RU2538683C2 - КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR - Google Patents

КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR Download PDF

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RU2538683C2
RU2538683C2 RU2011121508/15A RU2011121508A RU2538683C2 RU 2538683 C2 RU2538683 C2 RU 2538683C2 RU 2011121508/15 A RU2011121508/15 A RU 2011121508/15A RU 2011121508 A RU2011121508 A RU 2011121508A RU 2538683 C2 RU2538683 C2 RU 2538683C2
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cancer
rapamycin
dependent
mtor
target
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ГАРСИЯ-ЭЧЕВЕРРИЯ Карлос
МАИРА Совё-Мишель
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Новартис Аг
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    • A61K31/53751,4-Oxazines, e.g. morpholine
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RU2011121508/15A 2008-10-31 2009-10-29 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR RU2538683C2 (ru)

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Application Number Priority Date Filing Date Title
EP08168044.9 2008-10-31
EP08168044 2008-10-31
PCT/EP2009/064274 WO2010049481A1 (en) 2008-10-31 2009-10-29 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

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RU2014115188/15A Division RU2014115188A (ru) 2008-10-31 2014-04-15 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR

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RU2538683C2 true RU2538683C2 (ru) 2015-01-10

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RU2011121508/15A RU2538683C2 (ru) 2008-10-31 2009-10-29 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR
RU2014115188/15A RU2014115188A (ru) 2008-10-31 2014-04-15 КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR

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Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100048524A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
US8476282B2 (en) * 2008-11-03 2013-07-02 Intellikine Llc Benzoxazole kinase inhibitors and methods of use
PT2365802T (pt) 2008-11-11 2017-11-14 Univ Texas Microcápsulas de rapamicina e utilização para o tratamento de cancro
WO2010091306A1 (en) 2009-02-05 2010-08-12 Tokai Pharmaceuticals Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
US9283211B1 (en) 2009-11-11 2016-03-15 Rapamycin Holdings, Llc Oral rapamycin preparation and use for stomatitis
GB2478556A (en) * 2010-03-09 2011-09-14 Myrovlytis Technology Ventures Ltd A composition for use in the treatment of Birt-Hogg-Dubô sydrome
EP2675450B1 (en) * 2011-02-16 2016-02-10 Novartis AG Combinations of therapeutic agents for use in the treatment of neurodegenerative diseases
JP6130305B2 (ja) 2011-02-23 2017-05-17 インテリカイン, エルエルシー キナーゼ阻害剤の組み合わせおよびそれらの使用
US9127074B2 (en) * 2011-03-07 2015-09-08 Fondazione Telethon TFEB variants and uses thereof
US20140066474A1 (en) * 2011-04-25 2014-03-06 Novartis Ag Combination of phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
ES2618489T3 (es) 2011-05-04 2017-06-21 Intellikine, Llc Composiciones farmacéuticas combinadas y usos de las mismas
AU2012313888B2 (en) 2011-09-27 2016-03-31 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant IDH
CN106924741A (zh) * 2011-11-08 2017-07-07 因特利凯有限责任公司 使用多种药剂的治疗方案
US20130209543A1 (en) * 2011-11-23 2013-08-15 Intellikine Llc Enhanced treatment regimens using mtor inhibitors
UY34632A (es) * 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
RU2012112128A (ru) * 2012-03-29 2013-10-10 Холин Максим Николаевич ИНГИБИТОРЫ СИГНАЛЬНОГО ПУТИ PI3K/AKT/IKK/NF-kB, ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
WO2014160328A1 (en) 2013-03-13 2014-10-02 The Board Of Regents Of The University Of Texas System Mtor inhibitors for prevention of intestinal polyp growth
EP2968370A4 (en) 2013-03-14 2016-09-21 Univ Maryland AGENT FOR ANDROGEN RECEPTOR DOWNWARD CONTROL AND USES THEREOF
KR20150131224A (ko) 2013-03-14 2015-11-24 노파르티스 아게 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온
RU2015143437A (ru) 2013-03-15 2017-04-27 Дженентек, Инк. Способы лечения рака и предотвращения устойчивости к лекарственным препаратам для лечения рака
PE20161063A1 (es) 2013-05-01 2016-10-22 Hoffmann La Roche Compuestos de biheteroarilo y usos de los mismos
EP3033088A4 (en) 2013-08-12 2017-03-08 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
AU2014373683B2 (en) 2013-12-31 2020-05-07 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
WO2016168658A1 (en) 2015-04-15 2016-10-20 University Of Massachusetts Compositions and methods for xi chromosome reactivation
EP3297629A1 (en) 2015-05-20 2018-03-28 Novartis AG Pharmaceutical combination of everolimus with dactolisib
BR112019010470A2 (pt) 2016-11-23 2019-09-10 Novartis Ag métodos de realce de resposta imune com everolimo, dactolisib ou ambos
US10596165B2 (en) 2018-02-12 2020-03-24 resTORbio, Inc. Combination therapies
KR20210158019A (ko) 2020-06-23 2021-12-30 주식회사 온코빅스 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물
CN112294967A (zh) * 2020-09-30 2021-02-02 四川大学 一种mTOR抑制剂与抗癌药物的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2282461C2 (ru) * 2000-06-26 2006-08-27 Стрессджен Байотекнолоджиз Корпорейшн Лечение инфекции, вызываемой вирусом папилломы человека

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101039952A (zh) * 2004-10-13 2007-09-19 惠氏公司 作为pi3k抑制剂的17-羟基渥曼青霉素类似物
WO2007010012A2 (en) * 2005-07-20 2007-01-25 Novartis Ag Combination of a pyrimidylaminobenzamide and an mtor kinase inhibitor
KR101464384B1 (ko) * 2005-11-22 2014-11-21 쿠도스 파마슈티칼스 리미티드 mTOR 억제제로서 피리도피리미딘, 피라조피리미딘 및피리미도피리미딘 유도체
JO2660B1 (en) * 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
US7659274B2 (en) * 2006-01-25 2010-02-09 Osi Pharmaceuticals, Inc. Unsaturated mTOR inhibitors
WO2007120897A2 (en) * 2006-04-13 2007-10-25 The Trustees Of Columbia University In The City Of New York Compositions and intraluminal devices for inhibiting vascular stenosis
AU2008213808B2 (en) * 2007-02-06 2011-11-10 Novartis Ag PI 3-kinase inhibitors and methods of their use
RU2478387C2 (ru) * 2007-02-20 2013-04-10 Новартис Аг ИМИДАЗОХИНОЛИНЫ В КАЧЕСТВЕ ДВОЙНЫХ ИНГИБИТОРОВ ЛИПИДКИНАЗЫ И mTOR
CN101896177A (zh) * 2007-12-13 2010-11-24 诺瓦提斯公司 用于治疗癌症的治疗剂的组合

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2282461C2 (ru) * 2000-06-26 2006-08-27 Стрессджен Байотекнолоджиз Корпорейшн Лечение инфекции, вызываемой вирусом папилломы человека

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CHEN CY et al. [Effects of mTOR inhibitor rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Feb;36(2):156-60. Реферат [он-лайн] [найдено 2013-09-11] (Найдено из базы данных PubMed PMID: 19099956 ). *
KU 0063794 (CID 16736987) Create date 2007-09-27 Реферат [он-лайн] [найдено 2013-09-09] (Найдено из Интернет: www.pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16736987) *

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JP2017002058A (ja) 2017-01-05
CN102202668A (zh) 2011-09-28
RU2014115188A (ru) 2015-10-20
JP2018197243A (ja) 2018-12-13
WO2010049481A1 (en) 2010-05-06
CN105030784A (zh) 2015-11-11
US20180133226A1 (en) 2018-05-17
EP2349275A1 (en) 2011-08-03
JP2012506898A (ja) 2012-03-22
JP2015013883A (ja) 2015-01-22
AU2009309616A1 (en) 2010-05-06
RU2011121508A (ru) 2012-12-10
ES2627677T3 (es) 2017-07-31
AU2009309616B2 (en) 2014-02-13
AU2009309616A2 (en) 2011-07-07
CA2736361C (en) 2017-10-10
BRPI0921802A8 (pt) 2018-03-13
US20160136175A1 (en) 2016-05-19
EP2349275B1 (en) 2017-03-08
KR20110090911A (ko) 2011-08-10
CA2736361A1 (en) 2010-05-06
BRPI0921802A2 (pt) 2016-09-27
US20110195966A1 (en) 2011-08-11
MX2011004585A (es) 2011-06-01

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