RU2542582C2 - Производные бензимидазола, полезные при лечении состояний, ассоциированных с активностью р2х3 или р2х2/3 - Google Patents

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Publication number

RU2542582C2

RU2542582C2 RU2012124268/04A RU2012124268A RU2542582C2 RU 2542582 C2 RU2542582 C2 RU 2542582C2 RU 2012124268/04 A RU2012124268/04 A RU 2012124268/04A RU 2012124268 A RU2012124268 A RU 2012124268A RU 2542582 C2 RU2542582 C2 RU 2542582C2

Authority

RU

Russia

Prior art keywords

compound

formula

salt

animal

methyl

Prior art date

2009-11-18

Links

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• 230000000694 effects Effects 0.000 title claims abstract description 25
• 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
• 125000003785 benzimidazolyl group Chemical class N1=C(NC2=C1C=CC=C2)* 0.000 title 1
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• 238000000034 method Methods 0.000 claims abstract description 52
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• 239000003814 drug Substances 0.000 claims abstract description 24
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• 101710189970 P2X purinoceptor 3 Proteins 0.000 claims abstract description 21
• 150000003839 salts Chemical class 0.000 claims description 124
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• 208000035475 disorder Diseases 0.000 claims description 35
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• 230000036407 pain Effects 0.000 claims description 10
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• 241000124008 Mammalia Species 0.000 claims description 6
• 208000026723 Urinary tract disease Diseases 0.000 claims description 6
• 208000014001 urinary system disease Diseases 0.000 claims description 6
• 206010020853 Hypertonic bladder Diseases 0.000 claims description 3
• 208000009722 Overactive Urinary Bladder Diseases 0.000 claims description 3
• 208000020629 overactive bladder Diseases 0.000 claims description 3
• 239000000126 substance Substances 0.000 abstract description 8
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• -1 (2- (2,6-difluoro-4- (methylcarbamoyl) phenyl) -5-methyl-1H-benzo [d] imidazol-1-yl ) methyl Chemical group 0.000 description 39
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 25
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