuvante molecular. |
| PCT/CU2012/000004 WO2013029570A1 (es) | 2011-08-26 | 2012-08-24 | Uso del pacap como adyuvante molecular para vacunas |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014111465A RU2014111465A (ru) | 2015-10-10 |
| RU2580294C2 true RU2580294C2 (ru) | 2016-04-10 |
Family
ID=47046313
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014111465/15A RU2580294C2 (ru) | 2011-08-26 | 2012-08-24 | Применение расар в качестве молекулярного адъюванта для вакцин |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9549977B2 (enExample) |
| EP (1) | EP2749291B1 (enExample) |
| JP (1) | JP6077541B2 (enExample) |
| KR (1) | KR101857705B1 (enExample) |
| CN (1) | CN103874510A (enExample) |
| AU (1) | AU2012303887B2 (enExample) |
| BR (1) | BR112014004620B1 (enExample) |
| CA (1) | CA2844898C (enExample) |
| CL (1) | CL2014000386A1 (enExample) |
| CU (1) | CU24075B1 (enExample) |
| ES (1) | ES2648337T3 (enExample) |
| MX (1) | MX351725B (enExample) |
| MY (1) | MY191697A (enExample) |
| NO (1) | NO2749291T3 (enExample) |
| PH (1) | PH12014500397B1 (enExample) |
| PT (1) | PT2749291T (enExample) |
| RU (1) | RU2580294C2 (enExample) |
| SG (1) | SG11201400215SA (enExample) |
| WO (1) | WO2013029570A1 (enExample) |
| ZA (1) | ZA201401271B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190060057A (ko) | 2017-11-24 | 2019-06-03 | 유병희 | 웰빙 무드등 |
| WO2020230869A1 (ja) * | 2019-05-14 | 2020-11-19 | 千寿製薬株式会社 | Ｐａｃａｐペプチド又はｐａｃａｐの安定化ペプチドを含む神経栄養性角膜炎の予防又は治療用組成物 |
| CN117617183B (zh) * | 2023-11-29 | 2025-09-05 | 中国医学科学院医药生物技术研究所 | 突变体斑马鱼在制备凝血功能障碍疾病的动物模型中的应用 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2269354C2 (ru) * | 1999-09-28 | 2006-02-10 | Байер Корпорейшн | Агонисты рецептора-3(r3) пептида-активатора гипофизарной аденилатциклазы(расар) и способы их фармакологического применения |
| EP1956031A1 (en) * | 2005-11-22 | 2008-08-13 | Centro De Ingenieria Genetica Y Biotecnologia (Cigb) | Neuropeptides for the culture of aquatic organisms |
| CN103255089A (zh) * | 2013-05-03 | 2013-08-21 | 中国水产科学研究院黄海水产研究所 | 一株强毒迟缓爱德华氏菌疫苗株及其应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE65568B1 (en) * | 1990-10-22 | 1995-11-01 | Unilever Plc | Vaccine compositions for fish |
| GB0427267D0 (en) * | 2004-12-13 | 2005-01-12 | Maria Teresa De Magistris | Peptide adjuvants |
| JP5908406B2 (ja) * | 2009-11-02 | 2016-04-26 | ジ アドミニストレーターズ オブ ザ トゥレーン エデュケーショナル ファンド | 下垂体アデニル酸シクラーゼ活性化ポリペプチド（ｐａｃａｐ）の類似体およびその使用方法 |
-
2011
- 2011-08-26 CU CU2011000167A patent/CU24075B1/es active IP Right Grant
-
2012
- 2012-08-24 CA CA2844898A patent/CA2844898C/en active Active
- 2012-08-24 BR BR112014004620-4A patent/BR112014004620B1/pt not_active IP Right Cessation
- 2012-08-24 PT PT127751238T patent/PT2749291T/pt unknown
- 2012-08-24 MY MYPI2014700419A patent/MY191697A/en unknown
- 2012-08-24 ES ES12775123.8T patent/ES2648337T3/es active Active
- 2012-08-24 KR KR1020147006186A patent/KR101857705B1/ko not_active Expired - Fee Related
- 2012-08-24 US US14/238,377 patent/US9549977B2/en active Active
- 2012-08-24 MX MX2014002214A patent/MX351725B/es active IP Right Grant
- 2012-08-24 CN CN201280041829.5A patent/CN103874510A/zh active Pending
- 2012-08-24 NO NO12775123A patent/NO2749291T3/no unknown
- 2012-08-24 RU RU2014111465/15A patent/RU2580294C2/ru active
- 2012-08-24 WO PCT/CU2012/000004 patent/WO2013029570A1/es not_active Ceased
- 2012-08-24 PH PH1/2014/500397A patent/PH12014500397B1/en unknown
- 2012-08-24 SG SG11201400215SA patent/SG11201400215SA/en unknown
- 2012-08-24 AU AU2012303887A patent/AU2012303887B2/en not_active Ceased
- 2012-08-24 EP EP12775123.8A patent/EP2749291B1/en active Active
- 2012-08-24 JP JP2014526385A patent/JP6077541B2/ja active Active
-
2014
- 2014-02-14 CL CL2014000386A patent/CL2014000386A1/es unknown
- 2014-02-19 ZA ZA2014/01271A patent/ZA201401271B/en unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2269354C2 (ru) * | 1999-09-28 | 2006-02-10 | Байер Корпорейшн | Агонисты рецептора-3(r3) пептида-активатора гипофизарной аденилатциклазы(расар) и способы их фармакологического применения |
| EP1956031A1 (en) * | 2005-11-22 | 2008-08-13 | Centro De Ingenieria Genetica Y Biotecnologia (Cigb) | Neuropeptides for the culture of aquatic organisms |
| CN103255089A (zh) * | 2013-05-03 | 2013-08-21 | 中国水产科学研究院黄海水产研究所 | 一株强毒迟缓爱德华氏菌疫苗株及其应用 |
Non-Patent Citations (1)
| Title |
|---|
| LUGO JM et al. Differential expression pattern of pituitary adenylate cyclase-activating polypeptide (PACAP) alternative splicing variants and its receptors in the immune system of rainbow trout (Oncorhyncus mykiss). Fish Shellfish Immunol. 2011 Feb;30(2):734-8 Реферат [он-лайн] [найдено 20.04.2015] (Найдено из Интернет: www.ncbi.nlm.nih.gov/pubmed/21168508). * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012303887A1 (en) | 2014-03-06 |
| WO2013029570A1 (es) | 2013-03-07 |
| MX2014002214A (es) | 2014-04-30 |
| RU2014111465A (ru) | 2015-10-10 |
| KR20140064847A (ko) | 2014-05-28 |
| BR112014004620A2 (pt) | 2017-03-21 |
| JP2014524450A (ja) | 2014-09-22 |
| BR112014004620B1 (pt) | 2019-10-29 |
| PH12014500397B1 (en) | 2018-09-12 |
| CN103874510A (zh) | 2014-06-18 |
| CU20110167A7 (es) | 2013-06-28 |
| NO2749291T3 (enExample) | 2018-03-17 |
| CA2844898C (en) | 2021-06-22 |
| MY191697A (en) | 2022-07-07 |
| PH12014500397A1 (en) | 2014-04-14 |
| KR101857705B1 (ko) | 2018-06-20 |
| CL2014000386A1 (es) | 2014-07-11 |
| EP2749291B1 (en) | 2017-10-18 |
| EP2749291A1 (en) | 2014-07-02 |
| ZA201401271B (en) | 2015-04-29 |
| JP6077541B2 (ja) | 2017-02-08 |
| US20140294889A1 (en) | 2014-10-02 |
| PT2749291T (pt) | 2017-11-24 |
| ES2648337T3 (es) | 2018-01-02 |
| CA2844898A1 (en) | 2013-03-07 |
| US9549977B2 (en) | 2017-01-24 |
| MX351725B (es) | 2017-10-25 |
| SG11201400215SA (en) | 2014-09-26 |
| AU2012303887B2 (en) | 2017-06-22 |
| CU24075B1 (es) | 2015-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Caipang et al. | Genetic vaccines protect red seabream, Pagrus major, upon challenge with red seabream iridovirus (RSIV) | |
| Lorenzen et al. | DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout | |
| Chang et al. | Adjuvant activity of fish type I interferon shown in a virus DNA vaccination model | |
| JP7696960B2 (ja) | レプリコン粒子および油性アジュバントによるワクチン接種 | |
| Zhang et al. | Th17-like immune response in fish mucosal tissues after administration of live attenuated Vibrio anguillarum via different vaccination routes | |
| Dadar et al. | Protective and immunogenic effects of Escherichia coli-expressed infectious pancreatic necrosis virus (IPNV) VP2-VP3 fusion protein in rainbow trout | |
| Tang et al. | Interleukin-2 (IL-2) of flounder (Paralichthys olivaceus) as immune adjuvant enhance the immune effects of E. tarda subunit vaccine OmpV against Edwardsiellosis | |
| EP2950816B1 (en) | The use of dna sequences encoding an interferon as vaccine adjuvants | |
| Kurniaji et al. | Maternal immunity response and larval growth of anti CYHV-3 DNA vaccinated common carp (Cyprinus carpio) at different pre-spawning time | |
| EP4382533A1 (en) | Protein nanopellets for fish or teleost and crustacean vaccination | |
| EP2749291B1 (en) | Use of pacap as a molecular adjuvant for vaccines | |
| Sepúlveda et al. | Time-course study of the protection induced by an interferon-inducible DNA vaccine against viral haemorrhagic septicaemia in rainbow trout | |
| Chen et al. | An oral nervous necrosis virus vaccine using Vibrio anguillarum as an expression host provides early protection | |
| JP2019512456A (ja) | Ｖｈｓｖワクチン及びアジュバントを含有するワクチン組成物 | |
| WO2007146359A2 (en) | Sea lice antigen vaccines | |
| Patel et al. | Vaccination against diseases caused by Betanodavirus | |
| Sivasankar et al. | Analysis of immune gene expression in seabass (Lates calcarifer) immunized with inactivated vaccine against similar damselfish virus. | |
| WO2013171548A2 (es) | Peptidos que inducen en peces una respuesta inmune contra copepodos y/o un escudo mucoso, vacunas, usos y métodos para modular la respuesta inmune de un pez y/o inducir la generación de un escudo mucoso | |
| JP5971625B2 (ja) | アジュバント、及び水産用ワクチン | |
| Evensen | Future fish vaccinology | |
| Sivakumar et al. | Concepts and Types of Vaccines | |
| Carrera et al. | Evaluating the adjuvant potential of NK-lysin and HMGB1-derived peptides in enhancing immune responses in Salmo salar | |
| SIVASANKAR | HOST IMMUNE RESPONSES TO RANAVIRUS INFECTION IN MARINE AND FRESHWATER FISHES | |
| KR20230101401A (ko) | 바이러스성출혈성패혈증 예방용 불활화 백신 조성물 및 이를 이용한 바이러스성출혈성패혈증의 예방방법 | |
| Drennan | DNA vaccines encoding the glycoprotein genes of spring viremia of carp virus, snakehead rhabdovirus, or infectious hematopoietic necrosis virus induce protective immunity in rainbow trout (Oncorhynchus mykiss) against an infectious hematopoietic necrosis virus lethal challenge |