RU2567660C2 - Bifidobacterium longum ATCC BAA-999 (BL999) И КОНТРОЛИРОВАНИЕ ВЕСА - Google Patents
Bifidobacterium longum ATCC BAA-999 (BL999) И КОНТРОЛИРОВАНИЕ ВЕСА Download PDFInfo
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- RU2567660C2 RU2567660C2 RU2012117804/10A RU2012117804A RU2567660C2 RU 2567660 C2 RU2567660 C2 RU 2567660C2 RU 2012117804/10 A RU2012117804/10 A RU 2012117804/10A RU 2012117804 A RU2012117804 A RU 2012117804A RU 2567660 C2 RU2567660 C2 RU 2567660C2
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| WO2011114916A1 (ja) * | 2010-03-18 | 2011-09-22 | 森永乳業株式会社 | 貧血の予防又は治療用組成物 |
| EP2452575A1 (en) * | 2010-11-15 | 2012-05-16 | Nestec S.A. | Array of age-tailored nutritional formula with probiotics |
| FI20116008A0 (fi) | 2011-10-12 | 2011-10-12 | Maeyrae Maekinen Annika | Viskeraalisen rasvan estäminen ja diagnostisointi |
| WO2014138304A1 (en) | 2013-03-08 | 2014-09-12 | Axiom Foods, Inc., | Rice protein supplements |
| US9820504B2 (en) | 2013-03-08 | 2017-11-21 | Axiom Foods, Inc. | Rice protein supplement and methods of use thereof |
| JP6234331B2 (ja) * | 2014-06-13 | 2017-11-22 | 森永乳業株式会社 | 統合失調症治療剤 |
| TWI572713B (zh) * | 2014-10-31 | 2017-03-01 | 豐華生物科技股份有限公司 | 抗肥胖之乳酸菌菌株及其於食品組成物以及醫藥組成物之應用 |
| JP6650728B2 (ja) * | 2015-03-06 | 2020-02-19 | 株式会社ファンケル | ダイエット用の製剤 |
| DK3386523T3 (da) * | 2015-12-11 | 2020-01-06 | Alimentary Health Ltd | Bifidobacterium longum til behandling af fedme og associerede metabolske sygdomme |
| JP6847577B2 (ja) * | 2015-12-28 | 2021-03-24 | 森永乳業株式会社 | ビフィドバクテリウム属細菌および／または乳酸菌の増殖促進および／または減少抑制剤 |
| CA3020389A1 (en) * | 2016-04-14 | 2017-10-19 | Dupont Nutrition Biosciences Aps | Bifidobacteria for increasing lean body mass |
| IT201600105831A1 (it) * | 2016-10-20 | 2018-04-20 | Probiotical Spa | Una composizione a base di un estratto di Irvingia gabonensis e ceppi di Bifidobatteri per la regolazione e riduzione del peso corporeo |
| KR101920219B1 (ko) * | 2017-03-08 | 2018-11-20 | 서울대학교산학협력단 | 비피더스균을 포함하는 비만 예방 또는 개선용 조성물 |
| WO2018209131A1 (en) | 2017-05-12 | 2018-11-15 | Axiom Foods, Inc. | Rice products and systems and methods for making thereof |
| CA3073615A1 (en) | 2017-08-25 | 2019-02-28 | University College Cork - National University Of Ireland Cork | Bifidobacterium longum for treating obesity and weight management |
| AU2017438436B2 (en) * | 2017-10-31 | 2022-01-13 | Morinaga Milk Industry Co., Ltd. | Muscle-building composition |
| US20200345051A1 (en) | 2017-11-24 | 2020-11-05 | University College Cork, National University Of Ireland, Cork | A composition comprising a cohort of bacteria |
| WO2019199094A1 (ko) * | 2018-04-11 | 2019-10-17 | 한국생명공학연구원 | 비만의 예방 또는 치료 효과를 가지는 신규 비피도박테리움 롱검 균주 또는 락토바실러스 람노서스 균주 및 이의 용도 |
| CN111187734A (zh) * | 2019-12-25 | 2020-05-22 | 生合生物科技（扬州）有限公司 | 长双歧杆菌bl986、由其制备的冻干粉及冻干粉的应用 |
| JP7475155B2 (ja) * | 2020-02-14 | 2024-04-26 | 森永乳業株式会社 | 持久力向上用組成物 |
| JP2023526287A (ja) * | 2020-05-20 | 2023-06-21 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | ビフィドバクテリウム・ロンガムの生存性及び代謝活性に対するイネ科及び／又はマメ科繊維の有益な効果 |
| EP4070670A1 (en) | 2021-04-08 | 2022-10-12 | University College Cork-National University of Ireland Cork | Lacticaseibacillus paracasei em025-11 and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1974734A1 (en) * | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics for reduction of risk of obesity |
| WO2009021824A1 (en) * | 2007-08-10 | 2009-02-19 | Nestec S.A. | Lactobacillus rhamnosus and weight control |
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| JPS61109729A (ja) * | 1984-11-05 | 1986-05-28 | Advance Res & Dev Co Ltd | コレステロ−ル低下剤 |
| JP2687229B2 (ja) * | 1988-11-11 | 1997-12-08 | 株式会社ヤクルト本社 | 血圧降下剤 |
| JP4280016B2 (ja) * | 2002-02-28 | 2009-06-17 | 雪印乳業株式会社 | 糖尿病合併症予防・改善・治療剤 |
| JP2003252771A (ja) * | 2002-03-04 | 2003-09-10 | Snow Brand Milk Prod Co Ltd | 加齢に伴う代謝異常疾患の予防・改善・治療剤 |
| SE529185C2 (sv) * | 2005-10-07 | 2007-05-22 | Arla Foods Amba | Användning av probiotiska bakterier för tillverkning av livsmedel eller läkemedel för förhindrande av övervikt |
| JP2007169200A (ja) * | 2005-12-21 | 2007-07-05 | Morinaga Milk Ind Co Ltd | インフルエンザ感染予防のための医薬及び飲食品 |
| MX2008009726A (es) * | 2006-01-27 | 2009-03-05 | Danisco | Uso de microorganismos probioticos para el tratamiento y prevencion de la obesidad y trastornos relacionados. |
| PT1986669E (pt) * | 2006-02-15 | 2012-05-15 | Nestec Sa | Utilização de bifidobacterium longum para a prevenção e tratamento de inflamação |
| AU2007242314B2 (en) * | 2006-03-31 | 2010-07-01 | Morinaga Milk Industry Co., Ltd. | Interleukin production regulator, pharmaceutical composition or food comprising the interleukin production regulator, and method for production of the interleukin production regulator |
| KR20080075971A (ko) * | 2007-02-14 | 2008-08-20 | (주)네오팜 | 프로바이오틱스 복합 제제 |
| UA31009U (uk) * | 2007-10-18 | 2008-03-25 | Одесская Национальная Академия Пищевых Технологий | Кисломолочний напій діабетичного призначення |
| UA30077U (uk) * | 2007-10-18 | 2008-02-11 | Одесская Национальная Академия Пищевых Технологий | Композиція для йогурту діабетичного призначення |
| JP2009143820A (ja) * | 2007-12-12 | 2009-07-02 | Tsujido Chemical Corp | 高尿酸血症の予防または改善剤 |
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2009
- 2009-09-30 EP EP09171866A patent/EP2308499A1/en not_active Withdrawn
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2010
- 2010-09-28 SG SG10201406169VA patent/SG10201406169VA/en unknown
- 2010-09-28 EP EP10760993A patent/EP2482829A1/en not_active Withdrawn
- 2010-09-28 PH PH1/2012/500569A patent/PH12012500569A1/en unknown
- 2010-09-28 MX MX2012003612A patent/MX2012003612A/es not_active Application Discontinuation
- 2010-09-28 JP JP2012531354A patent/JP5911424B2/ja not_active Ceased
- 2010-09-28 US US13/499,535 patent/US20120244125A1/en not_active Abandoned
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- 2010-09-28 IN IN2463DEN2012 patent/IN2012DN02463A/en unknown
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1974734A1 (en) * | 2007-03-28 | 2008-10-01 | Nestec S.A. | Probiotics for reduction of risk of obesity |
| WO2009021824A1 (en) * | 2007-08-10 | 2009-02-19 | Nestec S.A. | Lactobacillus rhamnosus and weight control |
Non-Patent Citations (1)
| Title |
|---|
| AMENTA M. ET AL. Diet and chronic constipation. Benefits of oral supplementation with symbiotic zir fos (Bifidobacterium longum W11 + FOS Actilight). // Acta Biomed. 2006 Dec;77(3):157-62.ШЕНДЕРОВ Б.А. Медицинская микробная экология и функциональное питание. Том II. Социально-экологические и клинические последствия дисбаланса микробной экологии человека и жиовтных. М.: Издательство Грантъ, 1998, с. 127-130 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012003612A (es) | 2012-04-19 |
| US20120244125A1 (en) | 2012-09-27 |
| JP5911424B2 (ja) | 2016-04-27 |
| BR112012007109A2 (pt) | 2016-07-05 |
| WO2011039176A1 (en) | 2011-04-07 |
| CL2012000809A1 (es) | 2012-07-13 |
| IN2012DN02463A (enExample) | 2015-05-22 |
| JP2013506631A (ja) | 2013-02-28 |
| CN102665737A (zh) | 2012-09-12 |
| EP2482829A1 (en) | 2012-08-08 |
| EP2308499A1 (en) | 2011-04-13 |
| PH12012500569A1 (en) | 2012-10-22 |
| AU2010303020A1 (en) | 2012-04-19 |
| SG10201406169VA (en) | 2014-11-27 |
| AR078485A1 (es) | 2011-11-09 |
| CA2775976A1 (en) | 2011-04-07 |
| AU2010303020B2 (en) | 2014-11-20 |
| RU2012117804A (ru) | 2013-11-20 |
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