RU2560677C2 - Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ - Google Patents

Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ Download PDF

Info

Publication number
RU2560677C2
RU2560677C2 RU2012130421/15A RU2012130421A RU2560677C2 RU 2560677 C2 RU2560677 C2 RU 2560677C2 RU 2012130421/15 A RU2012130421/15 A RU 2012130421/15A RU 2012130421 A RU2012130421 A RU 2012130421A RU 2560677 C2 RU2560677 C2 RU 2560677C2
Authority
RU
Russia
Prior art keywords
composition
weight
peg
esters
surfactant
Prior art date
Application number
RU2012130421/15A
Other languages
English (en)
Russian (ru)
Other versions
RU2012130421A (ru
Inventor
Карстен ПЕТЕРССОН
Original Assignee
Лео Фарма А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Лео Фарма А/С filed Critical Лео Фарма А/С
Publication of RU2012130421A publication Critical patent/RU2012130421A/ru
Application granted granted Critical
Publication of RU2560677C2 publication Critical patent/RU2560677C2/ru

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
RU2012130421/15A 2009-12-22 2010-12-22 Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ RU2560677C2 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK2009000265 2009-12-22
DKPCT/DK2009/000265 2009-12-22
US29310510P 2010-01-07 2010-01-07
US61/293,105 2010-01-07
PCT/DK2010/000182 WO2011076207A2 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Publications (2)

Publication Number Publication Date
RU2012130421A RU2012130421A (ru) 2014-01-27
RU2560677C2 true RU2560677C2 (ru) 2015-08-20

Family

ID=43618132

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2012130421/15A RU2560677C2 (ru) 2009-12-22 2010-12-22 Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ

Country Status (13)

Country Link
US (2) US20120322776A1 (cg-RX-API-DMAC7.html)
EP (1) EP2515865B1 (cg-RX-API-DMAC7.html)
JP (1) JP5873439B2 (cg-RX-API-DMAC7.html)
CN (1) CN102781425B (cg-RX-API-DMAC7.html)
AU (1) AU2010335654B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012015433B8 (cg-RX-API-DMAC7.html)
CA (1) CA2785251A1 (cg-RX-API-DMAC7.html)
IL (1) IL220514A (cg-RX-API-DMAC7.html)
MX (1) MX2012007229A (cg-RX-API-DMAC7.html)
NZ (1) NZ600999A (cg-RX-API-DMAC7.html)
RU (1) RU2560677C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011076207A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201204620B (cg-RX-API-DMAC7.html)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5570442B2 (ja) * 2011-01-24 2014-08-13 株式会社シャネル化粧品技術開発研究所 水中油型乳化組成物及びその製造方法
WO2014083099A1 (en) * 2012-11-30 2014-06-05 Leo Pharma A/S A method of inhibiting the expression of il-22 in activated t-cells
US9638703B2 (en) * 2013-12-19 2017-05-02 Universiteit Gent Quantification of glucocorticoids in fish scales as biomarkers for chronic stress
CN104666312B (zh) * 2015-02-12 2017-11-07 重庆华邦制药有限公司 含有卡泊三醇和二丙酸倍他米松的制剂
CN106265485A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种稳定性改善的卡泊三醇组合物
CN106265511A (zh) * 2016-08-22 2017-01-04 江苏知原药业有限公司 一种性能优异的卡泊三醇倍他米松自微乳制剂
CN106442841B (zh) * 2016-12-16 2018-09-14 上海景峰制药有限公司 一种药物中阳离子表面活性剂的分离检测方法
US11433090B2 (en) 2017-06-16 2022-09-06 The Doshisha mTOR-inhibitor-containing medicine for treating or preventing ophthalmic symptoms, disorders, or diseases, and application thereof
KR102678365B1 (ko) * 2018-03-20 2024-06-26 재단법인 경기도경제과학진흥원 콜레칼시페롤의 가용화 조성물 및 그 제조방법
EP3741378A1 (de) 2019-05-23 2020-11-25 Dimitrios Tsakouridis Zusammensetzung zur topischen behandlung und pflege der psoriatischen haut
CA3091554A1 (en) * 2020-08-28 2022-02-28 Triple Hair Inc. Formulations for reducing hair loss and/or increasing hair regrowth
JP2024163642A (ja) * 2023-05-12 2024-11-22 アピ株式会社 外用組成物
JP7633712B2 (ja) * 2023-05-12 2025-02-20 アピ株式会社 外用組成物
CN118304279B (zh) * 2024-03-27 2025-04-25 青岛双鲸药业股份有限公司 一种骨化三醇自微乳口溶膜及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1040832A1 (en) * 1997-12-09 2000-10-04 Chugai Seiyaku Kabushiki Kaisha Creams containing vitamin d 3? derivatives
RU2165413C2 (ru) * 1996-06-04 2001-04-20 Лео Фармасьютикал Продактс Лтд. А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аналоги витамина d, способ их получения, фармацевтическая композиция
WO2006138056A1 (en) * 2005-06-15 2006-12-28 Apollo Pharmaceutical, Inc. Pharmaceutical composition comprising a mahonia aquifolium extract for the treatment of psoriasis

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2753377B1 (fr) * 1996-09-19 1999-09-24 Rhone Merieux Nouvelle association parasiticide a base de 1-n-phenylpyra- zoles et de lactones macrocycliques endectocides
US5639724A (en) * 1984-07-24 1997-06-17 Sandoz Ltd. Cyclosporin galenic forms
JP2655190B2 (ja) * 1989-06-21 1997-09-17 エスエス製薬 株式会社 コルチコステロイド含有軟膏剤
NZ243703A (en) * 1991-07-26 1995-12-21 Smithkline Beecham Corp Pharmaceutically acceptable, stable, self-emulsifying w/o microemulsions containing a water-soluble therapeutic agent, microemulsions
US5766628A (en) * 1992-02-24 1998-06-16 Merz + Co. Gmbh & Co. Bath and shower composition having vesicle-forming properties and method for the production and use thereof
USRE39706E1 (en) 1993-01-15 2007-06-26 Leo Pharma A/S Crystalline form of a vitamin D analogue
EP0753311B1 (en) 1993-04-19 2002-09-04 Institute For Advanced Skin Research Inc. Microemulsion preparation containing a substance which is difficult to be absorbed
GB9405304D0 (en) 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
GB9602111D0 (en) * 1996-02-02 1996-04-03 Unilever Plc Personal care composition
US5989531A (en) * 1998-11-13 1999-11-23 Colgate-Palmolive Company Antiperspirant formulation for porous applicator
GB9903547D0 (en) * 1999-02-16 1999-04-07 Novartis Ag Organic compounds
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6582683B2 (en) * 2000-01-04 2003-06-24 Skinvisible Pharmaceuticals, Inc. Dermal barrier composition
WO2006120681A2 (en) * 2005-05-10 2006-11-16 Dermipsor Ltd. Compositions and methods for skin care
IL154888A0 (en) * 2000-10-27 2003-10-31 Leo Pharma As Topical composition containing at least one vitamin d or one vitamin d analogue and at least one corticosteroid
US7005557B2 (en) * 2001-07-03 2006-02-28 The Procter & Gamble Company Film-forming compositions for protecting skin from body fluids and articles made therefrom
IL164163A0 (en) * 2002-04-09 2005-12-18 Pharmacia Corp Process for preparing a finely self-emulsifiable pharmaceutical composition
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
EP1643967A1 (en) * 2003-06-17 2006-04-12 E.I. Dupont De Nemours And Company Modified soy proteins in personal care compositions
DE602004027504D1 (de) 2003-07-24 2010-07-15 Leo Pharma As Aminobenzophenonverbindungen
US8795693B2 (en) * 2003-08-04 2014-08-05 Foamix Ltd. Compositions with modulating agents
US20090105336A1 (en) * 2004-04-19 2009-04-23 Strategic Science & Technologies, Llc Beneficial Effects of Increasing Local Blood Flow
FR2871694B1 (fr) * 2004-06-17 2008-07-04 Galderma Sa Composition pharmaceutique comprenant un onguent oleagineux et deux principes actifs solubilises
CA2567683A1 (en) * 2004-06-17 2005-12-29 Galderma S.A. Composition in spray form comprising a combination of a corticoid and a vitamin d derivative in an oily phase
CA2590479A1 (en) 2004-12-13 2006-06-22 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
MX2007007747A (es) * 2004-12-23 2007-08-14 Unilever Nv Emulsiones agua-en-aceite para tratamiento de cabello.
FR2887150B1 (fr) * 2005-06-17 2007-08-03 Galderma Res & Dev Composition pharmaceutique comprenant un elastomere organopolysiloxane et un principe actif solubilise
US20070249055A1 (en) * 2006-04-24 2007-10-25 The Procter & Gamble Company Method of measuring lotion and additive ingredient transfer
US20080260655A1 (en) * 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
FR2909284B1 (fr) * 2006-11-30 2012-09-21 Galderma Sa Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien
US8148537B2 (en) 2006-12-22 2012-04-03 Leo Pharma A/S Substituted acetophenones useful as PDE4 inhibitors
MY150075A (en) 2007-02-28 2013-11-29 Leo Pharma As Novel phosphodiesterase inhibitors
EP1970049A1 (en) * 2007-03-15 2008-09-17 Drug Delivery Solutions Limited Polyaphron topical composition with vitamin D and corticosteroid
EP2146703A1 (en) 2007-04-19 2010-01-27 Leo Pharma A/S Src family kinase inhibitors
WO2008134512A1 (en) * 2007-04-25 2008-11-06 Cytochroma Inc. Oral controlled release compositions comprising vitamin d compound and waxy carrier
EP2146780A1 (en) 2007-05-11 2010-01-27 Sonneborn Inc. Petrolatums having silicone-like properties
US20080299156A1 (en) * 2007-06-01 2008-12-04 L'oreal Skin care compositions containing a high internal phase emulsion
HRP20160488T1 (hr) 2008-12-19 2016-06-17 Leo Pharma A/S Triazolopiridini kao inhibitori fosfodiesteraze za liječenje kožnih bolesti
WO2011000765A1 (en) * 2009-06-29 2011-01-06 Glaxo Group Limited New medical use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2165413C2 (ru) * 1996-06-04 2001-04-20 Лео Фармасьютикал Продактс Лтд. А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аналоги витамина d, способ их получения, фармацевтическая композиция
EP1040832A1 (en) * 1997-12-09 2000-10-04 Chugai Seiyaku Kabushiki Kaisha Creams containing vitamin d 3? derivatives
WO2006138056A1 (en) * 2005-06-15 2006-12-28 Apollo Pharmaceutical, Inc. Pharmaceutical composition comprising a mahonia aquifolium extract for the treatment of psoriasis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Большой Энциклопедический Словарь Медицинских терминов. Под ред. Э.Г.Улумбекова. М., ГЭОТАР-Медиа. 2002. с. 653. *

Also Published As

Publication number Publication date
CA2785251A1 (en) 2011-06-30
JP2013515018A (ja) 2013-05-02
CN102781425A (zh) 2012-11-14
WO2011076207A3 (en) 2012-03-01
WO2011076207A2 (en) 2011-06-30
NZ600999A (en) 2014-06-27
AU2010335654B2 (en) 2015-04-09
CN102781425B (zh) 2014-08-13
MX2012007229A (es) 2012-07-30
US20120322776A1 (en) 2012-12-20
US20160324875A1 (en) 2016-11-10
AU2010335654A1 (en) 2012-07-26
RU2012130421A (ru) 2014-01-27
HK1177899A1 (en) 2013-08-30
JP5873439B2 (ja) 2016-03-01
IL220514A (en) 2017-01-31
BR112012015433B1 (pt) 2019-04-24
ZA201204620B (en) 2013-09-25
EP2515865B1 (en) 2016-12-14
BR112012015433A2 (pt) 2016-03-15
EP2515865A2 (en) 2012-10-31
BR112012015433B8 (pt) 2020-03-03

Similar Documents

Publication Publication Date Title
RU2560677C2 (ru) Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ
RU2500387C1 (ru) Фармацевтическая композиция, содержащая аналог витамина d и смесь сорастворитель - поверхностно-активное вещество
RU2559084C2 (ru) Фармацевтическая композиция, включающая растворяющую смесь и производное или аналог витамина d
US20140322331A1 (en) Calcipotriol monohydrate nanocrystals
AU2012324032B2 (en) Gel compositions
US9254296B2 (en) Pharmaceutical composition comprising vitamin D analogue and cosolvent-surfactant mixture
HK1177899B (en) Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
HK1177695B (en) Pharmaceutical composition comprising vitamin d analogue and cosolvent-surfactant mixture
HK1177696B (en) Pharmaceutical composition comprising solvent mixture and a vitamin d derivative or analogue