RU2538683C2 - КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR - Google Patents
КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR Download PDFInfo
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- RU2538683C2 RU2538683C2 RU2011121508/15A RU2011121508A RU2538683C2 RU 2538683 C2 RU2538683 C2 RU 2538683C2 RU 2011121508/15 A RU2011121508/15 A RU 2011121508/15A RU 2011121508 A RU2011121508 A RU 2011121508A RU 2538683 C2 RU2538683 C2 RU 2538683C2
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- cancer
- rapamycin
- dependent
- mtor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- Rheumatology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08168044.9 | 2008-10-31 | ||
| EP08168044 | 2008-10-31 | ||
| PCT/EP2009/064274 WO2010049481A1 (en) | 2008-10-31 | 2009-10-29 | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115188/15A Division RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2011121508A RU2011121508A (ru) | 2012-12-10 |
| RU2538683C2 true RU2538683C2 (ru) | 2015-01-10 |
Family
ID=40332588
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2011121508/15A RU2538683C2 (ru) | 2008-10-31 | 2009-10-29 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ (Р13К) И ИНГИБИТОРА mTOR |
| RU2014115188/15A RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014115188/15A RU2014115188A (ru) | 2008-10-31 | 2014-04-15 | КОМБИНАЦИЯ ИНГИБИТОРА ФОСФАТИДИЛИНОЗИТОЛ-3-КИНАЗЫ(PI3K) И ИНГИБИТОРА mTOR |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US20110195966A1 (enExample) |
| EP (1) | EP2349275B1 (enExample) |
| JP (4) | JP2012506898A (enExample) |
| KR (1) | KR20110090911A (enExample) |
| CN (2) | CN102202668A (enExample) |
| AU (1) | AU2009309616B2 (enExample) |
| BR (1) | BRPI0921802A8 (enExample) |
| CA (1) | CA2736361C (enExample) |
| ES (1) | ES2627677T3 (enExample) |
| MX (1) | MX2011004585A (enExample) |
| RU (2) | RU2538683C2 (enExample) |
| WO (1) | WO2010049481A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100048524A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| US20120064143A1 (en) | 2008-11-11 | 2012-03-15 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
| CN102686600A (zh) | 2009-02-05 | 2012-09-19 | 托凯药业股份有限公司 | 甾体cyp17抑制剂/抗雄激素物质的新型药物前体 |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| GB2478556A (en) * | 2010-03-09 | 2011-09-14 | Myrovlytis Technology Ventures Ltd | A composition for use in the treatment of Birt-Hogg-Dubô sydrome |
| EP2675450B1 (en) * | 2011-02-16 | 2016-02-10 | Novartis AG | Combinations of therapeutic agents for use in the treatment of neurodegenerative diseases |
| JP6130305B2 (ja) * | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| JP2014513925A (ja) * | 2011-03-07 | 2014-06-19 | フォンダッツィオーネ・テレソン | Tfeb変異体およびその使用 |
| BR112013027486A2 (pt) * | 2011-04-25 | 2017-02-14 | Novartis Ag | combinação de um inibidor de fosfatidilinositol-3-cinase (pi3k) e um inibidor de mtor |
| WO2012151562A1 (en) | 2011-05-04 | 2012-11-08 | Intellikine, Llc | Combination pharmaceutical compositions and uses thereof |
| MX342326B (es) | 2011-09-27 | 2016-09-26 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
| US20140377285A1 (en) * | 2011-11-08 | 2014-12-25 | Intellikine, Llc | Treatment regimens using multiple pharmaceutical agents |
| CA2856803A1 (en) | 2011-11-23 | 2013-05-30 | Intellikine, Llc | Enhanced treatment regimens using mtor inhibitors |
| UY34632A (es) * | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| RU2012112128A (ru) * | 2012-03-29 | 2013-10-10 | Холин Максим Николаевич | ИНГИБИТОРЫ СИГНАЛЬНОГО ПУТИ PI3K/AKT/IKK/NF-kB, ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| US20160030401A1 (en) | 2013-03-13 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of intestinal polyp growth and cancer |
| CA2904170A1 (en) | 2013-03-14 | 2014-09-25 | University Of Maryland, Baltimore | Androgen receptor down-regulating agents and uses thereof |
| PE20151939A1 (es) | 2013-03-14 | 2016-01-08 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidores de idh mutante |
| EP2968537A1 (en) | 2013-03-15 | 2016-01-20 | Genentech, Inc. | Methods of treating cancer and preventing cancer drug resistance |
| MA42164B1 (fr) | 2013-05-01 | 2019-12-31 | Hoffmann La Roche | Composes biheteroaryle et leurs utilisations |
| JP2016528252A (ja) | 2013-08-12 | 2016-09-15 | トーカイ ファーマシューティカルズ, インコーポレイテッド | アンドロゲン標的治療を使用する新生物障害の処置のためのバイオマーカー |
| CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
| DK3089737T3 (da) | 2013-12-31 | 2021-12-13 | Rapamycin Holdings Llc | Orale rapamycin-nanopartikelpræparater og anvendelse. |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| WO2016168658A1 (en) * | 2015-04-15 | 2016-10-20 | University Of Massachusetts | Compositions and methods for xi chromosome reactivation |
| EP3297629A1 (en) | 2015-05-20 | 2018-03-28 | Novartis AG | Pharmaceutical combination of everolimus with dactolisib |
| BR112019010470A2 (pt) | 2016-11-23 | 2019-09-10 | Novartis Ag | métodos de realce de resposta imune com everolimo, dactolisib ou ambos |
| US10596165B2 (en) | 2018-02-12 | 2020-03-24 | resTORbio, Inc. | Combination therapies |
| KR20210158019A (ko) | 2020-06-23 | 2021-12-30 | 주식회사 온코빅스 | 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| CN112294967A (zh) * | 2020-09-30 | 2021-02-02 | 四川大学 | 一种mTOR抑制剂与抗癌药物的用途 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2282461C2 (ru) * | 2000-06-26 | 2006-08-27 | Стрессджен Байотекнолоджиз Корпорейшн | Лечение инфекции, вызываемой вирусом папилломы человека |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7666901B2 (en) * | 2004-10-13 | 2010-02-23 | Wyeth | Analogs of 17-hydroxywortmannin as PI3K inhibitors |
| KR20080041206A (ko) * | 2005-07-20 | 2008-05-09 | 노파르티스 아게 | 피리미딜아미노벤즈아미드와 mtor 키나제 억제제의조합물 |
| HRP20120963T1 (hr) * | 2005-11-22 | 2012-12-31 | Kudos Pharmaceuticals Ltd | PIRIDO-, PIRAZO- I PIRIMIDOPIRIMIDINSKI DERIVATI KAO mTOR INHIBITORI |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| WO2007087395A2 (en) * | 2006-01-25 | 2007-08-02 | Osi Pharmaceuticals, Inc. | UNSATURATED mTOR INHIBITORS |
| EP2012794B1 (en) * | 2006-04-13 | 2014-09-17 | The Trustees of Columbia University in the City of New York | Compositions and intraluminal devices for inhibiting vascular stenosis |
| KR20090108124A (ko) * | 2007-02-06 | 2009-10-14 | 노파르티스 아게 | Pi 3-키나제 억제제 및 그의 사용 방법 |
| US9370508B2 (en) * | 2007-02-20 | 2016-06-21 | Novartis Ag | Imidazoquinolines as dual lipid kinase and mTOR inhibitors |
| JP2011506455A (ja) * | 2007-12-13 | 2011-03-03 | ノバルティス アーゲー | 癌を処置するための治療薬の組み合わせ剤 |
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2009
- 2009-10-29 RU RU2011121508/15A patent/RU2538683C2/ru not_active IP Right Cessation
- 2009-10-29 AU AU2009309616A patent/AU2009309616B2/en not_active Ceased
- 2009-10-29 CN CN2009801431736A patent/CN102202668A/zh active Pending
- 2009-10-29 WO PCT/EP2009/064274 patent/WO2010049481A1/en not_active Ceased
- 2009-10-29 EP EP09744391.5A patent/EP2349275B1/en not_active Not-in-force
- 2009-10-29 BR BRPI0921802A patent/BRPI0921802A8/pt not_active IP Right Cessation
- 2009-10-29 US US13/123,956 patent/US20110195966A1/en not_active Abandoned
- 2009-10-29 ES ES09744391.5T patent/ES2627677T3/es active Active
- 2009-10-29 CN CN201510402018.9A patent/CN105030784A/zh active Pending
- 2009-10-29 CA CA2736361A patent/CA2736361C/en not_active Expired - Fee Related
- 2009-10-29 KR KR1020117009771A patent/KR20110090911A/ko not_active Ceased
- 2009-10-29 JP JP2011533721A patent/JP2012506898A/ja not_active Withdrawn
- 2009-10-29 MX MX2011004585A patent/MX2011004585A/es active IP Right Grant
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2014
- 2014-04-15 RU RU2014115188/15A patent/RU2014115188A/ru not_active Application Discontinuation
- 2014-09-05 JP JP2014181069A patent/JP2015013883A/ja not_active Withdrawn
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2015
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2016
- 2016-07-06 JP JP2016134514A patent/JP2017002058A/ja not_active Ceased
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2018
- 2018-01-16 US US15/872,043 patent/US20180133226A1/en not_active Abandoned
- 2018-07-20 JP JP2018136756A patent/JP2018197243A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2282461C2 (ru) * | 2000-06-26 | 2006-08-27 | Стрессджен Байотекнолоджиз Корпорейшн | Лечение инфекции, вызываемой вирусом папилломы человека |
Non-Patent Citations (2)
| Title |
|---|
| CHEN CY et al. [Effects of mTOR inhibitor rapamycin on Smad 3 protein and collagen type I expression in rat myocardial fibroblasts infected with coxsackie virus B 3]. Zhonghua Xin Xue Guan Bing Za Zhi. 2008 Feb;36(2):156-60. Реферат [он-лайн] [найдено 2013-09-11] (Найдено из базы данных PubMed PMID: 19099956 ). * |
| KU 0063794 (CID 16736987) Create date 2007-09-27 Реферат [он-лайн] [найдено 2013-09-09] (Найдено из Интернет: www.pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=16736987) * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2014115188A (ru) | 2015-10-20 |
| JP2017002058A (ja) | 2017-01-05 |
| RU2011121508A (ru) | 2012-12-10 |
| AU2009309616B2 (en) | 2014-02-13 |
| AU2009309616A1 (en) | 2010-05-06 |
| CA2736361C (en) | 2017-10-10 |
| EP2349275A1 (en) | 2011-08-03 |
| JP2018197243A (ja) | 2018-12-13 |
| BRPI0921802A2 (pt) | 2016-09-27 |
| WO2010049481A1 (en) | 2010-05-06 |
| BRPI0921802A8 (pt) | 2018-03-13 |
| JP2012506898A (ja) | 2012-03-22 |
| US20110195966A1 (en) | 2011-08-11 |
| CN102202668A (zh) | 2011-09-28 |
| US20160136175A1 (en) | 2016-05-19 |
| US20180133226A1 (en) | 2018-05-17 |
| CA2736361A1 (en) | 2010-05-06 |
| ES2627677T3 (es) | 2017-07-31 |
| AU2009309616A2 (en) | 2011-07-07 |
| JP2015013883A (ja) | 2015-01-22 |
| CN105030784A (zh) | 2015-11-11 |
| KR20110090911A (ko) | 2011-08-10 |
| MX2011004585A (es) | 2011-06-01 |
| EP2349275B1 (en) | 2017-03-08 |
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Legal Events
| Date | Code | Title | Description |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20191030 |