JP2012506898A - ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 - Google Patents

ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 Download PDF

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JP2012506898A
JP2012506898A JP2011533721A JP2011533721A JP2012506898A JP 2012506898 A JP2012506898 A JP 2012506898A JP 2011533721 A JP2011533721 A JP 2011533721A JP 2011533721 A JP2011533721 A JP 2011533721A JP 2012506898 A JP2012506898 A JP 2012506898A
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ガルシア−エチェベリア，カルロス
マイラ，サウバー−ミシェル
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ノバルティス アーゲー
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011533721A 2008-10-31 2009-10-29 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤 Withdrawn JP2012506898A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08168044.9 2008-10-31
EP08168044 2008-10-31
PCT/EP2009/064274 WO2010049481A1 (en) 2008-10-31 2009-10-29 Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor

Related Child Applications (1)

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JP2014181069A Division JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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JP2012506898A true JP2012506898A (ja) 2012-03-22
JP2012506898A5 JP2012506898A5 (enExample) 2012-12-06

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JP2011533721A Withdrawn JP2012506898A (ja) 2008-10-31 2009-10-29 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2014181069A Withdrawn JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2016134514A Ceased JP2017002058A (ja) 2008-10-31 2016-07-06 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2018136756A Pending JP2018197243A (ja) 2008-10-31 2018-07-20 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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JP2014181069A Withdrawn JP2015013883A (ja) 2008-10-31 2014-09-05 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2016134514A Ceased JP2017002058A (ja) 2008-10-31 2016-07-06 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤
JP2018136756A Pending JP2018197243A (ja) 2008-10-31 2018-07-20 ホスファチジルイノシトール−３−キナーゼ（ＰＩ３Ｋ）阻害剤とｍＴＯＲ阻害剤との併用剤

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US (3) US20110195966A1 (enExample)
EP (1) EP2349275B1 (enExample)
JP (4) JP2012506898A (enExample)
KR (1) KR20110090911A (enExample)
CN (2) CN105030784A (enExample)
AU (1) AU2009309616B2 (enExample)
BR (1) BRPI0921802A8 (enExample)
CA (1) CA2736361C (enExample)
ES (1) ES2627677T3 (enExample)
MX (1) MX2011004585A (enExample)
RU (2) RU2538683C2 (enExample)
WO (1) WO2010049481A1 (enExample)

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JP2016518383A (ja) * 2013-05-01 2016-06-23 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ビヘテロアリール化合物及びその使用

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US8476431B2 (en) * 2008-11-03 2013-07-02 Itellikine LLC Benzoxazole kinase inhibitors and methods of use
CA2937492C (en) 2008-11-11 2019-08-13 The Board Of Regents Of The University Of Texas System Inhibition of mammalian target of rapamycin
EP2393827B1 (en) 2009-02-05 2015-10-07 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal cyp17 inhibitors/antiandrogens
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CN103391780B (zh) * 2011-02-16 2015-08-19 诺瓦提斯公司 用于治疗神经变性疾病的治疗剂的组合物
TWI592411B (zh) * 2011-02-23 2017-07-21 英特爾立秦有限責任公司 激酶抑制劑之組合及其用途
KR20130131461A (ko) * 2011-03-07 2013-12-03 폰다지오네 텔레톤 Tfeb 변종 및 그의 용도
WO2012148846A1 (en) * 2011-04-25 2012-11-01 Novartis Ag Combination of a phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
JP6047149B2 (ja) * 2011-05-04 2016-12-21 インテリカイン， エルエルシー 併用の医薬組成物およびその使用
MX342326B (es) 2011-09-27 2016-09-26 Novartis Ag 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante.
CN104080786A (zh) * 2011-11-08 2014-10-01 因特利凯有限责任公司 使用多种药剂的治疗方案
US9174994B2 (en) 2011-11-23 2015-11-03 Intellikine, Llc Enhanced treatment regimens using mTor inhibitors
UY34632A (es) * 2012-02-24 2013-05-31 Novartis Ag Compuestos de oxazolidin- 2- ona y usos de los mismos
RU2012112128A (ru) * 2012-03-29 2013-10-10 Холин Максим Николаевич ИНГИБИТОРЫ СИГНАЛЬНОГО ПУТИ PI3K/AKT/IKK/NF-kB, ИХ ФАРМАЦЕВТИЧЕСКИ ПРИЕМЛЕМЫЕ СОЛИ И СОДЕРЖАЩИЕ ИХ КОМПОЗИЦИИ ДЛЯ ПРОФИЛАКТИКИ И ЛЕЧЕНИЯ ВИРУСНЫХ ЗАБОЛЕВАНИЙ
US9296733B2 (en) 2012-11-12 2016-03-29 Novartis Ag Oxazolidin-2-one-pyrimidine derivative and use thereof for the treatment of conditions, diseases and disorders dependent upon PI3 kinases
US20160030401A1 (en) 2013-03-13 2016-02-04 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of intestinal polyp growth and cancer
CA2904170A1 (en) 2013-03-14 2014-09-25 University Of Maryland, Baltimore Androgen receptor down-regulating agents and uses thereof
CA2903979A1 (en) 2013-03-14 2014-09-18 Novartis Ag 3-pyrimidin-4-yl-oxazolidin-2-ones as inhibitors of mutant idh
HK1214533A1 (zh) 2013-03-15 2016-07-29 基因泰克公司 治疗癌症和预防癌症耐药性的方法
KR20160058774A (ko) 2013-08-12 2016-05-25 토카이 파마슈티컬, 아이엔씨. 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커
CN103483345B (zh) * 2013-09-25 2016-07-06 中山大学 Pi3k激酶抑制剂、包含其的药物组合物及其应用
US9700544B2 (en) 2013-12-31 2017-07-11 Neal K Vail Oral rapamycin nanoparticle preparations
EP3283127B1 (en) * 2015-04-15 2020-02-26 University of Massachusetts Compositions and methods for xi chromosome reactivation
US10576076B2 (en) 2015-05-20 2020-03-03 Novartis Ag Pharmaceutical combination of everolimus with dactolisib
JP2020500930A (ja) 2016-11-23 2020-01-16 ノバルティス アーゲー エベロリムス、ダクトリシブまたは両方で免疫応答を増強する方法
WO2019157516A1 (en) 2018-02-12 2019-08-15 resTORbio, Inc. Combination therapies
KR20210158019A (ko) 2020-06-23 2021-12-30 주식회사 온코빅스 포스파티딜이노시톨 3-키나제(pi3k) 억제제로써 pten 과오종 증후군에 의한 종양 세포의 성장 또는 증식을 억제하는데 유용한 신규한 피리미딘 유도체 및 이의 약제학적으로 허용가능한 염, 및 이를 유효성분으로 함유하는 약제학적 조성물
CN112294967A (zh) * 2020-09-30 2021-02-02 四川大学 一种mTOR抑制剂与抗癌药物的用途

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AU2009309616A2 (en) 2011-07-07
RU2538683C2 (ru) 2015-01-10
CA2736361C (en) 2017-10-10
WO2010049481A1 (en) 2010-05-06
EP2349275A1 (en) 2011-08-03
MX2011004585A (es) 2011-06-01
AU2009309616A1 (en) 2010-05-06
JP2017002058A (ja) 2017-01-05
ES2627677T3 (es) 2017-07-31
BRPI0921802A8 (pt) 2018-03-13
RU2014115188A (ru) 2015-10-20
AU2009309616B2 (en) 2014-02-13
JP2015013883A (ja) 2015-01-22
US20160136175A1 (en) 2016-05-19
CA2736361A1 (en) 2010-05-06
KR20110090911A (ko) 2011-08-10
US20110195966A1 (en) 2011-08-11
US20180133226A1 (en) 2018-05-17
BRPI0921802A2 (pt) 2016-09-27
RU2011121508A (ru) 2012-12-10
CN102202668A (zh) 2011-09-28
EP2349275B1 (en) 2017-03-08

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