CA2736361C - Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor - Google Patents
Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor Download PDFInfo
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- CA2736361C CA2736361C CA2736361A CA2736361A CA2736361C CA 2736361 C CA2736361 C CA 2736361C CA 2736361 A CA2736361 A CA 2736361A CA 2736361 A CA2736361 A CA 2736361A CA 2736361 C CA2736361 C CA 2736361C
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- treatment
- pharmaceutically acceptable
- acceptable salt
- mtor
- combination
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| US20100048913A1 (en) | 2008-03-14 | 2010-02-25 | Angela Brodie | Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity |
| US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| CN102292078A (zh) | 2008-11-11 | 2011-12-21 | 得克萨斯大学体系董事会 | 哺乳动物雷帕霉素靶蛋白的抑制 |
| EP2393827B1 (en) | 2009-02-05 | 2015-10-07 | Tokai Pharmaceuticals, Inc. | Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| GB2478556A (en) * | 2010-03-09 | 2011-09-14 | Myrovlytis Technology Ventures Ltd | A composition for use in the treatment of Birt-Hogg-Dubô sydrome |
| CN103391780B (zh) * | 2011-02-16 | 2015-08-19 | 诺瓦提斯公司 | 用于治疗神经变性疾病的治疗剂的组合物 |
| TWI592411B (zh) | 2011-02-23 | 2017-07-21 | 英特爾立秦有限責任公司 | 激酶抑制劑之組合及其用途 |
| US9127074B2 (en) * | 2011-03-07 | 2015-09-08 | Fondazione Telethon | TFEB variants and uses thereof |
| PH12013502077A1 (en) * | 2011-04-25 | 2013-12-16 | Novartis Ag | Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor |
| US20140357651A1 (en) * | 2011-05-04 | 2014-12-04 | Yi Liu | Combination pharmaceutical compositions and uses thereof |
| KR20140069235A (ko) | 2011-09-27 | 2014-06-09 | 노파르티스 아게 | 돌연변이체 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| EP2776441A4 (en) * | 2011-11-08 | 2015-04-08 | Intellikine Llc | TREATMENT METHOD WITH MULTIPLE PHARMACEUTICAL AGENTS |
| US20130209543A1 (en) * | 2011-11-23 | 2013-08-15 | Intellikine Llc | Enhanced treatment regimens using mtor inhibitors |
| UY34632A (es) | 2012-02-24 | 2013-05-31 | Novartis Ag | Compuestos de oxazolidin- 2- ona y usos de los mismos |
| RU2012112128A (ru) * | 2012-03-29 | 2013-10-10 | Холин Максим Николаевич | ИНГИБИТОРЫ СИГНАЛЬНОГО ПУТИ PI3K/AKT/IKK/NF-kB, ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ |
| US9296733B2 (en) | 2012-11-12 | 2016-03-29 | Novartis Ag | Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases |
| DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
| SG11201507093WA (en) | 2013-03-14 | 2015-10-29 | Univ Maryland Baltimore Office Of Technology Transfer | Androgen receptor down-regulating agents and uses thereof |
| KR20150131224A (ko) | 2013-03-14 | 2015-11-24 | 노파르티스 아게 | 돌연변이 idh의 억제제로서의 3-피리미딘-4-일-옥사졸리딘-2-온 |
| KR20150130451A (ko) | 2013-03-15 | 2015-11-23 | 제넨테크, 인크. | 암 치료 방법 및 항암제 내성 예방을 위한 방법 |
| EA038235B1 (ru) * | 2013-05-01 | 2021-07-28 | Ф.Хоффманн-Ля Рош Аг | Бигетероарильные соединения и их применения |
| SG11201600525XA (en) | 2013-08-12 | 2016-02-26 | Tokai Pharmaceuticals Inc | Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies |
| CN103483345B (zh) * | 2013-09-25 | 2016-07-06 | 中山大学 | Pi3k激酶抑制剂、包含其的药物组合物及其应用 |
| CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CA3019311A1 (en) | 2015-04-15 | 2016-10-20 | University Of Massachusetts | Compositions and methods for xi chromosome reactivation |
| EP3297629A1 (en) | 2015-05-20 | 2018-03-28 | Novartis AG | Pharmaceutical combination of everolimus with dactolisib |
| AU2017363970A1 (en) | 2016-11-23 | 2019-06-20 | Novartis Ag | Methods of enhancing immune response with everolimus, dactolisib or both |
| WO2019157516A1 (en) | 2018-02-12 | 2019-08-15 | resTORbio, Inc. | Combination therapies |
| KR20210158019A (ko) | 2020-06-23 | 2021-12-30 | 주식회사 온코빅스 | 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물 |
| CN112294967A (zh) * | 2020-09-30 | 2021-02-02 | 四川大学 | 一种mTOR抑制剂与抗癌药物的用途 |
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| AR051388A1 (es) * | 2004-10-13 | 2007-01-10 | Wyeth Corp | Analogos de 17-hidroxiwortmanina como inhibidores de pi3k |
| KR20130087058A (ko) * | 2005-07-20 | 2013-08-05 | 노파르티스 아게 | 피리미딜아미노벤즈아미드와 ｍｔｏｒ 키나제 억제제의 조합물 |
| EP1954699B1 (en) * | 2005-11-22 | 2012-09-19 | Kudos Pharmaceuticals Ltd | PYRIDO-, PYRAZO- AND PYRIMIDOPYRIMIDINE DERIVATIVES AS mTOR INHIBITORS |
| JO2660B1 (en) * | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| US7659274B2 (en) * | 2006-01-25 | 2010-02-09 | Osi Pharmaceuticals, Inc. | Unsaturated mTOR inhibitors |
| EP2012794B1 (en) * | 2006-04-13 | 2014-09-17 | The Trustees of Columbia University in the City of New York | Compositions and intraluminal devices for inhibiting vascular stenosis |
| EP2118087B1 (en) * | 2007-02-06 | 2012-03-28 | Novartis AG | Pi 3-kinase inhibitors and methods of their use |
| KR101472607B1 (ko) * | 2007-02-20 | 2014-12-15 | 노파르티스 아게 | 지질 키나제 및 ｍＴＯＲ의 이중 억제제로서의 이미다조퀴놀린 |
| US20100272717A1 (en) * | 2007-12-13 | 2010-10-28 | Novartis Ag | Combinations of therapeutic agents for treating cancer |
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2009
- 2009-10-29 ES ES09744391.5T patent/ES2627677T3/es active Active
- 2009-10-29 AU AU2009309616A patent/AU2009309616B2/en not_active Ceased
- 2009-10-29 US US13/123,956 patent/US20110195966A1/en not_active Abandoned
- 2009-10-29 CA CA2736361A patent/CA2736361C/en not_active Expired - Fee Related
- 2009-10-29 WO PCT/EP2009/064274 patent/WO2010049481A1/en not_active Ceased
- 2009-10-29 EP EP09744391.5A patent/EP2349275B1/en not_active Not-in-force
- 2009-10-29 BR BRPI0921802A patent/BRPI0921802A8/pt not_active IP Right Cessation
- 2009-10-29 CN CN201510402018.9A patent/CN105030784A/zh active Pending
- 2009-10-29 CN CN2009801431736A patent/CN102202668A/zh active Pending
- 2009-10-29 RU RU2011121508/15A patent/RU2538683C2/ru not_active IP Right Cessation
- 2009-10-29 KR KR1020117009771A patent/KR20110090911A/ko not_active Ceased
- 2009-10-29 JP JP2011533721A patent/JP2012506898A/ja not_active Withdrawn
- 2009-10-29 MX MX2011004585A patent/MX2011004585A/es active IP Right Grant
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2014
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- 2014-09-05 JP JP2014181069A patent/JP2015013883A/ja not_active Withdrawn
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2015
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2016
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2018
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- 2018-07-20 JP JP2018136756A patent/JP2018197243A/ja active Pending
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| Publication number | Publication date |
|---|---|
| MX2011004585A (es) | 2011-06-01 |
| AU2009309616B2 (en) | 2014-02-13 |
| CA2736361A1 (en) | 2010-05-06 |
| US20110195966A1 (en) | 2011-08-11 |
| AU2009309616A2 (en) | 2011-07-07 |
| RU2538683C2 (ru) | 2015-01-10 |
| BRPI0921802A2 (pt) | 2016-09-27 |
| JP2012506898A (ja) | 2012-03-22 |
| KR20110090911A (ko) | 2011-08-10 |
| JP2018197243A (ja) | 2018-12-13 |
| US20160136175A1 (en) | 2016-05-19 |
| EP2349275B1 (en) | 2017-03-08 |
| JP2015013883A (ja) | 2015-01-22 |
| EP2349275A1 (en) | 2011-08-03 |
| WO2010049481A1 (en) | 2010-05-06 |
| CN102202668A (zh) | 2011-09-28 |
| AU2009309616A1 (en) | 2010-05-06 |
| ES2627677T3 (es) | 2017-07-31 |
| RU2014115188A (ru) | 2015-10-20 |
| US20180133226A1 (en) | 2018-05-17 |
| CN105030784A (zh) | 2015-11-11 |
| BRPI0921802A8 (pt) | 2018-03-13 |
| JP2017002058A (ja) | 2017-01-05 |
| RU2011121508A (ru) | 2012-12-10 |
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