WO2011076207A3 - Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants - Google Patents

Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants Download PDF

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Publication number
WO2011076207A3
WO2011076207A3 PCT/DK2010/000182 DK2010000182W WO2011076207A3 WO 2011076207 A3 WO2011076207 A3 WO 2011076207A3 DK 2010000182 W DK2010000182 W DK 2010000182W WO 2011076207 A3 WO2011076207 A3 WO 2011076207A3
Authority
WO
WIPO (PCT)
Prior art keywords
analogue
vitamin
solvent
mixture
surfactants
Prior art date
Application number
PCT/DK2010/000182
Other languages
French (fr)
Other versions
WO2011076207A2 (en
Inventor
Karsten Petersson
Original Assignee
Leo Pharma A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2785251A priority Critical patent/CA2785251A1/en
Priority to EP10803218.6A priority patent/EP2515865B1/en
Application filed by Leo Pharma A/S filed Critical Leo Pharma A/S
Priority to US13/518,320 priority patent/US20120322776A1/en
Priority to NZ600999A priority patent/NZ600999A/en
Priority to AU2010335654A priority patent/AU2010335654B2/en
Priority to CN201080063418.7A priority patent/CN102781425B/en
Priority to BR112012015433A priority patent/BR112012015433B8/en
Priority to RU2012130421/15A priority patent/RU2560677C2/en
Priority to MX2012007229A priority patent/MX2012007229A/en
Priority to JP2012545090A priority patent/JP5873439B2/en
Publication of WO2011076207A2 publication Critical patent/WO2011076207A2/en
Publication of WO2011076207A3 publication Critical patent/WO2011076207A3/en
Priority to IL220514A priority patent/IL220514A/en
Priority to ZA2012/04620A priority patent/ZA201204620B/en
Priority to HK13105669.4A priority patent/HK1177899A1/en
Priority to US15/214,216 priority patent/US20160324875A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

A pharmaceutical composition comprising a vitamin D derivative or analogue as the active ingredient dissolved in a three-component surfactant-solvent mixture is useful in the treatment of dermal disorders or conditions.
PCT/DK2010/000182 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants WO2011076207A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
MX2012007229A MX2012007229A (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants.
RU2012130421/15A RU2560677C2 (en) 2009-12-22 2010-12-22 Skin composition, including vitamin d analogue and mixture of solvent and surface-active substances
US13/518,320 US20120322776A1 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
EP10803218.6A EP2515865B1 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
AU2010335654A AU2010335654B2 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin D analogue and a mixture of solvent and surfactants
CN201080063418.7A CN102781425B (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
JP2012545090A JP5873439B2 (en) 2009-12-22 2010-12-22 Skin composition comprising a vitamin D analog and a mixture of solvent and surfactant
CA2785251A CA2785251A1 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
NZ600999A NZ600999A (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
BR112012015433A BR112012015433B8 (en) 2009-12-22 2010-12-22 substantially anhydrous pharmaceutical composition for cutaneous application
IL220514A IL220514A (en) 2009-12-22 2012-06-19 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
ZA2012/04620A ZA201204620B (en) 2009-12-22 2012-06-21 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
HK13105669.4A HK1177899A1 (en) 2009-12-22 2013-05-13 Cutaneous composition comprising vitamin analogue and a mixture of solvent and surfactants
US15/214,216 US20160324875A1 (en) 2009-12-22 2016-07-19 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DK2009000265 2009-12-22
DKPCT/DK2009/000265 2009-12-22
US29310510P 2010-01-07 2010-01-07
US61/293,105 2010-01-07

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/518,320 A-371-Of-International US20120322776A1 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants
US15/214,216 Division US20160324875A1 (en) 2009-12-22 2016-07-19 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Publications (2)

Publication Number Publication Date
WO2011076207A2 WO2011076207A2 (en) 2011-06-30
WO2011076207A3 true WO2011076207A3 (en) 2012-03-01

Family

ID=43618132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2010/000182 WO2011076207A2 (en) 2009-12-22 2010-12-22 Cutaneous composition comprising vitamin d analogue and a mixture of solvent and surfactants

Country Status (14)

Country Link
US (2) US20120322776A1 (en)
EP (1) EP2515865B1 (en)
JP (1) JP5873439B2 (en)
CN (1) CN102781425B (en)
AU (1) AU2010335654B2 (en)
BR (1) BR112012015433B8 (en)
CA (1) CA2785251A1 (en)
HK (1) HK1177899A1 (en)
IL (1) IL220514A (en)
MX (1) MX2012007229A (en)
NZ (1) NZ600999A (en)
RU (1) RU2560677C2 (en)
WO (1) WO2011076207A2 (en)
ZA (1) ZA201204620B (en)

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JP5570442B2 (en) * 2011-01-24 2014-08-13 株式会社シャネル化粧品技術開発研究所 Oil-in-water emulsion composition and method for producing the same
JP6367819B2 (en) * 2012-11-30 2018-08-01 レオ ファーマ アクティーゼルスカブ Method for inhibiting IL-22 expression in activated T cells
WO2015091591A1 (en) * 2013-12-19 2015-06-25 Universiteit Gent Quantification of glucocorticoids in fish scales as biomarkers for chronic stress
CN104666312B (en) * 2015-02-12 2017-11-07 重庆华邦制药有限公司 Preparation containing Calcipotriol and dipropium dipropionate
CN106265511A (en) * 2016-08-22 2017-01-04 江苏知原药业有限公司 A kind of calcipotriol betamethasone self-micro emulsion formulation of excellent performance
CN106265485A (en) * 2016-08-22 2017-01-04 江苏知原药业有限公司 A kind of calcipotriol compositions of improved stability
CN106442841B (en) * 2016-12-16 2018-09-14 上海景峰制药有限公司 The method for separating and detecting of cationic surfactant in a kind of drug
CN110944668A (en) 2017-06-16 2020-03-31 学校法人同志社 Medicament comprising an mTOR inhibitor for treating or preventing ocular symptoms, disorders or diseases and uses thereof
EP3741378A1 (en) 2019-05-23 2020-11-25 Dimitrios Tsakouridis Topical composition for the treatment and care of psoriatic skin

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WO2008065316A2 (en) * 2006-11-30 2008-06-05 Galderma S.A. Ointment compositions comprising a vitamin d derivative

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Also Published As

Publication number Publication date
US20160324875A1 (en) 2016-11-10
HK1177899A1 (en) 2013-08-30
RU2012130421A (en) 2014-01-27
WO2011076207A2 (en) 2011-06-30
ZA201204620B (en) 2013-09-25
CN102781425B (en) 2014-08-13
NZ600999A (en) 2014-06-27
AU2010335654A1 (en) 2012-07-26
RU2560677C2 (en) 2015-08-20
EP2515865B1 (en) 2016-12-14
MX2012007229A (en) 2012-07-30
JP2013515018A (en) 2013-05-02
IL220514A (en) 2017-01-31
BR112012015433B8 (en) 2020-03-03
CA2785251A1 (en) 2011-06-30
EP2515865A2 (en) 2012-10-31
JP5873439B2 (en) 2016-03-01
BR112012015433B1 (en) 2019-04-24
CN102781425A (en) 2012-11-14
AU2010335654B2 (en) 2015-04-09
US20120322776A1 (en) 2012-12-20
BR112012015433A2 (en) 2016-03-15

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